PHYS4313_Syllabus_Biophysics_Xiex - Oklahoma State ...

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Oct 1, 2013 (3 years and 8 months ago)

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Syllabus

of PHYS4313/
PHYS5
110.368

Molecular Biophysics

Fall 2012

Oklahoma State University

Instructor:


Professor Aihua Xie


Time:

TBA

(Possible times: MW
8:30
-
9:45 or
MW
4:00
-
5:15pm
)
(If you are not available in
one of these timeslots, please email the instructor at
Aihua.xie@okstate.edu

asap.)

Locations
:

TBA

(
Lecture
s) &
220D HBRC

for FT
-
IR Studies of Proteins

Contact Info
:

Tel:
405
744
-
6589;

Office
: 230B HBRC; E
-
mail:

phys4313@okstate.edu

Webpage
:

http://physics.okstate.edu/axie/courses/4313/2012fall/index.html

Description:


Virtually every property that characterizes a living organism is affected by proteins
.”
This course is designed to engag
e students to explore the wonderland of
protein
s and to conduct
biophysical studies of proteins. The course plan is outlined below.

Topics

Content

Time

What Is Life?

Organization
,
molecular basis
, biological energy & evolution

~
1
.0

weeks

Getting to know proteins

Protein s
ynthesis, folding, function
/malfunction
,
&
degradation

~1.5

weeks

How to i
nvestigate proteins
?
*

Ask questions, select/develop tools, progresses, disputes, …

2.5

weeks

Bioinformatics of p
roteins

What is bioinformatics and how to use bioinformatics?

1 week

How to watch proteins in
action?

Infrared spectroscopy and
infrared structural biology

2.5

weeks

Research! Study proteins in action


Select problems, design experiments, perform measurements…

3.0

weeks

Write
a
manuscript for publication

Together, prepare and submit a manuscript
for publication

2.5 weeks

Presentation

Pick a topic, prepare a presentation based on literature studies

Pre
-
final
week

*
Learn by examples,

we will use
photoactive yellow protein (PYP)

as an example.

Pre
-
requisite:

General Physics I & II.
Knowledge on o
rganic chemistry and biochemistry are preferred
but not required.

References

(
reserved in the
Edmon Low
Library)
:

(1)

What is life
?
(Erwin Schrödinger,
providing inspiration to generations of bio
-
scientists
)

(Cambridge University Press)

(2)

The Physics of Proteins

(Hans Frauenfelder, Springer
)

(3)

THE CELL

(5
th

edition, Bruce Alberts et al, Garland Science)

(4)

PROTEINS
-
Structures and Molecular Properties (2
nd

edition, Thomas E. Crei
ghton, W.H.
Freeman and Company
)