Epidem&OMICS: The “omics” era of cancer epidemiology

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Oct 1, 2013 (4 years and 12 days ago)

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Epidem&OMICS: The “omics” era of cancer epidemiology

Spanish National Cancer Research Centre (CNIO), Madrid

November 28‐29, 2011


Organisers


Carlos Alberto González,
ICO, Barcelona, Spain


Núria Malats,
CNIO, Madrid, Spain



The
plethora

of
omics

data available at present also reaches epidemiologic studies providing a unique
opportunity to
further dissect complex exposures, genetic susceptibility, and phenotypes
. Nevertheless,
epidemiologists face several challenges in assessing and integrating, a
t the individual level, the complexity of
this kind of data jointly with extensive information on environmental factors and behaviours in large
epidemiological studies. Some of the challenges regard to the huge heterogeneity of the genetic alterations
foun
d through the new sequencing technologies, emphasising the notion of individualized diseases; the
need

to move from a candidate to an agnostic/exploratory exposure analysis incorporating epigenomics and
metabolomics markers to better dissect the still “mis
sing exposome”; the notion that nothing is static during
an individual’s lifespan and the need to model this dynamic process; the necessity to consider intermediate
outcomes such as gene expression and/or protein function and, at the same time, the need to

consider
comprehensive phenomes to better account for the underlying genetic pleiotropic effect in human
organisms living in selected environmental conditions. The integration of several levels of data, from
environmental exposures to epigenetics, metabol
omics, as well as genetics, genomics, transcriptomics, and
proteomics information, requires the development of innovative designs as well as methodology, including
bioinformatics and data reduction techniques. The course is addressed to the epidemiologic c
ommunity
with especial emphasis to the researchers interested/working on these topics interfacing biology and
epidemiology.

Faculty:


Antoni Agudo
, ICO, Barcelona, Spain


Angela Brand
, Maastricht University, The Netherlands


Eric Duell
, ICO, Barcelona,
Spain


Mario Fraga
, IUOPA, Oviedo


Núria Malats
, CNIO, Madrid, Spain


Roger Milne
, CNIO, Madrid, Spain


Paco Real
, CNIO, Madrid,


Núria Sala
,
ICO, Barcelona, Spain


Kristel van Steen
, University of Liège, Belgium


Alfonso Valencia
, CNIO, Madrid, Spain


Paolo Vineis
, Imperial College, London, UK


Topics:


The “EXPOSOME” versus Individual Exposures


METABOLOMICS: An agnostic strategy to assess exposures


EPIGENOMICS: The Exposome
-
Genome Interface


The GENOME: Candidate (SNP, Gene, Pathway) versus Agnostic

(
GWAS
) Approaches


Examples of Genetic Susceptibility Studies


Gene*Environment Interactions


The Phenome: from the Subphenotype to the Supraphenotype


Other OMICS: Transcriptomics, Proteomics, … Massive Parallel Sequencing


INTEGROMICS from the
Statistics


INTEGROMICS from the Bioinformatics


The Public Health Impact of Epidem&OMICS


Sponsors: RITCC
-
ISCIII, CNIO, ICO

Registration:
http://www.cnio.es/eventos/index.asp?ev=7