E/III ORAL PRESENTATIONS Chairman - Semmelweis Egyetem ...

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Nov 15, 2013 (3 years and 8 months ago)

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2012. április 12
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PHD TUDOMÁNYOS NAPOK

201
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____________________
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2012.

április
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2
-
1
3
.

Semmelweis Egyetem

Nagyvárad Téri Elméleti Tömb



PhD. Tudományos Napok
2012





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ELŐSZÓ


Az évente megrendezett PhD Tudományos Napok a Semmelweis Egyetem nyolc Doktori Iskolájában
tanulmányokat folytató hallgatók és doktorjelöltek kiemelkedő tudományos fórumává vált. Vonzó jelentőségét az
idei évben is a program iránti érdeklődés, az előadások

és poszter
-
bemutatók nagy száma jelzi.
A rendezvényen
résztvevők
az idei
évben is
a tudományos munka munltidiszciplináris seregszemléjének részesei lehetnek, hiszen
az Egyetem különböző tudományos műhelyeiben tevékenykedő PhD hallgatók és doktorjelöltek b
eszámolóin
keresztül a tudományterületek és tudományágak sokasága jelenik meg. A Semmelweis Egyetem Doktori
Iskoláinak hallgatóin kívül az előadók sorában az idei évben is örömmel üdvözöljük több hazai és külföldi
egyetem PhD hallgatóit.



A 2012. évi PhD
Tudományos Napok
on a
PhD hallgatók és doktorjelel
ö
ltek tudományos előadásain és poszter
-
bemutatóin kívül a 2011. évi Hugonnai Vilma Díj kit
ü
ntetettjeinek előadásait hallhatjuk. Dr. Zelkó Romána
egyetemi tanár és Dr. Müller Veronika egyetemi docens munkássá
ga, tudományos és oktatói elkötelezettsége
irányt mutat és példaképül szolgál a tudományos életpályájukat éppen megkezdő fiatalok számára. A rendezvény
programjának további részeként a Doktori Iskolák PhD hallgatói 9 előadás és 7 poszter szekcióban számoln
ak be
tudományos munkájuk eredményeiről.


Őszintén remélem, hogy 2012. évi PhD Tudományos Napok programja hasznos tapasztalatokkal szolgál és
emlékezetes élményt jelent minden kedves résztvevőnek és érdeklődőnek.


Budapest, 2012. április 12.







Dr
.
Rácz Károly


egyetemi tanár


a Doktori Tanács elnöke



PhD. Tudományos Napok
2012





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2012. április 12
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TUDOMÁNYOS PROGRAM



2012. április 12. csütörtök

08.30
-

08.50

Megnyitó: Dr. Tulassay Tivadar egyetemi tanár, a Semmelweis Egyetem

rektora

Dr. Rácz Károly egyetemi tanár, a Semmelweis Egyetem Doktori

Tanácsának elnöke

08.50
-

09.20


2011. évi ”Hugonnai Vilma Díjas” előadó: Dr. Zelkó Romána egyetemi

tanár

A pozitron annihilációs élettartam spektroszkópia gyógyszerészeti

alkalmazásának lehető
ségei

09.20
-

9.50

2011. évi ”Hugonnai Vilma Díjas” előadó: Dr. Müller Veronika

egyetemi docens

Celluláris stressz pulmonológiai kórállapotokban

09.50


10.20

Kávészünet

10.20
-

11.50

Előadások: E
-
I/1
-

E
-
I/9

11:50


13.00

Előadások: E
-
II/1


E
-
II/7

11.30
-

13.00

Poszterek: P
-
I/1
-

P
-
I/7

13.00
-

14.00

Ebédszünet

14.00
-

16.40

Előadások: E
-
III/1
-

E
-
III/16

14.00


15.00

Poszterek: P
-
II/1


P
-
II/5

15.10
-

15.40

Kávészünet

15.40


17:00

Poszterek: P
-
III/1
-

P
-
III/
7

16.40
-

18.50

Előadások:
E
-
IV/1


E
-
IV/13




2012.
április
13.
péntek

08.00


09.10

Előadások: E
-
V/1


E
-
V/7

09.10


11.20

Előadások: E
-
VI/1


E
-
VI/13

09.30
-

10.30

Poszterek: P
-
IV/1


P
-
IV/6

10.30


11.00

Kávészünet

11.20


13.00

Előadások: E
-
VII/1


E
-
VII/10

11.30


13.00

Poszterek: P
-
V/1


P
-
V/
10

13.00


14.00

Ebédszünet

14.00


15.50

Előadások: E
-
VIII/1


E
-
VIII/11

14.00


15.00

Poszterek: P
-
VI/1


P
-
VI/6

15.30


16.00

Kávészünet

15.50


17.40

Előadások: E
-
IX/1


E
-
IX/11

16.00


17.00

Poszterek: P
-
VII/1


P
-
VII/6

18.00
-

18.30

Zárszó, díjkiosztó




PhD. Tudományos Napok
2012





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2012. április 12
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7

TABLE OF CONTENTS


E/I ORAL PRESENTATIONS

Chairman: Prof. Dr. Zoltán Benyó

E/I
-
1

TRANSIENT OUTWARD PO
TASSIUM CURRENT IN D
OG ATRIAL
PREPARATIONS

Claudia Corici
, Zsófia Kohajda, Attila Kristóf, Tamás

Sz
él, Zoltán Husti, István Baczkó,

András Varró, László Virág, Norbert Jost

23

E/I
-
2

LATEST RESULTS OF TH
E RESPIRATORY ASPECT
S OF THE
INTERNATIONAL TWIN S
TUDY

David Laszlo Tarnoki
, Adam Domonkos Tarnoki, Emanuela Medda, Levente Littvay, Zsofia
Lazar, Rodolf
o Cotichini, Corrado Fagnani, Maria Antonietta Stazi, Lorenza Nisticó,
Pierleone Lucatelli, Emanuele Boatta, Chiara Zini, Fabrizio Fanelli, Claudio Baracchini,

Giorgio Meneghetti, Akos Koller, Janos Osztovits, Gyorgy Jermendy, István Préda, Róbert
Gábor Ki
ss, Kinga Karlinger, Agnes Lannert, Giuseppe Schillaci, Andrea Agnes Molnar,
Zsolt Garami, Viktor Berczi, Ildiko Horvath

24

E/I
-
3

SOPHISTICATED ARRHYT
HMIA DETECTION WITH
256
-
SLICE CT
ALLOWS DIAGNOSTIC CO
RONARY ARTERY IMAGIN
G IN PATIENTS WITH
ATRIAL
FIBRILLATION

CORONARY CT ANGIOGRA
PHY WITH 256
-
SLICE SCANNER IN PAT
IENTS
WITH ATRIAL FIBRILLA
TION

Mihály Károlyi
, Andrea Bartykowszki, Erik Formanek, Mohammed Muhemin, Csaba
Csobay
-
Novák, Nándor Pintér, Kálmán Hüttl, György Balázs, Béla Merkely, Pál Maurovi
ch
-
Horvat

26

E/I
-
4


THE ROLE OF MICRORNA
S IN RENAL ISCHEMIA
-
REPERFUSION INJURY

Tamás Kaucsár
, Csaba Révész, Mária Godó, Zsuzsanna Rácz, Róbert Tarszabó, Péter Hamar

27

E/I
-
5


ISOLATION AND CULTUR
E OF RAT BONE MARROW

MESENCHYMAL
STEM CELLS

Kinga Lakatos
,
Éva Szigetfű, Zsuzsanna Lendvai, Zoltán Nagy, Béla Merkely, Judit Skopál

28

E/I
-
6


CARDIOPULMONARY BYPA
SS IMPAIRS BRAIN OXY
GENATION AS
DEMONSTRATED BY NEAR
-
INFRARED SPECTROSCOP
Y

Peter Mukli

29

E/I
-
7


PREDICTORS OF CRT
-
INDUCED LEFT VENTRIC
ULAR REVERSE
REMODELING

Vivien Klaudia Nagy
, Valentina Kutyifa, Astrid Apor, Csilla Liptai, Eszter Édes, Gábor
Széplaki, Béla Merkely

30

E/I
-
8

LATEST RESULTS OF TH
E CARDIOVASCULAR AND

ANTHROPOMETRIC
ASPECTS OF THE IN
TERNATIONAL TWIN STU
DY

Adam Domonkos Tarnoki
, David Laszlo Tarnoki, Emanuela Medda, Maria Antonietta Stazi,
Rodolfo Cotichini, Corrado Fagnani, Lorenza Nisticó, Pierleone Lucatelli, Emanuele Boatta,
Chiara Zini, Fabrizio Fanelli, Claudio Baracchini,
Giorgio Meneghetti, Janos Osztovits,
Gyorgy Jermendy, István Préda, Róbert Gábor Kiss, Levente Littvay, Julia Metneki, Tamas
Horvath, Kinga Karlinger, Agnes Lannert, Andrea Agnes Molnar, Zsolt Garami, Pal Bata,
Gyorgy Baffy, Giuseppe Schillaci, Viktor Berc
zi

31



PhD. Tudományos Napok
2012





8

E/I
-
9


TWELVE
-
HOLES GOLD ELECTRODE

ABLATION CATHETER PR
OVED TO
BE EFFECTIVE AND SAF
E ALSO AT REDUCED IR
RIGATION FLOW RATE

Eszter Mária Végh
, Endre Zima, Tamás Szili
-
Török, Gábor Széplaki, Márta Hubay, Luc
Jordaens, László Gellér, Béla Merkely

33

E/
II ORAL PRESENTATIONS

Chairman: Dr. Gábor Békési

E/II
-
1


REGULATION OF GENE T
RANSCRIPTION BY GLUC
OCORTICOID
RECEPTOR (GR) ΒETA
-
ISOFORM

Bence T. Ács
, István Likó, Karolina Feldman, Péter M Szabó, Henrietta Butz, Károly Rácz,
Attila Patócs

37

E/II
-
2

THE
MYCOBACTERIAL DUTPAS
E: BIOCHEMISTRY, PHY
SIOLOGY AND
MOLECULAR INTERVENTI
ON

Rita Hirmondo
, Ildiko Pecsi, Anna Lopata, Amanda C. Brown, Tanya Parish, Beata G.
Vertessy, Judit Toth

38

E/II
-
3

ABSORPTION AND TENSI
LE STRENGTH OF CELL
-
COATED SUTURES

Denes
Horvathy
, Gabriella Vacz

39

E/II
-
4

DETECTION OF EARLY G
LAUCOMATOUS PROGRESS
ION WITH THE
RTVUE OPTICAL COHERE
NCE TOMOGRAPH AND SC
ANNING LASER
POLARIMETRY

Farzaneh Naghizadeh
, Anita Garas, Péter Vargha, Gábor Holló

40

E/II
-
5

COLORECTAL CARCINOGE
NESIS FROM
AN EPIGENETIC POINT
OF
VIEW: WHAT CAN DNA M
ETHYLATION ADD TO TH
E BETTER
MOLECULAR UNDERSTAND
ING OF ADENOMA
-
DYSPLASIA
-
CARCINOMA
SEQUENCE?

Árpád V. Patai
, Orsolya Galamb, Gábor Valcz, Alexanda Kalmár, Árpád Patai, Bálint
Péterfia, B. Wichmann, Katalin Leiszt
er, Kinga Tóth, Andrea Schöller, István Fűri, Barbara
Kinga Barták, Zsófia Brigitta Nagy, Sándor Spisák, Ferenc Sipos, Tibor Krenács, Béla
Molnár, Zsolt Tulassay

41

E/II
-
6

INVESTIGATION OF TRA
NSPORTER INTERACTION
S OF
ANTIMALARIALS IN VIT
RO

Péter Szerémy
,
Ildikó Makai, Márton Jani, Marton Lívia, Szilvia Gedey, Katalin Jakab, János
Márki
-
Zay, Péter Krajcsi

43

E/II
-
7


ANALYZING THE RELIAB
ILITY OF THE SPINAL
INSTABILITY
NEOPLASTIC SCORE

Zsolt Szövérfi
, Árpád Bozsodi

44

E/III ORAL PRESENTATIONS

Chairman:
Prof. Dr. Károly Cseh

E/III
-
1

PH REGULATION DURING

AMELOGENESIS


FUNCTIONAL EVIDENCE
OF BICARBONATE TRANS
PORT IN HAT
-
7 AMELOBLAST CELLS

Erzsébet Bori

47

E/III
-
2


AMBULATORY ARTERIAL
STIFFNESS INDEX IN C
HILDREN AFTER
KIDNEY TRANSPLANTATI
ON


CROSS SECTIONAL STUD
Y

Arianna Dégi
, Andrea Kerti, Attila J. Szabó, Péter Sallay, Éva Kis, Orsolya Cseprekál, George
S. Reusz

48



2012. április 12
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13
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9

E/III
-
3

CHANGES IN PHOTOPIGM
ENT EXPRESSION AND
PHOTORECEPTOR
MORPHOLOGY IN EARLY
DIABETES

Anna Énzsöly
, Arnold Szabó, Klaudia Szabó, Ákos Lukáts, János Németh

49

E/III
-
4


CLINICOPATHOLOGICAL
FEATURES OF LUNG CAN
CER WITH BRAIN
METASTASES

Katalin Fábián

50

E/III
-
5


POLYMORPHISM OF THE
HSD11B1 GENE PROMOTE
R INFLUENCES
BONE MINERAL DENSITY


Karolina Feldman
, Ágnes Szappanos, Zsófia Kövesdi, Miklós Tóth, István Likó, Péter
Lakatos, Károly Rácz, Attila Patócs

51

E/III
-
6


POSTCONDITIONING AS
A PREVENTION METHOD
AFTER LOW
ER LIMB
ISCHEMIA
-
REPERFUSION INJURY:
REDUCING DAMAGES OF
THE LUNG

Dávid Garbaisz
, Zsolt Turóczi, Olivér Rosero, Gábor Lotz, Zoltán Rakonczay, László
Harsányi, Attila Szijártó

52

E/III
-
7


ANTI
-
INFLAMMATORY EFFECTS

OF MOUSE MESENCHYMAL

STEM
CELLS ON
MICROGLIA

Beáta Hegyi

53

E/III
-
8


SIGMA
-
1 RECEPTOR AGONIST T
REATMENT IS PROTECTI
VE AGAINST
RENAL ISCHEMIA/REPER
FUSION INJURY

Ádám Hosszú
, Nóra Fanni Bánki, Zsuzsa Antal, Sándor Kőszegi, László Wagner, Ágnes
Prókai, Ádám Vannay, Veronika Müller, Attila Sza
bó, Andrea Fekete

54

E/III
-
9

NPHS2 P.V290M MUTATI
ON IN LATE
-
ONSET STEROID
-
RESISTANT
NEPHROTIC SYNDROME

Andrea Kerti
, Rózsa Csohány, Attila Szabó, Péter Sallay, György Reusz, Kálmán Tory

55

E/III
-
10


THE ROLE OF THE SIGM
A
-
1 RECEPTOR IN DIABET
IC
NEPHROPATHY

Sándor Kőszegi
, Bánki Nóra Fanni, Ádám Hosszú, László Wagner, Ágnes Prókai, Ádám
Vannay, Tivadar Tulassay, Andrea Fekete

56

E/III
-
11


ACTIVATION OF SMAD 2

AND 3 IN THE INTESTI
NAL MUCOSA OF
PEDIATRIC PATIENTS W
ITH INFLAMMATORY BOW
EL DISEASE AND

IN
HT
-
29 CELL LINES

Kriszta Molnar
, Ádám Vannay, Leonóra Balicza
-
Himer, Apor Veres
-
Székely, Dolóresz
Szabó, Nóra Fanni Bánki, András Arató, Gábor Veres

57

E/III
-
12


THE EFFECTS OF POSTC
ONDITIONING IN A LON
G
-
TERM PERIOD RAT
LIVER ISCHEMIC
-
REPERFUSION
EXPERIMENTAL MODEL

Rosero Olivér
, Ónody Péter, Garbaisz Dávid, Tamás Judith, Kocsis Ibolya, Lotz Gábor,
Harsányi László, Szijártó Attila

58

E/III
-
13


POSITIONAL IDENTITY
OF MURINE MESENCHYMA
L STEM CELLS
RESIDENT IN DIFFEREN
T ORGANS IS DETERMIN
ED IN THE
PO
STSEGMENTATION MESOD
ERM

Bernadett Sági

59

E/III
-
14


BIOMARKERS OF BONE F
ORMATION AND GUT PER
MEABILITY IN
LONG
-
TERM INFLIXIMAB THER
APY IN PEDIATRIC PAT
IENTS WITH
CROHN'S DISEASE

Doloresz Szabó
, Katalin Köles, Antal Dezsőfi, András Arató, Gábor Veres

60



PhD. Tudományos Napok
2012





10

E/III
-
15


9
-
CIS
-
RETINOIC ACID
-
INDUCED GENE EXPRESS
ION ALTERATIONS IN
AN ADRENOCORTICAL CE
LL LINE

Diana Rita Szabó
, Peter M. Szabó, Adrienn Zsippai, Katalin Éder, Attila Patócs, András
Falus, Károly Rácz, Peter Igaz

61

E/III
-
16



DIFFERENT ADJUVANT A
NTIOXI
DANT TREATMENTS IN F
ATTY LIVER

Viktor Hegedüs
, Dénes Kleiner, Kálmán Ditrói, József Prokisch, Hedvig Fébel, Éva Sárdi,
Gábor Lotz, Attila Szijártó, Anna Blázovics

62

E/IV ORAL PRESENTATIONS

Chairman: Dr. Péter Hamar

E/IV
-
1


THE FIRST CENTRAL
-
EUROPEAN
CARDIOVASCULAR PREVE
NTION
STUDY
-

BUDAKALASZ HEALTH EX
AMINATION SURVEY

Zsolt Bagyura
, Zsolt Szelid, Pál Soós, Loretta Kiss, Béla Merkely

65

E/IV
-
2


EFFECTS OF THE BENZO
DIAZEPINE DERIVATIVE
, 5
-
BDBD ON THE P2X
4

PURINERGIC RECEPTOR
CHANNEL

Bernadett Balázs
,
Tamás Dankó, Fanni Noémi Rocskó, Ákos Zsembery

66

E/IV
-
3


H
2
S PRECONDITIONING OF

THERAPEUTICALLY USED

STEM CELLS
INCREASES THEIR SURV
IVAL AND EFFICACY IN

AN IN VITRO MODEL
OF CELL
-
BASED THERAPY IN MYO
CARDIAL INFARCT

Zsolt Benkő
, Eleni Dongó, Ágnes
Csizmazia, Mónika Szepes, Zsófia Janicsek, Levente Kiss

67

E/IV
-
4


BILAYER EDGES CATALY
ZE LIPOSOME BINDING,

MOVEMENT AND
RUPTURE ON SOLID SUR
FACES

Tamás Bozó

68

E/IV
-
5


CORONARY INTERVENTIO
N LEADS TO COMPLEMEN
T ACTIVATION
THROUGH THE ALTERNAT
IVE PATHWAY

Zsófia Horváth
, Dorottya Csuka, Katarina Vargova, Andrea Kovács, Andrea Ágnes Molnár,
Leé Sarolta, Lilian Varga, Róbert Gábor Kiss, István Préda, George Füst

69

E/IV
-
6


NANOMECHANICS OF DES
MIN FILAMENTS EXPLOR
ED WITH OPTICAL
TWEEZERS

Balázs Kiss
,
Pasquale Bianco

70

E/IV
-
7

REVERSIBLE LOW
-
FORCE
-
DRIVEN STRUCTURAL TR
ANSITIONS IN
SKELETAL MUSCLE TITI
N REVEALED BY FORCE
-
CLAMP OPTICAL
TWEEZERS

Zsolt Mártonfalvi
, Pasquale Bianco, Miklós Kellermayer

71

E/IV
-
8


DETAILED HEMODYNAMIC

CHARACTERIZATION OF
ATHL
ETE’S
HEART USING LEFT VEN
TRICULAR PRESSURE
-
VOLUME ANALYSIS IN A

RAT MODEL

Attila Oláh
, Árpád Lux, Ede Birtalan, László Hidi, Balázs Németh, Béla Merkely, Tamás
Radovits

72

E/IV
-
9


MEASURMENT OF PLATEL
ET ADHESION USING IM
PEDANCE BASED
TECHNIQUE

Lívia
Polgár

73

E/IV
-
10


NANOMECHANICAL MANIP
ULATION OF MASON
-
PFIZER MONKEY
RETROVIRAL RNA FRAGM
ENT WITH OPTICAL TWE
EZERS

Melinda Simon
, Zsolt Mártonfalvi, Pasquale Bianco, Beáta Vértessy, Miklós Kellermayer

74



2012. április 12
-
13
.





11

E/IV
-
11


THE EFFECT OF THE OB
STRUCTIVE SLEEP APNE
A ON THE NIGHT
-
TIME GLUCOSE VARIABI
LITY IN PATIENTS WIT
H METABOLIC
SYNDROME

Orsolya A. Veber
, Andrea Dunai, Rezso Zoller, Zsofia Lendvai, Anett V. Lindner, Istvan
Mucsi

75

E/IV
-
12

THE ATHLETE’S HEART

Zsuzsanna Major
, Zsuzsanna Kneffel, Tímea Kováts,
Eszter Csajági

76

E/IV
-
13


DIFFERENT MITOCHONDR
IAL BIOGENESIS TO EX
ERCISE TRAINING IN
LOW AND HIGH EXERCIS
E RESPONDER RATS

Orsolya Marton
, Erika Koltai, Ferenc Torma, Steven Britton, Lauren Koch, Zsolt Radák

77

E/V ORAL PRESENTATIONS

Chairman: Dr. Árpád
Dobolyi

E/V
-
1


PROTEIN
-
PROTEIN INTERACTIONS

REGULATE THYROID HOR
MONE
ACTIVATION

Péter Egri
, Balázs Gereben

81

E/V
-
2


FASTING
-
INDUCED ALTERATIONS
IN THE Α
-
MSH
-

AND AGRP
-
IMMUNOREACTIVE INNER
VATION OF TRH
-
SYNTHESIZING NEURONS

IN THE HYPOTHALAMIC
PVN

Andrea
Kádár
, Edith Sanchez, Balázs Gereben, Ronald M. Lechan, Csaba Fekete

82

E/V
-
3


A REDUCTION IN THE A
CTIVITY OF ALPHA
-
KETOGLUTARATE
DEHYDROGENASE COMPLE
X DECREASES MATRIX S
UBSTRATE
-
LEVEL
PHOSPHORYLATION AND
PROMPTS RESPIRATION
-
IMPAIRED
MITOCHONDRIA TOWARDS

EXTRAMITOCHONDRIAL A
TP
CONSUMPTION

Gergely Kiss
, Csaba Konrád, Anatoly A. Starkov, Hibiki Kawamata, Giovanni Manfredi,
Steven F. Zhang, Gary E. Gibson, M. Flint Beal, Vera Adam
-
Vizi, Christos Chinopoulos

83

E/V
-
4


MONOCARBOXYLATE
-
TRANSPORTER
-
8 AND TYPE 3
DEIODINASE IN
AXON TERMINALS OF TH
E MEDIAN EMINENCE AL
LOW SYSTEM
-
SPECIFIC REGULATION
OF T3
-
ACTION IN HYPOTHALAM
IC
HYPOPHYSIOTROPIC NEU
ROSECRETORY NEURONS

Petra Mohácsik
, Imre Kalló, Barbara Vida, Anikó Zeöld, Zsuzsanna Bardóczy, Erzsébet
Farkas, Andrea
Kádár, Antonio C. Bianco, Zsolt Liposits, Csaba Fekete, B. Gereben

84

E/V
-
5


AGING COINCIDES WITH

MORPHOLOGICAL ALTERA
TIONS OF
KISSPEPTIN AND NEURO
KININ B NEURONS IN T
HE INFUNDIBULAR
NUCLEUS OF THE HUMAN

MALE

Csilla S. Molnár
, Barbara Vida, Máté Sipos, Im
re Kalló, Philippe Ciofi, Beáta Borsay, Stephen
R. Bloom, Mohammad A. Ghatei, Waljit S. Dhillo, Zsolt Liposits, Erik Hrabovszky

85

E/V
-
6



ALTERNATIVE SPLICING

OF EGFR ECD IN HUMAN

MELANOMA

Eleonóra Imrédi

86

E/V
-
7


MIRNA EXPRESSION PRO
FILE OF ADENOID
CYSTIC CARCINOMA OF
SALIVARY GLANDS AND
THE BREAST: PRELIMIN
ARY RESULTS

Orsolya Kiss
, Anna
-
Mária Tőkés, Sándor Spisák, Eszter Gábori, Anikó Bata, Subramanian
Kumar, Borbála Székely, Attila Marcell Szász, Janina Kulka

87



PhD. Tudományos Napok
2012





12


E/VI ORAL PRESENTATIONS

Chairmen:

Prof. Dr. István Bitter, Dr. János Réthelyi, Dr. Róbert Bódizs

E/VI
-
1


BEHAVIOURAL
-
EPIDEMIOLOGICAL ANAL
YSIS OF ADOLESCENTS’

SMOKING IN A POPULAT
ION OF A SMALL TOWN
BETWEEN 2008 AND 201
0

Mate A. Balazs
, Bettina F. Piko

91

E/VI
-
2


SUBTHRESHOLD PSYCHIA
TRIC

CONDITIONS IN CHILD
PSYCHIATRY: A
LONGITUDINAL STUDY

Eszter Anna Bertha

92

E/VI
-
3


RELATIONSHIP BETWEEN

PSYCHOLOGICAL RISK F
ACTORS AND
SOMATIC FACTORS IN A
CUTE CORONARY SYNDRO
MES

Beatrix Rafael
, Piroska Balog

93

E/VI
-
4


OBSTETRICAL AND GYNE
COLOGICAL CON
SEQUENCES OF EATING
DISORDERS

Szilvia Dukay
-
Szabó

94

E/VI
-
5


ADVERSE LIFE EVENTS
AND SUICIDE RISK IN
PEOPLE WITH
SCHIZOPHRENIA

Krisztina Kocsis
-
Bogár
, Dóra Perczel
-
Forintos, Mónika Miklósi

95

E/VI
-
6


EFFECTS OF CURRENT A
LCOHOL AND TOBACCO C
ONSUMPTION ON
PHYSICAL AGGRESSION
AND ADHD SYMPTOMS AM
ONG HUNGARIAN
ADOLESCENTS

Balázs Matuszka
, Erika Bácskai, József Gerevich

96

E/VI
-
7


THE EFFECT OF PERCEI
VED PARENTAL EFFICAC
Y ON PARENTS’
GENERAL DISTRESS AFT
ER THEIR CHILD’S SUR
GERY

Mónika Miklósi
, Elvira Galambos
i

97

E/VI
-
8


BEHAVIOURAL INHIBITI
ON AND IMPULSIVITY I
N ADULT ATTENTION
DEFICIT HYPERACTIVIT
Y DISORDER

Szilvia Papp
, László Tombor, Brigitta Kakuszi, Lívia Balogh, Viktória Simon, Pál Czobor

98

E/VI
-
9


QUANTITATIVE EEG IN
ADULT ATTENTION DEFI
CIT/

HYPERACTIVITY DISORD
ER (ADHD)

LÁSZLÓ TOMBOR
, SZILVIA PAPP, BRIG
ITTA KAKUSZI, LÍVIA
BALOGH,
VIKTÓRIA SIMON, PÁL
CZOBOR

99

E/VI
-
10


SUICIDAL BEHAVIOR: P
SYCHOLOGICAL AND ETH
NICAL DIFFERENCES
IN THE SERIOUSNESS O
F DELIBERATE SELF PO
ISONING

Mónika Ditta Tóth
,
András Székely, Szilvia Ádám, Tamás Zonda, Mária Kopp

100

E/VI
-
11


ASSOCIATION BETWEEN
LUNAR PHASE AND SLEE
P CHARACTERISTICS

Csilla Zita Turányi
, András Szentkirályi, Mária Czira, Andrea Dunai, Julianna Szőcs, Orsolya
Véber, Katalin Rónai, Andrea Kelemen,

Rezső Zoller, Márta Novák, István Mucsi

101

E/VI
-
12


COMORBID FACTORS OF
INDIVIDUALS WITH A T
ENDENCY TO
ORTHOREXIA NERVOSA

Márta Varga
, Szilvia Dukay
-
Szabó, Ferenc Túry, Eric F. van Furth

102

E/VI
-
13


VARIANTS IN CATECHOL
-
O
-
METHYLTRANSFERASE GE
NE ARE
ASSOCIATED WITH IMPU
LSIVITY AND EXECUTIV
E FUNCTION:
RELEVANCE FOR MAJOR
DEPRESSION

Dorottya Pap
, Ian M. Anderson, J.F. William Deakin, Gyorgy Bagdy, Gabriella Juhasz

103



2012. április 12
-
13
.





13

E/VII ORAL PRESENTATIONS

Chairman: Prof. Dr. Gábor Bánhegyi

E/VII
-
1


MODULATION OF
EXPERIMENTAL MODELS
OF AUTOIMMUNITY BY
EXTRACELLULAR VESICL
ES

Borbála Aradi
, Krisztina Pálóczi, Petra Misják, Bence György, Tamás G. Szabó, Ágnes Kittel,
Szilvia Bősze, Kata Horváthi, Krisztina Holló, Katalin Szabó
-
Taylor, Mária Pásztói, András
Falus, Edit

I. Buzas

107

E/VII
-
2


INQUIRING ABOUT AVIA
N THYMIC DENDRITIC C
ELLS

Ildikó Bódi

108

E/VII
-
3


ASSOCIATION AND MOLE
CULAR ANALYSIS OF TH
E WFS1 GENE

Zsuzsanna Elek

109

E/VII
-
4


IN VITRO AND CELLULA
R STUDY OF EGFR


C
-
MET KINASE INHIBITOR
S
IN NSCLC CELL
LINES

Pal Gyulavari
, Balint Szokol, Ibolya Kurko, Gyorgyi Bokonyi, Gabor Borbely, Csaba Szantai
-
Kis, Laszlo Orfi, Istvan Petak, Gyorgy Keri, Tibor Vantus

110

E/VII
-
5



ABSENCE OF CA2+
-
INDUCED MITOCHONDRIA
L PERMEABILITY
TRANSITION BUT PRESE
NCE OF BONGKREKA
TE
-
SENSITIVE
NUCLEOTIDE EXCHANGE
IN C. CRANGON AND P.

SERRATUS

Csaba Konrad
, Gergely Kiss, Beata Torocsik, Vera Adam
-
Vizi, Christos Chinopoulos

111

E/VII
-
6


IKZF1 AND ARID5B GEN
E POLYMORPHISMS INFL
UENCE THE
SUSCEPTIBILITY TO CH
ILDHOOD ACUTE LYMPHO
ID LEUKE
MIA

Orsolya Lautner
-
Csorba
, Ágnes F. Semsei, András Gézsi, Nóra Kutszegi, András Falus,
Csaba Szalai

112

E/VII
-
7


INVESTIGATION OF THE

MIRNA BINDING SITE P
OLYMORPHISMS OF
THE SNAP
-
25 GENE

Nóra Németh
, Réka Kovács
-
Nagy, Zsolt Rónai, Mária Sasvári
-
Székely

113

E/VII
-
8


REGULATION OF CASKIN
1 SCAFFOLD PROTEIN B
Y EPHB1 TYROSINE
KINASE

Szabolcs Pesti
, Annamária Balázs, Beáta Szabó, László Buday

114

E/VII
-
9


EFFECT OF EGCG ON MI
CROSOMAL CORTISOL PR
ODUCTION

Péter Szelényi

115

E/VII
-
10


SWITCHING ON RNA
SILENCING SUPPRESSOR

ACTIVITY BY
REMODELING THE ARGON
AUTE BINDING DOMAIN

Edit Szabó
, Máté Manczinger, Anikó Göblös, Lajos Kemény, Lóránt Lakatos

116

E/VIII ORAL PRESENTATIONS

Chairperson: Prof. Dr. Éva Szökő

E/VIII
-
1


INDICATION OF BRAIN
PENETRABLE COMPOUNDS

IN PLANT
EXTRACTS BY PAMPA
-
BBB


LC
-
MS ASSAY

Árpád Könczöl
, Ágnes Kéry, Judit Müller, Emília Földes, György T. Balogh

119

E/VIII
-
2


PHARMACOLOGICAL REGU
LATION OF TUMOR CELL

ADHESION AND
MIGRATION BY CYTOTOX
IC GNRH
-
III CONJUGATES AND R
-
DEPRENYL
DERIVATIVES TO PREVE
NT METASTASIS FORMAT
ION

Eszter Lajkó
, Lívia Polgár, Marilena Manea, Gábor Mező, Kálmán Magyar, László Kőhidai

120



PhD. Tudományos Napok
2012





14

E/VIII
-
3


IMPACT OF THE AQUATI
C POLLUTANT HUMAN PH
ARMACEUTICALS
AND THEIR MIXTURES O
N THE

PROLIFERATION AND MI
GRATORY
BEHAVIOR OF THE FRES
HWATER CILIATE TETRA
HYMENA
PYRIFORMIS

Júlia Láng
, László Kőhidai

121

E/VIII
-
4


DETERMINATION AND ST
UDY ON DOSE LINEARIT
Y OF THE
PHARMACOKINETICS OF
M
-
CHLOROPHENYLBIGUANID
E USING A
NEWLY DEVELOPED HPLC

UV
AND EC METHOD

Rudolf Laufer
, Péter Szegi, Viola Csomor, Kornélia Tekes

122

E/VIII
-
5


TRIPODAL ION
-
BINDING RECEPTORS: S
YNTHESIS AND
CHARACTERIZATION

Gábor Neumajer
, Attila Marosi, Szabolcs Béni, Béla Noszál

123

E/VIII
-
6


PHARMACOKINETICS OF
K203, A BIS
-
PY
RIDINIUM MONO
-
ALDOXIME
CHOLINESTERASE REACT
IVATOR IN RATS AND B
EAGLE DOGS


Zita Pöstényi
, Péter Szegi, Balázs Tasnádi

124

E/VIII
-
7


OPTIMIZATION PROCESS

AND HPLC BEHAVIOR OF

SOME NOVEL BIS
-
PYRIDINIUM ALDOXIMES

Péter Szegi
, Zita Pöstényi, Balázs Tasnádi,
Rudolf Laufer, Kamil Kuča

125

E/VIII
-
8


CHARACTERIZATION OF
OFLOXACIN
-
CYCLODEXTRIN COMPLEX
ATION

Gergő Tóth
, Réka Mohácsi, Ákos Rácz, Aura Rusu, Péter Horváth, Szabolcs Béni,

Béla Noszál

126

E/VIII
-
9


SAMPLE PRE
-
FRACTIONATION METHOD

FOR ANALYSIS OF
GLYCOPROTEINS FROM H
UMAN PLASMA

Eszter Tóth
, Oliver Ozohanics, Lilla Turiák

127

E/VIII
-
10


GLUCOSIDES OF MORPHI
NE CONGENERS: SYNTHE
SIS AND
CHARACTERIZATION

András Váradi
, Dóra Lévai, Gergő Tóth, Péter Horváth, Sándor Hosztafi

128

E/VIII
-
11


CHARACTERIZATION THE

EFFECTS OF A NOVEL P
KD1 INHIBITOR IN
VEGF SIGNALING PATHW
AY ON ENDOTHELIAL CE
LLS

Attila Varga
, Csaba Szántai
-
Kis, Zoltán Horváth, Zoltán Greff, László Őrfi, György Kéri,
Tibor Vántus

129

E/IX ORAL PRESENTATIONS

Chairman: Prof. Dr. Lás
zló Kopper

E/IX
-
1


CHANGES OF MIRNA EPR
ESSION PATTERN DURIN
G THE HUMAN
MELANOMA PROGRESSION

Tamás Barbai
, Erzsébet Rásó

133

E/IX
-
2

ANGIOGENESIS IS CHAL
LENGED IN EXPERIMENT
AL BRAIN
METASTASES

Edina Bugyik
, Vanessza Szabó, Katalin Dezső, Péter Nagy, Sándor

Paku

134

E/IX
-
3


HEPATOCARCINOGENESIS

IN MATRILIN
-
2 KNOCK OUT MICE

Alexandra Fullár
, Kornélia Baghy, Ferenc Deák, Bálint Péterfia, Zsuzsa Schaff, József Dudás,
Ibolya Kiss, Ilona Kovalszky

135



2012. április 12
-
13
.





15

E/IX
-
4


ONCOGENIC MUTATION D
EPENDENT EFFECT OF P
RENYLATION
INHIBITION IN MELANO
MA CELLS

Tamás Garay
, István Kenessey, Éva Juhász, Andrea Réti, Viktória László, Judit Dobos,
Violetta Piurkó, Walter Berger, József Tóvári, József Tímár, Balázs Hegedűs

136

E/IX
-
5


GENETIC AND EPIGENET
IC EXAMINATION OF TH
E SMARCB1/INI
1
GENE IN EPITHELIOID
SARCOMA

Gergő Papp

137

E/IX
-
6


EXAMINATION OF TARGE
TED SNP VARIANTS IN
SIX GENES WITH
POSSIBLE EFFECT ON A
DULT CRANIAL SUTURE
SYNOSTOSIS

Katalin Wolff
, Zoltán Vas, Éva Hadadi

138

E/IX
-
7


ANTIVIRAL EFFECTS OF

A FERMENTED WHEAT GE
RM
EXTRACT
(AVEMAR), IN THE FEL
INE AIDS MODEL

Balázs Stercz

139

E/IX
-
8


m
TORC1 AND C2 EXPRESS
ION IN HUMAN COLON C
ANCER

Tamás Sticz
, Anna Sebestyén, Ágnes Márk, Melinda Hajdu, Tamás Micsik, Noémi Nagy,
László Kopper

140

E/IX
-
9


CONNECTIONAL HIERARC
HY IN THE
PRIMARY SOMATOSENSOR
Y
CORTEX OF PRIMATES

Maria Ashaber
, Emese Pálfi, Cory Palmer, Orsolya Kantor, Robert M. Friedman, Anna W.
Roe, Laszlo Négyessy

141

E/IX
-
10



LAMINAR ANALYSIS OF
THE SLOW CORTICAL RH
YTHM IN RAT
SOMATOSENSORY CORTEX

UNDER KETAMINE/XYLAZ
I
NE ANESTHESIA

Richárd Fiáth
, Bálint Péter Kerekes, György Karmos, István Ulbert

142

E/IX
-
11


CENTRAL AMYLIN IS A
NOVEL NEUROPEPTIDE W
ITH POTENTIAL
MATERNAL FUNCTIONS I
N RAT

Éva Rebeka Szabó
, Melinda Cservenák, Árpád Dobolyi

143

P/I POSTER PRESENTATIONS

Chairman: Dr. Barna Vásárhelyi

P/I
-
1


EXAMINATION OF PHOTO
SENSITIZER
-
CELLULAR MEMBRANE MO
DEL
WITH OPTICAL SPECTRO
SCOPY METHODS

Dániel Veres
, Barnabás Bőcskei
-
Antal

147

P/I
-
2


RED BLOOD CELL DISTR
IBUTION WIDTH PREDIC
TS UNFAVOURABLE
OUTCOME FOLLOWING
CARDIAC RESYNCHRONIZ
ATION THERAPY

Annamaria Kosztin
, Gabor Szeplaki, Eszter Maria Vegh, Szabolcs Szilagyi, Istvan
Osztheimer, Levente Molnar, Endre Zima, Laszlo Geller, Zoltan Prohaszka, Bela Merkely

148

P/I
-
3


THE EFFECT OF OBESTA
TIN ON BEHAVIORAL
RESPONSES INDUCED
BY MORPHINE WITHDRAW
AL IN MICE

Nándor Lipták
, Roberta Dochnal, Krisztina Csabafi, Júlia Szakács, Gyula Szabó

149

P/I
-
4


ELASTIC, CONTRACTILE

AND ENDOTHELIAL PROP
ERTIES OF HUMAN
VEIN SEGMENTS STORED

IN A COMPLEX TISSUE
MEDIUM

Anna
Monori
-
Kiss
, Gábor Ferenc Molnár, Attila Nemes, Violetta Kékesi, Emil Monos,
György László Nádasy

150



PhD. Tudományos Napok
2012





16

P/I
-
5


COMPARISON OF EPITAX
IALLY AND SOLUTION
-
GROWN AMYLOID ß25
-
35
FIBRILS

Ünige Murvai
, Judit Somkuti, Katalin Soós, Botond Penke, László Smeller, Mikló
s S. Z.
Kellermayer

151

P/I
-
6


TEMPERATURE
-
PRESSURE STABILITY A
ND T
-
P PHASE DIAGRAM OF
PARVALBUMIN

Judit Somkuti
, Merima Bublin, Heimo Breiteneder, László Smeller

152

P/I
-
7


RENAL FUNCTION IS AS
SOCIATED WITH RED CE
LL DISTRIBUTION
WIDTH INDEPENDENT OF

IRON DEFICIENCY AND
NUTRITIONAL
STATUS IN KIDNEY TRA
NSPLANT RECIPIENTS

Ákos Ujszászi
, Mária Eszter Czíra, Ádám Remport, Csaba Pál Kövesdy, Anna Rudas, Miklós
Zsolt Molnár, István

Mucsi

153

P/II POSTER PRESENTATIONS

Chairman: Dr. Csaba Fekete

P/II
-
1


NMDA RECEPTORS IN GA
BAERGIC SYNAPSES DUR
ING POSTNATAL
DEVELOPMENT

Csaba Cserép
, Eszter Szabadits, András Szőnyi, Masahiko Watanabe, Tamás F. Freund,
Gábor Nyiri

157

P/II
-
2


POSTERIOR THALAMIC T
IP39 NEURONS PROJECT

TO THE MEDIAL
HYPOTHALAMUS AND REG
ULATE PROLACTIN SECR
ETION IN
MOTHERS

Melinda Cservenák
, Ibolya Bodnár, György M. Nagy, Ted B. Usdin, Miklós Palkovits,

Árpád Dobolyi

158

P/II
-
3


OPTOGENETIC APPROACH

FOR INVESTIGA
TION OF NEURONAL
MATURATION

Tímea Kőhidi

159

P/II
-
4


ALTERED DEVELOPMENT
OF HYPOTHALAMUS IN I
NTRAUTERINE
UNDER NOURISHED RATS

MAY CONTRIBUTE TO ME
TABOLIC
DISORDERS IN ADULTHO
OD

Katalin Könczöl
, Miklós Palkovits, Zsuzsanna E. Tóth

160

P/II
-
5


PHARMACOGENOMICAL SI
GNIFICANCE OF MITOCH
ONDRIAL DNA
SUBSTITUTIONS

Viktória Reményi
, György Máté Milley, Gábor Nyírő, Anikó Gál, Mária Judit Molnár

161



2012. április 12
-
13
.





17


P/III POSTER PRESENTATIONS

Chairman: Prof. Dr. Péter Lakatos

P/III
-
1


CAN HUMAN DNA ACTIVA
TE IMMUNE
CELLS VIA TLR9?

CYTOKINE PROFILE OF
HT
-
29 CELLS TREATED WIT
H HUMAN DNA
ISOLATED FROM HUMAN
CANCER CELLS

István Fűri
, Sándor Spisák, Árpád V. Patai, Ferenc Sipos, Barnabás Wichmann, Orsolya
Galamb, Gábor Valcz, Alexandra Kalmár, Bálint Péterfia, Katalin Lei
szter, Kinga Tóth,
Andrea Schöller, Barbara Kinga Barták, Zsófia Brigitta Nagy, Tibor Krenács, Béla Molnár,
Zsolt Tulassay

165

P/III
-
2


VENULAR DIAMETER REG
ULATORY ROLE OF THE
VASCULAR
ENDOTHELIAL GROWTH F
ACTOR (VEGF) IN DIFF
ERENT CONDITIONS
OF RAT GINGIV
A

Milán Gyurkovics
, Zsolt Lohinai, Adrienne Győrfi, Csaba Bodor, Andrea Dorottya Székely,
Elek Dinya, László Rosivall

166

P/III
-
3


GENE EXPESSION
-
BASED ANALYSIS OF CO
LORECTAL DYSPLASIA
-
CARCINOMA TRANSITION


Alexandra Kalmár
, Orsolya Galamb, Sándor Spisák,

Barnabás Wichmann, Ferenc Sipos,
Tibor Krenács, Kinga Tóth, Katalin Leiszter, Andrea Schöller, István Fűri, Zsófia Brigitta
Nagy, Barbara Kinga Barták, Zsolt Tulassay, Béla Molnár

167

P/III
-
4


RENIN
-
ANGIONTENSIN
-
ALDOSTERONE
-
SYSTEM BLOCKERS IN
DIABETIC NE
PHROPATHY: THE ROLE
OF THE SIGMA
-
1 RECEPTOR

Lilla Lénárt
, Nóra Fanni Bánki, Ágota Vér, László Wagner, Ágnes Prókai, Sándor Kőszegi,
Ádám Hosszú, Attila Szabó, Andrea Fekete

168

P/III
-
5


INVESTIGATION OF THY
MIDYLATE SYNTHASE GE
NE POLYMORPHISM
IN COLON
CANCER PATIENTS

Andrea Schöller
, Alexandra Kalmár, Árpád V. Patai, Zsófia Nagy, Barbara Barták, Orsolya
Galamb, Sándor Spisák, Lídia Sréter, Béla Molnár, Zsolt Tulassay

169

P/III
-
6


COGNITIVE FUNCTION I
N PATIENTS WITH TYPE

1 DIABETES

Barbara Szémán
, Géza

Nagy, Anna Veres
-
Székely, Mária Sasvári, Dávid Fitala, Adrienn
Szöllősi, Orsolya Hadarits, Zahra Al
-
Aissa, Anikó Somogyi

170

P/III
-
7


DETECTION OF METHYLA
TED SEPT9 PERIPHERAL

BLOOD SCREENING
MARKER IN BOTH LEFT
-

AND RIGHT
-

SIDED COLON CANCER A
ND
COMPAR
ISON TO FOBT AND CEA

Kinga Tóth
, Jürgen Beck, Kerstin Buser, Zsófia Brigitta Nagy, Barbara Kinga Barták, Robert
Stöhr, Henriette Golcher, Vera Schellerer, Zsolt Tulassay, Béla Molnár

171

P/IV POSTER PRESENTATIONS

Chairman: Dr. Attila Patócs

P/IV
-
1


THE COMPACT MUTATION

OF MYOSTATIN CAUSES
SKELETAL MUSCLE
HYPERPLASIA

Júlia Baán
, Tamás Kocsis, Anikó Keller
-
Pintér, Luca Mendler, László Dux

175

P/IV
-
2


A NOVEL BURSAL STEM
CELL ANTIGEN: CHARAC
TERIZATION AND
ONTOGENIC STUDY

Nóra Fejszák

176



PhD. Tudományos Napok
2012





18

P/IV
-
3


EFFECT OF THE COMPAC
T MUTATION ON THE GL
YCOGEN CONTENT
OF SKELETAL MUSCLE

Tamás Kocsis
, Júlia Baán, Luca Mendler, Anikó Keller
-
Pintér, László Dux

177

P/IV
-
4


EFFICIENCY OF TRANSF
ECTION ALONG THE REG
ENERATING SOLEUS
MUSCLE

Magdolna Kósa
, Ernő Zádor

178

P/
IV
-
5


MISPLACED PHOTORECEP
TORS DURING POSTNATA
L DEVELOPMENT
IN THE RAT RETINA

Klaudia Szabó
, Arnold Szabó, Anna Énzsöly, Ágoston Szél, Ákos Lukáts

179

P/IV
-
6


META
-
ANALYTIC COMPARISON
OF PROTEOMIC DATA ON

EXTRACELLULAR VESICL
E SUBSETS

Tamás G. Szabó
,
Petra Misják, Borbála Aradi, Bence György, Mária Pásztói, Zsuzsanna Pál,
Krisztina Pálóczi, Valéria László, Éva Pállinger, Erna Pap, Ágnes Kittel, K. Taylor
-
Szabó,
György Nagy, András Falus, Edit Buzás

180

P/V POSTER PRESENTATIONS

Chairmen: Dr. Lajos Simo
n, Dr. Katalin Hegedűs, Dr. György Purebl

P/V
-
1


POST
-
ERROR SLOWING IN PAT
IENTS WITH ATTENTION

DEFICIT/HYPERACTIVIT
Y DISORDER (ADHD)
-

A META
-
ANALYSIS

Lívia Balogh
, Szilvia Papp, László Tombor, István Bitter, Pál Czobor

183

P/V
-
2


THE ROLE OF CYP
POLYMORPHISMS IN THE

THERAPEUTIC EFFECT
AND ADVERSE REACTION
S OF PSYCHOTROP DRUG
S

Dóra Filipovits
, Gábor Csukly, István Bitter

184

P/V
-
3


SUICIDE PREVENTION.
THE FAMILY MEMBER'S
POSSIBILITIES AND
RESPONSIBILITY

Győző Orbán

185

P/V
-
4


SOCIO
-
CULTURAL
INFLUENCES ON BODY I
MAGE DISSATISFACTION

IN
ADOLESCENCE

Ildikó Papp
, Edit Czeglédi, Bernadett Babusa, Ferenc Túry

186

P/V
-
5



CONDUCTING CROSS
-
DISORDER WHOLE
-
GENOME ASSOCIATION
STUDIES: LIMITATIONS

AND SOLUTIONS

Attila J. Pulay
, János Réthelyi

187

P/V
-
6


IS DREAMING MERELY A

COGNITIVE PERFORMANC
E?

ANALYSIS OF THE CONT
ENT AND NARRATIVE ST
RUCTURE OF
CHILDREN’S DREAMS

Piroska Sándor
, Sára Szakadát, Orsolya Péntek, Róbert Bódizs

188

P/V
-
7


STUDY OF FEEDBACK
-
DRIVEN REINFORCEMENT

LEARNING IN
SCHIZOPHRENIA

Zsuz
sanna Somlai
, Szabolcs Kéri

189

P/V
-
8



EXPERIENCES WITH CHA
T COMMUNICATION IN M
AINTENANCE
TREATMENT FOR PATIEN
TS WITH BULIMIC SYMP
TOMATOLOGY

Ágnes Mezei
, Hayriye Güleç, Markus Moessner, Elisabeth Kohls, Ferenc Túry

190



2012. április 12
-
13
.





19

P/V
-
9


AFFECTIVE TEMPERAMEN
T
PROFILE IN PATIENTS
WITH
HYPERTENSION. FIRST
RESULTS WITH TEMPS
-
A IN PRIMARY CARE IN

HUNGARY

Ajándék Eőry
, Péter Torzsa, Xénia Gonda, László Kalabay, Zoltán Rihmer

191

P/V
-
10


EFFECTS BETWEEN DONA
TION ATTITUDE AND DO
NATION ACTIVITY
IN HUNGARIAN INTENSI
VE
CARE UNITS

Sándor Mihály

192

P/VI POSTER PRESENTATIONS

Chairman: Prof. Dr. József Tímár

P/VI
-
1


RTF1 GENE IN CARBOPL
ATIN RESISTANT OVARI
AN CANCER

Zsófia Pénzváltó
, András Lánczky, Balázs Győrffy

195

P/VI
-
2


ß
-
CATENIN, TRICELLULIN

AND EZH2 DIFFERENTIA
TE

FETAL AND
EMBRYONAL COMPONENTS

IN EPITHELIAL HEPATO
BLASTOMA

Kriszta Schlachter
, Mónika Gyugos, Gábor Lotz, Ilona Kovalszky, Kornélia Baghy, Péter
Nagy, Gábor Lendvai, András Kiss, Zsuzsa Schaff

196

P/VI
-
3


ASSOCIATION BETWEEN
THE INCIDENCE OF LYM
E DISEAS
E AND
TEMPERATURE IN HUNGA
RY, 1998
-
2010

Attila Trájer
, János Bobvos, Katalin Krisztalovics, Anna Páldy

197

P/VI
-
4


TUMOR CELLS AND CARC
INOMA
-
ASSOCIATED FIBROBLAS
TS
INTERACTION REGULATE
S MATRIX METALLOPROT
EINASES AND
THEIR INHIBITORS IN
ORAL SQUAMOSUS CELL

CARCINOMA

Alexandra Fullár
, József Dudás, Ilona Kovalszky

198

P/VI
-
5


MICRORNA EXPRESSION
DIFFERS IN EMBRYONAL

AND FETAL
SUBTYPES OF EPITHELI
AL HEPATOBLASTOMAS

Mónika Gyugos
, Krisztina Schlachter, Gábor Lotz, Ilona Kovalszky, Kornélia Baghy, Péter
Nagy,
András Kiss, Zsuzsa Schaff, Gábor Lendvai

199

P/VI
-
6



THE ROLE OF DIABETES

AND ANTIDIABETIC DRU
GS IN PANCREATIC
FIBROSIS AND CANCER

Katalin Kiss
, Gábor Firneisz, Ilona Kovalszky

200

P/VII POSTER PRESENTATIONS

Chairman: Dr. István Antal

P/VII
-
1


THE HIGHLY SELECTIVE


-
OPIOID AGONIST PEPTI
DE DAMGO SHOWED
PREDOMINANTLY PERIPH
ERAL ANALGESIA IN RA
T VISCERAL PAIN
MODEL

Erzsébet Lackó
, Pál Riba, Melinda Sobor, Júlia Timár, Shaaban A. Mousa, Michael Schäfer,
Susanna Fürst, Mahmoud Al
-
Khrasani

203

P/VII
-
2


EFFECT OF NATIVE AND

OLIGOTUFTSIN CONJUGA
TED W
-
SEWS
-
PEPTIDES ON THE ADHE
SION AND MIGRATION O
F TUMOR CELL LINES

Júlia Láng
, Katalin Pomázi, László Kőhidai

204

P/VII
-
3


CHARACTERIZATION OF
DRUG CARRIERS SYSTEM
S WITH DIFFERENT
HLB VALUES

Noémi Anna
Niczinger
, Lívia Budai, Mária Hajdú, Judit Dredán, István Antal

205



PhD. Tudományos Napok
2012





20

P/VII
-
4


DEVELOPMENT OF A MUL
TIPARTICULATE DRUG D
ELIVERY SYSTEM
FOR PETROSELINUM CRI
SPUM EXTRACT

Zsófia Edit Pápay
, Emese Balogh, Annamária Kósa, Ákos Ruszkai, Imre Boldizsár,

István Anta
l

206

P/VII
-
5


OPTIMIZATION OF A SI
MPLE CAPILLARY ELECT
ROPHORESIS METHOD
FOR THE SEPARATION O
F TWELVE QUINOLONE D
ERIVATIVES

Aura Rusu
, Gabriel Hancu, Gergő Tóth, Gergely Völgyi, Béla Noszál, Árpád Gyéresi

207

P/VII
-
6


SELECTIVITY PROFILIN
G OF FGF
RECEPTOR INHIBITORS

Zsákai Lilian
, Németh Gábor

208

AUTHORS AND TITLES OF ABSTRACTS

(LISTED UNDER THE CORRESPONDING DOCTORAL SCHOOLS)

209




2012. április 12
-
13
.





21

































E/
I

ORAL PRESENTATIONS


Chairman:

Prof. Dr. Zoltán Benyó



PhD. Tudományos Napok
2012





22



2012. április 12
-
13
.





23

E/I
-
1

TRANSIENT
OUTWARD POTASSIUM CU
RRENT IN DOG ATRIAL
PREPARATIONS


Claudia Corici
1
,
Zsófia
Kohajda
2
, Attila
Kristóf
2
, Tamás

Sz
él
1
, Zoltán
Husti
1
, István
Baczkó
1
,

András Varró
1,2
, László
Virág
1,2
,
Norbert
Jost
1,
2


1

Department of Pharmacology and Pharmacotherapy,
University of Szeged

2

Division of Cardiovascular Pharmacology, Hungarian Academy of Sciences,
Szeged



Repolarization in
cardiac

muscle is controlled by a fine balance of several inward and outward transmembrane
ionic currents and electrogenic pump mechan
isms
.

The aim of the present study was to investigate the role of
transient outward potassium current (I
to
) in atrial repolarization.

I
to

current was recorded
by

the whole
-
cell
configuration of the patch clamp technique
.

L
arge I
to

current was observed in dog atrial myocytes. The current
amplitude was
15
.
2
±
1
.
1

pA/pF at 50
mV (n=11). The inactivation

phase of the current was best fitted by two
exponentials (
fast time constant
:

11
.3
±
1
.2

ms,
fast
amplitude:
10
.4
±
0
.
8
pA
/pF; slow
time co
nstant
:
116
.
1
±
8
.2

ms,
slow
amplitude:
3
.7
±
0
.5

pA
/pF; n=10, test
potential: 50 mV). I
to

current during the action potential plateau
phase was measured as chromanol 293B sensitive current
, which drug effectively suppressed not only
the slow
delayed rectifier

potassium current

but also I
to
.

A
n atrial action potential waveform

was used

for the command
potential. It was found that I
to

carries large outward current in the plateau phase of the atrial action potential
. The
effects of I
to

blockade on the
action pote
ntial

repolarization were also investigated in dog atrial muscle by the
conventional

microelectrode technique.
The current was inhibited by application of
100 µM

chromanol 293B.
The drug

increased

the plateau potential
but failed to lengthen

the
action pot
ential in atrial preparations.
However, the
I
to

is large
during the plateau phase, blockade of the current did not lengthen the action potential in
dog atrial muscle.
Thus, u
nderstanding the role of transient outward potassium current in atrial repolarizat
ion
requires further investigations.

Doctoral School: Multidisciplinary
Medicine

Program: Biochemistry, biophysics, molecular and cell biology

Supervisor:

Nándor Jost

E
-
mail:

claudy_corici@yahoo.com



PhD. Tudományos Napok
2012





24


E/I
-
2

LATEST RESULTS OF TH
E RESPIRATORY ASPECT
S OF THE
INTERNATIONAL TWIN S
TUDY


David Laszlo Tarnoki
1
, Adam Domonkos Tarnoki
1
, Emanuela Medda
2
, Levente Littvay
3
,

Zsofia Lazar
4
, Rodolfo Cotichini
2
, Corrado Fagnani
2
, Maria Antonietta Stazi
2
, Lorenza Nisticó
2
,
Pierleone Lucatelli
5
, Emanuele Boatta
5
, Chiara Zini
5
, Fabrizio Fanelli
5
, Claudio Baracchini
6
,

Giorgio Meneghetti
6
, Akos Koller
7
, Janos Osztovits
8
, Gyorgy Jermendy
8
, István Préda
9,
10
,

Róbert Gábor Kiss
9,10
, Kinga Karlinger
1
, Agnes Lannert
11
, Giuseppe Schillaci
12
,

Andrea Agnes Molnar
9,10
, Zsolt Garami
13
,
Viktor Berczi
1
, Ildiko Horvath
4


1

Department of Radiology and Oncotherapy, Semmelwe
is University, Budapest

2


Istituto Superiore Di Sanitá,
Italian Twin Registry, Rome, Italy

3

Central Europe
an University, Budapest

4

Department of Pulmonology, Semmelwe
is University, Budapest

5


Vascular and Interventional Radiology Unit, Department of Rad
iological Sciences, La Sapienza
University of Rome, Rome, Italy

6


Department of Neurosciences, School of Medicine, University of Padua, Padua, Italy

7


Department of
Pathophysiology and Gerontol
ogy, University of Pécs

8


Bajcsy Zsilinszky Hospital, 3
rd

Department of Internal Medicine, Semmelwe
is University,
Budapest

9


Research Group for Inflammation Biology and Immunogenomics of Hungarian Academy of
Sciences and
Semmelwe
is University, Budapest

10


Department of Cardiology, State
Health Center, Budapest

11


Semmelweis University, School of Pharmacy
, Budapest

12


Unit of Internal Medicine, Department of Clinical and Experimental Medicine, University of
Perugia at Te
rni, Terni, Italy

13


The Methodist Hospital, DeBakey Heart and Vascular Center, Houston, TX, USA


Introduction
:

Nitric oxide, measured by fractional exhaled nitric oxide (FE
NO
), has an important modulatory
role on the structure and function of the airways

and vessel walls. The role of genetic factors on nicotine
dependence is well understood, however no information is available on secondhand smoke (SHS) exposure
sensibility.

Methods:

117 adult Hungarian, Italian and American twin pairs (83 monozygotic, MZ
and 34 dizygotic, DZ
pairs; age: 48
±
16 SD years) underwent FE
NO

measurement by an electrochemical sensor
-
based device. Markers
of arterial stiffness (brachial and aortic augmentation index, Aix
bra
, Aix
ao
;

aortic pulse wave velocity, PWV
ao
) were
determined
by oscillometric method (Arteriograph). Bivariate Cholesky decomposition models were applied. 161
Hungarian and 50 American twin pairs (151 monozygotic and 62 dizygotic; age:
44±17
years) replied to our
questionnaire concerning smoking characteristics and
SHS exposure.

Results
:

Genetic effects accounted for 59% (95% confidence interval, CI, 43
-
71) of the FE
NO

variation.
Significant negative correlation was observed between FE
NO

and Aix
bra

(r=
-
0.20; 95%CI:
-
0.34,
-
0.05), or Aix
ao

(r=
-
0.19; 95%CI:
-
0.33,
-
0.05).
No significant correlation was found between FE
NO

and PWV
ao
. Genetic factors
explained the entire phenotypic correlation between FE
NO

and Aix
bra

or FE
NO

and Aix
ao
. FE
NO

showed a
significant negative genetic correlation with Aix
bra

and Aix
ao
(r
g
=
-
0.29; 95%C
I:
-
0.49,
-
0.07). Higher concordance
was found in the disturbing effect of SHS in MZ versus DZ pairs (58 to 94% versus 39 to 79%, p<0.05 to
p<0.005). Smaller difference was observed in self
-
reported smoke pollution rate in MZ compared to DZ pairs


2012. április 12
-
13
.





25

concerning
the restaurants and cafés (
1.2±1.3 vs 1.8±1.5,
p<0.05) which was not present regarding restaurants,
cafés and transportation facilities.

Conclusions
:

FE
NO

variations are explained by genetic and non
-
shared environmental effects. Covariances
between FE
NO

an
d Aix are explained entirely by genetic factors providing a basis for further studies on
cardiovascular and respiratory diseases. Genetic influence on smoking habits and secondhand smoke sensibility
was estimated.


Doctoral School
:


Basic Medicine

Program:
Mechanism of normal and pathological functions of the circulatory system

Supervisor
:

Ildiko Horvath, Viktor Bérczi

E
-
mail
:


t
arnoki4@gmail.com



PhD. Tudományos Napok
2012





26


E/I
-
3

SOPHISTICATED ARRHYT
HMIA DETECTION WITH
256
-
SLICE CT
A
LLOWS DIAGNOSTIC COR
ONARY ARTERY IMAGING

IN PATIENTS
WITH ATRIAL FIBRILLA
TION


CORONARY CT ANGIOGRA
PHY WITH 256
-
SLICE SCANNER IN
PATIENTS WITH ATRIAL

FIBRILLATION


Mihály Károlyi
, Andrea Bartykowszki,
Erik Formanek
,
Mohamm
ed Muhemin,

Csaba Csobay
-
Novák
, Ná
ndor Pintér,
Kálmán Hüttl, György Balázs, Béla Merkely
,

Pál Maurovich
-
Horvat


Heart Center, Semmelweis University, Budapest


Purpose:

Atrial fibrillation (AF) is considered as a relative contraindication to coronary computed tomography
angiography (CCTA) due to the irregular heart rates resulting in motion artifacts. Thus, the aim of this study was
to evaluate the performance of 256
-
sli
ce CCTA (256
-
CCTA)
with sophisticated arrhythmia recognition software
for the visualization of coronary arteries in a population with atrial fibrillation and to explore the impact of
patients’ mean heart rate (HR) on image quality (IQ).

Methods:

Thirty
-
six

consecutive patients (25 male, 64.2±10.2 years old) with permanent AF were examined on
256
-
slice CT scanner (120 kV, 300 mAs/rot, 0.27 s rotation time, 2x128×0.625 mm collimation, Philips Brilliance
iCT) to evaluate the coronary arteries. Patients were di
vided into two groups: low/medium HR [LHR] group
(mean HR < 80 bpm, n=22) and high HR [HHR] group (mean HR≥80 bpm, n=14). The IQ assessment was
based on the American Heart Association's coronary segment classification scheme using a four
-
point likert
-
type
scale from excellent (1) to non
-
assessable (4).

Results:

467 coronary
segments

were analyzed
.
M
ean IQ score was 1.9±0.7
.
86.1% (402/467) of the segments
had diagnostic IQ
, resulting in 50.3% (235/467) excellent, 25.9% (121/467) good and 9.9% (46/467) mode
rate
IQ. Image quality of LHR group was better than that of HHR group (mean score 1.6±0.6 versus 2.4±0.7;
p=0.0014). The mean HR of LHR group and HHR group were 68.5±8.5 beats per minute (bpm) and 94.6±12.7
bpm (p<0.0001). There was no difference between t
he range of the variation of HR between the LHR group and
HHR group (mean difference between minimum and maximum HR: 53.1±26.9 versus 63.1±35.8 bpm; p=0.34).
The average radiation dose was 6.9±2.6 mSv (range: 3.5
-
15.0 mSv).

Conclusion:

Due to the sophisti
cated arrhythmia detection algorithm, wide detector coverage and high temporal
resolution of the 256
-
slice CT, it provides diagnostic image quality in patients even with AF, which should
otherwise be considered as a contraindication to CCTA examinations. P
atients’ mean HR has a significant impact
on IQ. The radiation dose of 256
-
CCTA in AF is lower than that of other CCTA in AF.


Doctoral School: Basic medicine

Program: Physiology and clinics of the heart and coronary diseases

Supervisor:
Béla Merkely

E
-
mai
l:
karolyimisi@gmail.com




2012. április 12
-
13
.





27


E/I
-
4

THE ROLE OF MICRORNA
S IN RENAL ISCHEMIA
-
REPERFUSION
INJURY


Tamás Kaucsár
, Csaba Révész, Mária Godó, Zsuzsanna Rácz, Róbert Tarszabó, Péter Hamar


Institute of Pathophysiology, Semmelweis University, Budapest


Introduction
:

Ischemia induced acute tubular necrosis (ATN) is one of the main causes of acute kidney injury.

Reperfusion paradoxically increases the injury due to apoptotic processes. The modulation of pro
-
apoptotic
genes is currently under investigation. MicroRNAs a
re posttranscriptional regulators of gene
-
expression. Our aim
was to investigate the miRNA expression profile and to elucidate their role in ischemia
-
reperfusion (IR) induced
ATN.

Methods:

At 1, 3, 6, 15, 24 and 48 hours after unilateral renal ischemia of
C57BL/6 mice, renal function (urea)
and morphology (PAS stain, NGAL) were assessed. The miRNA expression profile was evaluated at 24 hours
post
-
ischemia (Luminex multiplex assay). MiRNA expression pattern was analyzed during the reperfusion phase
(real
-
tim
e PCR) at the above time
-
points. Renal cell proliferation was evaluated by CyclinD1
immunohistochemistry on tissue microarray slides.

Results:

Three miRNAs (miR
-
21, miR
-
17
-
5p and miR
-
106a) were significantly elevated in IR injury after 24
hours of reperfus
ion (3.0, 1.5 and 1.4 fold, respectively, p<0.05). Real
-
time PCR analysis demonstrated, that these
miRNAs started to elevate after 24 hours of reperfusion further increasing at 48 hours (miR
-
21: 2.3 fold, p<0.01;
miR
-
17: 2.2 fold, p<0.01; miR
-
106a, 1.9 fol
d, p<0.01). Renal histology was pathologic already at 1, blood urea
started to elevate at 3, renal NGAL mRNA at 6 and plasma NGAL at 15 hours. CyclinD1 nuclear staining
decreased significantly after 1 hour (0.51 fold, p<0.01), but returned to control value
s at 48 hours of reperfusion,
suggesting improvement in renal tubular cell proliferation during this phase of IR injury.

Conclusion:

We identified three miRNAs with altered expression in IR injury, prior to amelioration of renal
tubular cell proliferation.

Validated targets of the identified miRNAs have mostly pro
-
apoptotic effects.
Therefore our results suggest that these miRNAs may be involved in the regeneration processes and could
represent possible therapeutic tools in the treatment of ATN.


Support: O
TKA:K81972


Acknowledgements: Dr. Tibor Krenács, 1st Department of Pathology and Experimental Cancer Research


Doctor
al School:
Basic Medicine

Program:
Physiology and pathophysiology of the regulation of fluids and electrolyte h
omeostasis

Supervisor:
Péter

Hamar

E
-
mail:
kautam@net.sote.hu




PhD. Tudományos Napok
2012





28


E/I
-
5

ISOLATION AND CULTUR
E OF RAT BONE MARROW

MESENCHYMAL STEM CEL
LS



Kinga Lakatos
, Éva Szigetfű
,

Zsuzsanna Lendvai
, Zoltán Nagy, Béla Merkely, Judit Skopál


Heart Center, Semmelweis University, Budapest


Introduction
:

Mesenchymal stem cells are a promising opportunity for the treatment of myocardial infarction
and can be isolated from the bone marrow of several species. Our aim was to isolate mesenchymal stem cells
from rat bone marrow, to cultivate them i
n standard conditions and to characterize the cells with cell surface
markers.

Materials and methods
:

Mesenchymal stem cells

were
isolated from male Sprague
-
Dawley rats according to the
protocol described by Caplan et al. Briefly,
cells
we
re

gained
from th
e marrow of
the femurs and tibia and

centrifuged
at 450 g for five minutes.
C
ells

w
e
re

planted in 25
cm
2

flasks at optimum seeding density in alpha
-
MEM, 10% FBS, 1% penicillin
-
streptomycin an
d 1% fungizone (amphotericin B). T
he medium
was changed
after 24
hours t
o remove

non
-
adherent cells
. T
hird passage
cells were used
for characterization.

C
ell surface
marker
s

CD 90 and CD 45
were used
for

immuno
staining.

Results:

We were able to isolate and cultivate rat bone marrow mesenchymal stem cells and to maintain

the
culture for three passages. The cells adhered to plastic, were able to proliferate and demonstrated typical
mesenchymal stem cell
-
like morphological features. The cells were triangle
-
shaped with elongated extensions at
the beginning of cultivation and

later on they showed spindle
-
shaped morphology. The cells stained positive for
CD 90
, which is one of the mesenchymal stem cell markers,

and negative for CD 45 thereby were free of
hematopoietic cells.

Discussion:

We were able to isolate and culture mesen
chymal stem cells from rat bone marrow.
Our future aim
is to develop cardiomyocytes from human mesenchymal stem cells in vitro and to evaluate factors which can
enhance the efficacy of cardiomyocyte transdifferentiation


Doctorial School:
Basic Medicine

Pr
ogra
m:
Physiology and clinics of the heart and coronary diseases

Supervisor:
Béla Merkely

E
-
mai
l: l
akatoskinga87@gmail.com




2012. április 12
-
13
.





29


E/I
-
6

CARDIOPULMONARY BYPA
SS IMPAIRS BRAIN OXY
GENATION AS
DEMONSTRATED BY NEAR
-
INFRARED SPECTROSCOP
Y


Peter Mukli


Institute of
Human Physiology and Clinical Experimental Research
,
Semmelweis University,
Budapest


Introduction:

Cerebral oxygenation is a tightly regulated, complex phenomenon.

At awake rest and under
pulsatile conditions, oxy
-

and deoxyhemoglobin

(HbO
2
,
H
Hb) levels

in the prefrontal cortex (PFC)
spontaneously
fluctuate in anticorrelated manner due to the impact of neural activity, as demonstrated earlier.
Oxygenation

of the brain cortex may be impaired during non
-
pulsatile cardiopulmonary bypass (NP
-
CPB)

tuned
to the

lower limit of cerebral autoregulation

(LL
-
CA)
. If so, a mismatch between

O
2

supply and

O
2

consumption
may well play a role in the frequent

and serious

complication of

NP
-
CPB

surgeries, termed post
-
ope
rative
cognitive dysfunction (POCD).

Objective:

Is

the

autoregulation and this

complex
fluctuation
pattern maintained
under
extracorpor
e
a
l non
-
pulsatile brain perfusion?

Methods:

Patients (5 male, 5 female,
70±7.
5 years)
underwent
NP
-
CPB

surgery
in the Department of Cardiac
Surgery, Semmelweis University
.
Our

study

observed the established protocols. Th
e cardiac index of NP
-
CPB
was 2.
4 L/min/m
2

and the MAP was targeted at 50
-
70 Hgmm. The changes of
Hb
-
concentration
s

were recorded
in 16 regions

of the PFC

by our NIRS
-
LEDI equipment at 3 Hz. Groups were created
in

control (C), before
(*M), during (M),
and
after NP
-
CPB (M*).
Tissue O
2
-
saturation (StO
2
[%]) was calculated from [

HbO
2
] and

[

H
Hb
]
, t
he cross
-
correlation coefficient (r
Hb
) between
[

HbO
2
] and

[

H
Hb
]
. r
Hb

structuring
was characterized
by their
spectral
index (

).

Results:

StO
2
[%] decreased

as
the anticorrelation

in
r
Hb

fluctuation disappeared

during extracorporeal circulation
(Table 1.).
NP
-
CPB

changed the spectral structuring
from correlated noise to near random noise, and then to
antipersistent motion.


Groups

C

*M

M

M*

p

StO
2
[%]


-
0
.
41±0,02


0
.
33±0,06
#

-
0
.
42±0
.
07


#
p<0.05

r
Hb

-
0.59±0.20

-
0.50±0.21

0.04±0.11
&

-
0.51±0.18

&
p<0.0001



of r
Hb

0.63±0.24


0.58±0.12


0.18±0.13
§


1.2
0
±0.25
§


§
p<0.0001

Table 1. Results are presented as mean
±

S.D.

and compared with repeated measures ANOVA (Newman
-
Keuls post hoc test)


Discussion:

Impairment of cerebral oxygenation should be considered when NP
-
CPB is performed in elderly
patients with a likely elevated LL
-
CA.
Since
r
Hb

reflects the dynamics
, and



reflects the structuring
of oxygen
equilibration in tissue, our results imply that
NP
-
CPB

severely
disturbed

the O
2
-
diffusion profiles in the brain
cortex
due to impaired cerebral autoregulation, which can contribute to POCD
.

Doctorial School: Basic M
edic
ine

Program: Mechanisms of normal and pathologic functions of the circulatory system

Supervisors: András Eke

E
-
mail:
mukli.peter@med.semmelweis
-
univ.hu




PhD. Tudományos Napok
2012





30


E/I
-
7

PREDICTORS OF CRT
-
INDUCED LEFT
VENTRICULAR REVERSE
REMODELING




Vivien Klaudia Nagy
, Valentina Kutyifa, Astrid Apor, Csilla Liptai, Eszter Édes,
Gábor Széplaki,
Béla Merkely


Heart Center
,

Se
mmelweis University
, Budapest



Background:

Cardiac Resynchronisation Therapy (CRT) is improving clinical status and inducing left ventricular
(LV) reverse remodeling in selected heart failure patients. However, one third of patients are non
-
responders
showing no improvement from treatment.

Aim:

Id
entifying parameters to predict favorable ech
ocardiographic response to CRT.

Methods:

LV remodeling was defined as a decrease of ≥ 15% in LV end
-
systolic volume.

Echocardiography data of
73
consecutive
CRT patients (mean age 67±11 yrs; 60 men)
were investi
gated before
device implantation and during
the
six
-
month follow
-
up. LV volumes, systolic function, pulmonary artery systolic
pressure (PASP) and the grade of mitral regurgitation (MI) were evaluated.
C
linical characteristics and renal
function were
also a
ssessed at baseline
.

Results:

CRT therapy was associated with significant improvement in LV ejection fraction (28,8±5,9 vs.
38,7±8,6%, p<0,001) decrease in LV end
-
diastolic (247±71 vs. 214±76 ml, p=0,006), end
-
systolic volume
(177±56 vs. 136±61 ml, p<0,001
), PASP (30±15 vs. 25±12 Hgmm, p=0,044) and grade of MI (1,9±1 vs.
1,4±0,9, p=0,001). We investigated potential clinical (age, QRS, NHYA class, etiology of heart failure, baseline
urea level) and echocardiographic predictors (LV ejection fraction, LA volum
e, grade of MI, PASP) in an
echocardiography response model using best subset regression analysis. After selection of best model multivariate
analysis revealed baseline urea level (HR=0.93, 95% CI: 0.88
-
1.00, p=0,042) to be
an
independent predictor of
echo
cardiographic response.

Conclusions:

CRT is associated with significant improvement in LV systolic function, diameters, MI and PASP.
Baseline urea level is an independent predictor of CRT
-
induced LV reverse remodeling in our patient population.

The scienti
fic project was
granted by TÁMOP 4.2.2.
-
08/1/KMR
-
2008
-
00

and NKTH
-
OTKA K68792
4
.


Doctorial School: Basic M
edicine

Program: Physiology and clinics of the heart and coronary diseases

Supervisor: Béla Merkely

E
-
mail:
nagyklaudiavivien@gmail.com



2012. április 12
-
13
.





31


E/I
-
8

LATEST

RESULTS OF THE CARDI
OVASCULAR AND
ANTHROPOMETRIC ASPEC
TS OF THE INTERNATIO
NAL TWIN
STUDY


Adam Domonkos Tarnoki
1
, David Laszlo Tarnoki
1
, Emanuela Medda
2
, Maria Antonietta Stazi
2
,
Rodolfo Cotichini
2
, Corrado Fagnani
2
, Lorenza Nisticó
2
, Pierleone Lucatelli
3
, Emanuele Boatta
3
,
Chiara Zini
3
, Fabrizio Fanelli
3
, Claudio Baracchini
4
, Giorgio Meneghetti
4
, Janos Osztovits
5
,

Gyorgy Jermendy
5
, István Préda
6,7
, Róbert Gábor Kiss
6,7
, Levente Littvay
8
, Julia Metneki
9
,

Tamas Horvath
10
, Kinga Karlinger
1
, Agnes Lannert
12
,

Andrea Agnes Molnar
6,7
, Zsolt Garami
13
,

Pal Bata
1
, Gyorgy Baffy
14
,
Giuseppe Schillaci
15
, Viktor Berczi
1



1


Department of Radiology and Oncotherapy, Semmelwe
is University, Budapest

2


Genetic Epidemiology Unit, National Centre of Epidemiology, Istituto
Superiore di Sanità, Rome,
Italy

3


Vascular and Interventional Radiology Unit, Department of Radiological Sciences, La Sapienza
University of Rome, Rome, Italy

4

Department of Neurosciences, School of Medicine, University of Padua, Padua, Italy

5


Bajcsy

Zsilinszky Hospital, III. Department of Internal Medicine, Semm
elweis University,
Budapest

6


Research Group for Inflammation Biology and Immunogenomics of Hungarian Academy of
Sciences and Semmelwe
is University, Budapest

7


Department of Cardiology, Stat
e
Health Center, Budapest

8


Central
European University, Budapest

9


National Centre for Healthcare Audit a
nd Inspection, Budapest

10


Institute of Human Ph
y
siology and Clinical Experimental Research, Semmelwe
is University,
Budapest

12


Semmelweis Univers
ity, Facul
ty of Pharmacy, Budapest

13


The Methodist Hospital DeBakey Heart and Vascular Center, Houston, TX, USA

14


Department of Medicine, VA Boston Healthcare System, Boston, MA, USA

15


Unit of Internal Medicine, Department of Clinical and
Experimental Medicine, University of
Perugia at Terni, Terni, Italy


Introduction
:

Central blood pressure, aortic stiffness, pathological body composition

and n
onalcoholic fatty
liver disease (NAFLD)

have been consistently reported as cardiovascular risk f
actors.

Methods:

154 monozygotic (MZ) and 42 dizygotic (DZ) twin pairs
(age
43±17 years) from Hungary and the
United States underwent brachial and central augmentation index (AIx), brachial and central pressure, and aortic
pulse wave velocity (PWV) measure
ments with the invasively validated Arteriograph (Medexpert Ltd, Budapest).
Bivariate Cholesky decomposition models were applied.
380 Hungarian, Italian and American twin pairs (230
MZ, 150 DZ pairs; age 49.1±15.4 years) participated in body composition me
asurement by using bioelectrical
impedance analysis (OMRON BF500). Ultrasonography was performed to detect steatosis and categorize severity
on 208 Hungarian twins (63 MZ, 41 DZ pairs; age
43.7±16.7 years)
. Carotid intima
-
media thickness (IMT) was
also mea
sured.

Results
:

Age
-
, sex
-

and country
-
adjusted
heritability was 60% for central systolic blood pressure (SBP) (95%
confidence interval /CI/, 45
-
70), 50% for aortic PWV (95%CI, 26
-
67), 49% for aortic AIx (95%CI, 2
-
74), 47%
for brachial AIx (95%CI, 1
-
74), 47% for central pulse pressure (PP) (95%CI, 12
-
61
), 30% for brachial PP
(95%CI, 0
-
53), 82% for
weight (95%CI: 78
-
85), 74% for waist and hip circumferences (95%CI: 68
-
79), body fat


PhD. Tudományos Napok
2012





32

percentage (95%CI: 69
-
79) and fat
-
free mass (95%CI: 69
-
79), and 79% for body mass index (95%CI: 74
-
83). No
discernible role f
or genetic components in the presence of NAFLD was indicated (95%CI, 0
-
36). Augmentation
indices and carotid IMT in twins with NAFLD were increased at most examined locations (p<0.05 to p<0.001).
Genetic factors explained a moderate phenotypic correlation
between central PP, SBP, brachial SBP and aortic
PWV.

Conclusions
:

Central and brachial pulse pressures and arterial stiffness are moderately heritable. A moderate
genetic covariance among aortic PWV and central PP, SBP and brachial SBP was found. S
trong h
eritability of
anthropometric parameters but no heritability of NAFLD was found.

Doctorial School: Basic Medicine

Program:
Cardiovascular disorders: physiology and m
edicine

Supervisors: Viktor Bérczi

E
-
mail: tarnoki2@gmail.com




2012. április 12
-
13
.





33


E/I
-
9

TWELVE
-
HOLES GOLD
ELECTRODE ABLATION C
ATHETER
PROVED TO BE EFFECTI
VE AND SAFE ALSO AT
REDUCED
IRRIGATION FLOW RATE


Eszter Mária Végh
1
, Endre Zima
1
, Tamás Szili
-
Török
2
, Gábor Széplaki
1
, Márta Hubay
3
,

Luc Jordaens
2
, László Gellér
1
, Béla Merkely
1


1

Heart Center, Semmelweis
University, Budapest

2

Erasmus MC, Rotterdam, The Netherlands

3

Department of Forensic Medicine, Semmelweis University, Budapest


Keywords:
radiofrequency ablation, catheter irrigation, ablation safety, animal model

At radiofrequency ablation (RF) in heart

failure patients amount of irrigation fluid can be an important
consideration. A novel, 12
-
holes, gold electrode was investigated at regular and reduced irrigation flow rate. We
have hypotized, that the gold catheter can be applied as effective and safe a
t reduced irrigation flow rate as a
standard catheter.

Methods:

5 mongrel dogs’ thigh muscle was prepared, by raising of skin edges cradle was formed, that was
flushed with blood during ablation application (37 °C, 250 ml/min). The catheters were tested in

perpendicular
and in paralell orientation at 8 and 15 ml/min irrigation flow; the contact force was 10g, the RF power was 30W
for 60 sec. Temperature of the catheter, coagulum formation and steam pops were recorded and lesion volumes
(V) were determined b
y histology. The AlCath Flux eXtra Gold (Au), 12
-
holes catheter was compared to AlCath
Flux FullCircle (PtIr) (Biotronik, Berlin, Germany) 6
-
holes catheter (both 7F, 3.5mm).

Results:

Coagulum was not found on the catheter or on muscle surface. Between the
occurence of steam
-
pops
and irrigation flow rate there was not significant connection. At reduced irrigation the Au catheter resulted larger
lesions compared to PtIr: at 8ml/min flow rate in paralel orientation VAu 861 vs VPtIr 504 mm³; in
perpendicular VA
u 908 vs VPtIr 629 mm³. Temperature of Au catheter remained lower, than temperature of PtIr
(parallel 39.4 vs. 53.8 °C, perpendicular 42.1 vs. 46.7 °C).

Conclusion:

The irrigation flow rate can be reduced without compromising ablation safety at these cathe
ters,
while Au catheter performes larger lesion at minor warming. Reduction of irrigation may be beneficial at heart
failure patients’ long procedures due to prevention of fluid overload.

Doctorial School:
Basic Medicine

Progra
m:
Physiology and clinics of
the heart and coronary diseases

Supervisor
s
:
László Gellér

E
-
mai
l:
vegh.eszter.m@gmail.com



PhD. Tudományos Napok
2012





34




2012. április 12
-
13
.





35
































E
/
II

ORAL PRESENTATIONS




Chairman:

Dr.
Gábor Békési



PhD. Tudományos Napok
2012





36



2012. április 12
-
13
.





37


E/II
-
1

REGULATION OF GENE T
RANSCRIPTION BY GLUC
OCORTICOID
RECEPTOR (GR)
Β
ETA
-
ISOFORM


Bence T. Ács
1,2
,
Istvá
n Likó
3
,

Karolina Feldman
1,2
,

Péter M Szabó
2
, Henrietta Butz
2
, Ká
roly R
á
cz
2
,
Attila Patócs
4,5


1

2
nd

Department of Medicine, Semmelweis University, Budapest

2

2
nd

Department of Medicine, Faculty of Medicine, Semmelweis University, Budapest

3

Gedeon Richter Ltd., Budapest

4

2
nd

Department of Medicine and
Molecular Medicine Research Group, Hungarian Academy of
Sciences
, Semmelweis University
Hungarian Academy of Scie
nces, Budapest

5


Laboratory Medicine Institute, Semmelweis University, Budapest


Introduction:

G
lucocorticoid
acts
trough
glucocorticoid receptor (GR). Two isoforms of the GR:
GR


and
GRβ with potential effect on gene transcription have been described.
G


differing in C
-
terminal region from
GRα

does not bind
ligands and it has
been shown
to
act as a dominant
-
negative inhibitor of GRα's
transactivational properties
. Its potential pathological role has been revealed in steroid resistant states

where
its
increased expression
has been reported.

Aims:

D
evelop
ing an in vitro model for evaluation of the GRβ related transcriptional regulation relevant in
development of steroid resistance.

Material and Methods:

Caco
-
2 intestinal cell line

was used for developin
g of the

GRß

stable expressing cell
line.

GRß

was cloned

form the GR


isoform

into
mammalian expression
pcDNA3.1
-
V5
-
His
-
TOPO

vector. The
plasmids verified by direct DNA sequencing were transfected into Caco
-
2 cell line and clonal selection was
performed wi
th neomycin treatment.
The GRβ expression was confirmed by q
u
antitative real time PCR and
Western blot analyses.
Gene expression profiles of both
the basic Caco
-
2 and
the
Caco
-
2
-
GRß
was evaluated
using Agilent
44K cDNA microarrays

in basal and after
Dexamet
hasone
treatment
(Dex, 100 nmol) for 8 h.

Results:

GRα/GRβ ratio on mRNA level was 1:0.6

vs. 1:0.001

in Caco
-
2GRβ cells compared to the wild type
Caco
-
2

cells
. 1048 transcripts were differentially (237 under
-

and 811 over
-
) expressed in Caco
-
2
-
GRß cells
compared to the basic Caco
-
2 cell line.
Dex. treatment affected the expression of 132 (85 up and 47 down) genes