Signal
-
Responsive Hybrid Biomaterials with
Built
-
in Boolean Logic
Evgeny Katz, Clarkson University,DMR 0706209
Nano
-
structured
signal
-
responsive
materials
were
coupled
with
enzyme
logic
systems
processing
biochemical
signals
.
Boolean
logic
gates
and
their
networks
composed
of
enzyme
assemblies
were
designed
for
logic
processing
multiple
biochemical
signals
to
yield
pH
changes
transduced
by
the
signal
responsive
materials
into
bulk
material
changes
.
The
hybrid
materials
were
integrated
with
various
functional
interfaces
.
Complex
bioelectronic
systems,
including
biocatalytic
electrodes,
bioelectronic
chips
and
biofuel
cells,
were
developed
with
the
use
of
“smart”
switchable
interfaces
composed
of
the
signal
-
processing
enzymes
and
signal
-
amplifying/actuating
polymeric
materials
.
The
designed
systems
represent
the
first
examples
of
future
physiologically
controlled
bioelectronic
devices
.
Logic
operations
AND
/
OR
performed
by
the
enzyme
-
based
systems
resulting
in
the
ON
and
OFF
states
of
the
bioelectrocatalytic
interface
followed
by
the
Reset
function
to
complete
the
reversible
cycle
.
Switchable
interface
functionalized
with
the
signal
-
responsive
material
coupled
with
the
enzyme
logic
systems
.
Bioelectronic chip functionalized with
signal
-
processing nanoparticles
Signal
-
controlled power
generated by a biofuel cell
Multiple
-
signal processing
enzyme logic network
Broader impact:
Novel concept of signal
-
responsive materials with
built
-
in Boolean logic was developed.
Novel bioelectronic devices based on the
biomolecular
-
hybrid materials were designed.
Future biomedical applications of the hybrid
materials and bioelectronic devices are
envisaged.
Education and collaboration:
New courses related Bioelectronics and
Bionanotechnology were developed.
A group of graduate and undergraduate students
participated in the research project.
Collaborative work was performed with visiting
students from Germany, Spain and Israel.
Dissemination
of
the
research
results
in
2009
:
25
papers
published
in
peer
review
journals
and
12
conference
presentations
at
national
and
international
meetings
with
participation
of
7
graduate
students
.
A higher level complexity was achieved upon integration of the enzyme
-
logic systems, signal
-
responsive materials and bioelectronic devices,
including electronic chips, biocatalytic electrodes, and biofuel cells
Evgeny Katz, Clarkson University, DMR 0706209
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