Information Sources for Biotech & Chemistry - SLING Diffusion

signtruculentBiotechnology

Oct 2, 2013 (3 years and 10 months ago)

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Information Sources for

Biotech & Chemistry

WELCOME

s p o n s o r e d b y

UNIVERSITA TA’ MALTA

Introductio
n

Prof.

Alex
Felice

University of Malta

Malta Chamber of Scientists

s p o n s o r e d b y

UNIVERSITA TA’ MALTA

How can the Knowledge Transfer
Office support you?

Dr
Ing
. Anton
Bartolo

University of Malta

s p o n s o r e d b y

UNIVERSITA TA’ MALTA

Commercialise
your

Research

Develop

Ideas

Knowledge Transfer Office

knowledgetransfer@um.edu.mt


Dr
Ing
. Anton
Bartolo

|
anton.bartolo@um.edu.mt

| 2340 2475

Martina Pace |
martina.pace@um.edu.mt

| 2340 3455

How Can We Support You?

I NDUS T RY


ACADE MI A COL L ABORAT I ON

Access
Funding

Protect
your
Intellectual
Property

Identify
the right
Academics

Find
Industrial
Partners

Internships /
Placements
& Incentives
for
Students

Raise
your
Profile

IPR in Biotechnology

Mr.

Godwin
Warr

Malta Intellectual Property Office

s p o n s o r e d b y

UNIVERSITA TA’ MALTA

Information Sources for

Biotech & Chemistry

SANDWICH LUNCH

s p o n s o r e d b y

UNIVERSITA TA’ MALTA

Further Development Of

The Malta
Biobank

&

The Malta Genome Project

Prof.

Alex
Felice

UNIVERSITA TA’ MALTA

MALTA BIO
-
BANK;

SPECIFIC GOALS & OBJECTIVES

1.
TO UPGRADE & ADD VALUE TO EXISTING
(CLINICAL) BIOBANK.


2.
TO FURTHER DEVELOP A UNIQUE
POPULATION BIOBANK ANCHORED ON
FAMILIES AND EMBEDDED IN ACADEMIC /
DIAGNOSTIC PROGRAMMES + BBMRI (Med
-
CoE
) FOR GENE DISCOVERY RESEARCH AND
SOCI0
-
ECONOMIC DEVELOPMENT.

? SIZE MATTERS


QUALITY

OF THE COLLECTION

MATTERS MORE THAN NUMBERS

THE MALTA BIOBANK

MALTA BIOBANK WEBSITE

Biomarkers & GWAS

Cardio
-
metabolic

Bio
-
collection +
d’base

Parkinson
a.o
.

NeuroSci
. &
behaviour

MALTA BIOBANK;

POPULATION BANK.


2011


20XX

OTHER !!!

50000

100000

150000

200000

250000

300000

350000

400000

Population Number

Phoenicians

Carthagenians

Romans

Arabs

Sicilians

0

1000

1250

1500

1750

2000

Constitutional

Independence and

Economic

Development

British

Forces

Valletta

Urbanisation

The Knights of

Malta

Catalan

Soldiers

Total

Maltese

Foreign

(Data from J. Brincat & S. Mercieca)

Bedouins

Tunisians

North African


Arabs

Saharawis

Moroccan Berbers

Palestinians

Syrians

Lebanese Muslims

Ashkenazi Jews

East Sicilians

Sephardic Jews

South Italians

Lebanese

Christians

Maltese

Sardinians

NW Sicilians

SW Sicilians

Djerba Jews

United Arab Emirates

Turkish

Cypriots

Kurdish Jews

Muslim Kurds

ADULT Hb EPIDEMIOLOGY 2004


2008 (N ~ 20,000)

CONTEXT

COMPREHENSIVE

ACADEMIC

PUBLIC HEALTH

INTEGRATED

ANTENATAL
-
MATERNAL

NEONATAL

NO TOPS

RECENT (HYPER)MIGRATION

European
Hemoglobinopathy
Forum


Paris 2009

50 Years of Integrated & Comprehensive
Maternal Ante
-
Natal and Neonatal
Haemoglobin

Testing ;

Mothers (1.8%) +
microcytosis

(< 80
fl
)

and increased HbA2 (4.6% +/
-

0.5)

or normal ferritin (> 80
ng

/ ml)


Targeted Neonate


β Globin DNA



Homozygotes
-
> Clinic





and heterozygotes;





Globins

(RPC)

AA

(29)



AT
(18)






β/α



0.15 +/
-

0.06

0.11+/
-

0.06






β/
Σγ



0.30
+/
-

0.16


0.18+/
-

0.08


Hb

F Malta I or
G
g

ㄱ㝁1朠⬠


V
慬汥at愠潲o
b
㠷8偲漠o㴠ㄮ㠥



䘠卡Fd楮楡i潲o
A
g
T

/ 㜵周爠㴠ㄲ7

䭌F
-

HPFH

Haemoglobin

F Malta I

(or α2Gγ2 117(G19) His


Arg
)




Hb

F Malta I heterozygote

Hb

F Malta I homozygote

Hb

F Malta
I +
Hb

F Sardinia

β

β
V

A
γ
T

A
γ
I

α

G
γ
117ARG

G
γ

β
V

β
A

α

G
γ
FMaltaI

G
γ

A
γ
I

A
γ
T

Quantification of
G
lobins

and
Hb

F (=
S g / S
湯n
-
a


By
R
everse Phase HPLC (C8 @ 40
o
C & %ACN
-
MTl
-
Saline)

Compound heterozygote;
Hb

F Malta I +
Hb

F Sardinia +
Hb

Valletta

Whole
G
enome Sequences

Hb

Profile

Genomics

KLF1

HEPs
Transcriptome

BCL11A

DOES GLOBIN


OMICS REVEAL FRIENDS OR

FOES OF KLF1 IN GLOBIN GENE CONTROL ?

[
Borg et al., (2010)
Nat Genet
. 42
(9):801
-
805
]





β

(Old friend)

(New tricks)

Others !

Distribution of SNPs in Maltese and Libyan T2DM patients and Reference Neonates


(Ashtar A et al; European Society of Human Genetics, Nice, France, 2007)









UNIVERSITA TA’ MALTA

Information Sources for

Biotech & Chemistry

COFFEE & REFRESHMENTS

s p o n s o r e d b y

UNIVERSITA TA’ MALTA

WORKSHOP 1:

Uniprot

Proteins Database

s p o n s o r e d b y

UNIVERSITA TA’ MALTA

WORKSHOP 2:

Searching Chemical Entities

s p o n s o r e d b y

UNIVERSITA TA’ MALTA

WORKSHOP 3:

Searching Sequences Databases

s p o n s o r e d b y

UNIVERSITA TA’ MALTA

WORKSHOP 4:

Searching Enzymes Databases

s p o n s o r e d b y

UNIVERSITA TA’ MALTA

Closing Address

Mr.

G
é
rard

Giroud

SLING Project Consultant

s p o n s o r e d b y

UNIVERSITA TA’ MALTA

Information Sources for

Biotech & Chemistry

APERITIVO & NIBBLES

s p o n s o r e d b y

UNIVERSITA TA’ MALTA