Slide 1 - Prof. Palpu Pushpangadan

whipmellificiumBiotechnology

Feb 20, 2013 (4 years and 3 months ago)

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R&D Activities

National Botanical Research
Institute, Lucknow



(Herbal Technology)

Dr. P. Pushpangadan

Director

National Botanical Research Institute,
Lucknow

National

Botanical

Research

Institute,

Lucknow

A

premier

plant

research

center

of

India

under

the

umbrella

of

CSIR

by

undertaking

both

basic

and

applied

research

in

various

aspects

of

plant

sciences

for

the

conservation

and

sustainable

utilization

of

plant

genetic

resources

for

human

welfare

and

sustainable
.


(Dr. P. Pushpangadan)

Management Council

Research Council

Economic Botany
Information Service

Information Liaison and
Common Facilities

Planning and
Coordination

Experimental
Research stations

House Keeping

Auxilliary

Natural Product
Development

Genetics & Plant Breeding
and Agrotechnology

Biomass Biology and
Environmental Sciences

Molecular Biology and
Genetic Engineering

Biotechnology and
Plant Physiology

Botanic garden and
Floriculture

Plant Biodiveristy and
Conservation Biology

Microbiology &

Plant Pathology

Mission

The

mission

of

the

National

Botanical

Research

Institute

is
:


To

act

as

a

premier

plant

research

centre

of

India

under

the

umbrella

of

CSIR

by

undertaking

both

basic

and

applied

research

in

various

aspects

of

plant

sciences

for

the

conservation

and

sustainable

utilization

of

plant

genetic

resources

for

human

welfare

and

sustainable

development
.

Vision


To

be

a

premier

national

and

international

centre

on

plant

science

research

and

development

in

the

areas

of

plant

biodiversity,

conservation

&

sustainable

utilization

of

non
-
crop

and

wild

Plant

Genetic

Resources

(PGR),

bioprospecting,

biofuels,

bioinformatics

and

plant

biotechnology
.


To

be

a

prime

catalyst

in

conversion

of

plant

wealth

into

economic

wealth

in

an

ecologically

sound

and

economically

rewarding

manner
.


To

develop

as

a

national

referral

centre

for

all

knowledgebase

related

to

plant

biodiversity
.

Mandate

To

undertake

both

basic

and

applied

research

on

plant

sciences

in

taxonomy

(including

biosystematics

and

molecular

taxonomy),

conservation

biology,

pharmacognosy,

ethnopharmacology,

biomass

biology,

environmental

sciences,

microbiology,

plant

biotechnology

(tissue

culture

and

molecular

biology

including

genetic

engineering),

plant

physiology,

Phytochemistry,

genetics

and

plant

breeding,

floriculture

and

bioinformatics

of

the

non
-
crop

and

wild

plant

genetic

resources

of

India
.

Biodiversity

research

by

inventorying,

monitoring,

assessment,

conservation

and

sustainable

utilization

of

plant

genetic

resources

of

India

with

special

focus

on

medicinal,

aromatic,

dye


Bioprospecting

for

search

of

commercially

valuable

genes,

biodynamic

compounds

and

development

of

scientifically

validated,

value
-
added

and

standardized

noval

plant

products
-
herbal

drugs,

pharmaceuticals,

nutraceuticals

and

cosmaceuticals
.


Biomass

biology

including

biopesticides,

biofuels

and

petroleum

alternatives

and

environmental

sciences

including

phytoremediation

and

abatment

of

terrestrial

and

aquatic

pollution

including

studies

on

greenhouse

gas

emission
.


MAJOR R & D PROGRAMMES

Biotechnology

(biotech

process/products)

including

trans
-
disciplinary

studies

on

molecular

biology

and

genetic

engineering

for

development

of

transgenic

plants
.


Genetics,

plant

breeding

and

agrotechnology

Selection

and

genetic

enhancement

for

development

of

new

promising

varieties

of

economically

important

non
-
crop

plants
.


Bioinformatics

by

developing

computerized/

electronic

databases

on

Indian

plants

with

special

focus

on

medicinal,

aromatic,

dyes,

gum

and

tannin

yielding

plants

and

products

and

applications

of

IT

in

plant

science

research
.

MAJOR R & D PROGRAMMES

Herbal products developed

by NBRI


Herbal fermented drink


Herbal Soft Drink


Herbal lipstick (Luvstik)


Herbal Gulal


Nutraceuticals products


Neem products


Organic cultivation using microbial
technology/ vermiculture etc.

Products in pipeline


Wound healing ointment


Anti
-
ulcer formulation


Anti
-
diarrhoreal syrup


Anti
-
oxidant formulation

Aims and objectives of

Pharmacognosy & Ethnopharmacology
Division



To

carry

out

detailed

pharmacognostic

studies

which

includes

correct

taxonomic

identification

of

plants

and

it

parts,

macro
-

and

microscopical

details

and

histochemical

analysis

of

the

plant

parts

used

as

medicine
.

The

SEM

studies

are

also

under

taken

for

the

identification/authentication

of

those

commercial

samples,

which

are

available

in

broken

or

small

pieces
.



To

develop

chemical

markers

for

the

identification,

quality

and

batch
-
to
-
batch

consistency

of

herbal

drugs

with

the

help

of

HPTLC,

HPLC,

GLC

&

DNA

finger

printings

etc
.

Contd..


To

develop

physico
-
chemical

standards

of

crude

as

well

as

finished

herbal

drugs/products
.



To

detect

the

microbial

contamination

including

the

detection

of

mycotoxins

in

herbal

drugs

(raw

as

well

as

finished)

in

accordance

with

the

latest

WHO

guidelines
.



To

estimate

concentration

of

heavy

metals

and

pesticide

residue

in

herbal

drugs

as

per

WHO

guidelines
.



A

small

animal

house

and

a

pharmacology

lab

has

also

been

established

to

cover

the

safety

aspects

or

toxicity

and

other

pharmacological

evaluation

of

herbal

products
.



Besides,

the

survey

work

for

collection

of

authentic

samples

i
.

e
.

resource

survey,

market

surveillance,

shelf
-
life

studies,

seasonal

and

ecological

variations,

effect

of


Shodhan

Sanskar


and

scientific

validation

of

ethnobotanical

claims

are

some

of

the

important

activities

of

the

group
.

The Current Innovation

Herbal slimming/ anti
obesity agent


Based

on

certain

traditional

leads

we

have

screened

a

large

number

of

medicinal

plants

and

identified

the

potential

ones
.

Further

screening

narrowed

down

to

the

most

promising

ones
.



These

were

then

subjected

to

detailed

chemical

and

pharmacological

standardization

including

the

various

ecotypes

of

the

species

selected
.

Contd…


Activity

guided

extraction(s)

and

their

various

combination

their

of

were

made

and

evaluated

pharmacologically
.


Various

combinations

were

made

with

the

help

of

the

best

Ayurveda

experts
.


The

final

formulation

(including

standardized

extracts)

was

made

by

a

team

of

scientists

drawn

from

Ayurveda,

Pharmacognosy,

Medicinal

chemistry,

Pharmacology

and

Pharmacy
.


Formulation


Contain

4

medicinal

plants
.


The

extracts

of

the

selected

plants

were

lyophilized

and

used

in

the

preparation

of

the

final

formulation
.


Chemical evaluation


Some

chemical

moieties/marker

compounds

present

in

the

chosen

plants

were

identified
.


Chemo/

fingerprint

profiling

of

the

extracts

were

done

using

modern

sophisticated

techniques

like

HPTLC/

HPLC
.


Profiling

of

the

final

product

was

also

recorded
.

Pharmacological evaluation

S D Rats (over weight) were used in
experimentation

Monitored:


Body weight profile

Biochemical estimations



Triglycerides


Cholestrol


Phosphilipids

Pharmacological findings


Over weight was significantly reverted
back.


Significant reduction in



PHOSPOLIPIDS and CHOLESTROL
TRIGLYCERIDE level

was maintained in
the treated groups.

Toxicological evaluation

Given orally does not shown any
gross abnormality or mortality in
acute toxicity studies


IPR

It is protected by
patenting in

US and PCT
.

Contact


Dr. P. Pushpangadan

Director

National Botanical Research Institute,


Rana Pratap Marg, Post Box 436


Lucknow
-
226 001 (U.P.) India


Ph.: 0522
-
2205848, 2205839


Fax: 0522
-
2205836, 2205839

email:
pushpangadan@satyam.net.in