BSU CityLab Visits

mexicorubberBiotechnology

Feb 20, 2013 (4 years and 8 months ago)

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Ar e you a hi gh s c hool or mi ddl e s c hool t ea c her i nt er es t ed i n hands
-
on,
i nqui r y
-
ba s ed ac t i vi t i es i n bi ot ec hnol og y?


I f s o, c ons i der a v i s i t t o BS U’ s Ci t y L a b pr ogr a m wi t h you
r

s t udent s.

The purpose of BSU CityLab is to provide biotechnology learning activ
ities for grades
6

through 12 which supplement and
complement classroom curricula
.

It is hoped that easier access to the advanced equipment and introductory lessons related to
molecular biology, microbiology, biochemistry, and biotechnology is of benefit t
o both students and teachers. The curriculum
modules offer components that align directly with the Massachusetts
curriculum frameworks and with N
ational Science
S
tandards.


Mo d u l e s Av a i l a b l e:


C r uc i a l C onc e nt r a t i on


The
Crucial Concentration

module is most

appropriate for middle school classes. The students are "hired" by the Perfect Solution
Company and challenged to investigate the protein content of sports drinks in the context of "truth in advertising.” This mod
ule
introduces students to the use of

micropipettes

for measuring small volumes of liquid. Students perform colorimetric assays with
spectrophotometers to determine the actual amount of protein in drinks from three differen
t manufacturers.


Math skills are
involved in

analyzing the data
, including graphing and determining linear relationships between variables.


Language arts skills are
incorporated in the assessment when students write letters back to the Perfect Solution C
ompany describing the procedure they
used and the results they obtained.


My s t e r y of t he C r ook e d C e l l

In this module, which

is most appropriate for middle school classes, students explore the molecular basis of sickle cell anemia. Acting
as medical technol
ogists, they are asked to determine what might be causing a collection of symptoms in an imaginary patient.
Students are introduced to the micropipettes, and they use protein gel electrophoresis as a diagnostic tool to differentiate
sickle cell
hemoglobin
from normal hemoglobin. A language arts component is included as a form of assessment when students write a letter
to the physician who "hired" them describing their diagnosis and laboratory methods used. Pre
-
lab and post
-
lab activities help
students explo
re the nature of this hereditary disease.


Both t
he

Mystery of the Crooked Cell

module
and the
Crucial Concentration

module were

designed by the
f
aculty and staff
of

Boston University Scho
ol of Medicine's CityLab

program.


L a b L a r c e ny

The

Lab Larceny

module is most appropriate for high school biology classes
.
It

is a forensic mystery in which high school students
are hired as employees of the Forensic Institute of Bridgewater (FIB).


The

students perform DNA fingerprinting on samples isolated
from “blood” found at the site of suspected industrial espionage at FIB headquarters.


Techniques are based on restriction fragment
length polymorphism (RFLP) and involve agarose gel electrophoresis
to resolve the DNA fingerprints.

Careful analysis of the data
and critical thinking skills are encouraged in solving this "who done it?" The activity introduces students to micropipettes,

since
sections of

Pipetting 101

are included as a preliminary activity.



Lab Larceny

is based on the
Boston University School of Medicine's CityLab

module entitled

Case of the Cr
own Jewels
.


F or mor e i nf or mat i on, pl eas e c ont a c t Ki m Mc Coy at
k mc c oy @br i dg ew.edu

or
( 5 08 ) 5 31
-
263 0
.