Current trends in antimicrobial agent research: chemo- and ...

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Oct 1, 2013 (4 years and 1 month ago)

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Current trends in antimicrobial agent research: chemo
-

and
bioinformatics approaches

Author(s):

Hammami, R
(Hammami, Riadh)
1
;
Fliss, I
(Fliss, Ismail)
1


Source:
DRUG DISCOVERY TODAY


Volume:

15


Issue:

13
-
14


Pages:

540
-
546


DOI:

10.1016/j.drudis.2010.
05.002


Published:

JUL 2010

Times Cited:

7

(from Web of Science)

Cited References:

65

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Abstract:

Databases and chemo
-

and bioinformatics tools that contain genomic, proteomic and functional
information have become indispens
able for antimicrobial drug research. The combination of
chemoinformatics

tools, bioinformatics tools and relational databases provides means of analyzing, linking and comparing online
search results. The development of computational tools feeds on a
diversity of disciplines, including mathematics,
statistics, computer science, information technology and molecular biology. The computational approach to
antimicrobial agent discovery and design encompasses genomics, molecular simulation and dynamics, mol
ecular
docking, structural and/or functional class prediction, and quantitative structure
-
activity relationships. This article
reviews progress in the development of computational methods, tools and databases used for organizing and
extracting biological m
eaning from antimicrobial research.

Accession Number:

WOS:000280034200006

Document Type:

Review

Language:

English

KeyWords Plus:

WORLD
-
WIDE
-
WEB; PROTEIN
-
STRUCTURE; PEPTIDES; DATABASE; PREDICTION;
DESIGN; SIMULATION; DISCOVERY; RESISTANCE; TOOL

Reprint Address:

Hammami, R (reprint author), Univ Laval, STELA Dairy Res Ctr, Nutraceut & Funct Foods Inst,
Quebec City, PQ G1K 7P4, Canada.

Addresses:


1. Univ Laval, STELA Dairy Res Ctr, Nutraceut & Funct Foods Inst, Quebec City, PQ G1K 7P4, Canada

E
-
mail Address:

riadh.hammami@fsaa.ulaval.ca


Publisher:

ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB,
OXON, ENGLAND

Web of Science Categories:

Pharmacology & Pharmacy

Research Areas:

Pharmacology & Pharmacy

IDS Number:

627JB

ISSN:

1359
-
6446