Biotechnology - evitherm

messengerrushBiotechnology

Feb 22, 2013 (4 years and 7 months ago)

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Biotechnology

Thermal “Needs”

Paul Nesvadba

EVITHERM meeting at PTB Berlin,

17
th

May 2004

Biotechnology


Technology of 21
st

century


Practical applications of biological
organisms or their components


Genetic engineering, genomics,
proteomics, transgenic crops and animals


Brewing beer, treatment of sewage,
wastewater, drug development, agriculture

Fields of Biotechnology


Molecular / Cell Biology


Biochemistry


Genetics / Genomics / Proteomics


Immunology


Microbiology / Virology


Biological/ Biochemicals/ Chemicals Manufacturing


Pharmaceutical Science & Research


Plant Sciences / Agribiotech


Bioprocessing / Bioengineering


Ecology / Environment


Diagnostics


Food & Drink


Bioinformatics


Vaccines


Molecular Biology & Bioinformatics


Genetic and Molecular basis of disease



Gene editing (e.g. GM crops)



Discovery systems (e.g. drug discovery)



Protein separation and fusion systems




Antibody engineering



High throughput

Heat and Temperature


“Bioinformatics”


Low energy, high precision of control (e.g.
PCR
-

polymerase chain reaction)



Large scale Industrial processes


High energy consumption


Optimisation


Knowledge for reducing environmental impact


“Hardware” in Biotechnology

Laboratory


PCR Thermocyclers


Tissue Culture
-

Incubators


Industrial


Vaccines / Pharmaceuticals


TTIs
-

TIs


Fermenters


heat removal!


Waste treatment plants

Industrial Fermentation



The optimum fermentation temperature is
about 32
°
C



The heat of formation of ethanol is
1.2 MJ / kg of ethanol



Cooling is necessary in order for the yeast
to survive and work efficiently


Brewing


The oldest biotechnology process



8000 years ago in Babylon



Today’s large scale brewing is highly
sophisticated



Involves many heating and cooling steps



Heat Exchangers


Energy efficiency (higher heat transfer
coefficient, recycling)


Small size, low mass, easy capacity modification


Ease of cleaning


Shell
-
and
-
tube exchangers (traditional)


Plate

Tubular Heat Exchanger

(Alfa Laval Viscoline
TM
)





Heating, cooling, heat regeneration



Pasteurisation



UHT treatment of viscous fluids

Plate Heat Exchanger

(Alfa Laval)



Waste Water Treatment



The need for efficient handling of wastewater and sludge
is increasing worldwide.




Processes and equipment






Decanter centrifuges for dewatering





Spiral heat exchangers




Heating, cooling, heat recovery and pasteurisation




Drum thickeners/dryers for sludge volume reduction





Decanter autopilot optimising plant operation

Objective:

To reduce the volume of wastewater

Compilation of contacts


Alfa Laval (UK, Sweden)


Biometra Gmbh (G
öttingen, Germany)


BioProcess Engineering Services Ltd (UK)


GE Healthcare and GE Bio
-
Sciences (UK)


Grant Instruments (Cambridge, UK)


New Brunswick Scientific (UK) Ltd


Thermo Electron Corporation (USA)


Technical University Berlin, Inst. Food Technology

Conclusions


Biotechnology


Large area


Diverse processes


Scale from laboratory to industrial



Identification of users in need of EVITHERM



Started compiling a list of users



Contacting users