Bioinformatics at the NIH - Rosen Center for Advanced Computing

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Oct 2, 2013 (4 years and 12 days ago)

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Bioinformatics at the NIH


Cheryl Kraft, M.S.

Purdue Cyberinfrastructure Days

December 9, 2010


National Institutes of Health


The National Institutes of Health (NIH), a part of the U.S.
Department of Health and Human Services, is the
primary Federal agency for conducting and supporting
medical research.


NIH is made up of 27 Institutes and Centers, each with a
specific research agenda, often focusing on particular
diseases or body systems.


The NIH invests over $32.2 billion annually in medical
research.


NIH is the largest source of funding for medical research
in the world.


NIH leadership and staff play an active role in shaping
the agency's activities and outlook.

Top 5 Institutes by Funding FY11


National Cancer Institute (NCI)
-

$5.2 B



National Institutes of Allergy and Infectious Diseases (NIAID)
-

$4.9B



National Heart, Lung and Blood Institute (NHLBI)
-

$3.1B



National Institute of General Medical Sciences (NIGMS)
-

$2.1B



National Institute of Diabetes and Digestive and Kidney Diseases
(NIDDK)
-

$2B




Source:
http://dhhs.gov/asfr/ob/docbudget/2011budgetinbrief.pdf

NIH Priorities



Genomics:
Science
-
driven increases in genomics and other high
-
throughput technologies in FY 2011 will support a range of bold and
innovative efforts against cancer and autism.



Cancer:
In FY 2010 the NIH began to invest over $6 billion for
cancer research across NIH, reflecting the first year of an eight
-
year
strategy to double cancer research by FY 2017.



Autism:
In FY 2010 the NIH budget included $141 million for
research into the causes of and treatments for autism spectrum
disorders (ASD).







NIH Priorities continued


NIH Common Fund:

An incubator for new projects that can
overcome complex research barriers and accelerate the pace of
discovery for new disease treatments, prevention strategies, and
diagnostics across all Institutes and Centers.



New Investigators:

Stem the trend of increases in the average age
of first
-
time principal investigators obtaining independent research
funding from NIH. NIH is aiming to have similar success rates
between new investigators and new applications from established
principal investigators.



Clinical Research Translation:

NIH developed a new Clinical and
Translational Science Award (CTSA) beginning in FY 2006. These
awards help advance information technology, integrate research
networks, stimulate the development of computer
-
assisted outcome
measurement, and improve workforce training. (NCRR)


Bioinformatics Priorities


Subject privacy and anonymity.


Data sharing, data interoperability.


Ontologies, ie standard phenotypes.


Novel tool development.


Analysis


Visualization


Prediction


Reuse and secondary analysis of data to
produce novel findings.


Multi
-
scale modeling of disease process and
human immune system.



Innovations in Biomedical Computational
Science and Technology



PAR
-
09
-
218


Investigators may target one or multiple
areas of biomedical computing that will
enable progress in biomedical research.


genomic sequences, gene expression,
proteomics, pathway data, scientific and
biomedical images, qualitative descriptors for
health and social science, and remote
sensing and geospatial images.



Innovations in Biomedical Computational
Science and Technology



PAR
-
09
-
218


Tools for data acquisition, archiving, querying,
retrieval, visualization, integration and
management.


Platform
-
independent translational tools for data
exchange and for promoting interoperability.


Analytical and statistical tools for interpretation
of large data sets.


New models or simulations of complex biological
processes at single and multiple levels or across
multiple scales (and the development of
computational and/or mathematical tools for the
analysis of these processes).

RFA
-
RM
-
10
-
010



NIH Common Fund Transformative Research
Projects Program


Groundbreaking


Exceptionally innovative


High risk


Original and/or unconventional research
with the potential to create new scientific
paradigms or challenge existing ones


What are they looking for?


Innovation, innovation, innovation


Team science, cross disciplinary teams


Broad applicability


Well written proposal


Clearly described concepts


Specificity

Informatics grants at NIH


FY 2010


1579 grants and contracts
awarded.


FY 2009


1767 grants and contracts
awarded.


FY 2008


1329 grants and contracts

Top Institutes funding informatics in
FY10


NCI


NCRR


NLM


NIGMS


NHLBI

Some current programs at NIAID

Resources Abound


www.nih.gov


www.bisti.nih.gov


Funding Opportunities related to NIAID
available at:
http://www.niaid.nih.gov/ncn/budget/opps.
htm


Resources Abound


Public resources for research content


www.immport.org


www.immunepitope.org


www.systemsimmunology.org