DAVID K. WELSH, M.D., Ph.D.
Department of Psychiatry
University of California, San Diego
9500 Gilman Drive #0603, La Jolla, CA 92093
-
0603
e
-
mail:
welshdk@ucsd.edu
; phone: (858) 246
-
0894
Academic Positions:
Universi
ty of California, San Diego, Department of Psychiatry
Assistant Clinical Professor, 4/03
-
6/03
Assistant Professor, 7/03
-
date
NIMH Mentored Clinical Scientist Development Award, K08 MH067657, 4/03
-
3/08
NIMH Research Project Grant, R01 MH082945, 3/
08
-
date
Veterans Affairs San Diego Healthcare System, San Diego, CA, Staff Physician, 7/03
-
date
Career Development Award 2, 11/08
-
date
Education:
Stanford University, Stanford, CA, 9/79
-
6/84, B.A.S. in Biological Sciences and Psychology,
With Dis
tinction, Phi Beta Kappa
Harvard Medical School, Boston, MA, 9/85
-
6/97, M.D., Ph.D. in Neurobiology
Predoctoral Fellow, Howard Hughes Medical Institute, 7/88
-
6/93
Chronobiology Research Program, U.S. Air Force Office of Scientific Research, 7/93
-
8/
95
Medical Scientist Training Program, National Institutes of Health, 7/93
-
6/97
Marine Biological Laboratory, Woods Hole, MA, 6/89
-
8/89, Neurobiology course
University Health Center of Pittsburgh, Western Psychiatric Institute and Clinic, 6/97
-
6/98
Internship in Medicine and General Psychiatry
Western Psychiatric Institute & Clinic, Pittsburgh, 7/98
-
6/01, Residency in General Psychiatry
Outstanding Resident Award, National Institute of Mental Health, 1999
Laughlin Fellow, American College of Psy
chiatrists, 2000
Lilly Fellow, Society of Biological Psychiatry, 2000
University of California, San Diego, 7/01
-
3/03, Research Fellow, Department of Psychiatry
Postdoctoral Fellowship in Biological Psychiatry and Neuroscience, UCSD
Research Associate,
Department of Cell Biology, The Scripps Research Institute
Oral Presentations at National or International Meetings:
Gerontological Society of America, San Francisco, 1983
Society for Neuroscience, New Orleans, 1991
Society for Neuroscience, Miami, 1994
Gordon Research Conference on Chronobiology, Il Ciocco, Barga, Italy, 1995
Society for Research on Biological Rhythms, Jacksonville, FL, 1996
Suprachiasmatic Nucleus 25th Anniversary Symposium, Harvard Medical School, Boston, 1997
Workshop on Biomathematic
al Models of Circadian Rhythmicity, Sleep Regulation, and
Neurobehavioral Function in Humans, Boston, 1999
Society for Research on Biological Rhythms, Whistler, BC, Canada, 2004
Society for Research on Biological Rhythms, Destin, FL, 2006
Workshop on Model
ing Circadian Rhythmicity, Sleep Regulation, and Neurobehavioral
Function, Joint SIAM/SMB Conference on the Life Sciences, Raleigh, NC, 2006
David K. Welsh
2
12/4/13
Imaging Neurons and Neural Activity, Cold Spring Harbor Laboratory, NY, 2007
Gordon Research Conference on Chronobi
ology, Aussois, France, 2007
Physiological Society of Japan, Tokyo, 2008
Society for Research on Biological Rhythms, Destin, FL, 2008
International Congress of Physiological Sciences, Kyoto, Japan, 2009
International Symposium on Biological Rhythm, Sapporo
, Japan, 2009
Society for Research on Biological Rhythms, Destin, FL, 2010
Assembling a Multi
-
Cellular Circadian Pacemaker, Lorentz Center Workshop, Leiden
University, Leiden, The Netherlands, 2010
“It’s About Time!”
–
Biological Clocks and Neural Function
, Rushton Lecture Series, Florida
State University, Tallahassee, FL, 2011
Publications
:
1) Wandell BA, Welsh D, Maloney L. Adaptation in the long
-
wavelength pathways.
Vision
Res
22:1071
-
1074, 1982.
2) Wandell BA, Ahumada P, Welsh D. Reaction times to we
ak test lights.
Vision Res
24:647
-
652, 1984.
3) Welsh DK, Richardson GS, Dement WC. A circadian rhythm of hippocampal theta activity in
the mouse.
Physiol Behav
35:533
-
538, 1985.
4) Welsh DK, Nino
-
Murcia G, Gander PH, Keenan S, Dement WC. Regular 48
-
hour
cycling of
sleep duration and mood in a 35
-
year
-
old woman: use of lithium in time isolation.
Biol
Psychiatry
21:527
-
537, 1986.
5) Welsh DK, Engel EMRA, Richardson GS, Dement WC. Precision of circadian wake and
activity onset timing in the mouse.
J Comp P
hysiol A
158:827
-
834, 1986.
6) Welsh DK, Richardson GS, Dement WC. Effect of age on the circadian pattern of sleep and
wakefulness in the mouse.
J Gerontology
41:579
-
586, 1986.
7) Welsh DK, Richardson GS, Dement WC. Effect of running wheel availability o
n circadian
patterns of sleep and wakefulness in mice.
Physiol Behav
43:771
-
777, 1988.
8) Nadakavukaren JJ, Welsh DK, Reppert SM. Aluminum fluoride reveals a phosphoinositide
system within the suprachiasmatic region of rat hypothalamus.
Brain Res
507:181
-
188, 1990.
9) Welsh DK, Moore
-
Ede MC. Lithium lengthens circadian period in a diurnal primate,
Saimiri
sciureus
.
Biol Psychiatry
28:117
-
126, 1990.
10) Welsh DK, Logothetis DE, Meister M, Reppert SM. Individual neurons dissociated from rat
suprachiasmatic
nucleus express independently phased circadian firing rhythms.
Neuron
14:697
-
706, 1995.
David K. Welsh
3
12/4/13
11) Welsh DK, Reppert SM. Gap junctions couple astrocytes but not neurons in dissociated
cultures of rat suprachiasmatic nucleus.
Brain Res
706:30
-
36, 1996.
12) Noll
E, Welsh DK, Fan M
-
H, Canales M, Black PM. Towards a lineage
-
based classification
system for gliomas: innovation or imagination?
Crit Rev Neurosurg
8:6
-
18, 1998.
13) Monk TH, Buysse DJ, Welsh DK, Kennedy KS, Rose LR. A sleep diary and questionnaire
study
of naturally short sleepers.
J Sleep Res
10:173
-
179, 2001.
14) Monk TH, Welsh DK. The role of chronobiology in sleep disorders medicine.
Sleep Med Rev
7:455
-
473, 2003.
15) Welsh DK, Yoo SH, Liu AC, Takahashi JS, Kay SA. Bioluminescence imaging of indivi
dual
fibroblasts reveals persistent, independently phased circadian rhythms of clock gene
expression.
Curr Biol
14:2289
-
2295, 2004.
16) Welsh DK, Kay SA. Bioluminescence imaging in living organisms.
Curr Opin Biotechnol
16:73
-
78, 2005.
17) Welsh DK, Ima
izumi T, Kay SA. Real
-
time reporting of circadian
-
regulated gene expression
by luciferase imaging in plants and mammalian cells.
Meth Enzymol
393:269
-
288, 2005.
18) Welsh DK. Genetics of circadian rhythm disorders.
Psychiatric Times
22(14):37
-
40, 2005.
1
9) Sato TK, Yamada RG, Ukai H, Baggs JE, Miraglia LJ, Kobayashi TJ, Welsh DK, Kay SA,
Ueda HR, Hogenesch JB. Feedback repression is required for mammalian circadian clock
function.
Nat Genet
38:312
-
319, 2006. [
PMCID: PMC1994933
]
20) Welsh DK. Comment: Gat
e cells see the light.
J Biol Rhythms
22:26
-
28, 2007.
21) Welsh DK. VIP activates and couples clock cells. Focus on “Disrupted neuronal activity
rhythms in the suprachiasmatic nucleus of vasoactive intestinal polypeptide
-
deficient mice”.
J
Neurophysiol
97
:1885
-
1886, 2007.
22) Liu AC*, Welsh DK*, Ko CH, Tran HG, Zhang EE, Priest AA, Buhr ED, Singer O, Meeker
K, Verma IM, Doyle FJ III, Takahashi JS, Kay SA. Intercellular coupling confers robustness
against mutations in the SCN circadian clock network.
Cell
129:605
-
616, 2007.
23) Forger D, Gonze D, Virshup D, Welsh DK. Beyond intuitive modeling: combining
biophysical models with innovative experiments to move the circadian clock field forward.
J
Biol Rhythms
22:200
-
210, 2007.
24) Pulivarthy SR*, Tanaka N*,
Welsh DK, De Haro L, Verma IM, Panda S. Reciprocity
between phase shifts and amplitude changes in the mammalian circadian clock.
Proc Natl
Acad Sci USA
104:20356
-
20361, 2007. [
PMCID: PMC2154435]
David K. Welsh
4
12/4/13
25) Yan L, Karatsoreos I, LeSauter J, Welsh DK, Kay S, Fole
y D, Silver R. Exploring
spatiotemporal organization of SCN circuits.
Cold Spring Harb Symp Quant Biol
72:527
-
541, 2007.
26) Liu AC, Tran HG, Zhang EE, Priest AA, Welsh DK, Kay SA. Redundant function of REV
-
ERB
and
and non
-
essential role for Bmal1 cycl
ing in transcriptional regulation of
intracellular circadian rhythms.
PLoS Genet
4(2):e1000023, 2008. [
PMCID: PMC2265523
]
27) Mirsky HP, Liu AC, Welsh DK, Kay SA, Doyle FJ 3
rd
. A model of the cell
-
autonomous
mammalian circadian clock.
Proc Natl Acad Sci U
SA
106:11107
-
12, 2009. [
PMCID:
PMC2699375
]
28) Wang LM
-
C, Dragich JM, Kudo T, Odom IH, Welsh DK, O’Dell TJ, Colwell CS.
Expression of the circadian clock gene
Period2
in the hippocampus: possible implications for
synaptic plasticity and learned behaviour.
ASN Neuro
1(3):art:e00012, 2009. [
PMCID:
PMC2695588
]
29) Westermark PO, Welsh DK, Okamura H, Herzel H. Quantification of circadian rhythms in
single cells.
PLoS Comput Biol
5(11):e1000580, 2009. [
PMCID: PMC2776301
]
30) Welsh DK. Limits of single
-
cell au
tonomy in the suprachiasmatic nucleus.
Sleep Biol
Rhythms
7:252
-
9, 2009. [PMC Exempt]
31) Welsh DK, Ptácek LJ. Circadian rhythm dysregulation in the elderly: advanced sleep phase
syndrome. In: Pandi
-
Perumal SR, Monti JM, Monjan AA (Eds),
Principles and Pr
actice of
Geriatric Sleep Medicine
, Cambridge, UK: Cambridge University Press, 2010, pp. 131
-
142.
[PMC Exempt]
32) Welsh DK, Takahashi JS, Kay SA. Suprachiasmatic nucleus: cell autonomy and network
properties.
Annu Rev Physiol
72:551
-
77, 2010. [PMC Exempt
]
33) Ko CH*, Yamada YR*, Welsh DK*, Buhr ED, Liu AC, Zhang EE, Ralph MR, Kay SA,
Forger DB, Takahashi JS. Emergence of noise
-
induced oscillations in the central circadian
pacemaker.
PLoS Biol
8(10):e1000513, 2010
. [
PMCID: PMC2953532]
34) Welsh DK, Noguc
hi T. Cellular bioluminescence imaging. In: Yuste R (Ed),
Imaging: A
Laboratory Manual
, Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press, 2011,
pp. 369
-
385
. [PMC Exempt]
35) Vacic V, McCarthy S, Malhotra D, Murray F, Chou HH, Peoples A, Makarov
V, Yoon S,
Bhandari A, Corominas R, Iakoucheva LM, Krastoshevsky O, Krause V, Larach
-
Walters V,
Welsh DK, Craig D, Kelsoe JR, Gershon ES, Leal SM, Aquila MD, Morris DW, Gill M,
Corvin A, Insel PA, McClellan J, King MC, Karayiourgou M, Levy DL, DeLisi LE,
Sebat J.
Genomic duplications of the neuropeptide receptor VIPR2 confer significant risk for
schizophrenia.
Nature
471:499
-
503, 2011
.
David K. Welsh
5
12/4/13
36) Foley N, Tong TY, Foley D, LeSauter J, Welsh DK, Silver R. Characterization of orderly
spatiotemporal patterns of clo
ck gene activation in mammalian suprachiasmatic nucleus.
Eur J Neurosci
33:1851
-
65, 2011.
37)
Meeker K, Harang R, Webb AB, Welsh DK, Doyle FJ, Bonnet G, Herzog ED, Petzold LR.
Wavelet measurement suggests cause of period instability in Mammalian circadi
an neurons
.
J Biol Rhythms
26: 353
-
62, 2011.
38) McCarthy MJ, Nievergelt CM, Shekhtman T, Kripke DF, Welsh DK, Kelsoe JR. Functional
genetic variation in the Rev
-
Erb
pathway and lithium response in the treatment of bipolar
disorder.
Genes Brain Behav
: In
Press, 2011.
* equal contributions
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