WELCOME TO BIOTECHNOLOGY WORLD - Muncy School District

mexicorubberBiotechnology

Feb 20, 2013 (4 years and 5 months ago)

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Name ____________________________ Name __________________________ Period ____

WELCOME TO BIOTECHNOLOGY WORLD

{use the website given or a general web search to complete the following}

What is Biotechnology?

http://www.biotechno.netfirms.com/Biotechnology.htm


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The simple yeast (in the Fungus Kingdom of Life) was needed for the first “biotechnology” uses. The
ancient Sumerians and Babylonians may have been the first to use biotec
hnology when they used yeast to
ferment beer!


__________ when did they first make beer?


Do a web search and
briefly
tell me who the Sumerians and Babylonians were (include where they lived).


Sumerians: __________________________________________________
__________________________



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Babylonians: __________________________________________________________________________



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____________________________



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___________________________

Do a web search and
briefly
describe fermentation (what is it?).


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___________

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__________ When did the Egyptians first use yeast to make bread (hmmm,

more early biotechnology).

By the way, bread was around before the Egyptians started to use yeast to make it. What the yeast does is so
important that virtually all the breads you eat today use yeast. What did the yeast
do

to the bread (why even
mess wi
th adding yeast)?


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__________________________

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Other ancient biotechnology that used fermentation included making …


_______________ using mold.


_______________using a bacteria (that make
s lactic acid) with milk.


For a long time (1100


1700 AD), the theory of
spontaneous generation

was accepted by all scientists (and
the common people too). What is this theory? [NOTE: later, biotechnology helps to disprove this theory.]

http://www.accessexcellence.org/RC/AB/BC/6000BC
-
1700AD.html


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______________________________________


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BONUS ROUND!
Can you give an example of what

common people may have used to show “spontaneous generation?


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Another name for spontaneous generation is
abiogenesis
. First define the word and then break the word
dow
n into its component parts, define each component part. {Maybe use dictionary.com}


Abiogenesis = _______________________________________________________________________


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___________________________________________________________________________________


A


BIO


GENESIS


A = ________________________________________________________________________________


Bio = ___________________________________________________________
___________________


Genesis = ___________________________________________________________________________


Hmmmm, we now accept the theory of BIOGENESIS. Looking at the work you have done for the word
abiogenesis, what would the theory of biogeneis state
?


___________________________________________________________________________________


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___________________________________________________________________________________


Let’s

get back to our walk through biotechnology history……

Biotechnology was not only being used for food production through this time but medicine was being
influenced too.


_____________ If this is the year 2008 AD, how long ago was 500 BC?


Use dictio
nary.com or something similar for help, but explain to a third grader what an
antibiotic

is.


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____________________________________________________________________________
________


____________________________________________________________________________________


http://www.biotechinstitute.org/what_is/timeline.html

In 500 BC, the Chinese used biotech
nology to create an antibiotic. What did they use to make the antibiotic
and what problem did it cure?


________________________________________________________________________ (what they used)


____________________________________________________________
____________ (what it cured)


Use dictionary.com or something similar for help, but explain to a third grader what a
vaccine

is.


____________________________________________________________________________________


________________________________________
____________________________________________


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What did Edward Jenner do in 1797 that gets him mentioned on a biotechnology timeline?


____________________________________
________________________________________________


____________________________________________________________________________________


Smallpox was a
deadly viral

disease of the 1700’s. Estimates of the number of deaths caused by this disease
in Europe ar
e astounding. The disease causes pus
-
filled holes on the skin (pox) and is very contagious.


_______________________________________________________________________Define contagious.


Smallpox actually is credited with helping to defeat major civilization
s such as the Aztecs and Incas. Many
Europeans were immune to the disease but carried it to the New World were it was transmitted to the native
populations and killed many.


It was imperative that a cure for the disease be found.

http://www.accessexcellence.org/RC/AB/BC/1750
-
1900.html



______________________________________
What

disease did Edward Jenner see as similar to smallpox?


What is the difference between being “inoculated” a
nd being “vaccinated” against a disease?


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Now, a little historical biological question solving……Black Death style!


During 1346
-
1350, more than 25 million people died because of "Black Death". The symptoms were visible,
painful, large
, dark
-
colored swellings called buboes that were located in the lymph glands. The cause of the
disease was uncertain and resulted in many bizarre speculations. In 1894, a Swiss scientist, Alexander
Yersin, discovered the bacteria that caused "Black Death".

This, however, was not the end of the quest.
Three years later, Paul Louis Simond discovered the vector that transmitted the disease from rats to humans.


Symptoms
-
Characteristics of the disease include
-
quick onset, high temperature, fast pulse



rate, a

white coating on the tongue, nervous energy, and mental confusion. Incubation



period varies from 2 to 10 days, but is most commonly 4
-
6 days. Eventually, pain



occurs in the groin, axilla (armpit), and neck (all areas that contain lymph glands).



L
ater, intense pain will cause the victim to concentrate on the visible "buboes", the



hard lumps that begin to appear on the inner thigh, neck, and axilla. These areas will



begin to turn black. Autopsies have reported that the bacteria,
Yersinia pesti
s,

have



been found in the pericardial sac, spleen, liver, lymph nodes, and bone marrow.


Treatments
-
Ancient methods of treatment: bathing in human urine; wearing own excrement;



placing of "stinks" (dead animals) in your dwelling, use of leeches, and
drinking



molten gold and powdered emeralds. Modern methods of treatment: best if diagnosed



during early onset; the use of sulphonamides was popular in the 1930's; currently, use



of streptomycin
-
the most effective therapeutic agent tested in the t
reatment of bubonic



plague (excellent alternates
-
chloramphenicol and tetracycline).Penicillin is useless.


Control measures
-

attempting to control rat populations
-
use of rodenticides ; attempting to

control flea populations
-
use of insecticides


What
is a rodenticide?


_______________________________________________________________________________________


What is an insecticide?


_______________________________________________________________________________________


What, then, is a pesticide?


_____
__________________________________________________________________________________


If Edward Jenner would have been around during this period of time…could his work have led to a cure to
the Black Death? Give a reason for your answer.


________ Yes, it w
ould have.


________ No, it would not have.


My reason for selecting what I did is:


___________________________________________________________________________


___________________________________________________________________________


_________________
__________________________________________________________


And back to the timeline:

http://www.accessexcellence.org/RC/AB/BC/1750
-
1900.html


Although fermentation had been used by m
any civilizations for many, many years, it was not until the mid to
late 1850s that a very noted scientist described that fermentation is actually the result of the work of tiny
living organisms called microbes.


_______________________________Who was the
scientist? Actually these microbes were two different
types of organisms. Name the organisms:


________________________________ and ______________________________


1863 saw this scientist develop a biotechnological process that is still used today. What

was the process?


____________________________________________ Describe the process _________________________


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_________________________________



The march of biotechnology continued touching all branches of sciences and all parts of human life.
Discovers started to come at much faster rates.

In 1953, Watson and Crick finally won one of the most important races

in biotechnology’s history. What did
they discover?


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This discovery caused even faster advances in the field of biotechnology. In 1982, Genentech, Inc. is the
first

company to produce a genetically engineered drug. What drug did they produce?


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In 1984, biotechnology makes what will become a huge part of criminal investigations a
nd court proceedings
as British scientist Alec Jeffreys introduces what? [By the way, it was first used in a court in 1985]


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In 1993, George Washington University did so
mething that caused a lot of outcry. What did they do?


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In 1997, the first mammal was cloned (copied) in Scotland. What animal was cloned and what was its
name?


____
____________________ animal _____________________ clone’s name


For the next question you will have to do a web quest. What eventually happened to the first mammal
successfully cloned?


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______


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Culminating activities:


TWO MYSTERIES TO SOLVE



“Arctica” and “The Blackout Syndrome”
:


Myst
ery #1
-

“Arctica
” go

to:

http://www.accessexcellence.org/AE/mspot/arc/

In 1833, amid rumors of sickness, poison and madness, a British expedition to the Arctic disappeared
without a trace.
Can you use the clues you find in the ice to determine the truth of their fate, once and for
all?



"Arctica" has four parts to it. The story begins with Episode One, continues in Episode Two, continues again
in Episode Three, and wraps up in the Conclusi
on. Each episode presents clues and culminates in a
mystery
question that you (or your team)

must answer. The

story responds to each your

choices, rewarding correct
answers and presenting helpful h
ints as appropriate. Each person or team will experience

th
e story in an
individual way

(
There are links to illuminating sidenotes and appendices scattered throughout the story,
written by scientists and experts on the subject
)
.

Episode One emphasis: medical science and human health. Episode Two: microbiology and
life science.
Episode Three: biochemistry. Literacy, problem solving skills and deductive reasoning are tested
throughout.

IS IT TRUE SCIENCE?
The narrative itself is fictional, but the scenario is taken straight from actual history
and contemporary scienc
e research and discoveries.

EPISODE ONE:

What is the first cause you tried for the deaths of the
Arctica

crew members in Ice Graves #1 through #5 at
the end episode one?


_________________________________________


Why did you choose it? _________________
_________________________________________________


Were you right or wrong? _______________________________________________________________


If you were wrong, what determined that you were wrong? ___________________________________


______________________
________________________________________________________________


What was the correct answer? _____________________________________________________________


What is the proof it is the correct answer? ___________________________________________________


_
____________________________________________________________________________________


EPISODE TWO:

What is the first cause you tried

to answer the mystery of what killed the four without graves at the end
episode two
?


___
________________________________
______


Why did you choose it? __________________________________________________________________


Were you right or wrong? _______________________________________________________________


If you were wrong, what determined that you were wrong? ___________
________________________


______________________________________________________________________________________


What was the correct answer? _____________________________________________________________


What is the proof it is the correct answer? ______
_____________________________________________


_____________________________________________________________________________________



EPIS
O
D
E THREE:

What is the first cause you tried

to answer the mystery of what

affected the brains of the crew from the
A
rctica,
causing almost all of them to go mad
at the end episode three
?


___
______________________________________


Why did you choose it? __________________________________________________________________


Were you right or wrong? _______________________
________________________________________


If you were wrong, what determined that you were wrong? ___________________________________


______________________________________________________________________________________


What was the correct answer? ____
_________________________________________________________


What is the proof it is the correct answer? ___________________________________________________


_____________________________________________________________________________________


Now complete
the mystery.


Go to M
ystery #2
-

“The Blackout Syndrome”
http://www.accessexcellence.org/AE/mspot/tbs/

You

are a medical investigator working for Dr. Susan Lydell. As a blackout paralyzes the c
ity, you are called in to
investigate an outbreak of a new disease. You must take steps to identify how it's transmitted, characterize it
(virus? bacterium? fungus?), and figure out how to treat it.

"The Blackout Syndrome" is a four
-
part mystery.

Medical
science, biology, microbiology; emphasis on
microbiology and human health. You learn about disease outbreaks, pathogens, Gram stain, control groups
and hemophobia. The mystery tests literacy, problem solving skills and deductive reasoning.

"The Blackout Sy
ndrome" science mystery has three Episodes and a Conclusion. In the first Episode, you
investigate the homes of people that have fallen ill, looking for a common thread that leads back to the origin of
the mysterious disease. In the second Episode, you tes
t the disease in a lab, in order to determine what sort of
pathogen it is. When you solve this part, you enter the third Episode, where you must determine which of the
anti
-
pathogenic agents you have on hand would be the best to counter the disease. Finall
y, you read the
Conclusion, which concludes the story and gives you links for further research into the story themes.

SOLVING THE MYSTERY

You will need to use your problem
-
solving skills to solve the

mystery. Some basic techniques:



You should have a pen a
nd pencil at your side, to take notes as you go through the story.




You should organize and label your notes as you go, under broad categories such as "The Allinger
Apartment ," "The Belindo House," "Disease Facts," and so on.




Evaluate your information. I
s this a fact or an opinion?



EPISODE ONE:

Wh
at is the first thing you thought

made both Isabella Allinger and Troy Belindo sick

at the end episode
one?


_________________________________________


Why did you choose it? __________________________________
________________________________


Were you right or wrong? _______________________________________________________________


If you were wrong, what determined that you were wrong? ___________________________________


_______________________________________
_______________________________________________


What was the correct answer? _____________________________________________________________


What is the proof it is the correct answer? ___________________________________________________


__________________
___________________________________________________________________


EPISODE TWO:

What is the first thing you thought was

the pathogen in the milk?"



___
______________________________________


Why did you choose it? _______________________________________
___________________________


Were you right or wrong? _______________________________________________________________


If you were wrong, what determined that you were wrong? ___________________________________


____________________________________________
__________________________________________


What was the correct answer? _____________________________________________________________


What is the proof it is the correct answer? ___________________________________________________


_______________________
______________________________________________________________


EPISODE THREE:

At first,
w
hich antibiotic did you think would be most likely to kill the pathogenic bacterium, and save the
bleeding man's life
at the end episode three
?


___
________________
______________________


Why did you choose it? __________________________________________________________________


Were you right or wrong? _______________________________________________________________


If you were wrong, what determined that you were wr
ong? ___________________________________


______________________________________________________________________________________


What was the correct answer? _____________________________________________________________



What is the proof it is
the corre
ct answer? ___________________________________________________


_____________________________________________________________________________________


Now complete the mystery.

Make sure you read the “Epilog”.


FINAL PROJECT:


Design a poster that fulfils

the rules and regulations and has a biotechnology theme for the “BioDreaming”
poster competition. You may use any of the websites we have used in this project to help you develop the
theme for your poster but it must be an original idea.




DOW AGROSCIEN
CES
-
LILLY

BIODREAMING POSTER C
OMPETITION



POSTER SPECIFICATION
S



Posters must be submitted on poster or illustration board.



The overall dimensions shall be a minimum of 8.5 inches by 11 inches (21 cm by 29 cm) and maximum of 18 inches by 24
inches (45 cm

by 60 cm).



All artwork must be original. Copyrighted characters, such as Superman ©, or copyrighted clip art, or copyright
-
free clip
art will not be accepted.



Computer generated posters will not be accepted.



Any media may be used with the exception of
glitter.



Chalk, charcoal, and pastel must be sealed with a fixative spray to prevent smearing and smudging. Keep in mind most
posters may be on public display and should be easy to see or read.



Three
-
dimensional entries will not be accepted. Nothing may
be glued, stapled, or attached to the artwork in any way.



Framed, matted, or laminated artwork will not be accepted.



The use of lettering, numbering, or a corporate logo in any language on the front of the poster is not allowed with the
exception of the
Biotechnology Institute logo.



Stenciled, traced, computer
-
generated, or commercially manufactured stick
-
on lettering or graphics is prohibited.



All posters will become the property of the Biotechnology Institute.



Posters will be judged on both the clari
ty of the message and the quality of the art.

IDENTIFICATION

The following information
must

appear on the back of the poster:



Artist's name, age, grade



Home address



Telephone number



E
-
mail address



Name of parents



School name, address, telephone numbe
r



Name and E
-
mail address of art instructor or classroom teacher



E
-
mail address of art instructor/classroom teacher (Optional)



Signed statement of authenticity and originality

POSTER SUBMISSION

Folded posters will not be accepted. Artwork should be roll
ed and shipped in a mailing tube or be packed and wrapped flat. Please
read the poster specifications carefully as only posters that meet competition rules will be considered.