Professional vita - Southeast Missouri State University

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Feb 20, 2013 (4 years and 3 months ago)

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Walt W. Lilly



Professor of Biology (573) 651
-
2359

Southeast Missouri State University

Cape Girardeau, MO 63701


EDUCATION:




1979

Ph.D.

(Botany)


University of Minnesota



1975

B.S.

(Biology)


Southwest Missouri State University


POSITIONS:

1989
-
date

Professor of Biology, Southeast Missouri State University

1985
-
1989

Associate Professor of Biology, Southeast Missou
ri State University

1982
-
1985

Assistant Professor of Biology, Southeast Missouri State University

1979
-
1982

Assistant Professor of Biology, Lake Forest College


CURRENT PROFESSIONAL INTERESTS:



Biochemistry and molecular biology of autolytic processes in wo
od
-
decaying fungi.



Basidiomycete Genomics



Especially Protease Genomics



Annotation collaborator for
C. cinereus, S. commune, P. ostreatus, A. bisporus

and
S.
lacrymans

genomes.



Role of the lytic compartment in growth and development of higher fungi.


ADDITIONAL EXPERIENCE




Sabbatical Leave, University of North Carolina, Spring 2010



Radiation Safety Officer Training, DO
T

Radioactive Materials Shipping Certification
Training, 2000, 2002, 2005, 2007
, 2008
, 2011



NSF Panel Member:
Collaborative Research in

Undergraduate Institutions

(1999)
,
Graduate Assistants K
-
12
(
1999
),

Small Business Innovative Research
(
1995
)

Research Experiences for Undergraduates
(
1992
-
1993
)



Sabbatical leave, University of North Carolina, Spring 1993


ACADEMIC AWARDS AND HONORS



2008

College of Science and Mathematics Service Award.



2002

Southeast Faculty Merit Award



2002

Missouri Governor’s Award for Teaching Excellence



2001

College of Science and Mathematics Service Award



1998

College of Science and Technology PRIDE Award



1992

American Men and Women of Science



1991


Who's Who in Science and Engineering



1990


College of Science and Technology Research Merit Award




1987


College of Science and Technology Research Merit Award



1980


Sigma Xi



1975
-
79

Bush Foundation Doctoral
Fellowship



1975


Phi Kappa Phi

Walt W. Lilly



Page 2

CURRENT COURSES TAUG
HT



BI 151 Biological Reasoning



BI154 Genetics and Cell Biology



BI400/600 Health Physics




BI 404/604 Cell Biology




BI 414/614 Problems in Cell and Molecular Biology



BI 450/650 Inv
estigative Molecular Biology and Biotechnology


SIGNIFICANT CURRICUL
UM DEVELOPMENT ACTIV
ITIES



Proposed and revised over 25 courses in 26 years at Southeast



Chaired two major curriculum revisions undertaken by the Department of Biology (1983
-
1985;
1998
-
2000) since 1980 and was a member of the committee for core revision
2003
-
2005.



Chaired Biology Curriculum Committee during development of lower
-
division University
Studies courses.



Chaired Long Range Academic Planning Committee during External Review

of
Departmental Programs


UNDERGRADUATE AND GR
ADUATE MENTORSHIP



Directed
S
eventeen

Masters Students since 1990.



External Committee Member on three Ph.D. theses and on Masters thesis.



Directed over
75

undergraduate research projects (many multiyear) since
1990.



25 former students with earned PhDs


SIGNIFICANT PROFESSI
ONAL SERVICE ACTIVIT
IES



Ad hoc reviewer for: National Science Foundation, USDA


NRI, NWO


Netherlands
research foundation,
Mycologia, Experimental Mycology, Fungal Genetics and Biology,
Gene
tics, Mycological Research, New Phytologist, Biotechnology and Bioengineering
,
Molecular Microbiology, J. Basic Microbiology
.




U
niversity Radiation Safety Officer
: Oversight responsibility for cleanup project in
excess of $
4
,
5
00,000 of historical
contamination in Magill Hall.



Member, multiple university
-
level committees including Faculty Compensation, Budget
Review, Phase I, II, and III
A
cademic
R
eview



Member, Cape Public Schools Foundation Grants Committee.



Member, Comprehensive School Improvement

Plan Steering Committee, Cape Public
Schools.



Member and University Coordinator, Steering Committee for Cape Public Schools
“Complete the Mission” Campaign 2000



Member, Cape Public Schools Finance committee (1999)



WebMaster, Cape Central Marching Band (
h
ttp://marchingtigers
.com)


Walt W. Lilly



Page 3


GRANTS HELD


Internal, over $7
6
,000
;
External, over $1,300,000.


Biology of the widely expanded M43B family of metallopeptidases of Coprinus cinereus.
Southeast GRFC. March 2010. $5300.


Functional analysis of Coprinus cinereus proteases using gene silencing by RNA interference.
2008. $5900. Grants and Research Funding Committee


Determination of substrate specificity of heterologously
-
expressed
Coprinus cinereus

metzincin
protease usin
g phage display technology. 2006. $4300
.

Grants and Research Funding
Committee


Characterization of the M36 family of metalloproteases produced by the basidiomycete
Coprinus cinereus
. 2005. $4500. GRFC


Potential
Coprinus cinereus

genes involved in bre
akdown of organophosphates. 2004.
$2456.50. GRFC


A bioinformatics/laboratory approach to discovery of proteases in the industrially important
fungus
Phanerocheate chrysoporium
. 2003. $2282. GRFC


Target of Rapamycin (TOR) Pathway Genes in
Schizophyllum commune.

2002. $4230.
GRFC.


Green fluorescent protein as a marker for protein synthesis and autolysis in the wood decaying
fungus
Schizophyllum commune
. 2000. $4248. GRFC. With Allen Gathman.


Development of an Expressed Sequenc
e Tag Database for
Schizophyllum commune
. 2000.
$5000. GRFC. With Allen Gathman


Free amino acid composition and amino acic
-
specific Nitrogen Assimilatory Enzymes as
Regulators of the Nitrogen Stress Response in
Schizophyllum commune
. 1999. $5860.
G
RFC. With Allen Gathman


Analysis of OG910F, a potential nitrogen
-
limitation transcription regulator the wood
-
decaying
fungus, Schizophyllum commune. GRFC. 1999. $5900. With Allen Gathman


Investigative experiences in molecular biology. Southeast M
issouri State University. Funding

For Results Award. 1998
-
1999. $20,345. With Allen Gathman


The
Coprinus cinereus

genome project. 2004
-
2008. $750,000 NSF/USDA Interagency Grant.
With Allen Gathman, Pat Pukkila (University of North Carolina) and
Fred Dietrich (Duke
University)

Biochemistry of nitrogen
-
limited growth of wood
-
decaying fungi. National Science Foundation.



1996
-
1999. $205,000. + 40,689 in ROA and REU supplements. With Allen Gathman.


Biochemistry of nitrogen
-
limited growth of
wood
-
decaying fungi. National Science Foundation.
1993
-
1996. $160,000 + $14,625 in REU supplements. With Allen Gathman.


Walt W. Lilly



Page 4


Biochemistry of nitrogen
-
limited growth of wood
-
decaying fungi. National Science Foundation.
1990
-
19
93. $127,500 + $6,750 in REU supplements.


Protease activity, protein turnover and nitrogen nutrition during growth of
Schizophyllum
commune
. Research Corporation. 1988
-
1990. $19,000.


Internal Grants from the Grants and Research Funding Committee.
Southeast Missouri State
University. $18000 over the period 1983
-
1992.


PUBLICATIONS (Underline = Undergraduates, *=Graduate Students.)


Daniel C. Eastwood, Dimitrios Floudas, Manfred Binder, Andrzej Majcherczyk, Patrick
Schneider, Andrea Aerts, Fred
O. Asiegbu, Scott E. Baker, Kerrie Barry, Mika Bendiksby,
Melanie Blumentritt, Pedro M. Coutinho, Dan Cullen, Ronald P. de Vries, Allen Gathman
Barry Goodell, Bernard Henrissat, Katarina Ihrmark, Hävard Kauserud, Annegret Kohler,
Kurt LaButti, Alla Lapidus
, José L. Lavin, Yong
-
Hwan Lee, Erika Lindquist, Walt Lilly,
Susan Lucas, Emmanuelle Morin, Claude Murat, José A. Oguiza, Jongsun Park, Antonio
G. Pisabarro, Robert Riley, Anna Rosling, Asaf Salamov, Olaf Schmidt, Jeremy Schmutz,
Inger Skrede, Jan Stenlid
, Ad Wiebenga, Xinfeng Xie, Ursula Kües, David S. Hibbett, Dirk
Hoffmeiste, Nils Högberg, Francis Martin, Igor V. Grigoriev, Sarah C. Watkinson. 2011.
The plant cell wall
-
decomposing machinery underlies the functional diversity of forest
fungi. Science 33
3: 762
-
765.


Stajich JE,
Wilke SK
, Ahrén D, Au CH, Birren BW, Borodovsky M, Burns C, Canbäck B,
Casselton LA, Cheng CK, Deng J, Dietrich FS, Fargo DC, Farman ML, Gathman AC,
Goldberg J, Guigó R, Hoegger PJ, Hooker JB, Huggins A, James TY, Kamada T, Kilaru

S, Kodira C, Kües U, Kupfer D, Kwan HS, Lomsadze A, Li W, Lilly WW, Ma LJ, Mackey
AJ, Manning G, Martin F, Muraguchi H, Natvig DO, Palmerini H, Ramesh MA, Rehmeyer
CJ, Roe BA, Shenoy N, Stanke M, Ter
-
Hovhannisyan V, Tunlid A, Velagapudi R, Vision
TJ, Zeng

Q, Zolan ME, Pukkila PJ. 2010.
Insights into evolution of multicellular fungi
from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus
cinereus
).

Proc Natl Acad Sci U S A.10
711889
-
118
94.


Ohm RA, de Jong JF, Lugones LG, Aerts A, Kothe E, Stajich JE, de Vries RP, Record E,
Levasseur A, Baker SE, Bartholomew KA, Coutinho PM, Erdmann S, Fowler TJ,
Gathman AC, Lombard V, Henrissat B, Knabe N, Kües U, Lilly WW, Lindquist E, Lucas
S,
Magnuson JK, Piumi F, Raudaskoski M, Salamov A, Schmutz J, Schwarze FW, vanKuyk
PA, Horton JS, Grigoriev IV, Wösten HA. 2010.
Genome sequence of the model
mushroom
Schizophyllum commune
.

Nat
ure

Biotechnol
ogy
. 28:957
-
963


Burns C, Stajich JE, Rechtsteiner A, Casselton C, Hanlon SE, Wilke SK, Savytskyy OP, AC,
Lilly WW, Lieb JD, Zolan ME, Pukkila PJ. 2010.
Analysis of the Basidiomycete
Coprinopsis cinerea

Reveals Conservation of the Core Meiotic Expression Program over
Half a Billion Ye
ars of Evolution
. PLoS Genet
ics

6(9): e1001135.


Lilly WW, Stajich JE, Pukkila PJ, Wilke SA, Inoguchi N, and Gathman AC. 2008. An
expanded family of fungalysin metalloproteases of
Coprinus cinereus
.
Mycological
Research

112: 389
-
398
.


Walt W. Lilly



Page 5


Ulrich CE, Gathman AC, and Lilly WW. 2007. Amino acid pool composition of the
basidiomycete,
Coprinus cinereus
.
Canadian Journal of Microbiology
: 53: 1278
-
1281
.


Stajich JE, Birren

B, Burns C, Casselton LA, Dietrich F, Fargo DC, Gathman AC, James TY,
Kamada T, Lilly WW, Ma L
-
J, Muraguchi H, Palmerini H, Rehmeyer C,
Wilke S
, Zolan M,
Pukkila PJ, 2006. Genomic Analysis of
Coprinus cinereus
. Proceedings of the
International Symposiu
m on Mushroom Science, Akita Prefectural University, pp59
-
74.


Co
-
Author. Over 4000 gene sequences from
Coprinus cinereus

in GenBank. With Allen
Gathman and many student co
-
authors. 2004
-
2006.


Hanks JN, Hearnes JM
, Gathman AC, and Lilly WW. 2003.
Nitrogen Starvation Induced
Changes in Amino Acid and Free Ammonium Pools of
Schizophyllum commune
.
Current
Microbiology
. 47: 444
-
449.


Guettler S*,
Jackson EN, Lucchese SA, Honaas L,

Green A*,
Hittinger CT
, Tian Y*, Lilly WL,
Gathman AC. 2003. ESTs fr
om the basidiomycete
Schizophyllum commune

grown on
nitrogen replete and nitrogen
-
limited media.
Fungal Genetics and Biology
. 39: 191
-
198.


Co
-
Author. Over 300 gene sequences from
Schizophyllum commune

in GenBank. With Allen
Gathman and many student

co
-
authors. 2000
-
2002.


Johnston, JM, Ramos, ER,
Bilbrey*, RE, Gathman, AC, and Lilly, WW. 2000. Characterization
of ScPrI, a small serine protease from mycelia of
Schizophyllum commune
.
Mycol. Res.
104: 726
-
731.


Inselman, AL
, Gathman, AC and Lilly, W
W. 1999. Two fluorescent markers identify the
vacuolar system of
Schizophyllum commune.

Curr. Microbiology.

38: 295
-
298.


Hummel, KM, Inselman, AL, Ramos, ER,
Gathman, AC and Lilly WW.

1998. Extracellular
protease production by submerged cultures of
Schizophyllum commune. Mycologia
90:
883
-
889.


Bilbrey, RE
, *Penheiter, AR, Gathman, AC, and Lilly, WW. 1996. Characterization of a novel
phenylalanine
-
specific aminopeptidase from th
e basidiomycete,
Schizophyllum
commune
.
Mycol. Res.
100: 462
-
466.


Hummel, KM
, *Penheiter, AR, Gathman, AC, and Lilly, WW. 1996. Anomolous estimation of
protease molecular weights using gelatin
-
containing SDS
-
PAGE.
Anal. Biochem.

233:
140
-
142.


*Gor
don, LJ, and Lilly WW. 1995. Quantitative analysis of
Schizophyllum commune

metalloprotease ScPrB activity in SDS
-
gelatin PAGE reveals differential myclelial
localization of nitrogen limitation
-
induced autolysis.
Current Microbiol.
30: 337
-
343.





Wal
t W. Lilly



Page 6


Lilly, WW,
Bilbrey RE
,
Williams BL
,
Loos LS
, *Venable, DF, and *Higgins, SM. 1994. Partial
characterization of the proteolytic system of
Schizophyllum commune.

Mycologia
86:
564
-
570.


*Higgins, SM, and Lilly, WW. 1993. Multipl
e responses to heat stress by the basidiomycete
fungus
Schizophyllum commune
.
Current

Microbiol.

26: 123
-
127.



*Wallweber, GJ, and Lilly, WW. 1992. Purification and characterization of the two constitutive
acid phosphatase isozymes from
Schizophyllum

commune
.
Mycological

Res

96:792
-
797.


Lilly, WW, *Wallweber GJ, and
Lukefahr, TA.

1992. Cadmium absorption and its effects on
growth and mycelial morphology of the basidiomycete fungus,
Schizophyllum commune

Microbios

72: 227
-
237.


Lilly, WW, *
Wallweber, GJ, and
Higgins, SM

. 1991. Proteolysis and amino acid
recycling during nitrogen deprivation of
Schizophyllum commune
.
Current

Microbiology

23: 27
-
32.


Lilly, WW,
Higgins, SM
, and *Wallweber, GH. 1990. Electrophoretic detection of multiple

proteases from
Schizophyllum commune
.
Mycologia

82: 504
-
507.


Lilly, W.W.,
Higgins, SM

and *Wallweber, GJ. 1990. Uptake and translocation of 2
-
aminoisobutyric acid by
Schizophyllum commune
.
Experimental

Mycology

14:
169
-
177.


May, GD
, and Lilly, W
W. 1988. A rapid method for the

extraction of membrane
-
grown
fungal cultures.
Mycologia

80:247
-
249.


Lilly, WW, and Charvat, I. 1987. Activities and isozymes of acid phosphatase in
Schizophyllum commune
.
Mycologia

79: 314
-
319.


Schorey, J
S, and Lill
y, WW. 1986. Derepression of extracellular acid phosphatase
activity in
Schizophyllum commune
.
Microbios

Letters

32: 87
-
90.


Sessoms, DB
, and Lilly, WW. 1986. Derepressible proteolytic activity in homokaryotic
hyphae of
Schizophyllum commune
.
Exper
imental

Mycology

10: 294
-
300.


Lilly, WW, and
Henson, TL
. 1985. Mycelial phosphorus content of
Schizophyllum
commune
.
Mycologia

77:545
-
548.


Lilly, WW, and
Owens, J
. 1984. Inhibition of growth and acid phosphatase activity of
Schizophyllum commune

by vanadate.
Mycologia

76:700
-
704.




Walt W. Lilly



Page 7


SELECTED RECENT PROFESSIONAL PRESENTATIONS

(Underline = Undergraduates,
*=Graduate Students.)


Lilly, WW. 2012.
Magill Hall and Am241: The Almost Final Chapter. Pennsylvania State
University Radiation Safety Roundtable. Sept. 2012.


Lilly, WW. 2012.
Magill Hall: Lessons learned from an historical Am241 contamination event.
International Dosimetry and Records Symposium. Hilton Head, SC. June 2012


Lilly WW. 2009. DNA to D&D:
A molecular biologist’s ten year diversion into Am241 health
physics


cleaning up Magill Hall. Pennsylvania State University Radiation Safety
Officers Roundtable. Sept 2009 State College, PA
; Delaware Valley Radiation Safety
Association, Mar 2010 Phi
ladelphia, PA; Midwest Radiation Safety Officers Roundtable,
May 2010 Kansas City, MO; National Institutes of Health Radiation Safety

Group Oct
2010, Bethesda MD.


Lilly WW, Gathman AC, Wilke SK, Pukkila.

2009. An initial look at nutrient
-
driven changes in
global gene expression in Coprinus cinereus. Fungal Genetics Conference. Mar 2009.
Asilomar, CA


Lilly WW, Wilke SK,
Koester MK
, Pukkila PJ, Stajich JE, Gathman AG. 200
9
. Proteolytic
systems of b
asidiomycetes
. 2009. Fungal Genetics Conference
. Ma
r

200
9
.
Asilomar,
CA (Invited speaker)


Burns C, Stajich JE, Lieb JD, Hanlon SE, Lilly WW, Gathman AC

, Wilke SK,. Zolan ME, Pukkila
PJ. 2008. Genetics and Cell Biology of Basidiomycetes VII. May 2
008. Cape
Girardeau, MO


Gathman AC, Wilke SK, Pukkila PJ, Muraguchi H, Dietrich F, Lilly WW. 2008. Full
-
chromosome assembly of the
Coprinus cinereus

genome. Genetics and Cell Biology of
Basidiomycetes VII. May 2008. Cape Girardeau, MO


Stajich JE, Gathman AC, Lilly WW, Muraguchi H, Wilke SK,

Pukkila, PJ. 2008. Comparative
analyses of the
Coprinopsis cinerea

(
Coprinus cinereus
) genome. Genetics and Cell
Biology of Basidiomycetes VII. May 2008. Cape Girardeau, MO


Burns C, Stajich J, Lieb J, Hanlon S, Lilly W, Gathman A,
Wilke S
, Zolan M, Pukkila P. 2007.
Whole transcriptome analysis of
Coprinus cinereus

meiotic development. Annual
Meetings of the American Society for Cell Biology. December 2007. Washington


Burns C, Stajich J, Lieb J, Hanlon S, Lilly W, Gathman A,
Wilke S
, Zolan M, Pukkila P. 2007.
Whole transcriptome analysis of
Coprinus cinereus

meiosis: A nosey look at mushroom
sex. Fungal Genetics Conference. March 2007. Asilomar, CA.


Lilly WW,
Gathman AC,
Wilke SK
, Stajich, J, Pukkila PJ. 2006. An eight member family of
fungalysin
-
like extracellular metalloprotease genes in the basidiomycete
Coprinus
cinereus
. Annual Meetings of the American Society for Microbiology, May 2006, Orlando
Fl. .

Walt W. Lilly



Page 8


Kües U, Pukkila P, Stajich J, Dietrich F, Gathman A, Kilaru S, Hoegger PJ, James TY, Lilly W,
Velagapudi R, Chaisaena W, Dwivedi RC, Holzwarth F, Majcherczyk A, Navarro
-
Gonzalez M, Pemmasani KJ Rühl M, Saathoff A, Srivilai P. 2005.

A mushroom in the
genomic era. Molecular Biology of Fungi
-

Molekularbiologie der Pilze. Bochum
Germany. September 2005. (co
-
author)


Gathman AC, Lilly WW, Stajich J,
Carlson M, Murphy B, Smith A
, Fargo D, Dietrich F, Pukkila
PJ. The
Coprinus cinereu
s

genome project. Genetics and Cellular Biology of
Basidiomycetes VI,. Pamplona, Spain. June 2005.


Pukkila PJ, Stajich J, Fargo D, Mulamba R, Hooker JB, Lawson K, Lilly W, Gathman A, and
Dietrich F. 2005. The
Coprinus cinereus

genome project. 23
rd Fungal Genetics
Conference, Asilomar CA. March 2005.


Flemming K, Lilly W, and Moos J. 2001.

Bioassays to determine exposures from a historical
Americium spill. Health Physics Society Annual Meetings. Cleveland, OH


Passig S, Lilly W, and Moos J.

2001. Decontamination of building and equipment surfaces
contaminated as a result of a historical Americium spill. Health Physics Society Annual
Meetings, Cleveland, OH.


*Guettler S,
Lucchese S, Honaas L
, Lilly WW, and GathmanAC
. 2001. Construction and
analysis of EST databases from Schizophyllum commune. Genetics and Cell Biology of
Basidiomycetes 5. Toronto.


Smith JN, Straub CL, Johnston JM

Gathman AC, and Lilly WW. 2001. Amino acid pool
composition and amino acid tra
nslocation in growing mycelia of Schizophyllum commune.
Genetics and Cell Biology of Basidiomycetes 5. Toronto.