Name: Akhilesh K. Tamrakar Designation: Scientist Department ...

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Feb 20, 2013 (4 years and 1 month ago)

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Name:

Akhilesh K. Tamrakar


Designation:

Scientist

Department:

Biochemistry

Phone (off.):

0522
-
2612411
-
18 (Ext. 4346)

Phone (mob.):

8081519931

Email:

akhilesh_tamrakar@cdri.res.in

akhileshcdri@gmail.com



Academic Background

M.Sc. in Biotechnology (2000) from Jiwaji University Gwalior, M.P.

Ph.D. in Biotechnology (2006) from Defence Research and Development
Establishment,

Gwalior, M.P.

Professional Experience



One year teaching experience as lecturer at Govt. P.G. College Guna, M.P.



One year postdoc experience as BOYSCAST fellow at The Hospital for sick Children,
Toronto, Canada
.


Research Interest



Search towards the natu
ral modulator of GLUT4 translocation for the treatment of
insulin resistance
.



Exploration of the role of innate immune components in inflammation
-
induced
insulin resistance.



Development of new cellular model of insulin resistance and investigation of novel
mechanism involved in induction of insulin resistance.




Discovery and development of
new
antidiabetic molecules

and investigation of
underlying mechanism of action
.

Publi
cations

1.

Jaiswal N, Maurya CK, Venkateswarlu K, Sukanya

P, Srivastava AK, Narender T,
Tamrakar
AK
.

4
-
Hydroxyisoleucine stimulates glucose uptake by increasing surface GLUT4 level in
skeletal muscle cells via Phosphatidylinositol
-
3
-
kinase
-
dependent pathway.

European
Journal of Nutrition

(2012) in press.

2.

Jaiswal N, Bhatia V, Srivastava SP, Srivastava AK,

Tamrakar AK
.

Antidiabetic effect of

Eclipta alba

associated with inhibition of alpha
-
glucosidase and aldose reductase.

Natural Product Research
(2012) in pr
ess.

3.

Naresh G, Jaiswal

N, Sukanya

P, Srivastava

AK,
Tamrakar

AK
, Narender T. Glucose uptake
stimulatory effect of 4
-
Hydroxypipecolic acid by increased GLUT 4 translocation in
skeletal muscle cells.
Bioorganic Medicinal Chemistry Letters

(2012) in press.

4.

Teixeira SS,

Tamrakar AK
, Goulart
-
Silva F, Serrano
-
Nascimento C, Klip A, Nunes MT.
Triiodothyronine (T3) acutely stimulates glucose transport into L6 muscle cells without
increasing surface GLUT4, GLUT1 or GLUT3.
Thyroid
(2012)
22 (7): 747
-
754
.

5.

Varshney K
, Gupta S, Rahuja N, Rawat AK, Singh N,
Tamrakar AK
, Srivastava AK,

Saxena
AK. Synthesis, structure
-
activity relationship and docking studies of substituted aryl
thiazolyl phenylsulfonamides as potential protein tyrosine phosphatase

1B inhibitors.
ChemMedChem.
(2012) 7(7):

1185
-
1190.

6.

Khan MF, Kumar P, Pandey J, Srivastava AK,
Tamrakar AK
, Maurya R. Synthesis of novel
imbricatolic acid analogues via insertion of N
-
substituted piperazine at C
-
15/C
-
19
positions, displaying glucose uptake stimulation in

L6 skeletal muscle cells.
Bioorganic
Medicinal Chemistry Letters

(2012) 22 (14): 4636
-
4639.

7.

Kumar A, Sharma S, Gupta LP, Ahmad P, Srivastava SP, Rahuja N,

Tamrakar AK
,
Srivastava AK. Synthesis of propiophenone derivatives as new class of antidiabetic
agents reducing body weight in db/db mice.
Bioorganic & Medicinal Chemistry
(2012)
20: 2172
-
2179
.

8.

Kha
n

MF, Dixit P, Jaiswal N,

Tamrakar AK
, Srivastava AK, Maurya R.

Chemical
constituents of

Kigelia pinnata

twig and their GLUT4 translocation modulatory effect in
skeletal muscle cells
.

Fitoterapia

(2012
)

83
: 125
-
129
.


9.

Jaiswal N, Yadav PP, Maurya R, Srivastava AK,
Tamrakar AK
. Karanjin from

Pongamia
pinnata

induces GLUT4 translocation in skeletal muscle cells in a phosphatidylinositol
-
3
-
kinase
-
independent manner.
European Journal of Pharmacology
(2011)

670:

22
-
28.

10.

Schertzer JD,
Tamrakar AK
, Magalhães JG, Pereira S, Bilan PJ,
Fullerton MD, Liu Z,
Steinberg

GR, Giacca A,
Philpott DJ, Klip A. NOD1 activators link innate immunity to
insulin resistance.
Diabetes
(2011)

60(9):

2206
-
2215.


11.

Tamrakar AK,
Jaiswal N, Yadav PP, Maurya R, Srivastava AK.
Pongamol from
Pongamia
pinnata

stimulates glucose uptake by inc
reasing surface GLUT4 level in skeletal muscle
cells.
Molecular and Cellular Endocrinology
(2011)
339
: 98
-
104.


12.

Tamrakar AK
, Schertzer JD, Chiu TT, Foley KP, Bilan PJ, Philpott DJ, Klip A. NOD2
activation induces muscle cell
-
autonomous innate immune
responses and insulin
resistance.

Endocrinology
(2010
)
151(12)
: 5624
-
5637.

13.

Kumar M, Rawat P, Khan MF,
Tamrakar AK
, Srivastava AK, Arya KR, Maurya R. Phenolic
glycosides from
Dodecadenia grandiflora

and their glucose
-
6
-
phosphatase inhibitory
activity.
Fit
oterapia
(2010)
81(6)
: 475
-
479.


14.

Kumar A, Sharma S, Tripathi VD, Maurya RA, Srivastava SP, Bhatia G,
Tamrakar AK
,
Srivastava AK. Design and synthesis of 2,4
-
disubstituted polyhydroquinolines as
prospective antihyperglycemic and lipid modulating agents.
Bioorganic & Medicinal
Chemistry
(2010)
18:

4138

4148.


15.

Rawat P, Khan MF, Kumar M,
Tamrakar AK
, Srivastava AK, Arya KR, Maurya R.
Constituents from fruits of
Cupressus sempervirens.

Fitoterapia
(2010)
81
: 162
-
166.

16.

Singh AB,

Tamrakar AK
, Sweta, Narender T

and Srivastava AK. Antihyperglycemic effect
of an unusual amino acid (4
-
hydroxyisoleucine) in C57BL/KsJ
-
db/db mice.

Natural
Products Research
(201
0) 24 (3)
: 258
-
265
.

17.

Kumar A, Maurya RA, Sharma S, Ahmad P, Singh AB,
Tamrakar AK
and

Srivastava AK.
Design a
nd synthesis of 3,5
-
diarylisoxazole derivatives as novel class of anti
-
hyperglycemic and lipid lowering agents.

Bioorganic and Medicinal Chemistry
(2009) 17:
5285

5292.

18.

Saxena N, Pandey J,

Tamrakar AK
, Srivastava AK and Tripathi RP. BF3
-
Oet2 catalyzed
man
nosylation of phenolics with 2,3,4,5
-
di
-
O
-
isopropylidene
-
D
-
mannofuranose
accompanied by selective

in situ
deketalization.

Trends in Carbohydrate Research

(2009)

1(2): 29
-
37

19.

Singh FV, Parihar A, Chaurasia S, Singh AB, Singh SP,
Tamrakar AK
, Srivastava AK,
Goel A.
5,6
-
Diarylanthranilo
-
1,3
-
dinitriles as a new class of antihyperglycemic agents.

Bioorganic and Medicinal Chemistry Letters
(2009)

19 (8)
:

2158
-
61


20.

Bisht SS, Fatima S,
Tamrakar AK
, Rahuja N, Jaiswal N, Srivastava AK, Tripathi RP.
Synthetic studi
es in butenonyl C
-
glycosides: Preparation of polyfunctional alkanonyl
glycosides and their enzyme inhibitory activity.

Bioorganic and Medicinal Chemistry
Letters
(2009)

19 (10)
:

2699
-
703.

21.

Tamrakar AK
, Singh AB and Srivastava AK. db/+ mice: An alternate model in antidiabetic
drug discovery research.

Achieves of Medical research
(2009) 40: 73
-
78.


22.

Raj K, Misra N, Pachauri G, Sharma M,
Tamrakar AK
, Singh AB, Srivastava AK, Rao CVN
and Prubhu SR. Novel c
lass of hybrid natural
products as antidiabetic agents.

Natural
Product Research
(2009) 23 (1): 60
-
69.


23.

Maurya R, Gupta P, Ahmad G, Yadav DK, Chand K, Singh AB,
Tamrakar AK
, and
Srivastava AK. Synthesis of 3,5
-
disubstituted isoxazolines as protein tyrosine

phosphatase 1B inhibitors.
Medicinal Chemistry Research

(2008) 17: 123
-
136.

24.

Tiwari P,
Tamrakar AK
, Ahmad R, Srivastava MN, Kumar R, Lakshmi V, and Srivastava
AK.
Antihyperglycemic activity of
ceriops tagal

in nornmoglycaemic and streptozotocin
induced diabetic rats.
Medicinal Chemistry Research

(2008) 17: 74
-
84.

25.

Tamrakar AK
, Tiwari P, Ahmad R, Kumar R, Lakshmi V, Srivastava MN, and Srivastava
AK. Antihyperglycaemic activity of
Sinularia firma

and
Sinularia

erecta

in streptozotocin
induced diabetic

rats.

Medicinal Chemistry Research

(2008) 17: 62
-
73.

26.

Tamrakar AK,
Yadav PP, Tiwari P,

Maurya R and Srivastava AK. Identification of
pongamol and karanjin as lead compounds with antihyperglycemic activity from
Po
ngamia pinnata

fruits.
Journal of Ethnopharmacology

(2008) 18: 435
-
439.

27.

Dixit M, Saeed U, Kumar A, Siddiqi MI,
Tamrakar AK
, Srivastava AK and Goel A.
Synthesis, molecular docking and PTP1B inhibitory activity of functionalized 4,5
-
dihydronaphthofurans and dibenzofurans.
Medicinal Chemistry

(2008)
4 (1):18
-
24.

28.

Tamrakar AK,

Kumar R, Sharma R, Lakshmi V and Srivastava AK.
Stimul
atory effect of
Ceriops tagal

on hexose uptake in L6 muscle cells in culture.
Natural products Research

(2008) 22 (7): 592
-
599.

29.

Pandey J, Dwivedi N, Singh N, Srivastava AK,
Tamrakar AK

and Tripathi RP.
Diastereoselective synthesis of glycosylated prolines as α
-
glucosidase inhibitors and
organocatalyst in asymmetric aldol reaction.
Bioorganic and Medicinal Chemistry Letters
(2007)

17:1321
-
1325.

30.

Dixit M, Tripathi BK,
Tamrakar AK
, Srivasta
va AK, Kumar B and Goel A. Synthesis of
benzofuran scaffold
-
based potential PTP
-
1B inhibitors.
Bioorganic and Medicinal
Chemistry
(2007)
15:

727
-
734.

31.

Ahmad G, Mishra PK, Gupta P, Tiwari P,
Tamrakar AK
, Srivastava AK, and Maurya R.
Synthesis of novel benzofuran isoxazolines as potent protein tyrosine phosphatase
-
1B
inhibitors.
Bioorganic and Medicinal Chemistry Letters
(2006)
16:

2139
-
2143.

32.

Tamrakar AK,

Goel AK, Kamboj DV and Singh L. Surveillance meth
odology for
V. cholerae
in environmental samples.

International Journal of Environmental Health Research

(2006)
16 (4):

305
-
312.

33.

Goel AK,
Tamrakar AK
, Kamboj DV and Singh L. Direct immunofluorescence assay for
rapid environmental detection of
Vibrio choler
ae
O1.
Folia Microbiologica
(2005)

50 (5):

448
-
452.

34.

Goel AK,
Tamrakar AK
, Nema V, Kamboj DV and Singh L. Detection of viable toxigenic
Vibrio cholerae

from environmental water sources by direct cell duplex PCR assay.
World
Journal of Microbiology and Biot
echnology
(2005)
21
:

973
-
976.

35.

Verma SS, Mishra RC,
Tamrakar AK
, Tripathi BK, Srivastava AK, and Tripathi RP.
Reductive amination of glycoyl aldoses: Synthesis of N
-
glycosylated β

glycosyl amino
alcohols and their antidiabetic potential.
Journal of Carbohydrate Chemistry
(2004)
23
(8/9)
: 493
-
511.