ALSPAC: The future - bristol.ac.uk

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Oct 2, 2013 (3 years and 11 months ago)

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ALSPAC: The future

George Davey Smith, Scientific Director, Avon Longitudinal Study of
Parents and Children


18 April 2012

“A

Longitudinal

Study

of

Pregnancy

and

Childhood

(ALSPAC)

is

being

planned

by

the

University

of

Bristol

and

is

due

to

start

in

11

months’

time
.

The

aim

is

to

determine

which

biological,

environmental,

social,

genetic,

psychological,

and

psychosocial

factors

are

associated

with

the

survival

and

health

of

the

fetus,

infant

and

child
.

The

cohort

will

consist

of

all

births

in

the

three

Avon

health

districts

over

a

12
-

month

period,

and

women

and

their

partners

will

be

recruited

to

the

study

as

soon

as

possible

after

confirmation

of

pregnancy
.

Collaboration

with

other

research

groups

or

individuals

is

being

sought
.

Potential

collaborators

should

contact

Dr

Jean

Golding,

Division

of

Epidemiology,

Institute

of

Child

Health



Bristol
.


Anon. (1989) Study on factors influencing child health.
Lancet

334:

518.

Pearson H. Children of the 90s: Coming of age. Nature 2012: 484: 155
-
158.


G0

Mother originally recruited to
ALSPAC

G0

Mother originally recruited to
ALSPAC

Questionnaires passed on to
ALSPAC mother’s partner



G0

Mother originally recruited to
ALSPAC

Questionnaires passed on to
ALSPAC mother’s partner



Female ALSPAC YP

G1

Male ALSPAC YP

G0

Mother originally recruited to
ALSPAC

ALSPAC mother’s partner now
being formally enrolled



Female ALSPAC YP

G1

Male ALSPAC YP

G0

Mother originally recruited to
ALSPAC

ALSPAC mother’s partner now
being formally enrolled



Female ALSPAC YP

G1

Male ALSPAC YP

Sibling of YP

Sibling of YP

G0

Mother originally recruited to
ALSPAC

ALSPAC mother’s partner now
being formally enrolled



Female ALSPAC YP

G1

Male ALSPAC YP

Sibling of YP

Sibling of YP

Partner of YP

Partner of YP

G0

Mother originally recruited to
ALSPAC

ALSPAC mother’s partner now
being formally enrolled



Female ALSPAC YP

G1

Male ALSPAC YP

Sibling of YP

Sibling of YP

Partner of YP

Partner of YP

Offspring of
ALSPAC YP

Offspring of
ALSPAC YP

G2

COCO90s

Planned data collection

With thanks to Mel Lewcock and Debbie Lawlor

Some current activities


Record linkage, questionnaires and online data
collection


Improving participation


The next generation


Fathers / partners clinic


Sibling recruitment


Recall by genotype / other recall


Collaborations


scaling up and scaling down


Increase access to and use of data


Integrating ‘Omics Technologies with Epidemiology

Lifecourse

Development

To

Ageing

Bioinformatics

& Statistics

Data integration

Data mining

Analysis methods


SNPs


CNVs


mtDNA

variants


Rare variants


Whole genome sequencing




DNA methylation


miRNA expression


Chromatin analysis


LCL gene


expression


Tissue specific
expression profiles


NMR metabolites


One carbon


intermediates


Questionnaires


Clinical assessment


Health records


Recall


Imaging


Educational


attainment


Data capture


Questionnaires


Environmental
monitoring


Biological sample


analysis



Orbitrap
-
MS


intact protein


analysis

Metabolomics


measuring small molecules

Kettunen et al.
Nature Genetics
2012; 44(3):269
-
76

Making the most of multi
-
dimensional data

-

Integration and data mining

ALSPAC Publications as First or Last author


ALSPAC Publications 2006
-
2011

Pembrey M. Cohort of Genes. Nature 1990;348:280

Nature 12 April 2012;
484
: 155
-
158

ALSPAC: The future

George Davey Smith, Scientific Director, Avon Longitudinal Study of
Parents and Children


18 April 2012

With thanks

University of Bristol

Medical Research Council/
Wellcome

Trust

National Institutes of Health

ESRC

European Research Council

British Heart Foundation

BBSRC

EU FP7

Arthritis Research UK

World Cancer Research Fund

Autism Speaks

23andMe

Diabetes UK

ALSPAC: The future

George Davey Smith, Scientific Director, Avon Longitudinal Study of
Parents and Children


18 April 2012

With thanks

With thanks






Sarah Wordsworth


Dara O’ Hare