Integration of Bioinformatics into Inquiry Based Learning - Hinsdale ...

hordeprobableBiotechnology

Oct 4, 2013 (3 years and 10 months ago)

78 views

Integration of

Bioinformatics into

Inquiry Based Learning


by Kathleen Gabric



The Biology WorkBench is a revolutionary
web
-
based tool for biologists. The
WorkBench allows biologists to search
protein and DNA databases around the
world. Database searching is integrated with
access to a wide variety of analysis and
modeling tools, all within a point and click
interface.

bi∙o∙in∙for∙mat∙ics

The use of mathematical and informational
techniques to solve biological problems by using
computer programs. One of the main applications of
bioinformatics is the data mining in and analysis of
the data gathered in genome projects. Other
applications are amino acid and nucleic acid
sequence alignment, protein structure prediction, and
virtual evolution.

Science Inquiry

The science and education communities agree
that investigative science is a highly effective
way to teach science. In this way, students build
their scientific understanding and investigative
skills through active inquiry, connecting their
previous knowledge with new ideas and
evidence.




Design


Investigate


Construct

meaning


Connect


Students learn about the Human Genome
project by using real data from Argonne
Laboratories.


Dr. Kay, a father of a District 86 student, is
the contributing scientist.




DNA Sequence

Sequencing DNA

Lorenzo’s Oil




Students take a real DNA sequence and
translate it into the amino acid sequence
using Biology Student Workbench


Students then mutate the original DNA
sequence in different ways and translate
each mutation


Finally students compare the original
protein to mutated variations

Lorenzo’s Oil




As a result, students learn about
missense
, nonsense, and silent mutations
through a hands on activity


In their own explanations of what happens
to the protein they use words like
substitution, deletion, addition, and

frame”shift
, early stop

Basis of Human Genetic Diseases




Students identified genes that were linked to human
disease states.



Students used bioinformatic

tools to identify the disease

process from gene to protein

to disease state.



Students created a website to


display their research.




Student Projects on
Genetic Diseases

Outcomes & Observations



Understood the basis of human genetic
diseases.


Connected symptoms to biochemical imbalance


Predicted means of treatment


Understood the difference between treatment of
symptoms and curing the disease


Realized the power of bioinformatics and how
they could use it in future research……Evolution


Student Projects on
Evolution

Outcomes & Observations



Understood the basis of evolution on a genetic
level.


Correlated genetic evolution to organismal
evolution.


Realized that “our”


similarities are greater


than our differences.


Overall Outcomes and Observations


Integration of bioinformatics into the
high school classroom using inquiry
methods was successful.


Students were able to use the tools to
generate real data, but more
importantly were able to apply these
applications and independently
problem solve.


Students showed a greatly increased ability to make connections
between units of study: protein structure, protein function,
nucleic acids, genetics, genetic disease, and evolution.


Students performed research that will be used to guide future
research in UIUC’s cell & molecular biology laboratory.


Student Comments on Biology Workbench



Even though it was quite confusing at times, Bio
-
Workbench was highly
beneficial to our learning experience. It was interesting to use the same
computers that real scientists used to do their research. The using of
bioinformatics was key in the expansion of our minds.


It helped us get more involved with the concepts we were learning since it
made everything more realistic


It helped save time and make information clearer to me. it also gave me
visuals for things that I wouldn’t have been able to picture from just
reading about, it helped me understand amino acid sequences a lot.


It has allowed us to connect DNA to real life. We are able to see how little
a change in DNA how great a change they could have upon the final
product.


Thanks to
my hardworking

Biology
Classes


To see the projects they have done with bioinformatics visit our website

https
://www.hinsdale86.org/staff/kgabric/HBprojects.html