Marine and Agricultural Microbiology & Biotechnology Group


Feb 12, 2013 (5 years and 3 months ago)


Marine and Agricultural Microbiology & Biotechnology Group
陈秀兰 Xiu-Lan Chen Professor
State Key Laboratory of Microbial Technology,
Shandong University, Jinan, 250100
Tel: 0531-88364326, Fax: 0531-88564326, Email:

Education and experience
2004-present, Professor of Microbiology, Shandong University
2002-2004, Associate professor of Microbiology, Shandong University
1998-2002, Ph. D. in Microbiology, Shandong University
1992-1998, Assistant researcher, Shandong Academy of Agricultural Sciences
1985-1992, B. Sc in Biology, M. Sc in Botany, Shandong Normal University

Research interest
1. Diversity of marine protease-producing bacteria
2. Diversity and biochemistry of marine bacterial proteases
3. Degradation mechanism of marine organic nitrogen
4. Biotechnology of marine bacterial proteases

Some new marine bacterial species and novel marine bacterial proteases studied:

Selected publications:
1. Xiu-Lan Chen, Bin-Bin Xie, Fei Bian, Guo-Yan Zhao, Hui-Lin Zhao, Hai-Lun He, Bai-Cheng Zhou,
Yu-Zhong Zhang, Myroilysin, a Novel Bacterial M12 Metalloprotease with Elastinolytic Activity and
Synergistic Role with Collagenase in Collagen Hydrolysis by Swelling Collagen: Implication for Its
Ecological Function in Biodegradation of Deep-Sea High-Molecular-Weight Organic Nitrogen, Applied and
Environmental Microbiology, 2009, 75: 1838-44.
2. Ming-Yang Zhou, Xiu-Lan Chen (co-first author), Hui-Lin Zhao, Hong-Yue Dang, Xi-Wu Luan, Xi-Ying
Zhang, Hai-Lun He, Bai-Cheng Zhou, Yu-Zhong Zhang, Diversity of both the Cultivable Protease-producing
Bacteria and Their Extracellular Proteases in the Sediments of the South China Sea, Microbial Ecology, 2009,
DOI: 10.1007/s00248-009-9506-z
3. Guo-Yan Zhao, Xiu-Lan Chen (co-first author), Hui-Lin Zhao, Bin-Bin Xie, Bai-Cheng Zhou, Yu-Zhong
Zhang, Hydrolysis of insoluble collagen by deseasin MCP-01 from deep-sea Pseudoalteromonas sp. SM9913:
Collagenolytic characters, collagen-binding ability of C-terminal PKD domain and Implication for its novel
role in deep-sea sedimentary particulate organic nitrogen degradation, Journal of Biological Chemistry,2008,
283 (52): 36100-36107.
4. Xiu-Lan Chen, Bin-Bin Xie, Jing-Tao Lu, Hai-Lun He, Yu-Zhong Zhang,A novel type of subtilase from the
psychrotolerant bacterium Pseudoalteromonas sp. SM9913: catalytic and structural properties of deseasin
MCP-01,Microbiology-SGM,2007, 153: 2116-2125.
5. Xiu-Lan Chen, Yuzhong Zhang, Jing-Tao Lu, Bin-Bin Xie, Cai-Yun Sun, Bing Guo,Autolysis of a novel
multidomain subtilase—Cold-adapted deseasin MCP-01 is pH-dependent and the surface loops in its catalytic
domain, the linker, and the P-proprotein domain are susceptible to proteolytic attack, Biochem. Biophys. Res.
Commun., 2007, 358(3): 704-709.