Angelita B. Frando, MD

kayakjokeMécanique

22 févr. 2014 (il y a 3 années et 6 mois)

70 vue(s)

Angelita B. Frando, MD

Board Certified in Family Medicine

Board Certified , Medical Acupuncture





Definition:


complex biological response to harmful stimuli
(pathogens, damaged cells or irritants)


Protective attempt to remove the injurious stimuli and
initiate the healing process


Important for survival


Causes wounds and infections to heal (acute)


Chronic = progressive destruction of tissue =>disease
and degenerative changes



Manifestations (Signs):


Calor (Heat)


Rubor (Redness)


Tumore (Swelling)


Dolor (Pain)


Functio laesa (loss of function)

Causes:


Burns


Chemical irritants


Frostbite


Toxins


Infection by pathogens


Physical injury, blunt or penetrating


Immune reactions due to hypersensitivity


Ionizing radiation


Foreign bodies (
ie
., splinters, dirt and debris)


Stress


Trauma


Alcohol




Types: Acute & Chronic


Names Based on body systems / organs involved: ( “
-
itis
”)


Appendicitis


Arthritis


Bursitis


Colitis


Cystitis


Dermatitis


Myositis


Meningitis


Tendonitis


Tonsillitis


Vasculitis





Acute
vs

Chronic

Causative agent:


Bacteria, injured tissues




Immediate onset


Duration: Few days


Outcome:


Resolution, abscess, or
chronic inflammation


Persistent acute
inflammation, viruses,
persistent foreign bodies,
autoimmune reactions


Delayed Onset


Up to many months or years


Outcome:


Tissue destruction, fibrosis,
necrosis

Process of Acute Inflammation:


Injury/pathogen => cells activated to release
inflammatory mediators:


Vasodilatation => Increased blood flow => redness and
heat


Increased blood vessel permeability => leakage of
plasma proteins and fluid into tissues (swelling)


Some mediators increase sensitivity to pain



Other biochemical reactions occur (complement
system, coagulation and
fibrinolysis

systems, etc.)

Cell derived mediators:


Lysosome

granules


Histamine


Interferon (cytokines)


IL
-
8 (Interleukin 8)


Leukotriene

B4


Nitric oxide


Prostaglandins


TNF
-
alphaand

IL
-
1

Inflammatory Markers:


CRP (C
-
reactive protein)


Increased levels associated with increased risk of heart
attacks, strokes, high blood pressure, muscle weakness
and fragility


ESR (erythrocyte sedimentation rate)


Homocysteine

levels


Tumor necrosis factor

alpha (TNF
-
@)


Interleukin 6, 8, 18 (IL
-
6, IL
-
8, IL18)


Blood glucose, insulin and
leptin

(especially for obese)

Disorders associated with Inflammation:


Acne
vulgaris


Allergies


Asthma


Atherosclerosis


Autoimmune disease


Cancer


Celiac disease


Chronic
prostatitis


Degenerative arthritis,


Hypersensitivities


Interstitial cystitis


Inflammatory bowel / Digestive tract
disordes

(Pancreatitis,
Crohn’s

disease, Regional enteritis,
Enteropathies
, Hepatitis, etc.)


Kidney diseases (Diabetic Nephropathy,
Glomerulonephritis
, etc)


Myopathies


Obesity


Osteoporosis


Pelvic inflammatory disease


Reperfusion injury


Rheumatoid arthritis , Lupus, and other connective tissue disorders


Skin: Psoriasis, Dermatitis


Sarcoidosis


Transplant rejection


Vasculitis




Medications
vs

Inflammation


Aspirin


Works on prostaglandins


Watch for gastrointestinal ulcers and bleeding


NSAIDS


May cause gastric/duodenal ulcers


May damage kidneys with prolonged use


Cox
-
2 inhibitors


Steroids:


Problems with prolonged use


Weight gain, metabolic syndrome, gastric ulcers, blunts
adrenal function, etc.



Supplements
vs

Inflammation


Arthritis:


OPC3


Omega 3


Glucosatrin

(
Boswellia

with Cox
-
2 inhibition)




Supplements
vs

Inflammation


Acne
vulgaris
:


Prevaderm


Digestive enzymes

Supplements
vs

Inflammation


Asthma/ Allergies:


OPC3


Aloe


ORAC

Supplements
vs

Inflammation


Atherosclerosis


OPC3


Heart Health


Omega 3


Activated Vitamin B


Resveratrol

Supplements
vs

Inflammation


Autoimmune diseases:


OPC3


Omega 3


Resveratrol

(do not give with Coumadin or breast
cancer)


Co
-
Q
-
10


Vitamin B


Multivitamins/Minerals

Supplements
vs

Inflammation


Cancer


During remissions


Breast Cancer


B complex


Vitamin D3


Calcium


CoQ
-
10


OPC3


Multivitamins/
multiminerals

Supplements
vs

Inflammation


Cancer


During remissions (not during treatment)


Colon Cancer


Resveratrol


Fiber powder


B complex


CoQ
-
10


OPC3


Multivitamins/
multiminerals

Supplements
vs

Inflammation


Celiac disease


Digestive enzymes


Aloe


Supplements
vs

Inflammation


Degenerative arthritis:


Omega 3


OPC3


Glucosatrin

Supplements
vs

Inflammation


Inflammatory GI/bowel disorders, etc.


Crohn’s

disease


OPC3, Digestive enzymes, Aloe


Irritable Bowel Syndrome


OPC3, Aloe, Digestive
enzymes


Diverticulitis


(after bowel rest and antibiotics) Aloe,
Digestive enzymes, fiber powder (for
diverticulosis
),
OPC3


Pancreatitis


Digestive enzymes


Gastric / Duodenal Ulcer


Aloe, Digestive enzymes


Hepatitis


Digestive enzymes,
Hepatocleanse

Supplements
vs

Inflammation


Kidney disease due to diabetes:


OPC3



Interstitial cystitis


OPC3

Supplements
vs

Inflammation


Osteoporosis:


Calcium plus


Vitamin D3 with K2 (IF Vitamin D deficient)


D3 levels should be optimally placed at around 40
-
60
nmol
/l


Monitor blood levels to avoid toxicity



Supplements
vs

Inflammation


OBESITY:



Associated with chronic inflammation


Waist circumference correlates to inflammatory response



OPC3


Resveratrol


Omega 3


Transitions

Supplements
vs

Inflammation



Reperfusion Injury (Heart and Brain):


Post
-

Myocardial infarction and Post
-
Stroke


OPC3


Resveratrol


Omega 3



Psoriasis:


OPC3

Keep Inflammation in moderation