book chapters - Carter-Bernan Consulting, LLC

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Feb 20, 2013 (4 years and 3 months ago)

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Valerie S. Bernan & Guy T. Carter


Recent Invited Lectures
:


1.

Carter GT. 2006. Pharmaceutical profiling in drug discovery, Natural Products
Discovery and Production: New Challenges; New Opportunities, Engineering
Conferences International, Santa Fe, NM,

June 5, 2006.

2.

Carter GT. 2006. Refocused efforts on natural products
-
based drug discovery:
Why the time is right, Award Symposium honoring Dr. George Ellestad, National
Medicinal Chemistry Symposium, Seattle, WA, June 28, 2006.

3.

Carter GT. 2006.
New Prod
ucts from “Old” Pathways: The Value of
Perseverance
.
.




2006 Society for Industrial Microbiology Annual Meeting,
Baltimore, MD, July 31, 2006.

4.

Carter GT.

2006. The Resurgence of Natural Product Drug Discovery:
Renaissance or Reformation? Realizing Natur
e’s Potential: The Once and
Future King of Drug Discovery. A Symposium Honoring the Lifetime
Achievements of Dr. Gordon Cragg of the National Cancer Institute. Hosted by
the William L. Brown Center for Plant Genetic Resources and the Missouri
Botanical
Garden. Nov. 11, 2006, St. Louis, MO.

5.

Carter GT. 2007. “The Evolution of Natural Product Drug Discovery”, plenary lecture,
Nordic Natural Products Conference, Zealand, Denmark, June 13, 2007.

6.

Carter GT. 2007. “ Pathways for Natural Products Drug Discover
y”, NIH
Chemistry Seminar Series, Bethesda, MD, Sept. 14, 2007.

7.

Carter, G.T. 2008. Pathways for Natural Product Drug Discovery, New York Academy of
Sciences Symposium “Rethinking Natural Products as a Source
for Drug Leads”, New
York, NY,
Jan. 22, 2008.

8.

Carter, G.T.
2008.

Rapamycin Analogs: New Chemistry/New Indications, Royal
Society of Chemistry Symposium “Drugs from Natural Products IV, Cambridge,
UK, April 7, 2008

9.

Carter, G. T.


Are
Natural Products Still a Viable Source for New Antimicrobial
Agents?


ICAAC/IDSA Symposium, Role of Medicinal Chemistry in Antimicrobial
Drug Discovery, Washington, DC.


Oct. 26, 2008.

10.

Carter
, G. T.


2008.
Rapamycin Analogs: New Chemistry/New Indications,
Kenneth L. Rinehart Lectures in Chemical Biology, University

of Illinois, Urbana,
Nov. 13,
2008.

11.

Carter, G.T. 2009.
Harnessing Marine Natural Products for Drug Discovery:
Practical Marine Microbiology, Experimental Biology 2009, New Orleans, LA,
April 19, 2009.

12.

Carter, G.T. 2009. Marine Natural Products: Pharmace
utical Potential.
Symposium "Drugs from the Deep: The Ocean's Role in Modern Healthcare",
Capitol Hill Ocean Week, Washington, DC, June 11, 2009

13.

Carter, G.T. 2009.
Strategies to Enhance the Neuroprotective Properties of
Rapamycin Analogs, RSC Conference "
Functional Molecules from Natural
Sources", Oxford, UK, July 6, 2009

14.

Carter, G. T., Natural Products & Drug Discovery: Rapalog Strategies, Seminar
at the University of Minnesota Center for Drug Design, Minneapolis, MN, April 21,
2010

15.

Carter, G. T.,
Discovery & Development of Natural Products: Challenges and
Opportunities, BIOPROSP 2011, 5
th

International Conference on Marine
Bioprospecting, Feb.24, 2011, Tromso, Norway

16.

Carter, G. T., Strategies for Natural Products Drug Discovery, NatPharma:
Nature A
ided Drug Discovery, June 7, 2011, Naples, Italy

17.

Carter, G. T., Strategies for survival in pre
-
clinical development, 52
nd

Annual
Meeting of the American Society of Pharmacognosy, July 31, 2011, San Diego,
CA


Selected peer
-
review
ed publications

(of 150
total)


1.

He, Haiyin; Ding, Wei
-
Dong; Bernan, Valerie S.; Richardson, Adam D.; Ireland, Chris
M.; Greenstein, Michael; Ellestad, George A., Carter, Guy T. 2001.
Lomaiviticins A
and B, Potent Antitumor Antibiotics from
Micromonospora lomaivitiensis
,

Journal o
f
the American Chemical Society. 123(22), 5362
-
5363


2.

Bugni, Tim S.; Bernan, Valerie S.; Greenstein, Michael; Janso, Jeffrey E.; Maiese,
William M.; Mayne, Charles L.; Ireland, Chris M. 2003.
Brocaenols A
-
C: Novel
Polyketides from a Marine
-
Derived
Penicilli
um brocae
,

Journal of Organic Chemistry,
68(17), 6846


3.

Ireland, Chris; Aalbersberg, William; Andersen, Raymond; Ayral
-
Kaloustian,
Semiramis; Berlinck, Roberto; Bernan, Valerie; Carter, Guy; Churchill, Alice; Clardy,
Jon; Concepcion, Gisela; De Silva, Dil
ip; Discafani, Carolyn; Fojo, Tito; Frost, Philip;
Gibson, Donna; Greenberger, Lee; Greenstein, Michael; Harper, Mary Kay; Mallon,
Robert; Loganzo, Frank; Nunes, Maria; Poruchynsky, Marianne; Zask, Arie. 2003.
Anticancer agents from unique natural products

sources
,

Pharmaceutical Biology
(Lisse, Netherlands) ,41(Suppl. 1), 15
-
38


4.

Ritacco, F. V.; Haltli, B.; Janso, J. E.; Greenstein, M.; Bernan, V. S. 2003.
Dereplication of Streptomyces

soil isolates and detection of specific biosynthetic
genes using an automated ribotyping instrument
,

Journal of Industrial Microbiology &
Biotechnology 30(8), 472
-
479


5.

Graziani, Edmund I.; Ritacco, Frank V.; Summers, Mia Y.; Zabriskie, T. Mark; Yu,
Ker;
Bernan, ValerieS.; Greenstein, Michael; Carter, Guy T. 2003.
Novel Sulfur
-
Containing Rapamycin Analogs Prepared by Precursor
-
Directed Biosynthesis.

Organic Letters, 5(14), 2385
-
238


6.

Magarvey, Nathan A.; Keller, Jessica M.; Bernan, Valerie; Dworkin, Martin
; Sherman,
David H. 2004.
Isolation and characterization of novel marine
-
derived actinomycete
taxa rich in bioactive metabolites
,

Applied a
nd Environmental Microbiology,
70(12),
7520
-
7529


7.

Bernan, V. S.; Greenstein, M.; Carter, G. T. 2004.
Mining marine m
icroorganisms as
a source of new antimicrobials and antifungals
,

Current Medicinal Chemistry: Anti
-
Infective Agents, 3(3), 181
-
195



8.

F.E. Koehn, G.T. Carter.
2005. “The Evolving Role of Natural products in Drug
Discovery”
, Nature Reviews
-

Drug Discovery

4(3):206
-
220.


9.

Graziani, Edmund I.; Ritacco, Frank V.; Bernan, Valerie S.; Telliez, Jean
-
Baptiste.
2005.
Phaeochromycins A
-
E, Anti
-
inflammatory Polyketides Isolated from the Soil
Actinomycete
Streptomyces phaeochromogenes

LL
-
P018
,

Journal of Natural
Produ
cts,
68(8), 1262
-
1265


10.

Janso, Jeffrey E.; Bernan, Valerie S.; Greenstein, Michael; Bugni, Tim S.; Ireland,
Chris M. 2005.
Penicillium dravuni
, a new marine
-
derived species from an alga in
Fiji.

Mycologia, 97(2), 444
-
453


11.

F.V. Ritacco, E.I. Graziani, M.M
. Summers, M.T. Zabriske, K. Yu, V.S. Bernan, G.T.
Carter, M. Greenstein. 2005 “Production of Novel Rapamycin Analogs by Precursor
-
Directed Biosynthesis”
,

Applied and Environmental Microbiology
,
71(4):1971
-
1976.


12.

F. Kong, M.P. Singh, G.T. Carter. 2005 “
Pseudopyronines A and B,
-
Pyrones
Produced by a Marine
Pseudomonas

sp. F92S91, and Evidence for the Conversion
of 4
-
Hydroxy
-
-
pyrone to 3
-
Furanone”
,


J. Nat. Prod.
68(3):920
-
923.


13.

P. Cai, F. Kong, M.E. Ruppen, G. Glasier, G.T. Carter. 2005.

Hygrocins A and B,
naphthoquinone macrolides from
Streptomyces hygroscopicus
,

J. Nat. Prod.
68(12):1736
-
1742.


14.

R.D. Charan, G. Schlingmann, V.S. Bernan, X. Feng, G.T. Carte
r. 2006.
“Dioxyapyrrolomycin Biosynthesis in
Streptomyces fumanus

,

J. Nat. Prod. 69:29
-
33
.


15.

Toral
-
Barza, Lourdes; Zhang, Wei
-
Guo; Huang, Xinyi; McDonald, Leonard A.;
Salaski, Edward J.; Barbieri, Laurel R.; Ding, Wei
-
Dong; Krishnamurthy, Girija; Hu
,
Yong Bo; Lucas, Judy; Bernan, Valerie S.; Cai, Ping; Levin, Jeremy I.; Mansour,
Tarek S.; Gibbons, James J.; Abraham, Robert T.; Yu, Ker. 2007.
Discovery of
lactoquinomycin and related pyranonaphthoquinones as potent and allosteric
inhibitors of AKT/PKB:

mechanistic involvement of AKT catalytic activation

loop
cysteines
,

Molecular Cancer Therapeutics 6(11), 3028
-
3038


16.

G. Schlingmann, T. Taniguchi, H. He, R. Bigelis, H.Y. Yang, F.E. Koehn, G.T. Carter,
N. Berova. 2007.
“Reassessing the structure of
pyranonigrin
”,

J. Nat. Prod. 70:1180
-
1187.


17.

M.Y. Summers, F. Kong, X. Feng, M.M. Siegel, J.E. Janso, E.I. Graziani, G.T.
Carter. 2007.

Septocylindrins A and B: Peptaibols produced by the terrestrial fungus
Septocylindrium

sp. LL
-
Z1518
,

J. Nat. Prod. 70(
3):391
-
396.


18.


L. Di, E.H. Kerns, S.Q. Li, G.T. Carter. 2007.

Comparison of cytochrome P450
inhibition assays for drug discovery using human liver microsomes with LC
-
MS,
rhCYP450 isozymes with fluorescence, and double cocktail with LC
-
MS
,

International J
ournal of Pharmaceutics. 335(1
-
2):1
-
11.


19.

B. Ruan, K. Pong, F. Jow, M. Bowlby, R.A. Crozier, D. Liu, S. Liang, Y. Chen, M.L.
Mercado, X. Feng, F. Bennett, D. von Schack, L. McDonald, M.M. Zaleska, A. Wood,
P.H. Reinhart, R.L. Magolda, J. Skotnicki, M.N. Pa
ngalos, F.E.
Koehn, G.T. Carter,
M. Abou
-
Gharbia, E.I. Graziani.
2008.

Binding of rapamycin analogs to calcium
channels and FKBP52 contributes to their neuroprotective activities
,

Proceedings of
the National Academy of Sciences of the United States of
America. 105(1):33
-
38.


20.

A.S. Ratnayake, B. Haltli, X. Feng, V.S. Bernan, M.P. Singh, H. He, G.T. Carter.
2008.

Investigating the biosynthetic origin of the nitro group in pyrrolomycins
,

J.
Nat. Prod. 71(11):1923
-
1926.


21.

J.B. McAlpine, A.H. Banskota, R.
D. Charan, G. Schlingmann, E. Zazopoulos, M.
Piraee, J. Janso, V.S. Bernan, M. Aouidate, C.M. Farnet, X. Feng, Z. Zhao, G.T.
Carter.

2008.
Biosynthesis of diazepinomicin/ECO
-
4601, a Micromonospora
secondary metabolite with a novel ring system
,

J. Nat.
Prod. 71(9):1585
-
1590.


22.

L. Di, E.H. Kerns, X.J. Ma, Y. Huang, G.T. Carter. 2008.

Applications of high
throughput microsomal stability assay in drug discovery
,

Combinatorial Chemistry &
High Throughput Screening. 11(6):

469
-
476.


23.

Di, Li; Kerns, Edward
H.; Ma, Xuewen JoAnn; Huang, Youping; Carter, Guy T. 2008.

Applications of high throughput microsomal stability assay in drug discovery
,


Combinatorial Chemistry & High Throughput Screening 11(6), 469
-
476.


24.

X. Feng, A.S. Ratnayake, R.D. Charan, J.E.
Janso, V.S. Bernan, G. Schlingmann, H.
He, M. Tischler, F.E. Koehn, G.T. Carter. 2009. Probing natural product biosynthetic
pathways using Fourier transform ion cyclotron resonance mass spectrometry,
Bioorg. & Med. Chem.
17:2154

2161.


25.

H.L.
Liu, H.Jiang,
B.Haltli, K.Kulowski, E.Muszynska, X.
Feng
, M.Summers, M.Young,
E.I.Graziani, F.E.Koehn, G.T.Carter, M.He. 2009.

Rapid Cloning and Heterologous
Expression of the Meridamycin Biosynthetic Gene Cluster Using a Versatile
Escherichia coli

Streptomyces

Artificial Chromosome Vector, pSBAC
,

J. Nat. Prod.

72
, 389, (2009)


26.

A.S. Ratnayake, J.E. Janso, X. Feng, G. Schlingmann, I. Goljer, G.T. Carter. 2009.
Evaluating Indole
-
Related Derivatives as Precursors in the Directed Biosynthesis of
Diazepinomicin Analo
gues
,

J. Nat.
Prod.

72
(3):496


27.

J.E. Janso, G. T. Carter. 2010. Biosynthetic Potential of Phylogenetically Unique
Endophytic Actinomycetes from Tropical Plants
,
Appl. Environ. Microbiol. 76: 4377
-
4386


28.

J.N. Andexer, S.G. Kendrew, M. Nur
-
e
-
Alam, O. Lazos
, T.A. Foster, A
-
S.
Zimmermann, T.D. Warnick, D. Suthar, N.J. Coates, F.E. Koehn, J.S. Skotnicki, G.
T. Carter, M.A. Gregory, C.J. Martin, S.J. Moss, P.F. Leadlay, B. Wilkinson, 2011,
Biosynthesis of the immunosuppressants FK506, FK520, and rapamycin invol
ves a
previously

undescribed family of enzymes acting on chorismate
, PNAS, 108: 4776
-
4781


29.

G. T. Carter, Natural Products and Pharma 2011: Strategic changes spur new
opportunities, Natural Products Reports, 2011: DOI: 1039/c1np00033k




BOOK CHAPTERS


1.

Bernan, Valerie S. 2001.
Metabolites of free
-
living, commensal, and symbiotic

benthic marine microorganisms.

Editor(s): McClintock, James B.; Baker, Bill J.
Marine Chemical Ecology. 567
-
592. Publisher: CRC Press LLC, Boca Raton, FL


2.

G.T. Carter. 2008
. Discovering Anti
-
infectives from the Sea. In Walsh, P.J.,
Smith, S.L., Fleming, L.E., Solo
-
Gabriele, H.M., & Gerwick, W.H. (eds.), Oceans
and Human Health: Risks and Remedies from the Seas, pp.453
-
468, Academic
Press, Boston


3.

G.T. Carter. 2010.
Natural Products in Drug Discovery. In Krogsgard
-
Larsen, P.,
Stromgaard, K., & Madsen, U. (eds.), Texbook of Drug Design and Discovery,
4th Edition, pp. 89
-
105, CRC Press, Boca Raton


4.

E H. Kerns, L. Di, G. T. Carter, ADMET In Vitro Profiling: Utility and
Applications
in Lead Discovery, in Burger’s Medicinal Chemistry, Drug Discovery and
Development, Vol. 7 (Published Online Sept. 15, 2010)


5.

G. T. Carter, V. S. Bernan, F. E. Koehn, New Strategies for Natural Products
Lead Generation, in Burger’s Medicinal
Chemistry, Drug Discovery and
Development, Vol. 7 (Published Online Sept. 15, 2010)