BI7523 Biological Foundation For Bioinformatics, Credits: 3.00
Bioinformatics is relatively easy to master for a mathematician or a chemist. However
deep knowledge of biology is essential to be able not only to use bioinf
solving already assigned problems but to independently offer new challenging problems
and to interpret the results of bioinformatical tools work.
Biology is a vast and intensely expanding area of science nowadays. It is impossible to
ology in all details. Therefore it is necessary to have a universal guide and steady
landmarks in the field. This course is organized basing on the 'Chinese box' principle,
thus offering a fundamental overview of biology with the gateways to further levels
material complexity for those who wish to study particular issues deeper.
Information in modern biology is kept and updated in a large number of specific
databases. This course is oriented to practical familiarization with these resources.
An intensive review of those aspects of biochemistry, molecular biology and cell biology
necessary to begin research in bioinformatics and to enter graduate courses in biology.
The areas covered will include cell structure, DNA replication, t
protein synthesis, intracellular sorting, and protein functions, cellular signaling (i.e.
receptors), cell cycle, growth and death and also cells in their social context (cell
junction, and adhesion, histology, immune, and nervou
s systems). General used methods
are included into each subject. Supplementing the course with data
allow to expose the students to the common databases and tools that take advantage to
this repository of biochemical information.
The feedback system of the course is based on the three major sources of grades. They
results of your accomplishment of
the tasks attached to each of the 12 units;
the individual practical project;
and the final test.
The current task
s specifically reflect the material of the units they are attached to. The
results are assessed either as 0 pts (“
”), 1 pt (“+
”) or 2 pts (“+”). It is also possible to
get 3 pts (“++”) as a bonus. You have to collect 24 points as a total to accomplish t
course. This allows you to use a "++" to compensate for a "+/
An individual project represents a complex practical task and requires general
understanding of the material of the whole course. It will be given in several weeks
before the end of the
course leaving you enough time for the work. An additional 13
week spare of theoretical material and other tasks will also be given for this purpose. The
project will help you to integrate the knowledge and skills acquired in the course. The
from 0 to 100 points.
The final test sums up your theoretical knowledge acquired in the course. The grade
ranges from 0 to 100 points.
The course is based only on web
resources. They are indicated in the text of the course.
acknowledge Dr. V. Furalev for his help in selection of the material for untis 7 and 8.
I also thank A. Ivliev and N. Tolmacheva, students of the Department of Bioingeneering
and Bioinformatics, Moscow State University, for efficient reading
of the lecture
materials from the students' viewpoint and for helpful discussion.