Proposed Guidelines on Genetic Engineering - Pediatrics

puffautomaticBiotechnology

Dec 10, 2012 (4 years and 9 months ago)

147 views

1985;75;1159Pediatrics
Proposed Guidelines on Genetic Engineering



http://pediatrics.aappublications.org/content/75/6/1159
the World Wide Web at:
The online version of this article, along with updated information and services, is located on

ISSN: 0031-4005. Online ISSN: 1098-4275.
PrintIllinois, 60007. Copyright © 1985 by the American Academy of Pediatrics. All rights reserved.
by the American Academy of Pediatrics, 141 Northwest Point Boulevard, Elk Grove Village,
it has been published continuously since 1948. PEDIATRICS is owned, published, and trademarked
PEDIATRICS is the official journal of the American Academy of Pediatrics. A monthly publication,
by guest on December 9, 2012pediatrics.aappublications.orgDownloaded from
0
Council on Research
PEDIATRICS Vol.75 No.6 June 1985 1159
Proposed Guidelines on Genetic Engineering
The American Academy of Pediatrics has become
aware of a proposal to National Institute of Allergy
and Infectious Diseases (NIAID) that “NIH [Na-
tional Institutes of Health] prohibit any experimen-
tation involving the transfer of a genetic trait from
one mammalian species into the germ cell of an-
other,unrelated mammalian species.” An advisory
committee rejected this proposal on Oct 29,1984.
For the record and in any event of further at-
tempts to impose such a prohibition,the Academy,
on recommendation of its Council on Research,has
the following statement:
Without specific study of the referenced experi-
ments by Dr Ralph Brinster of the University of
Pennsylvania,the American Academy of Pediatrics
believes that such a blanket prohibition would be
scientifically dangerous and detrimentalto research
efforts into understanding human disease,includ-
0 ing cancer,and potentially to the development of
new therapies.
There is no true scientific basis for the proposed
prohibition.The fact is that a large number of
molecular structures,including complex ones,are
held in common among the mammalian species.In
reality,the species are much more similar than they
are different.The species borders that the proposer
talks about are a continuum and a blend rather
0
PEDIATRICS (ISSN 0031 4005).Copyright © 1985 by the
American Academy of Pediatrics.
than a sharp demarcation (as is evidenced in cell
culture by the ability to fuse cells from many spe-
cies).
The prohibition would militate against certain
possibilities for research and therapy related to
inborn errors of metabolism.A gene for the produc-
tion of an enzyme in one species often makes an
enzyme that would produce the same kind of prod-
uct found in the human.Such a gene could poten-
tially function to ameliorate a genetic disease.We
agree that such research as is referenced must be
carefully monitored and have very specific scientific
goals,particularly if and when it would be applied
to human infants,children,or adults.However,we
believe that current NIH review processes and the
close monitoring and tight regulations with refer-
ence to recombinant DNA research are sufficient.
COUNCIL ON RESEARCH,1984-1985
Robert H.Parrott,MD,Chairman
Robert L.Brent,MD
Norman Kretchmer,MD
Robert C.Neerhout,MD
Robert W.Miller,MD
James M.Sutherland,MD
Liaison Representatives
Lawrence M.Gartner,MD (APS)
Joseph B.Warshaw,MD (AMSPDC)
Paul McCarthy,MD (APA)
Robert P.Kelch,MD (SPR)
by guest on December 9, 2012pediatrics.aappublications.orgDownloaded from
1985;75;1159Pediatrics
Proposed Guidelines on Genetic Engineering


Services
Updated Information &
http://pediatrics.aappublications.org/content/75/6/1159
including high resolution figures, can be found at:
Permissions & Licensing
http://pediatrics.aappublications.org/site/misc/Permissions.xhtml
or in its entirety can be found online at:
Information about reproducing this article in parts (figures, tables)
Reprints
http://pediatrics.aappublications.org/site/misc/reprints.xhtml
Information about ordering reprints can be found online:
Online ISSN: 1098-4275.
Copyright © 1985 by the American Academy of Pediatrics. All rights reserved. Print ISSN: 0031-4005.
American Academy of Pediatrics, 141 Northwest Point Boulevard, Elk Grove Village, Illinois, 60007.
has been published continuously since 1948. PEDIATRICS is owned, published, and trademarked by the
PEDIATRICS is the official journal of the American Academy of Pediatrics. A monthly publication, it
by guest on December 9, 2012pediatrics.aappublications.orgDownloaded from