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polarbearfellowshipBiotechnology

Dec 12, 2012 (4 years and 8 months ago)

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4
th

Yearly Meeting of the Coordinators

of the Centres of Excellence

LIFE/MED

Eva Syková


ARICY


Agricultural Research Institute,
Nicosia,
Cyprus


BIER


Jagiellonian University,
Faculty of Biotechnology, Krakow,
Poland


BIOREGION
-
SZEGED


Biological Research Centr
e
, H
AS, Szeged,
Hungary


BLOODVESSELS


Institute of Cellular Biology and Pathology
,
Romania


CEBIOLA


Vilnius University, Vilnius,
Lithuania


CENEXFOOD


Inst
.

of

Animal Reproduction and Food Research
, PAS,
Olsztyn
,
Poland


DESMOL


Centre of Molecular and Macromolecular Studies
,

PAS, Lodz,
Poland


EMBEU


Institute of

Biochemistry and Biophysics
,

PAS
, Warsaw,
Poland


EURO
-
NEURO
-
NETWORKS

Institute of Experimental Medicine
, HAS, Budapest,
Hungary


EXCELLENT PLANT BIOTECH


AgroBioInstitute
, Sofia,
Bulgaria


GENEMILL


Estonian Biocentre
, Tartu,
Estonia


MEDIPRA


Institute of Experimental Medicine, A
SCR, Prague,
Czech Republic


STRESSNUTS


Institute of Experimental Endocrinology, SAS
, Bratislava,
Slovakia

EU Centres of Excellence Bio
-
Med parallel Group





CoE
Acronym
:
EXCELLENT PLANT BIOTECH


AgroBioInstitute, (ABI), Sofia, Bulgaria

Coordinators:

Prof. Atanas Atanassov

Dr. Ivan Atanassov

“Promoting of sustainable and environment friendly
agriculture through development, adoption and application
of up to date biotechnology methods and know
-
how”





CoE Excellent Plant Biotech:

years of expending
research and networking capacity


2000

Institute of Genetic Engineering


(starting of CoE project)


2001

AgroBioInstitute

(extanding of agrobiotech applications)


2002

new
location

of AgroBioInstitute

(modern research facilities)


2003

AgroBioTech Park

(joining of reserach, training and business
activities)


2004

Biotechnology Information Center
and

Genome Cente
r

(public relations, genomics and metabolomics)

Agricultural Research Institute,
ARICY


Coordinator


I. Papadopoulos



Engaged in applied and basic research in plant
and animal production


Provide high quality scientific results,
environmentally and socially sustainable

The genetic basis of Scrapie and the
utilization of molecular techniques

for its control in sheep


1 2 3 4 5 6 7

Polymorphic codon genotypes are:

171 Arg/Arg (lanes 1, 2, 3, 5, 6) and
171 Arg/Gln (lanes 4, 7)


The infection is associated
with the PrP gene.


The allelomorph RR is
associated with resistance to
the disease. The onjective is to
increase the frequency of
resistant genotypes in the
population.


Mission:



Basic research in neuroscience,


genetic ecotoxicology, cell biology and molecular pharmacology.



Bridging the gap between basic research and clinical
application.

Institute of Experimental Medicine

Academy of Sciences of the Czech Republic

MEDIPRA

Coordinator
: Prof
essor

Eva Sykov
á


European collaborations in MEDIPRA


Mechanisms underlying development, aging,
neurodegenerative diseases,

brain and spinal cord injury


Stem cell research
, in vivo

MR
tracking


of implanted stem
cells

using
superparamagnetic nanoparticles


Propagation and controlled differentiation of human
embryonic stem cells


Molecular epidemiological studies: Biomarkers of exposure
to mutagens and carcinogens and the embryotoxicity of
genotoxic compounds

Most important scientific result
s

Clinical study

Bone marrow stem cell implantation to treat spinal cord injury

Most important scientific results

Estonian Biocentre, GENEMILL


Main
Mission:


Basic and applied research in molecular medicine and

human

genomics

HUNGARIAN ACADEMY OF SCIENCES

INSTITUTE OF EXPERIMENTAL MEDICINE

BUDAPEST
,
HUNGRAY

Prof. E. Sylvester Vizi

Prof. Zsolt Liposits

NEUROSCIENCE RESEARCH


CNS DRUG DEVELOPMENT


HEALTHY SOCIETY

Bioregion
-
Szeged


Biological Research Center

Hungarian Academy of Sciences

Szeged, Hungary

CoE
: BIOREGION
-
Szeged

Regional Initiative for Improvement of Quality of Life through



Research,
Education, and Innovation in Molecular and Cell Biology



Biological Research Center
,
Hungarian Academy of Sciences


Coordinator: Prof. D
ÉNES DUDITS


Training: schools, symposia


Bioinformatics: PL, HU


ITC lecture course and practicals (yearly)


Biophysics:


Molecular structures and dynamics of energy converting membranes
(23
.

J
un
e
-
2
.

J
uly 2001)


32 invited speakers from 11 European countries, the school was attended by 42 students
from 11 European countries

Biological Research Center

Hungarian Academy of Sciences

Szeged, Hungary

CoE
: BIOREGION
-
Szeged

Research deliverables


15 work packages


More than

150 refereed publications


Outstanding activities


Plant cell and molecular biology








Nanobiotechnology





Light
-
driven micromachinery


produced and driven by light

Molecular structure of the NORK protein

Nitrogen fixing root nodules

Biological Research Center

Hungarian Academy of Sciences

Szeged, Hungary

CoE
: BIOREGION
-
Szeged


Cell Biology and Lasers:

Towards New Technologies

CEBIOLA


Co
ordinators
:

Prof. Benediktas Juodka



Prof. Algis Piskarskas


The mission of the center
:

to promote research, advanced studies and training

in
the
field

w
here

cell biology meets light technologies

giving birth to diverse and ever
-
widening range of laser
applications in life sciences


Vilnius University
, Lithuania



ALA
-
injection

Laser treatment

Accumulation

Necrosis

PHOTOSENSITIZED LASER TUMOUR
THERAPY

700 patients treated successfully in Lithuania

LASERNET/LASERLAB
-
EUROPE

LENS: Firenze, Italy

ULF
-
FORTH: Iraklion, Greece

LIF
-
LOA: Palaiseau, France

LLC: Lund, Sweden

LCVU: Amsterdam, Netherlands

MBI: Berlin, Germany

LULI: Palaiseau, France

CLF: Chilton, England

GSI: Darmstadt, Germany

PALS: Prague, Czech Republic

CEA: Saclay,

France


TU Vienna: Vienna, Austria

CEA: Bordeaux,


France


LRC VU: Vilnius, Lithuania


CELIA: Bordeaux, France


CUSBO: Milano,


Italy

http://www.lasernet
-
europe.de

Molecular Biotechnology
-

Integration of Education and
Research

BIER

Jagiellonian University, Faculty of Biotechnology

Krakow, Poland

Main mission of the Centre BIER
:

Combining research and teaching

of molecular biotechnology at the European level

Co
-
ordinator: Professor Aleksander Koj


Substantial progress in understanding of molecular
mechanisms of stress tolerance in plant cells:

--

Elucidation of the effect of heavy metals on formation of
photosynthetic apparatus;

--

Description of the cyclic electron flow around photosystem
II in overexcitation conditions with a special emphasis on
cytochrome b
559
.

The most important scientific result
(one selected from many):

The

model

showing

photoreduction

sites

of

cyt

c

in

thylakoids

under

low

and

medium

light

intensity

(black

‘cyt

c


symbol)

and

occurring

additionally

at

high

light

intensities

(white

‘cyt

c


symbol)
.

The

action

sites

of

the

used

electron

transport

inhibitors

are

also

shown
.

The most important outcome of BIER activity:


International recognition of BIER as an expert
teaching and research centre in molecular
biotechnology



Promotion of the Institute of Molecular Biology to
the Faculty of Biotechnology located on a new
Campus and offering full curriculum in
biotechnology

Main mission:



training of young researchers in
FOOD SCIENCE



promoting trans
-
border mobility



pan
-
European networking

Co
-
ordinator:

Prof. Halina Kozłowska

CENTRE OF EXCELLENCE FOR KNOWLEDGE TRANSFER,

RESEARCH AND EDUCATION IN FOOD AND HEALTH

for CENTRAL & EASTERN EUROPE

CENEXFOOD

Exceptionally good relationship between scientists form Olsztyn

and Norwich

led to start the process of twining of both cities (Sister Cities).

From science to local scocieties


DESMOL


Designed Molecules and Macromolecules


Their Assemblies and Biological Functions


Center of Molecular and Macromolecular Studies, Łódź, Poland

Coordinators:

Professor Marian Mikołajczyk

Professor Przemysław Kubisa


about 130 researchers and PhD

students involved

M
ission
:

-

t
o combine the research activity

and

expertise of research teams
working in the area of heteroorganic

chemistry, bioorganic
chemistry and macromolecular
science

-

to develop new interdisciplinary approaches to molecular and
macromolecular engineering, aimed at manufacturing of new
materials for applications in medicine and modern technology.


DESMOL


Designed Molecules and Macromolecules


Their Assemblies and Biological Functions


Center of Molecular and Macromolecular Studies, Łódź, Poland

0
50
100
150
200
250
222
o
C
172
o
C
Temperature /
o
C
+
(
S
)
-
P
L
A


































(
R
)
-
P
L
A
H
O
H
O
O
H
O
H
O
H
O
H
H
O
H
O
O
H
O
H
O
H
O
H
H
O
H
O
O
H
O
H
O
H
O
H
H
O
H
O
O
H
O
H
O
H
O
H
S
T
E
R
E
O
C
O
M
P
L
E
X
Melting temperature increases by 50
0
C


(wider range of application)



Most important scientific result:


New biodegradable materials based on polymers
with special topologies (star
-
polymers and their
stereocomplexes) obtained from renewable
sources (lactic acid)


Those materials may serve as biodegradable

comodity plastics or specialty materials for

application in medicine.


Centre of Excellence

in Molecular Biotechnology

EMBEU


Coordinator: Prof. Andrzej Rabczenko

Institute of Biochemistry and Biophysics

Polish Academy of Sciences

Warsaw, Poland

Member of
Ochota Campus Consortium

EMBEU achievements

selected from over 80 publications


Proteomics study resulting in identification of new
markers for Alzheimer’s disease


Novel inhibitors of HCV helicase


Application of comparative genomics for
identification of new protein targets to fight malaria


New technology to use protease inhibitors in drug
protection (patented)


Genomics of clinically relevant plasmids

EMBEU
a
ctivity


E
xchange visits


Organization of
conferences, numerous workshops
and courses


Networking other CoEs
(Cyprus, Bulgaria, Hungary, Poland)


Inducing 4 new CoEs in our campus


Promotion of the European cooperation resulting in
15 FP5 and FP6 projects


Establishment of FP5 Marie Curie Training Site


Education and Research in Molecular Biology

Institute of Cellular Biology and Pathology

“Nicolae Simionescu”

ROMANIAN ACADEMY

Member of UNESCO Global Network for Molecular and Cell Biology

Center of Excellence:

“Blood Vessels”

Coordinator
:

Dr. Maya Simionescu

Research

Program

Understanding

the

molecular

and

cellular

mechanisms

occurring

in

the

normal

vessels,

and

the

alterations

of

the

arterial

wall

leading

to

the

cardiovascular

diseases

Title of the project


Function and dysfunction of blood vessels:
transcytosis in normal/pathological states,
alterations in atherosclerosis and diabetes;
their therapeutic control


Our Credo :

“Cellular and Molecular Biology for

the Benefit of Human Health”

Anti
-
atherogenic drugs effects


tested on the hyperlipemic and/or hyperglycemic hamster:




statins (simvastatin, atorvastatin);



calcium channel blockers (nifedipine, amlodipine);



ACE inhibitors (enalapril, captopril);



anti
-
thrombotic (enoxaparin, aspirin);



vitamins (E and C);



L
-
Arginine;



"intelligent liposomes" for an efficient drug delivery.

Pharmacological Modulation of Endothelial Cell Function



The effect of drugs on the cells of the vascular wall



EC depend relaxation


= Structure



Arterial pressure



Atherosclerosis


STRESSNUTS


Institute of Experimental Endocrinology

Slovak Academy of Sciences

Bratislava, Slovakia

Coordinator
:

Assoc.

Prof. Daniela Je
ž
ová


M
ain „mission” of
this

Centre


To provide e
xperimental and clinical

data

leading to
specific recommendations aimed
at

reducing

the
negative impact of
environmental factors

on human health

Most important scientific result

(one selected
from

many)

Evidence has been obtained to support

further clinical research on the following

substances to
modulate hormone release


and treat the negative impact of demanding

stressful situations, anxiety and depression:




mood stabilizers



extract of Ginkgo biloba



pentoxifylline



antidepressants



selected amino acids

Salivary cortisol
(ng/ml)
-0.5
0
0.5
1
1.5
0
15
30
45
min
changes from basal values
stress
time: p<0.001
treatment: p<0.05
placebo

lamotrigine

STRESSNUTS

In all EU Centers of excellence t
he program
has greatly contributed

towards:


Mobility of
s
cientists



Exchange of experience and know
-
how



Training at all levels




Through networking and twinning, excellent

co
-
operation has been realized



Consortiums of
s
cientists and
i
nstitutions for joint
projects for the 6
th

FP have been established


Increased international recognition of the Institute
s



Participation of scientists in the 5
th

and 6
th

FP


Success in obtaining national and international funding


Expansion of the Institute
s


Strengthened collaboration
in EU


Start of clinical studies based on research conducted in the

CoE


A
ppointment of several outstanding young researchers


Increased quality of scientific results
and of
publications


New training activities, teaching courses


Public lectures and press conferences

Most important outcomes of the CoE


programme:


The program has undoubtedly fulfilled its
purposes. It has contributed immensely
towards the spirit of co
-
operation and exchange
of scientific information between the scientific
community


This indisputable fact should be further
promoted and supported (morally and
financially) by engaging in similar programs
for the benefit of the peoples of the new
members of the United Europe

CoE Projects
-

bridge to the EU