Wayfinding: RFID

inspectorwormsElectronics - Devices

Nov 27, 2013 (3 years and 11 months ago)

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Wayfinding
: RFID

0

Telemedical

Retinal Imaging of :
Diabetic Retinopathy, Glaucoma,

Macular Degeneration

1

Hearing and Tinnitus


Developing
new devices to
expand diagnostic
opportunities




Development of Tinnitus
Management Program


From inception through
implementation







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3

Spinal
Cord Injury Translational Collaborative

Consortium for

Regenerative
Research


Goal : Develop and translate novel therapies bench to bedside


Focus: Restoration of upper limb function with 2 research teams



Discover genes responsible for axon growth and inhibition of growth in the adult spinal cord



Testing of combination therapies in non
-
human primate (NHP) models



(cells, growth factors and drugs)



Long
-
term, chronic effects cell
-
based therapies on functional recovery in NHP models




Determining best approach overcome formation of
glial

scar


(body’s attempt repair injured cord)



Use cells and biologics already used for other clinical indications


Speed up regulatory process towards “investigational new drug” indication by FDA



Built
-
in replication criterion :Teams must reproduce results



Use rodent & NHP contusion &
hemisection

models for scale
-
up,


feasibility of therapy



Must overcome obstacle translating animal to human



West Haven: Human
Oligodendrocyte

Precursor for
Myelination

of Axons

4


Testing safety and ability of GERON cells used in clinical trials to form myelin
around injured axons after lesion in NHP spinal cord


Cells are safe: survival studies up to
3

years post
-
transplantation with no tumor
formation or adverse side effects


GERON cells form myelin and are superior to “self
-
repair”




Self


repair 1 year after lesion

Geron

OPC 7 wks after lesion

San Diego: Human Neural Progenitor Cells
(
NeuralStem
™) Form Functional Axon Bridges
with Host Spinal Cord


I
dentified genetic signaling molecules involved in promoting and retarding
growth of axons post
-
SCI



Studies blocking genetic signals that retard axon growth demonstrate increase in
growth post
-
injury in rodents. Removing inhibition results in growth



Transplantation of
NeuralStem


result in clinically relevant growth


up to 20
segments in rats, equivalent to inches in humans



Now being tested in NHP



5

Neural Prostheses:

Functional Electrical Stimulation (FES)

Don
Crago
,
U.S
. Army
Veteran
injured while on active duty
Fort
Carson,
CO

Result
of car accident he is
paralyzed from
chest
down
uses
FES
system for exercise and
limited walking at
home

6

Traumatic Brain Injury (TBI):

Intensive Multimodal Rehabilitation

Advanced
Rehab
Devices

Recreation
Therapy

Physical
Therapy

Assistive
Devices

7

Rehabilitation
Robotics:

Physical
Therapy


Clinical Trial of
Robot
-
Assisted
Physical
Therapy


http//www.nejm.org/doi/full/10.1056/NEJMoa0911341

8

DEKA arm:

Research Plan Past and Future


Congressional Hearing 2004



DARPA’s “Revolutionizing
Prosthetics 2007/2009” Programs
began 2005



VA Prosthetic Arm Optimization
Study 2008
-
2012 (3 VA, 1 DoD site)



“Take
-
Home” Study to begin 2012



Transition to Additional
Applications



Collaborations with other agencies
(
DoD
/DARPA)



9

Artificial Limbs:

Ankle
-
Foot Prosthesis

Dr. Hugh Herr

Powered
Electronic
Ankle
-
Foot
Prosthesis


May
Improve
Mobility of
Veteran
Amputees to
Walk


10

Osseointegration



Biohybrid

limb combining living tissue with

external prosthetic device consisting of a
titanium rod


Device is
of
the leg
stump fused into bone


Problem has been infection


Salt
Lake City VA
made
progress
by using
porous
disc placed under the
skin


animal
studies


1
-
year
infection free without
antibiotics


Recently received FDA approval for human
trial



Photo from work in Europe

11

Brain
-
Computer Interface













http
://www.nature.com/nature/journal/v485/n7398/full/nature11076.html



12

Journal of Rehabilitation Research &
Development: JRRD












http
://
www.rehab.research.va.gov/jour/jourindx.html


13


JRRD sponsored by RR&D


Scientific peer reviewed
journal


Fully accessible online:
sign up today!





















ORD/RR&D Supported Research:

Available to the Public



Search on NIH RePORTER website


Merit, Pilot, Career Development (recent
addition)


Other award types to follow as forms are
generated for use in eRA



Search on Clinical Trials website








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