Teacher Notes - Bioinformatics Activity Bank

raviolirookeryBiotechnology

Oct 2, 2013 (3 years and 9 months ago)

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Using Bioinformatics to Solve Medical Problems: An HIV Case Study


Overview and concepts

Overview

Students will develop an understanding of how bioinformatics allows us to solve problems; without the
combination of knowledge and technology that we now have, solving such problems would not be
possible.
Students will analyze data to determine if a dentis
t was the source of the HIV transmitted to a
patient(s).



Grade level

10
th

Grade


Concepts covered

bioinformatics, problem solving


Prior knowledge required
:

virus, HIV, DNA


Activ
ity notes

Time frame



1/2 day
-

(40 min of 80 min period)


Materials:



Whiteboard



Computers with access to the internet.



Optional: printed copy of activity (at
http
://bioquest.org/bioinformatics/edgridbeloit/activities.html#dentist
) and data sets


Teaching Tips



Big Idea: Bioinformatics is important in problem solving and also extending and building upon
current knowledge. It allows us to use computers to process biol
ogical information, search
biological information and connect the dots between evidence found and theories to further
develop knowledge and understanding of science content.



This activity in this lesson is found at
http://bioquest.org/bioinformatics/edgridbeloit/activities.html#dentist



Activities:

1.

Discuss and list as a class what they think bioinformatics is on the whiteboard (5
-
10 min).

2.

Using computers or printed copies, complete the activity and analysis of data. S
tudents work
in pairs to complete analysis (25


30 min).

3.

Conduct a class discussion of results of analysis and the implications on society (10
-
15 min).


Extensions



CDC article on 1991 Dentist Case:
http://www.cdc.gov/mmwr/preview/mmwrhtml/00001679.htm



Article on Patients in Case:
http://www.cdc.gov/mmwr/preview/mmw
rhtml/00014428.htm



One year later


patients:
http://www.cdc.gov/mmwr/preview/mmwrhtml/00016712.htm



Later study completed:
http://www.cdc.gov/mmwr/preview/mmwrhtml/00020479.htm



Although the reports support the hypothesis that the dentist was the source of HIV infection, there
were always doubts concerning the mode of viral transmission. See following article debating if

case
is really closed:
http://www.annals.org/cgi/content/full/124/2/250


Acknowledgments

Kathryn Miller designed this lesson plan based on the activity found at
http://bioquest.org/bioinform
atics/edgridbeloit/activities.html#dentist
.