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CLASS: P.G.I.D.C.


I

St. JOSEPH’S COLLEGE (AUTONOMOUS) TIRUCHIRAPPALLI


620 002

SEMESTER EXAMINATIONS


APRIL 2010

TIME: 3 Hrs.








MAXIMUM MARKS: 100

SEM

SET

PAPER CODE

TITLE OF THE PAPER

II

2009

08PBT2401

BASIC BIOINFORMAT
ICS


SECTION


A

Answer all the questions:







20 x 1 = 20

Choose the correct answer:

1.

_____ present in information resources enable users to easily navigate their browsers to related
resources.


a)

Hyperlinks

b)

File systems


c)

File transfer
protocol

d)

Uniform resource identifier

2.

National center for Biotechnology information is a part of


a)

NIH

b)

DDBJ


c)

EMBL

d)

None of the above

3.

_____ is a manually curated biological database of protein sequences.


a)

SWISS PROT

b)

EMBL


c)

DDBJ

d)

NCBI

4.

Which enzymes converts the single strand mRNA into double strand cDNA?


a)

Reverse Transcriptase

b)

RNA Polymerase


c)

DNA polymerase

d)

Both a & c

5.

In physical mapping, the genomic DNA is cut by a _____.


a)

Restriction enzyme

b)

M
echanical shearing


c)

DNA Polymerase

d)

None of the above


State True or False:

6.

Genome mapping is the creation of a genetic map assigning DNA fragments to chromosomes.

7.

Data’s available in dbEST is not curated.

8.

PROSITE is a database of DNA

sequences.

9.

SAKURA is a nucleotide sequence data submission system for DDBJ.

10.

Bioinformatics helps in the prediction of secondary structure of proteins.


Fill in the blanks:

11.

_____ is a string of characters used to identify a name or a resour
ce on the Internet.

12.

_____ submission of DNA sequences can be done for ESTs.

13.

BLOCKS utilized to find out the _____ sequence among DNA / proteins.

14.

_____ is a text


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Answer in one or two sentences:

16.

Define Internet.

17.

Critically comment on bulk submission of DNA / proteins.

18.

IDENTIFY database.

19.

Dotplot

20.

Human genome.


SECTION


B


Answer all the questions:








5 x 4 = 20

21.

a.

Write short notes on world wide web.


OR


b.

Give a short account on the applications of bioinformatics.

22.

a.

Il
lustrate the various divisions available in Genbank.


OR


b.

Discuss the importance of EMBL applications in bioinformatics.

23.

a.

Compare and contrast BLOCKS and IDENTIFY database.


OR


b.

Give a short account on the structure of PROSITE.

24.

a.

How the 5’ ESTs can be generated?


OR


b.

Define a) BLAST


b) FASTA

25.

a.

Discuss the applications of genome annotation.


OR


b.

How will you predict the secondary structure of proteins?



SECTION


C

Answer any FOUR questions:






4 x 1
5 = 60


26.

Explain the structural organization of computers.

27.

Describe the structure and entry of GenBank.

28.

Write brief notes on protein structural databases.

29.

How will you perform the phylogenetic analysis of an organism? Explain.

30.

Gi
ve a brief account on the comparative genomics between organisms.


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