Overview: Bioinformatics Core - Louisiana Biomedical Research ...

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Oct 2, 2013 (3 years and 6 months ago)

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Howard Aulick

Executive Director

June 7, 2003

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WV
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BRIN Principal Cores


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Administrative (AC)


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Bioinformatics (BC)


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Research Development (RDC)


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Training & Mentoring (TMC)

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Complementary Two Prong
Approach



Enhance biomedical research and
education in cellular and molecular
biology at the PUIs


Establish a targeted clinical research
focus in cardiovascular genetics
through the Appalachian
Cardiovascular Research Network
(ACoRN)

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Appalachian
Cardiovascular
Research Network

(ACoRN)

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ACoRN OVERALL GOALS

Scientific Goal
: Discover genes that
predispose to cardiovascular disease


Programmatic Goals
:


(1) develop a network approach to
dissection of complex human diseases


(2) provide training in genetic analysis


(3) provide access to human data and
samples to network investigators

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ACoRN TEAM

CLINICIANS at four rural clinics and three major
hospitals: Identify CV affecteds

RESEARCH NURSES: Patient recruitment and
data collection

DATABASE MANAGER: Centralized data
organization and sharing

GENETIC ANALYSTS: Map location of
susceptibility gene

MOLECULAR GENETICIST: Uses map data to
identify disease gene(s)

PHYSIOLOGISTS: Develop and test models of
disease progression

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ACoRN HIGHLIGHTS

PUI investigators and students play
key roles in the gene discovery
progress

Two faculty received training in
genetic analysis at the Duke
University Center for Human
Genetics

Three ongoing research projects


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ACoRN Research Projects

1.
GeneCard
: early onset
atherosclerosis


2.
OCARD
: modifier genes that
predispose to CV disease in obese
individuals


3.
Familial Combined
Hypercholesteremia

(FCH): elevated
triglycerides and cholesterol



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Administrative Core (AC)


Comprised of co
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PIs and Core
Directors (n=9)



Provide overall program development
and management



Biweekly conference calls, video
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conferences and day retreats



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Bioinformatics Core (BC)

Facilitate development of bioinformatics
literacy


Administer systems and software
packages (GCG/Wisconsin)


Support communications infra
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structure
and deploy secure data networks to
clinic sites

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BC Goal 1: Communications
Infrastructure


Evaluate data and video connectivity
to PUIs; identify and address
deficiencies as needed



Create and maintain web site
(http://www.wv
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email lists, etc.



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BC Goal 2: Systems and Software
Administration


Hire and train database
administrator




Assist TMC in bioinformatics
training

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BC Goal 3: Secure Data
Networks to Rural Clinics


Evaluate data and video connectivity
to PUIs; identify and address
deficiencies as needed



Deploy and support systems,
networks and security needs at
clinics to facilitate data collection,
clinical consultations and training

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Research Development Core (RDC)



Create a networked infrastructure for
development of cellular & molecular
biomedical research and education
at the PUIs



Develop Appalachian Cardiovascular
Research Network (ACoRN) to serve
as a research and training resource
for the PUIs


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RDC Program Support for PUIs



Equipment Grants



Pilot Research Grants



Faculty Development Awards

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RDC: Equipment Grants



Building research infrastructure
at the WV
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BRIN PUIs:



$866,044 requested



$360,167 awarded


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RDC: Pilot Research Grants


To support PUI investigator
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initiated
research projects:



Awarded $195,000 in Year 2:


6 grants @ $30,000


2 grants @ $ 8,000



Available for Year 3:
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$236,000


6 grants @ $ 30,000/yr


7 grants @ $ 8,000/yr


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RDC: Faculty Development Awards


2 new PUI faculty positions
were funded in 2003:


$50,000/yr salary + FB


$40,000 start
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up



Institutional commitments



One new faculty position
available in Year 3 for 2003
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4

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Training & Mentoring Core (TMC)


Increase interest and capacity for
biomedical science research among PUI
faculty and students



Establish summer research and training
opportunities with established
investigator mentors



Promote continued PUI development of
and focus on biomedical research


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TMC Goal 1: Increase PUI
interest and capacity for
biomedical research


Recruit mentors from among
established investigators at WVUHSC
and MUSOM


published directory
(n=50)



Conduct PUI visits to explain TMC
programs to faculty and students



Develop and distribute newsletter

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TMC Goal 2: Establish summer
research and training
opportunities for PUIs


Conduct summer research program



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8 PUI faculty & 16 students



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8
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9 weeks



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WVUHSC and MUSOM



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Research Day



Maintain communication with PUI summer
student interns and faculty fellows



Facilitate long
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term collaborations with
established investigators



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TMC Goal 3: Promote continued PUI
development of and focus on
biomedical research


Establish travel grant program to
encourage participation in local and
national meetings



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10 awards ($1,500 ea.)



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6 faculty & 4 students



Develop PUI speakers’ bureau
program in biomedical research


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Planned Future Developments


Support development of
bioinformatics degree programs (BS
and MS) at PUIs



Development of Academic Training
Centers to focus coordination of
program development



Increase role of PUI in program
management and development

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PROBLEMS AND SOLUTIONS


Shotgun marriage



State budget crisis


10 to 15% cuts in higher ed budgets


faculty and staff reductions


increased teaching loads



Wolf at the door



A different culture