Heart Health System

noodleproudSoftware and s/w Development

Oct 29, 2013 (3 years and 5 months ago)

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Product Information Sheet

Heart Health


Sys
tem

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Primary Benefits



Heart Health


System

Primary Benefits

These statements have not been eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not

i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
1





Heart Health Essential Omega III Fish Oil with Vitamin E



Each daily serving provides 6000 mg of fish oil to supply

1800 mg of EPA† and 1200 mg DHA†



Helps enhance mood



Helps maintain
healthy levels of C
-
reactive protein



Helps maintain normal blood flow



Helps maintain normal cholesterol levels



Helps maintain normal triglyceride levels in the blood



Promotes a healthy complexion



Promotes healthy blood pressure levels



Promotes overall card
iovascular health



Heart Health TriActive™



B vitamins promote the healthy formation of red blood cells



Helps maintain a strong heart muscle



Helps maintain normal homocysteine levels (which promotes

cardiovascular and arterial health)



Helps maintain
normal levels of cholesterol



Promotes a normal rate of cholesterol production



Promotes absorption of healthy levels of cholesterol and bile

acids from the intestines



Promotes normal fat absorption by various lipases in the intestine



Provides antioxidant p
rotection of LDL particles



Heart Health Advanced LipiTrim® Ultra



Antioxidant



Helps promote delivery of healthy levels of LDL throughout the body



Promotes a normal rate of cholesterol production



Promotes healthy levels of total cholesterol, LDL cholesterol

and triglyceride levels



Supports normal synthesis of triglycerides in the liver

13847: Single Box



Advanced LipiTrim® Ultra



Essential Omega III Fish Oil



TriActive

30 Day Supply: $99.95


What Makes
Heart Health System

Unique?

The Heart Health System is comprised of Heart Health Essential Omega III Fish Oil with Vitamin E, Heart
Health TriActive™, and Heart Health Advanced LipiTrim® Ultra, all designed to promote overall
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shopper.com

Product Information Sheet

Heart Health


Sys
tem

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Primary Benefits



Heart Health


System

Primary Benefits

These statements have not been eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not

i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
2


cardiovascular health. Heart Health Essential Omega III Fi
sh Oil with Vitamin E provides the three
grams of EPA† (eicosapentaenoic acid) and DHA† (docosahexaenoic acid) that studies reveal is the
most effective amount to promote overall cardiovascular health. Heart Health Advanced LipiTrim®
Ultra is composed of S
ytrinol®, a patented proprietary formula derived from natural citrus
polymethoxylated flavones (PMFs) and palm tocotrienols, designed to promote overall cardiovascular
health. Sytrinol works in the liver without inhibiting the production of CoQ10. Advanced

LipiTrim Ultra
is a powerful antioxidant; it helps promote delivery of healthy levels of LDL throughout the body,
promotes a normal rate of cholesterol production, promotes healthy levels of total cholesterol, LDL
cholesterol and triglyceride levels, and
promotes the normal synthesis of triglycerides in the liver.
Heart Health TriActive™ targets three major areas, the arteries, cholesterol and homocysteine levels to
promote the healthy performance of the body’s cardiovascular system. This unique formula us
es a
combination of natural ingredients that have been shown to safely and effectively support optimal
arterial function and help maintain normal cholesterol and homocysteine levels.*


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Product Information
Sheet

Heart Health


System

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Key Ingredients



Heart Health


System

Key Ingredients

These statements have not been eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
3


Fish Body Oils (50% Purity) 3000 mg [EPA† 900 mg and DHA† 600 mg]

Fish oils, or marine oils, are lipids (fats) found in fish, particularly c
old water fish like herring, kipper,
mackerel, menhaden, pilchard, salmon, sardine and trout, and phytoplankton (the sources of fish oil in
Heart Health™ Omega III Fish Oil are sardines and anchovies, tested by the manufacturer and an
independent testing c
ompany to be virtually free of mercury lead, PCB and other heavy metals). Fish
oils are rich sources of omega
-
3 long
-
chain polyunsaturated fatty acids. EPA (eicosapentaenoic acid)
and DHA (docosahexanenoic acid) are the two most studied fish oils. DHA is a

necessary component of
the phospholipids in human cellular membranes, especially those found in the brain and retina. Clinical
studies have shown omega
-
3 fatty acids to help maintain healthy triglyceride levels. A strong
correlation has also been shown be
tween fish oil consumption and the ability to maintain healthy
levels of C
-
reactive protein. Fish oils are also important in the maintenance of normal blood flow, as
they support normal fibrinogen levels (coagulation or blood clotting), which contributes
to normal
platelet activity.*


EPA and DHA have several mechanisms of action to help maintain normal triglyceride and cholesterol
levels, help maintain normal blood flow and pressure, and support normal platelet activity. EPA and
DHA help maintain normal
triglyceride levels by promoting normal lipogenesis and supporting normal
fatty acid oxidation in the liver. EPA and DHA promote the normal transcription of genes coding for
lipogenesis enzymes and promote the normal transportation of the regulatory enzyme
s of fatty acid
oxidation. Activating PPAR (peroxisome proliferator
-
activated receptor)
-

alpha, helps to support
normal fatty acid oxidation. The promotion of normal lipogenesis is done through down
-
regulation of
SREBP (sterol regulatory element binding pr
otein)
-
1c messenger RNA.*


EPA is the precursor to series
-
3 prostaglandins (PG), the series
-
3 thrombaxanes (TX) and the series
-
5
leukotrienes (LT). More specifically, EPA is a precursor to eicosanoids (TXA3 and LTB5), which promote
normal platelet activit
y and promote normal vasodilation. These effects demonstrate EPA’s potential
ability to help maintain normal blood pressure and support normal blood clotting. Fish oils inhibit the
arachidonic acid synthesis of thromboxane A2, which help to promote normal
platelet activity and
vasodilation. Fish oil may also contribute to the normal production of prostacyclin, a prostaglandin that
promotes normal vasodilation and supports normal platelet activity.*


Omega
-
3 fatty acids compete metabolically with omega
-
6 fat
ty acids found in higher amounts in typical
western diets. Omega
-
6 fatty acids may inhibit the incorporation of omega
-
3 fatty acids into tissue
lipids. Omega
-
3 fatty acids may inhibit the conversion of many omega
-
6 fatty acids into arachidonic
acid. Consum
ption of omega
-
3 fatty acids DHA and EPA, a corresponding increase of these fatty acids,
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Product Information
Sheet

Heart Health


System

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Key Ingredients



Heart Health


System

Key Ingredients

These statements have not been eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
4


appears to occur in cell membranes and circulatory lipids along with a simultaneous reduction in
omega
-
6 fatty acids.*

Hawthorn Berry 75 mg

The bioflavonoid content of

hawthorn berry aids in supporting healthy blood vessels, supports a strong
heart muscle and promotes the structural integrity of arteries. Several studies have also shown that
hawthorn berry is beneficial in maintaining optimal heart health.*

Beta
-
Sitoste
rol 250 mg (as Cholestatin®)

Beta
-
sitosterol, a close relative of cholesterol, competes with cholesterol for absorption in the small
intestine, thereby supporting a healthy amount of cholesterol absorption.

Cassia nomame 50 mg

Cassia nomame supports health
y levels of fat absorption from foods by supplying flavonoids that
promote healthy levels of pancreatic lipases (enzymes that degrade fat) in the small intestine. Cassia
Nomame extract is a lipase inhibitor. A lipase inhibitor inhibits the enzyme responsib
le for the
breakdown of fat, thereby inhibiting its function. Subsequently, some fat molecules remain undigested
and unabsorbed into the bloodstream.*

Guggulsterones 5 mg

Guggul is a resin produced by the mukul mirth tree. The extract contains guggulsteron
es that help
maintain healthy cholesterol levels by acting in the intestine to promote normal excretion of bile acids
from the body. Guggul extract has also been shown to help maintain healthy blood flow. Guggul
appears to promote healthy cholesterol by in
hibiting the activities of the Farnesoid X Receptor in the
cells of the liver and intestine. FXR is activated in the presence of bile salts for the re
-
uptake of bile
salts back into the body from the small intestine. Guggul appears to promote normal activi
ty of the FXR
and the bile salt export pump (BSEP), which promotes the normal excretion of bile from the body.
Cholesterol, as a component of bile, is therefore excreted. By promoting the normal output of
cholesterol in bile salts, the body is forced to us
e stored cholesterol to synthesize new bile salts.*

Cyanocobalamin (Vitamin B12): 500 mcg

Vitamin B12, a bacterial product is naturally found in organ meats, liver, beef, pork, eggs, whole milk,
cheese, whole wheat bread, and fish. B12 can only be found

in animal products, with small amounts
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Product Information
Sheet

Heart Health


System

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Key Ingredients



Heart Health


System

Key Ingredients

These statements have not been eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
5


derived from the fermented soy products miso and tempeh and peanuts. It is essential that vegetarians
consume a Vitamin B12 supplement to maintain optimal health. Vitamin B12, when ingested, is stored
in the liver an
d other tissues for later use. The synthetic form of B12, Cyanocobalamin, is not derived
from either plants or animals and is intrinsic in the maintenance of normal functioning body cells,
especially those of the nervous system (maintaining the health of t
he sheaths of nerve cells), bone
marrow and intestinal tract. These tissues are first to exhibit signs of B12 depletion. Vitamin B12 itself
is responsible for maintaining optimum energy levels as it plays a vital role in the Krebs energy cycle. It
is also
a great anti
-
aging ingredient and helps increase concentration.*

Folate (Folic Acid): 300 mcg (as Metafolin®)

Folic acid is mainly found in fruits and vegetables. Dark leafy greens, oranges, orange juice, beans and
peas are the best sources as well as Brew
er’s yeast, which supply additional B vitamins. Folic acid plays
a key role by boosting the benefits of B12 supplementation. These two B vitamins work together in
maintaining normal red blood cells. Folic acid assists in the normal utilization of amino aci
ds and
proteins, as well as constructs the material for DNA and RNA synthesis. Scientific studies have found
that when working in tandem with folic acid, B12 is capable of promoting normal homocysteine levels.
This works toward supporting a healthy cardiov
ascular and nervous system.*

Riboflavin 5
-
Phosphate (Vitamin B2): 3 mg

Vitamin B2 is found in liver, dairy products, dark green vegetables and some types of seafood. Vitamin
B2 serves as a co
-
enzyme, working with other B vitamins. It promotes healthy red
blood cell formation,
supports the nervous system, respiration, antibody production and normal human growth. It supports
healthy skin, nails, hair growth and promotes normal thyroid activity. Vitamin B2 plays a crucial role in
turning food into energy as a

part of the electron transport chain, driving cellular energy at the
molecular level. Riboflavin can be useful for pregnant or lactating women, as well as athletes due to
their increased caloric needs. Vitamin B2 aids in the breakdown of fats while functi
oning as a cofactor
or helper in activating B6 and folic acid. Vitamin B2 is water
-
soluble and cannot be stored by the body
in significant amounts. It must be replenished daily.*


Under some conditions, vitamin B2 can act as an antioxidant. The riboflavin
coenzymes are also
important for the transformation of vitamin B6 and folic acid into their active forms and they promote
the normal conversion of tryptophan into niacin.*

Pyridoxine HCl (Vitamin B6): 15 mg

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Product Information
Sheet

Heart Health


System

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Key Ingredients



Heart Health


System

Key Ingredients

These statements have not been eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
6


Poultry, fish, whole grains and bananas are the
main dietary sources of vitamin B6. B6 is a co
-
factor
required for protein and amino acid metabolism, and helps maintain proper fluid balance. It also assists
in the maintenance of healthy red and white blood cells. B6 is required for hemoglobin synthesis.

Vitamin B6 is involved in the synthesis of neurotransmitters in brain and peripheral nerve cells. It has
been recommended as a nutrient to enhance mental function, specifically mood, and to support
normal nerve conduction. Some athletic supplements includ
e vitamin B6 because it promotes the
conversion of glycogen to glucose for energy in muscle tissue. Vitamin B6, when taken with folic acid,
has been shown to help maintain normal plasma levels of homocysteine, which promotes optimal
cardiovascular health.
Vitamin B6 should be administered as a part of a complex of other B
-
vitamins for
best results.*

Thiamin HCl (Vitamin B1): 2.6 mg

Thiamin plays an important role in carbohydrate metabolism and nerve function. Thiamin is required
for a healthy nervous syste
m, and to promote the normal production of the neurotransmitters
acetylcholine and gamma
-
aminobutyric acid (GABA). It is used to manufacture hydrochloric acid and,
therefore, supports digestion, increases energy and helps promote mental clarity.*

D
-
Calcium

Pantothenate (Vitamin B5): 12.5 mg

Pantothenic acid (B5) is the transfer agent for choline to acetylcholine, which promotes proper
neurotransmitter activity in the brain. Pantothenic acid is also known as the anti
-
stress vitamin
because it detoxifies brai
n tissue, helps relieve physical and emotional stress, and promotes the normal
secretion of hormones.*

Niacinamide (Vitamin B3): 25 mg

Niacin is a water
-
soluble vitamin necessary for many aspects of health, growth and reproduction. It is
part of the
vitamin B complex. Niacin promotes the normal functioning of the digestive system, skin
and nerves. It is also important for the conversion of food to energy. Niacin (also known as vitamin B
-
3)
is found in dairy products, poultry, fish, lean meats, nuts an
d eggs, as well as legumes and enriched
breads and cereals.*

Biotin (Vitamin B7): 150 mcg

Biotin can be found in food sources such as egg yolks, peanuts, beef liver, milk (10 mcg/cup), cereals,
almonds and Brewer’s yeast. Biotin supports healthy cell growt
h, the production of fatty acids,
metabolism of fats, and amino acids. It plays a role in the citric acid cycle, the process in which
biochemical energy is generated during aerobic respiration. Biotin not only assists in various metabolic
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Product Information
Sheet

Heart Health


System

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Key Ingredients



Heart Health


System

Key Ingredients

These statements have not been eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
7


chemical conversi
ons, but also supports the normal transfer of carbon dioxide. Biotin is helpful in
maintaining a steady blood sugar level. Biotin is often recommended for strengthening hair and nails.

Sytrinol® 300 mg (Polymethoxylated Flavones, Palm Tocotrienols)

Sytrino
l is a patented proprietary formula derived from natural citrus polymethoxylated flavones
(PMFs) and palm tocotrienols. This combination results in a synergistic effect for helping to maintain
healthy cholesterol, LDL cholesterol and triglyceride levels. S
ytrinol has also been shown to help
maintain healthy HDL levels. Sytrinol is a powerful antioxidant with numerous heart health benefits. It
promotes cardiovascular health, supports glycemic control and promotes normal blood platelet
aggregation.

Polymethox
ylated Flavones (PMFs)

Polymethoxylated Flavones are extremely bioactive potent bioflavonoids found in citrus fruits. This is
especially true for tangeretin and nobiletin, two of the most common flavonoids found in nutrient
-
rich
foods. More than 25 years o
f documented research provides evidence that these particular
bioflavonoids deliver heart health benefits. Specific PMFs, including nobiletin and tangeretin, have
been found to promote normal levels of LDL cholesterol.


In vitro, Sytrinol was shown to hel
p maintain normal cytokine activity; cytokines such as interleukin
-
6
and interleukins 1
-
beta. Sytrinol was also shown to promote normal t
-
lymphocyte mitogenic response
and thymidine uptake by activated lymphocytes.

Palm Tocotrienols

Palm tocotrienols, alon
g with tocopherols, are members of the vitamin E family and are extracted from
the fruit of the palm tree. Like vitamin E, palm tocotrienols degrade HMG
-
CoA reductase, a key enzyme
in our bodies used by the liver to produce cholesterol. New data on the bio
logical activity of
tocotrienols in cardiovascular health maintenance, along with its antioxidant properties, have raised
tocotrienols to a new level of prominence in the scientific community.


A completely new perspective has developed as to the role toco
trienols play in heart health and their
importance as a supplement to a healthy diet. Some of the key areas of interest have centered on its
role in maintaining and supporting a healthy cardiovascular system by promoting healthy cholesterol,
and supporting

healthy blood platelet activity. In a recent study that was published in the Journal of
Atherosclerosis, researchers at the Kyoto Prefectural University of Medicine in Japan found that
tocotrienols were more effective than vitamin E in promoting heart hea
lth. The study revealed that
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Product Information
Sheet

Heart Health


System

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Key Ingredients



Heart Health


System

Key Ingredients

These statements have not been eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
8


tocotrienols accumulate at levels that are 25
-
95 times greater than alpha tocopherol in human aortic
endothelial cells.


Tocotrienols are also potent antioxidants. In human studies, researchers observed that alpha
tocotrienols
reduced the oxidation of LDL. The antioxidant properties of tocotrienols can mitigate the
damage caused by free radicals while protecting cell membranes for better cellular communication.

--------------------

A clinical trial consisting of 60 adults showed that four weeks of treatment with 300 mg of patented
Sytrinol daily promoted nor
mal levels of total cholesterol, LDL cholesterol, and triglycerides. Follow
-
up
clinical studies have provided further support that Sytrinol promotes cardiovascular health.

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shopper.com

Product Information Sheet

Heart Health


System

Jennifer Vattima

Independent Distributor

40
W Ridley Ave

Ridley Park, PA 19078

610.405.6419

In The News



Heart Health


System

In The News

These statements have not been evaluated by the Food and Drug Administration.

This product(s) is not intended to diagnose, treat, cure or prevent any disease.


Pg.
9




American Heart Association recommends fish and omega
-
III fatty acids

http://www.americanheart.org/presenter.jhtml?identifier=4632




In Europe its Fish Oil After Heart Attacks, but not in US

New York Times, Published October 3, 2006 by Elizabeth
Rosenthal

http://www.nytimes.com/2006/10/03/health/03fish.html?ex=1162008000&en=899eb5c33e00d1fd&ei=5070




Natural Vitamin E Tocotrienol Reaches B
lood at Protective Levels

September 15, 2006

http://www.newstarget.com/020435.html


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Product Information Sheet

Heart Health


System

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Scientific Studies



Heart Health


System

Scientific Studies

These statements have not
been eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
10


Advanced LipiTrim® Ultra



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359.

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w.thecomplete
shopper.com

Product Information Sheet

Heart Health


System

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Scientific Studies



Heart Health


System

Scientific Studies

These statements have not
been eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
11




Horowitz, R.M, Gentili, B. Flavonoid constituents of Citrus. In Citrus Science and Technology; Nagy, S., Shaw,
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Kurowska, E.M., Morley, K., and Gapor, A. Regulation of apo B production in HepG2 cells by tocotrienols
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219, 1999.



K
urowska EM, Spence JD, Jordan J, Wetmore S, Freeman DJ, Piche LA, Serratore P. HDL
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Manach C, Morand C, Gil
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Izquierdo A, Bouteloup
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Dem
ange C, Remesy C. Bioavailability in humans of the
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Feb;57(2):235
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42.



Manthey JA, Grohmann K, Guthrie N. Biological properties of citrus flavonoids p
ertaining to cancer and
inflammation. Curr Med Chem. 2001 Feb;8(2):135
-
53. Review.



Mensink, R.P., van Houwelingen, A.C., Kromhout, D., and Hornstra, G. A vitamin E concentrate rich in
tocotrienols had no effect on serum lipids, lipoproteins, or platelet fu
nction in men with mildly elevated
serum lipid concentrations. Am. J. Clin. Nutr., 69:213
-
219, 1999.



Monforte, M.T., Trovato, A., Kirjavainen, S., Forestieri, A.M., and Galati, E.M. Biological effects of hesperidin,
a citrus flavonoid. (note II): hypolipid
emic activity on experimental hypercholesterolemia in rat. Farmaco
50:595
-
599, 1995.

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Heart Health


System

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Scientific Studies



Heart Health


System

Scientific Studies

These statements have not
been eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
12




Murakami A, Koshimizu K, Ohigashi H, Kuwahara S, Kuki W, Takahashi Y, Hosotani K, Kawahara S, Matsuoka
Y. Characteristic rat tissue accumulation of nobiletin, a chemopreve
ntive polymethoxyflavonoid, in
comparison with luteolin. Biofactors. 2002; 16(3
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4): 73
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82.



Murakami A, Kuwahara, S., Takahashi Y , Ito, C., Furukawa, H., Ju
-
Ichi, M. In Vitro absorption and metabolism
of nobiletin, a chemopreventive polymethoxyflavonoid in

citrus fruits. Biosci., Biotechnol., Biochem. 2001.
65. 194
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197.



Nielsen SE, Breinholt V, Cornett C, Dragsted LO Biotransformation of the citrus flavone tangeretin in rats.
Identification of metabolites with intact flavane nucleus. Food Chem Toxicol. 2000

Sep;38(9):739
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46.



Nielsen SE, Breinholt V, Justesen U, Cornett C, Dragsted LO. In vitro biotransformation of flavonoids by rat
liver microsomes. Xenobiotica. 1998 Apr;28(4):389
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Parker, R.A., Pearce, B.C., Clark, R.W., Gordon, D.A., and Wright J.J.K.
Tocotrienols regulate cholesterol
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transcriptional suppression of 3
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hydroxy
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3
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coenzyme
A reductase. J. Biol. Chem., 268:11230
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11238, 1993.



Pearce, B.C., Parker, R.A., Deason, M.E., Quereshi, A.A., and Wri
ght J.J.K. Hypercholesterolemic activity of
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3606, 1992.



Quereshi, A.A., Bradlow, B.A., Brace, L. et al. Response of hypercholesterolemic subjects to administration of
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Quereshi, A.A., Bradlow, B.A., Salser, W.A., and Brace, L.D. Novel tocotrienols of rice bran modulate
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298, 1997.



Quereshi, A.A., Pearce, B.C., Nor,
R.M., Gapor, A., Peterson, D.M. and Elson. C.E. Dietary a
-
tocopherol
attenuates the impact of g
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tocotrienol on hepatic 3
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hydroxy
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3
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methylglutaryl coenzyme a reductase activity
in chickens. J. Nutr., 126:389
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Quereshi, A.A., Quereshi, N., Hasler
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R
apacz, J.O. et al. Dietary tocotrienols reduce concentrations of plasma
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Am. J. Clin. Nutr. 53 (1991) 1042S
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1046S.



Quereshi, A.A., Quereshi, N., Wrig
ht J.J.K., Shen, Z., Kramer, G., Gapor, A., Chong, Y.H., DeWitt, G., Ong,
A.S.H., Peterson, D.M., and Bradlow, B.A. Lowering of serum cholesterol in hypercholesterolemic humans by
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1026S, 1991.



Quereshi
, N. and Quereshi, A.A. Tocotrienols: Novel hypocholesterolemic agents with antioxidant
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347.



Spencer JP, Chowrimootoo G, Choudhury R, Debna
m ES, Srai SK, Rice
-
Evans C. The small intestine can both
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-
30



Theriault, A., Chao, J.T., Wang, Q., Gapor, A. and Adeli, K. Tocotrienol: A review of its therapeutic potential.
Cli
n. Biochem 32 (1999) 309
-
319.

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Product Information Sheet

Heart Health


System

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Scientific Studies



Heart Health


System

Scientific Studies

These statements have not
been eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
13




Theriault, A., Wang, Q., Gapor, A., and Adeli, K. Effects of g
-
tocotrienol on apoB synthesis, degradation, and
secretion in HepG2 cells. Arterioscler. Tromb. Vac. Biol., 19:714
-
712, 1999.



Theriault, A., Wang, Q., Gapor, A.,
and Adeli, K. Effects of g
-
tocotrienol on apoB synthesis, degradation, and
secretion in HepG2 cells. Arterioscler. Tromb. Vac. Biol., 19:714
-
712, 1999.



Thrift, R.N., Forte, T.M., Cahoon, B.E., and Shore, V.G., Characterization of lipoprotein produced by th
e
human liver cell line HepG2, under defined conditions, J. Lipid Res., 27: 236
-
250, 1986.



Tomeo AC, Geller M, Watkins TR, Gapor A and Bierenbaum ML. Antioxidant effects of tocotrienols in
patients with hyperlipidemia and carotid stenosis. Lipids 30:1179
-
1
183, 1995.



Watkins, T., Lenz, P., Gapor, A., Struck, M., Tomeo, A., and Bierenbaum, M. g
-
Tocotrienol as a
hypocholesterolemic and antioxidant agent in rats fed atherogenic diet. Lipids 28:1113
-
1118, 1993.



Wilcox, L.J., Borradaile, N.M. and Huff, M.W. Antia
therogenic properties of naringenin, a citrus flavonoid.
Cardiovasc. Drug Rev. 17 (1999) 160
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178.



Wilcox LJ, Borradaile NM, de Dreu LE, Huff MW. Secretion of hepatocyte apoB is inhibited by the flavonoids,
naringenin and hesperetin, via reduced activity an
d expression of ACAT2 and MTP. J Lipid Res. 2001 May;
42(5): 725
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34.



Wilcox, L.J., Borradaile, N.M., Kurowska, E.M. Telford, D.E., and Huff, M.W., Naringenin, a citrus flavonoids,
markedly decreases apoB secretion in HepG2 cells and inhibits acyl CoA: chol
esterol acyltransferase,
Circulation, 98: 1
-
537, 1998.



Delaney B, Phillips K, Vasquez C, Wilson A, Cox D, Wang HB, Manthey J.Genetic toxicity of a standardized
mixture of citrus polymethoxylated flavones. Food Chem Toxicol. 2002 May;40(5):617
-
24.



Delaney B
, Phillips K, Buswell D, Mowry B, Nickels D, Cox D, Wang HB, Manthey J. Immunotoxicity of a
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94.



Kawaii S, Tomono Y, Katase E, Ogawa K, Yano M. Antiproliferative

activity of flavonoids on several cancer cell
lines. Biosci Biotechnol Biochem. 1999 May; 63(5):896
-
9.



Manthey JA, Guthrie N. Antiproliferative activities of citrus flavonoids against six human cancer cell lines. J
Agric Food Chem. 2002 Oct 9; 50(21): 583
7
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43.



Manthey JA, Grohmann K. Phenols in citrus peel byproducts. Concentrations of hydroxycinnamates and
polymethoxylated flavones in citrus peel molasses. J Agric Food Chem. 2001 Jul; 49(7): 3268
-
73.



Manthey JA, Grohmann K, Montanari A, Ash K, Manthey CL.

Polymethoxylated flavones derived from citrus
suppress tumor necrosis factor
-
alpha expression by human monocytes. J Nat Prod. 1999 Mar; 62(3): 441
-
4.



Mora A, Paya M, Rios JL, Alcaraz MJ. Structure
-
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-
enzymic lipid peroxidation. Biochem Pharmacol. 1990 Aug 15; 40(4): 793
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7.



Takanaga H, Ohnishi A, Yamada S, Matsuo H, Morimoto S, Shoyama Y, Ohtani H, Sawada Y.
Polymethoxylated flavones in orange juice are inhibitors of P
-
glyc
oprotein but not cytochrome P450 3A4. J
Pharmacol Exp Ther. 2000 Apr; 293(1):230
-
6.



Essential Omega III Fish Oil with Vitamin E

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Product Information Sheet

Heart Health


System

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Scientific Studies



Heart Health


System

Scientific Studies

These statements have not
been eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
14




Madsen T, Skou HA, et al, C
-
reactive protein, dietary n
-
3 fatty acids, and the extent of coronary artery
disease. Am J
Cardiol 88:1139
-
42 (2001)



Rigelsky, JM, et al, Hawthorn: pharmacology and therapeutic uses. Am J Health Syst Pharm 59:417
-
22
(2002)



Kris
-
Etherton PM, et al, fish consumption, fish oil, omega
-
3 fatty acids, and cardiovascular disease.
Arterioscler Thromb
Vasc Biol 23(2):e20
-
e30 (2003)



Morris, MC, Sacks F, Rosner B. Does fish oil lower blood pressure? A meta
-
analysis of controlled trials.
Circulation 88(2):523
-
533 (19930



Howe PR. Dietary fats and hypertension. Focus on fish oil. Ann NY Acad Sci 827:33
9
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352 (1997)



Morris MC, et al, The effect of fish oil on blood pressure in mild hypertensive subjects: a randomized
crossover trial. Am J Clin Nutr 57(1):59
-
64 (1993)



Knapp HR, FitzGerald GA. The antihypertensive effects of fish oil. A controlled study
of polyunsaturated
fatty acid supplements in essential hypertension. J Engl J Med 320(16):1037
-
1043 (1989)



Bonaa, KH, et al, Effect of eicosapentaenoic and docosahexaenoic acids on blood pressure in hypertension.
A population
-
based intervention trial fro
m the Tromso study. N Engl J Med 322(12):795
-
801 (1990)



Chan JK, et al, Dietary alpha
-
linolenic acid is as effective as oleic acid and linoleic acid in lowering blood
cholesterol in normolipidemic men. Am J Clin Nutr 53(5):1230
-
1234 (1991)



Harris WS, et
al, Dietary omega
-
3 fatty acids prevent carbohydrate
-
induced hypertriglyceridemia.
Metabolism 33(11):1016
-
1019 (1984)



Nestel PJ. Fish oil attenuates the cholesterol induced rise in lipoprotein cholesterol. Am J Clin Nutr
43(5):752
-
757 (1986)



Tsai PJ, Lu

SC. Fish oil lowers plasma lipid concentrations and increases the susceptibility of low density
lipoprotein to oxidative modification in healthy men. J Formos Med Assoc 96(9):718
-
726 (1997)



Garrido A, et al, Ingestion of high doses of fish oil increases

the susceptibility of cellular membranes to the
induction of oxidative stress. Lipids 24(9):833
-
835 (1989)



TriActive



Bronstrup A et al. Effects of folic acid and combinations of folic acid and vitamin B12 on plasma
homocysteine concentrations in health
y young women. American of Journal Clinical Nutrition 68:1104
-
10,
1998.



Brouwer I et al. Low
-
dose folic acid supplementation decreases plasma homocysteine concentrations: a
randomized trial. American of Journal Clinical Nutrition 69:99
-
104, 1999.



den Heij
er Met al. Vitamin supplementation reduces blood homocysteine levels: a controlled trial in patients
with venous thrombosis and healthy volunteers. Arteriosclerosis Thrombosis and Vascular Biology 18:356
-
61, 1998.



Doshi S et al. Folic acid improves endoth
elial function in coronary artery disease via mechanisms largely
independent of homocysteine lowering. Circulation 105(1):22
-
26, 2002.

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Product Information Sheet

Heart Health


System

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Scientific Studies



Heart Health


System

Scientific Studies

These statements have not
been eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
15




Friso S et al. Low plasma vitamin B
-
6 concentrations and modulation of coronary artery disease risk.
American of Journ
al Clinical Nutrition 79(6):992
-
998, 2004.



Gouni
-
Berthold I and Berthold H. Policosanol: clinical pharmacology and therapeutic significance of a new
lipid
-
lowering agent. American Heart Journal 143:356

365, 2002.



Hatano T et al. Flavan dimers with lipase i
nhibitory activity from Cassia nomame Phytochemistry 46 (5): 893
-
900, 1997.



Kitanaka S. and Takido M. Demethyltorosaflavones C and D from Cassia nomame. Phytochemistry 31:(8)
2927
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2929, 1992.



Mas R et al. Effects of policosanol in patients with type II hyp
ercholesterolemia and additional coronary risk
factors. Clinical Pharmacology and Therapeutics 65: 439
-
47, 1999.



McCaddon A et al. Effect of supplementation with folic
-
acid on relation between plasma homocysteine,
folate, and vitamin B12. Lancet 360:173, 2
002.



McCarty M et al. Policosanol safely down
-
regulates HMG
-
CoA reductase
-

potential as a component of the
Esselstyn regimen. Medical Hypotheses 59(3):268
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79, 2002. Review.



Moghadasian M. Effects of dietary phytosterols on cholesterol metabolism and
atherosclerosis: clinical and
experimental evidence. American Journal of Medicine 107: 588
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94, 1999. Review.



Normen L et al. Soy sterol esters and beta
-
sitostanol ester as inhibitors of cholesterol absorption in human
small bowel. American Journal Clinical

Nutrition 71: 908
-
13, 2000.



Rigelsky J et al. Hawthorn: pharmacology and therapeutic uses. American Journal of Health
-
System
Pharmacy 59(5):417
-
22, 2002. Review.



Schwinger R et al. Crataegus special extract WS 1442 increases force of contraction in human

myocardium
cAMP
-

independently. Journal of Cardiovascular Pharmacology 35(5):700
-
707, 2000.



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Metabolism. 13:275
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6, 2002.



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antioxidant effects of Commiphora mukul as an adjunct to dietary therapy
in patients with hypercholesterolemia. Cardiovascular Drugs and Therapy 4(8):659
-
664, 1994.



Tilvis R et al. Serum plant sterols and their relation to cholesterol absorption. Ameri
can Journal of Clinical
Nutrition 43:92
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97, 1986.



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coronary artery disease. Journal of the American College of Cardiology 36:758
-
765, 2000.



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et al. A natural product that lowers cholesterol as an antagonist ligand for FXR. Science
296(5573):1703
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6, 2002.



Urizar N et al. Gugulipid: a natural cholesterol
-
lowering agent. Annual Review in Nutrition 23:303
-
13, 2003.
Review.



Van den Berg M et al. Com
bined vitamin B
-
6 plus folic acid therapy in young patients with arteriosclerosis
and hyperhomocysteinemia. Journal Vascular Surgery 20(6):933
-
940, 1994.



van Oort F et al. Folic acid and reduction of plasma homocysteine concentrations in older adults: a d
ose
-
response study. American of Journal Clinical Nutrition 77:1318
-
23, 2003.

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Product Information Sheet

Heart Health


System

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Scientific Studies



Heart Health


System

Scientific Studies

These statements have not
been eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
16




Wald D et al. Randomized trial of folic acid supplementation and serum homocysteine levels. Archives of
Internal Medicine 61:695
-
700, 2001.



Wang X et al. The hypolipidemic natura
l product Commiphora mukul and its component guggulsterone
inhibit oxidative modification of LDL. Atherosclerosis 172(2):239
-
246, 2004.



Ward M et al. Plasma homocysteine, a risk factor for cardiovascular disease, is lowered by physiological
doses of foli
c acid. QJM: An International Journal of Medicine 90:519
-
24, 1997.



Woo K et al. Long
-
term improvement in homocysteine levels and arterial endothelial function after 1
-
year
folic acid supplementation. American Journal of Medicine 112(7):535
-
539, 2002.

www.thecomplete
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m

Product Information Sheet

Heart Health


System

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Frequently Asked Questions



Heart Health


System

Frequently Asked
Questions

These statements have not been
eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
17


What exactly is cardiovascular health?

The term cardiovascular health (als
o referred to as heart health) is used to describe a cardiovascular
system that is strong and in good physical condition. By leading a more healthful lifestyle and through
proper supplementation, you can significantly increase your chances of maintaining g
ood
cardiovascular health.

What does lifestyle have to do with heart health?

There are simple, everyday things you can do to help maintain proper heart health. Among these are:



Not smoking



Maintaining a healthy height
-
to
-
weight ratio



Eating a diet rich in
fruits, vegetable and whole grains



Limiting the consumption of total and saturated fat



Exercising regularly



Working with your physician to monitor cholesterol, blood pressure, homocysteine and C
-
reactive protein
levels



Starting a complete nutritional suppl
ementation program designed to help maintain proper cardiovascular
health

What is homocysteine?

Homocysteine is a marker of cardiovascular risk. Homocysteine is a toxic amino acid that, when found
in high concentrations in the blood, is associated with a h
igh risk of heart disease and stroke. According
to some experts, homocysteine, as a marker for CVD, is as important a factor as cholesterol or
smoking. Homocysteine levels can become elevated as a result of smoking, high alcohol consumption,
low levels of
selected B
-
vitamins in the diet, and it is associated with poor cardiovascular health.

Is the fish oil tested to be free of heavy metals?

Yes. The fish oil used in Essential Omega III is tested twice; once from the manufacturer and then by an
independent
testing company. The fish oil used in Essential Omega III is laboratory tested for mercury,
lead, PCB and other heavy metals. We only use fish oil that meets or exceeds standards set by Canada
(CFIA), the European Union (EU) and the United States (CRN).*

Is this product vegetarian?

www.thecomplete
shopper.co
m

Product Information Sheet

Heart Health


System

Jennifer Vattima

Independent Distributor

40 W Ridley Ave

Ridley Park, PA 19078

610.405.6419

Frequently Asked Questions



Heart Health


System

Frequently Asked
Questions

These statements have not been
eval uated by the Food and Drug Admi ni strati on.

Thi s product(s) i s not i ntended to di agnose, treat, cure or prevent any di sease.


Pg.
18


No. This product contains gelatin and fish oils.

What is meant by 50 percent purity?

The 50 percent purity refers to the fish body oils, EPA and DHA. This is the highest quality fish oil
available at this time. The other 50 perc
ent are assorted fatty acids contained within the fish body oils.

Why is LDL cholesterol considered bad?

When too much LDL cholesterol circulates in the blood, it can slowly build up in the inner walls of the
arteries that feed the heart and brain. Togethe
r with other substances, it can form plaque, a thick, hard
deposit that can clog those arteries. If a clot forms and blocks a narrowed artery, it can cause serious
heart problems.

Why is HDL cholesterol considered good?

About one
-
third to one
-
fourth of bl
ood cholesterol is carried by high
-
density lipoprotein (HDL). HDL
cholesterol is known as the good cholesterol because a high level of it seems to protect against heart
problems. Medical experts think that HDL tends to carry cholesterol away from the arter
ies and back to
the liver where it's passed from the body. Some experts believe that HDL removes excess cholesterol
from plaque in arteries, thus slowing the buildup.

What are triglycerides and how are they related to HDL and LDL?

Triglyceride is a form of

fat. It comes from food and is also made in your body. People with high
triglycerides levels often have high overall cholesterol, which is high LDL and low HDL cholesterol
levels.

How many servings are in the Heart Health System?

The Heart Health System contains 60 servings and is a 30 day supply.