Genentech_2013_UoS_Advertx - University of Southampton

thelemicbathBiotechnology

Feb 20, 2013 (4 years and 7 months ago)

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Genentech:

Ref: 258259

Location: California, USA

Paid Status / Salary: Paid / $
19
-
21 p/h (UG), $23 p/h (PG) + UoS stipend

Organisation: Excel Southampton Placement Programme

Occupational

Area:

Scientific

Services
-

Pharmaceuticals


The University of
Southampton has secured an opportunity

to support
the right candidate
(s)

to
join the
paid summer internship
scheme
with

Genentech, a leading

global

biotech

company
.

Considered the founder of the biotechnology industry, Genentech has been delivering on the
promise of biotechnology for more than 35 years, using human genetic information to
discover, develop, manufacture and commercialize medicines to treat patients with serious or
life
-
threatening medical conditions. Today, Genentech is among the world's lead
ing biotech
companies, with multiple products on the market and a promising development pipeline.

Genentech’s internship programmes are among the best in the industry, offering students the
chance to receive rigorous and meaningful work experience in one o
f the leading
biotechnology companies. As an intern you will contribute daily to important projects and
work side
-
by
-
side with biotech industry experts in a

flexible and diverse workforce.

As an intern with Genentech you will work on challenging, business
critical projects and
present your projects findings at the end of the summer to senior management. Alongside
your work you will have the opportunity to network with interns from
Berkeley, Harvard and
MIT
throughout your work and
during training developmen
t programmes and social events
including Major League Baseball games and intern lunches. You will also have an
opportunity to meet with senior management and be considered for full
-
time positions within
Genentech.

The appointed intern(s) will undertake a p
aid 9
-
12 week placement

programme

within
Genen
tech.

The majority of the internships are b
ased within the Genentech HQ, San
Francisco, California, USA.

The length of the internship will be dependent on the appointed
role within the organisation.
Interns wil
l be paid
around $800 per week in addition to a
University of Southampton stipend of £
1,000 per month

to assist with payment for flights and
living expenses in California.

Accommodation is not provided however you will be given
assistance
with relocation
t
o

California
.

This is a two stage application process. The first stage consists of an application to the
University of Southampton to be considered for the scheme. In an average ye
ar Genentech
receive around 50,
000 applications to their
summer
internship

p
rogrammes
. As part of a stage
one application process to the University of Southampton

applicants will complete a
n

application form and submission of a professional CV aligned to

their preferred business area
within Genentech. Shortlisted applicants will b
e screened by the University of Southampton
and will be invited to interview early in 2013

(Thursday 10
th

January 2013)
. Successful
candidates will then apply directly to a business area within Genentech at which point the
University of Southampton will
liaise with the relevant recruitment manager(s) in support

of
your application.
Successful applicants at this stage will receive an offer of employment from
Genentech and the process to help facilitate your relocation to the USA will commence.

Person Requi
rements:



A passion for science with a strong academic record within your chosen field of study.



Enjoy the challenges associated with complex problem solving.



A motivated self
-
starter who can confidently manage their own and colleagues’
schedules in order t
o successfully drive forward initiative and projects.



A team player with excellent interpersonal skills who is diligent and
organised



Confident and assertive within a professional workplace environment



Ambitious with business acumen



Relevant work experienc
e in research labs or the biotechnology industry is highly
desirable.




Degree Requirements:


As a minimum you will have completed your second year of study at undergraduate level by
summer 2013 and have an academic background within Biology, Chemistry
and/or Chemical
Engineering.

Preferred disciplines include

chemical and biochemical engineering, biomedical
engineering, bioengineering, pharmaceutical engineering, analytical chemistry, biochemistry,
molecular biology, microbiology, biology or related
disciplines.

Applications will be
considered for a variety of business areas within Genentech which should be expressed on the
application form.


Contact Details / How To Apply:


Please provide a completed application form
(available

from
Career Destinations
)

and
a
professional
CV to
placements@soton.ac.uk

as part of the stage one application process.



Further Detail
s:


Full
-
Time / Part Time:

FT

Job Status:


Fixed Term

Level of Qualification:

UG/PGT/PGR

Benefits:


Gain valuable paid work experience through a structured placement
.

Website:

www.gene.com/gene/careers/interns_coops.html

and
www.gene.com/gene/careers/research_and_development.html


Number of Posts:



340 in total within Genentech.

Location Details:

Gen
entech’s
California, USA

offices
.

Start Date Details:

Summer 2013

(see application form)

Closing Date:


Midnight,
Sunday, 6
th

January






Sample Projects and Hiring Departments:

Information taken from
the Genentech Students & Recent Graduates web pages.
Explore
online

via the Sample Projects link at
www.gene.com/gene/careers/interns_coops.html
.




Analytical Operations

B.S., M.S.

Chemistry, Biology


The Analytical Operations Department provides value
-
oriented analytical support by running,
improving and maintaining quality assays that support both product development and process
improvement efforts.


Capillary Electrophoresis assays, Glycans and auto
mation




Antibody Engineering

B.S., M.S., Ph.D.

Biology, Biochemistry, Cell or Molecular Biology, Biotechnology, Bioinorganic Chemistry, Physiology,
Biophysics, Bacteriology


The Antibody Engineering Department's mission is to discover antibodies for the treatment of
unmet medical needs. We collaborate closely with Protein Engineering, Assay & Automation
Technology (AAT) and Immunology in developing new antibody technologies, a
nd with
groups throughout Research and Development on specific antibody projects.


Antibody Engineering will provide students with the opportunity to find antibodies against
MRSA (Methicillin Resistant Staphylococcus Aureus) using a bacterial display plat
form in
E.coli.Ê Methods include: expression, cloning and PCR to achieve the goal.




Assay Automation & Technology (AAT)

B.S., M.S., Ph.D.

Biology, Biochemistry, Cell or Molecular Biology, Biotechnology, Bioinorganic Chemistry, Physiology,
Biophysics, Bacteriology


The Department of Assay & Automation Technology (AAT) develops critical and innovative
biochemical and cell
-
based assay technolo
gies that are fundamental for the discovery and
characterization of potential therapeutic molecules. The department focuses on developing
and implementing assays for proteins, nucleic acids and small molecules to support all
aspects of early to late stage
research projects.


Interns in Assay Automation & Technology will contribute to the characterization and
implementation of a new type of consumable while taking full advantage of state
-
of
-
the
-
art
automation. They will also collaborate extensively with oth
er investigators in the Antibody
Engineering Department and participate in a hig
hly collaborative environment.



Biochemical Pharmacology

B.S., M.S., Ph.D.

Biology, Biochemistry, Cell or Molecular Biology, Biotechnology, Bioinorganic Chemistry, Physiolog
y,
Biophysics, Bacteriology


Biochemical Pharmacology develops relevant, innovative biochemical and cellular assays to
support the Small Molecule Drug Discovery lead
-
finding and lead optimization efforts. Our
lead
-
finding techniques will include ultra
-
hig
h
-
throughput screening of Genentech's small
molecule compound collection, fragment screening in conjunction with the Structural
Biology group and characterization of compounds identified from virtual or knowledge
-
based
screening.


Biochemical Pharmacology interns will analyze existing high
-
throughput screening and
follow
-
up assay data to extract information and/or to identify trends in the data. Example
analyses include assessing hit rates in various segments of our screening librar
y, evaluating
various detection technologies for compound interference, tracking compound progression
through screening and hit follow up and examining magnitudes and distributions of Hill
slopes for dose
-
response curves across multiple assays.




Bioinformatics & Computational Biology

B.S., M.S., Ph.D.

Bioinformatics or Biostatistics


Bioinformatics & Computational Biology provide the information systems including the
methods, software, databases, infrastructure and training required for Researc
h to access and
analyze DNA and protein sequence information and related biological data. These
information systems can be utilized to analyze biological information and to identify genes of
therapeutic interest.



Interns working in this area will develop

software and statistical methodology for
longitudinal data with informative censoring.




Cancer Targets & Pathways

B.S., M.S., Ph.D.

Biology, Biochemistry, Cell or Molecular Biology, Biotechnology, Bioinorganic Chemistry, Physiology,
Biophysics, Bacte
riology


The mission of the WNT Signaling Pathways group is to discover cancer therapeutics in the
WNT signaling pathway.


Interns in Cancer Targets &

Pathways will focus on immunohistochemistry (IHC) staining,
which localizes antigens in cells of a tissue section. Tasks include using cancer tumor cells,
testing combinations of monoclonal antibodies and staining them with UV fluorescent
secondary antibo
dies. interns will also have the opportunity to work with microscope
-
imaging programs.



Cell Regulation

B.S., M.S., Ph.D.

Biology, Biochemistry, Cell or Molecular Biology, Biotechnology, Bioinorganic Chemistry, Physiology,
Biophysics, Bacteriology


Ce
ll Regulation is focused on the cell biology of normal and diseased cells, notably cancer
cells. Our scientists are working to develop cellular assays to better reflect tumor killing, to
discover new targets controlling cell cycle and cell growth, to valid
ate and develop existing
targets and to build profiles of sensitivity to chemotherapeutics to inform our diagnostic and
patient selection efforts.


Students will have the opportunity to explore a new research initiative centered on using
advanced biochemi
cal, cell biological and genomic technologies in an oncology research
program. Interns will work independently and creatively in a collaborative, team
-
oriented
setting.




Discovery Chemistry

B.S., M.S., Ph.D.

Biology, Biochemistry, Cell or Molecular Biology, Biotechnology, Bioinorganic Chemistry, Physiology,
Biophysics, Bacteriology


The mission of Discovery Chemistry is to design and synthesize safe and effective medicines
for treating significant unmet medic
al needs by applying state
-
of
-
the
-
art structure
-
driven and
property
-
based design principles in a multi
-
disciplinary, team
-
based culture.


Interns in Discovery Chemistry will explore the utility of the C
-
H insertion reaction in
synthesizing a chiral, cyclic organic compound. The target molecule is similar to a compound
that has been identified as biologically active against Rheumatoid Arthrit
is. Students will be
tasked with perfecting the C
-
H insertion scheme and testing its scope.





Drug Metabolism and Pharmacokinetics (DMPK)

B.S., M.S., Ph.D.

Biology, Biochemistry, Cell or Molecular Biology, Biotechnology, Bioinorganic Chemistry, Physio
logy,
Biophysics, Bacteriology


The mission of DMPK is to enable the discovery, selection, development and
commercialization of safe and effective medicines for significant unmet medical needs by
elucidating the absorption, distribution, metabolism, elimi
nation and pharmacokinetic
properties of small molecule drug candidates. They accomplish this through application of
state
-
of
-
the
-
art technologies and sciences of bioanalysis, drug metabolism and disposition,
innovative thinking, effective collaboration an
d teamwork.


DMPK interns will Investigate the hepatobiliary disposition of compounds utilizing B
-
Clear
(sandwich cultured hepatocytes) technology or brain microdialysis work (focused on in vitro
and bioanalytical techniques).



Early Development (PKPD)

B.S., M.S., Ph.D.

Biology, Biochemistry, Cell or Molecular Biology, Biotechnology, Bioinorganic Chemistry, Physiology,
Biophysics, Bacteriology


Early Development formulates and implements scientifically robust, patient
-
focused,
nonclinical and clinical development plans to provide life
-
changing therapies for patients.


Students in Early Development will assist in experiments related to the develo
pment of
probes which support the mechanistic understanding of protein metabolism and
biodistribution. Lab activities will include chemical organic synthesis, use of radioisotopes, in
vitro assays as well as use of preclinical models to determine the biodi
stribution of our
biotherapeutic molecules. Students will have opportunities to interact and learn from
scientists and research associates, as well as participate in group meetings and journal clubs
including presentation of his/her own data collected duri
ng the intern period.




Epidemiology

Ph.D.

Epidemiology



Epidemiology hopes to provide evidence
-
based epidemiological strategy, expertise and data
to optimize Genentech's therapeutic molecule selection, development and commercialization.



Epidemiology interns will work under the supervision of experienced epidemiologists on
drug development projects in the fields of oncology, immunology, ophthalmology and
pulmonology. Epidemiologic projects will include providing estimates of disease incide
nce
and prevalence. After completing assignments, interns will present a summary of their work
to the epidemiology staff.




Health Outcomes Payer Support (MA
-
HOPS)

B.S., M.S., Ph.D.

Bioinformatics or Biostatistics


Biometrics, Health Outcomes and Paye
r Support (BHOPS) generates and communicates
credible scientific evidence of the value of our medicines to patients, physicians and payers.
We identify and employ innovative methods in the strategic support of appropriate use and
access for our products.


Students will develop methods and software for computing the posterior probability of a
positive clinical trial, and apply methods to actual clinical trials. Interns will develop software
and statistical methodology for longitudinal data with informative
censoring.






Immunology

B.S., M.S., Ph.D.

Biology, Biochemistry, Cell or Molecular Biology, Biotechnology, Bioinorganic Chemistry, Physiology,
Biophysics, Bacteriology


The Immunology Department seeks to expand the fundamental understanding of human
immune disorders by discovering and developing innovative drugs for the treatment of
immune and inflammatory disorders.


Interns in Discovery Chemistry will explore the utili
ty of the C
-
H insertion reaction in
synthesizing a chiral, cyclic organic compound. The target molecule is similar to a compound
that has been identified as biologically active against Rheumatoid Arthritis. Students will be
tasked with perfecting the C
-
H i
nsertion scheme and testing its scope.




Late Stage Pharmaceutical and Process Development

B.S., M.S., Ph.D.

Protein Biochemistry, Chemical Engineering


Late Stage Pharmaceutical and Process Development develops and implements the dosage
form, deliver
y system and packaging for Phase III and Marketed products as well as ensures
robust, reliable manufacturing processes to meet timelines and corporate goals. This is
accomplished through effective collaborations with Early Stage Pharmaceutical Development,

partners and by providing technical expertise, project leadership and on going support to
resolve issues and introduce new technologies and processes.


Students working in this area will assess processes to produce protein microspheres for high
dose SC a
dministration.




Medicinal Chemistry

B.S., M.S., Ph.D.

Organic Chemistry, Synthetic Chemistry


The primary mission of Bioorganic Medicinal Chemistry is the design and synthesis of non
-
peptide drug candidates for oral delivery. We utilize a wide variety of modern computer
-
aided design, analytical and synthetic organic chemistry techniques to this end
.


Interns within Medicinal Chemistry will conduct the multi
-
step synthesis, purification and
analysis of novel, bioactive small molecules. They will present their work at biweekly
chemistry team meetings and will describe their results at the conclusion
of the term at a
poster session or in a project team presentation.







Microbial Pathogenesis

B.S., M.S., Ph.D.

Biology, Biochemistry, Cell or Molecular Biology, Biotechnology, Bioinorganic Chemistry, Physiology,
Biophysics, Bacteriology


The mission

of the Microbial Pathogenesis Department is to harness the explosion of new
information in pathogen and host biology and to define critical events in infection amenable
to therapeutic intervention, with the goal to develop novel therapies for infectious d
iseases.


Interns will contribute to characterizing and evaluating targets for treatment of infectious
diseases.




Neuroscience

B.S., M.S., Ph.D.

Biology, Biochemistry, Cell or Molecular Biology, Biotechnology, Bioinorganic Chemistry, Physiology,
Biophysics, Bacteriology


The Neuroscience Department is dedicated to discovering fundamental principles related to
the biology and diseases of the nervous system and to translating these discoveries into
therapies for the treatment of neurological and psychiatric diseases.


Stude
nts will have the opportunity to study the role of different cell
-
surface receptors in
proper development of the BBB using live imaging in the model organism zebrafish.




Operations Rotational Development Program (ORDP)

B.S., M.S.

Chemical Engineering, Biomedical Engineering, Biotechnology, Chemistry, Biological Sciences, Biochemistry,
Electrical Engineering, Mechanical Engineering, Industrial Engineering


The Operations Rotational Development Program (ORDP) is a rotation developme
nt program
that attracts top talent who have recently graduated from college, and prepares them for
successful contributions to Genentech Technical Operations (GT). The program gives recent
graduates the opportunity to gain a broad perspective on the core
GT functions that are
critical to the manufacturing of Genentech products.


An ORDP intern may work within multiple departments including Biochemical
Manufacturing, Supply Chain, Corporate Engineering, Pharma Technical Development,
Regulatory, Quality, Op
erational Excellence or Manufacturing Collaborations. Sample
projects may include developing a tool to predict the number of vials of product loss expected
for clinical filling runs or training on buffer prep, chromatography and assay
dilutions/submission.








Protein Chemistry

B.S., M.S., Ph.D.

Biology, Biochemistry, Cell or Molecular Biology, Biotechnology, Bioinorganic Chemistry, Physiology,
Biophysics, Bacteriology


Protein Chemistry provides and supports the protein purification and characterization needs
of research. This includes both large
-
scale reagent and micropurifications. The department is
largely responsible for the maintenance of the protein request system,

a web
-
based system
that allows researchers to request protein purifications.


Protein Chemistry interns will work with a lead candidate for the antibody
-
antibiotic
-
conjugate (AAC) platform, specifically a monoclonal antibody. The monoclonal antibody is
reactive to all Staphylococcus clinical strains, in vitro and in vivo. Interns wi
ll determine the
mechanism of modification on the group of proteins.



Protein Engineering

B.S., M.S., Ph.D.

Biology, Biochemistry, Cell or Molecular Biology, Biotechnology, Bioinorganic Chemistry, Physiology,
Biophysics, Bacteriology


The Protein Engineering Department combines biological, structural, chemical and
combinatorial approaches to explore protein functions and molecular interactions. Our goal is
to advance novel therapies and to maintain scientific innovation and excellence.


Protein Engineering allows students the experience of cloning mutant constructs and
evaluating how these mutations affect the post
-
translational modification of the target protein.
This work will include designing and cloning expression constructs, trans
fecting these
constructs into mammalian cells and utilizing standard biochemical techniques to assess the
effect of these mutations on the target protein.




Small Molecule Drug Discovery (SMDD)

B.S., M.S., Ph.D.

Biology, Biochemistry, Cell or Molecular

Biology, Biotechnology, Bioinorganic Chemistry, Physiology,
Biophysics, Bacteriology


Small Molecule Drug Discovery is responsible for all primary biochemical enzyme, protein
and cell
-
based assays to assess quantitative structure
-
activity relationships for projects that
have advanced beyond high
-
throughput screening.


With the aid of an ex
perienced scientist, interns will plan, design and execute the multi
-
step
synthesis of novel chemical entities. Interns will also be tasked with the purification of
compounds (crystallization, flash chromatography) and characterization of compounds (NMR,
I
R, MS).







Tumor Biology & Angiogenesis

B.S., M.S., Ph.D.

Biology, Biochemistry, Cell or Molecular Biology, Biotechnology, Bioinorganic Chemistry, Physiology,
Biophysics, Bacteriology


The mission of Tumor Biology &

Angiogenesis is to discover and advance new drugs for the
treatment of cancer and other serious diseases through an improved understanding of
angiogenesis, growth factor signaling and tumor stem cell biology.

Interns will study the effects of disease in
whole organ models. Using a combination of
chemical treatments and two photon microscopy, we are able to see structures that are buried
deep within issue samples. Interns will prepare samples, acquire high resolution images and
develop image analysis routi
nes to quantify what is seen.