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Dec 1, 2012 (4 years and 22 days ago)

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ABIC 2002 Background


New Scientific Tools:
Plants, Pentiums & Pharmaceuticals

More information on ABIC 2002 program, registration, sponsor, and exhibitor information can
be found a
t
www.abic.net

or by phone CANADA (306) 683
-
2242.


ABIC 2002 Background
3/16/2013


Page
1

of
2


New Scientific Tools

will be the topic of a session on Tuesday, September 17, 2002.


DAPHNE PREUSS, Ph.D.


Daphne Preuss is a Professor in the Department of Molecular Genetics and Cell Biology at
the University of Chicago and an Assistant Investigator at

the Howard Hughes Medical Institute.
She also has appointments at the University's Institute for Biophysical Dynamics, the Materials
Research Science and Engineering Center, and the Committees on Genetics and Developmental
Biology.

Preuss is a David and L
ucile Packard Fellow, a Searle Scholar, received the Women in Cell
Biology Junior Award from the American Society for Cell Biology (1998), was listed by
Discover Magazine as one of twenty outstanding young American scientists (2000), and was this
year's re
cipient of the American Society of Cell Biology
-

Promega Early Career Life Scientist
Award. She serves on many scientific advisory boards and panels, was on the Board of Directors
of the Genetics Society of America, and on the editorial board of several s
cientific journals. She
has recently addressed the controversy surrounding the development of genetically modified
foods by drafting policy statements on behalf of the Genetics Society and American Society for
Cell Biology, by addressing the US House of Re
presentatives Biomedical Caucus, and by
serving as an advisor to The Einstein Institute for Science, Health and the Courts. Preuss recently
co
-
founded a biotechnology company, Chromatin, which is focusing on engineering crop
chromosomes.


For more informat
ion:
http://preuss.bsd.uchicago.edu


ABSTRACT: Plant Chromosome Dynamics


Centromeres are specialized chromosomal structures that bind to spindle fibers and direct
chromosome assortment during cell division.
We are using DNA sequencing, combined with
genetic and molecular assays, to unravel centromere function in the model system

Arabidopsis
thaliana

plant. In this organism, unique genetic tools allow a precise definition of centromere
functions; a virtually c
omplete DNA sequence of the centromere regions makes it possible to
investigate centromere structure and modification. Recently, our laboratory used genetic analysis
to define the regions that provide centromere function in Arabidopsis; these regions under
go far
less meiotic recombination than the rest of the genome. We are expanding our analysis of
centromeres, determining the relationship between the primary DNA sequence and secondary
structure, as well as investigating the evolution of centromere DNA seq
uences in closely related
species. The centromeric regions that we defined contain a surprisingly large number of
predicted genes, both in the areas immediately flanking the centromere, as well as within the
centromere itself. Surprisingly, the genes withi
n the centromere regions are often highly
methylated, yet also highly expressed. These observations indicate unique mechanisms for
regulating gene expression are likely in place in the centromeric regions. This work has practical
implications as well
-

wit
h centromere sequences in hand, it becomes possible to design
chromosomes useful for manipulation of plant genomes.


ABIC 2002 Background


New Scientific Tools:
Plants, Pentiums & Pharmaceuticals

More information on ABIC 2002 program, registration, sponsor, and exhibitor information can
be found a
t
www.abic.net

or by phone CANADA (306) 683
-
2242.


ABIC 2002 Background
3/16/2013


Page
2

of
2


Other speakers in this session include:


Lawrence Schook, Ph.D.,
President and Chief Scientific Officer of Pyxis Genomics, Inc.


Commerci
al Applications of Food Animal Genomics


Derek Lydiate, Ph.D.,
Head, Molecular Genetics Section, Agriculture and Agri
-
Food Canada,
Saskatoon Research Centre

Genomics Overview


Steffen Nock, Ph.D.,
VP of Biochemistry, Zyomyx, Inc.

Protein Microarrays


Prem

Bhalla, Ph.D.
,
Associate Professor,

University of Melbourne, Australia


Allergen Biotechnology: Removal of Allergens through Biotechnology


Mohan Singh, Ph.D.
,
Associate Professor, Institute of Land and Food Resources, University of
Melbourne, Australia

Allergen Biotechnology: Novel Allergy Therapeutics through Biotechnology