Statistics from 478 endogenous protein-protein ... - POINeT

richessewoozyBiotechnology

Oct 1, 2013 (3 years and 10 months ago)

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Statistics from 478 endogenous protein
-
protein interactions examined in HeLa
cells that are in the 28 KEGG pathways.


28 pathways

matched
genes
a

total genes
in
pathway
b

matched
gene
coverage
c

no. of
positive
PPIs
d

total
PPIs
e

PPI
coverage
f

Pathways in
cancer

163

332

0.49

286

1564

0.18

mTOR signaling pathway

22

52

0.42

19

105

0.18

Prostate cancer

50

89

0.56

63

358

0.18

Endometrial cancer

28

52

0.54

27

167

0.16

MAPK signaling pathway

98

269

0.36

139

1004

0.14

Apoptosis

32

88

0.36

43

319

0.13

ErbB signaling pathway

42

87

0.48

42

418

0.10

Wnt signaling pathway

32

151

0.21

33

355

0.09

Progesterone
-
mediated
oocyte maturation

19

105

0.18

13

190

0.07

Regulation of actin
cytoskeleton

31

216

0.14

34

566

0.06

T cell receptor
signaling
pathway

30

108

0.28

22

408

0.05

Chemokine signaling
pathway

31

190

0.16

34

632

0.05

Cell cycle

30

129

0.23

36

733

0.05

Leukocyte
transendothelial migration

15

118

0.13

11

232

0.05

Adherens junction

15

77

0.19

13

275

0.05

Alzheimer's disease

12

171

0.07

9

200

0.05

Fc epsilon RI signaling
pathway

14

79

0.18

9

237

0.04

Natural killer cell
mediated cytotoxicity

16

137

0.12

14

390

0.04

Calcium signaling
pathway

9

178

0.05

8

224

0.04

Huntington's disease

12

185

0.06

8

226

0.04

Fc gamma R
-
mediated
phagocytosis

12

97

0.12

8

260

0.03

Tight junction

11

134

0.08

7

237

0.03

Systemic lupus
erythematosus

4

140

0.03

2

70

0.03

Jak
-
STAT signaling
pathway

13

155

0.08

11

470

0.02

Antigen processing and
presentation

4

89

0.04

2

127

0.02

Cell adhesion molecules
(CAMs)

3

134

0.02

2

164

0.01

Complement and
coagulation cascades

4

69

0.06

2

169

0.01

TGF
-
beta signaling
pathway

4

87

0.05

2

282

0.01

The statistical results from 478 PPIs in different KEGG pathways are shown. Genes
(matched genes) from validated PPIs (no. of positive PPIs) were mapped with events
from the KEGG pathways.

a
: The number of genes in 478 PPIs
for each designated KEGG pathway

b
: The
total number of genes in each designated KEGG pathway

c
: The coverage rate of the genes from 478 PPIs for the total number of genes in the
pathway

d
: The number PPIs from the 478 validated PPIs involved in the pathway

e
: The
total number of PPIs
among the ~
8
0,000 PPIs collected

f
: The coverage rate of the validated PPIs for the total number of PPIs in the pathway