Signal-Responsive Hybrid Biomaterials with

Signal
-
Responsive Hybrid Biomaterials with
Built
-
in Boolean Logic

Evgeny Katz, Clarkson University,DMR 0706209

Nano
-
structured

signal
-
responsive

materials

were

coupled

with

enzyme

logic

systems

processing

biochemical

signals
.

Boolean

logic

gates

and

their

networks

composed

of

enzyme

assemblies

were

designed

for

logic

processing

multiple

biochemical

signals

to

yield

pH

changes

transduced

by

the

signal

responsive

materials

into

bulk

material

changes
.

The

hybrid

materials

were

integrated

with

various

functional

interfaces
.

Complex

bioelectronic

systems,

including

biocatalytic

electrodes,

bioelectronic

chips

and

biofuel

cells,

were

developed

with

the

use

of

“smart”

switchable

interfaces

composed

of

the

signal
-
processing

enzymes

and

signal
-
amplifying/actuating

polymeric

materials
.

The

designed

systems

represent

the

first

examples

of

future

physiologically

controlled

bioelectronic

devices
.

Logic

operations

AND

/

OR

performed

by

the

enzyme
-
based

systems

resulting

in

the

ON

and

OFF

states

of

the

bioelectrocatalytic

interface

followed

by

the

Reset

function

to

complete

the

reversible

cycle
.


Switchable

interface

functionalized

with

the

signal
-
responsive

material

coupled

with

the

enzyme

logic

systems
.

Bioelectronic chip functionalized with
signal
-
processing nanoparticles

Signal
-
controlled power
generated by a biofuel cell

Multiple
-
signal processing
enzyme logic network

Broader impact:

Novel concept of signal
-
responsive materials with
built
-
in Boolean logic was developed.

Novel bioelectronic devices based on the
biomolecular
-
hybrid materials were designed.

Future biomedical applications of the hybrid
materials and bioelectronic devices are
envisaged.

Education and collaboration:

New courses related Bioelectronics and
Bionanotechnology were developed.

A group of graduate and undergraduate students
participated in the research project.

Collaborative work was performed with visiting
students from Germany, Spain and Israel.

Dissemination

of

the

research

results

in

2009
:

25

papers

published

in

peer

review

journals

and

12

conference

presentations

at

national

and

international

meetings

with

participation

of

7

graduate

students
.

A higher level complexity was achieved upon integration of the enzyme
-
logic systems, signal
-
responsive materials and bioelectronic devices,
including electronic chips, biocatalytic electrodes, and biofuel cells

Evgeny Katz, Clarkson University, DMR 0706209