Biology Of Disease - fccljohnson

sixcageyMécanique

22 févr. 2014 (il y a 3 années et 3 mois)

71 vue(s)

ARTHRITIS

Rheumatoid Arthritis

Presented By:


Ali
Raza

Ansar


Qudsia

Sehar



Hafsa

Kabir


Introduction


Joint disorder that cause inflammation


Over 100 types of Arthritis


Most Common is Rheumatoid Arthritis and
osteoarthritis, both are autoimmune diseases.


Symptoms



Inability to use the

hand

or

walk



Malaise

and a feeling of tiredness


Weight loss


Poor

sleep


Muscle aches

and pains


Tenderness


Difficulty moving the joint


Biology Of Rheumatoid Arthritis

1.
Genetic Basis of RA:


HLA genes:
HLA
-
DR1 and DR4 are
associated with disease


PDAI:
Peptidyl

arginine
deaminase

gene


PTN22 gene:
Regulates kinases

2.
Autoantibodies:


Rh factor:
Antibody, binds to the Fc region
of
IgG
.



ACPA:
Anti
-
citrullinated

protein antibody,
MHC class
-
II, specially bearing “shared
epitope” bind efficiently with
citrullinated

proteins. An immune response is triggered
producing ACPA.

3.
Inflammation and bone deformity:


Different cytokines are involved


IL
-
1, IL
-
6 and TNF
α

are important


Normal bone remodeling


Osteoblasts


Osteoclasts


NF
-
κ
B plays significant role in RA
pathogenesi


Role of estrogen



Diagnosis of Arthritis


Diagnostic

Tools


1.
Physical Examination


2.
Laboratory Tests



3.
Medical Imaging

Laboratory Tests



Rheumatoid factor


Erythrocyte sedimentation Rate


C
-
reactive protein


Anti
-
cylic

citullinated

Peptide Antibody Test


Antinuclear Antibodies


Compete blood count


Treatment


Drug treatment


Occupational/physical therapy


Surgery


Biologics

Drug Treatment


Pain killers


NSAID’S (non
-
steroidal
anti inflammatory
drug)


Cox
-
2 inhibitors


Gold injections




Physical therapy



Surgery


Performed when patients are non
-
responsive
for treatment

Biotechnological

Applications
in
Treatment


Biologics


Use specifically for rheumatoid arthritis


Target specific


Act only on immune system


Anti
-

t.f

is an example


Current Research Projects



DEVELOPMENT
OF ANTISENSE
THERAPY OF
ARTHRITIS



DEVELOPMENT
OF A BIOMARKER FOR
RA



Development of Antisense Therapy
of Arthritis




Developed by BGN technologies




Target cPLA
-
2



Inhibits
the synthesis of
c
-
PLA 2
ENZYME

Development of a Biomarker For
RA




RA
biomarker based on 14
-
3
-

protein



It is
an
intracellular
protein



S
uffering
from RA it is involved in joints
deformation and is released inside joints

QUESTIONS