Biology Unit 6 Packet—Human Genetics & Genetic Engineering

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Dec 11, 2012 (4 years and 8 months ago)

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1

Biology Unit 6 Packet

Human Genetics & Genetic Engineering


Chapters
13 & 14

Topics:








Textbook Correlations



Manipulating DNA








Concepts 13
-
1



Cell Transformation







Concepts 13
-
2



Applications








Concepts 13
-
3



S
ex determinat
ion & Linkage







Concepts 14
-
1



Mutations








Concepts 14
-
1



Pedigrees & Disea
ses







Concepts 14
-
1



Sex
-
linked disorders







Concepts 14
-
2



Nondisjunction








Concepts 14
-
2


Key Terms

a.

Karotype

b.

Sex
-
chrom
osome

c.

Autosome

d.

Pedigree

e.

Sex
-
linked traits

f.

Nondisjunction

g.

Point mutation

h.

Carrier

i.

Mutation



Rec
ommended work for Chapters 13 & 14
:

Chapter 13



Section 13
-
2 #1



Section 13
-
3 #1, 2



Section 13
-
4 #1, 2

Ch
apter 14



Section 14
-
1 #1
-
5



Section 14
-
2 #1
-
5



Chapte
r Revie
w #1
-
10, 12, 14, 15, 18, 19,


Biology Unit 6 Packet

Human Genetics & Genetic Engineering


Human Chromosomes




How many chromosomes do humans have?______________________




Identify

the sex chromosomes?______________________________


o

What is the role of the
X chromosome?



o

What is the role of the Y chromosome?



o

Identify a genetic female_________________


o

Identify a genetic male___________________




What is a karotype? Describe how it’s used.


2


Biology Unit 6 Packet

Human Genetics & Genetic Engineering




What is

a pedigree?






Go to page 343. Complete the “Problem Solving”
-

Using a Pedigree. Read each
section and write out your answers below.

o

Defining the Problem





o

Organizing the Problem














o

Creating a Solution










o

Presenting Your Plan
(Prepare a
step
-
by
-
step outline of your plan.)







3

Biology Unit 6 Packet

Human Genetics & Genetic Engineering



Beyond Mendelian Genetics

These are the basics of inheritance. However, genes do not operate in isolation from one
another; this makes genetics more comp
lex than Mendel’s experiments and the Punnett
square might suggest. Many different factors can affect phenotype and genotype in
offspring.
Explain and give examples of the following topics:


1.

Incomplete dominance











2.

Codominance














3.

Multipl
e alleles





4.

Linked genes








4

Biology Unit 6 Packet

Human Genetics & Genetic Engineering


Human Genetic Disorders


Explain a single
-
gene defect.







Describe the following single
-
gene defects.



Autosomal recessive disorders

(a)

Sickle
-
cell anemia






(b)

Ph
enylketonuria (PKU)






(c)

Cystic fibrosis






(d)

Tay
-
Sachs disease











Autosomal dominant disorders

(a)

Huntington’s disease





5

Biology Unit 6 Packet

Human Genetics & Genetic Engineering


Explain sex
-
linked disorders (inheritance). What is the role of the mo
ther and of the
father in sex
-
linked inheritance?











Describe the following sex
-
linked disorders:

(a)

Hemophilia










(b)

Red
-
green color blindness









(c)

Duchenne’s muscular dystrophy













6

Biology Unit 6 Packet

Human Genetics & Genetic Engineeri
ng


Disorders Involving Whole Chromosomes


Explain nondisjunction.











Describe the following nondisjunction disorders:

(a)

Trisomy
-
21 (Down Syndrome)









(b)

Turner’s syndrome










(c)

Klinefelter’s syndrome












7

Biology Unit 6 Packet

Human Genetic
s & Genetic Engineering


Recombinant DNA

Recombinant DNA is a hybrid of DNA from two or more sources. For example, DNA
with a gene of interest from eukaryotic organisms can be transferred into a bacterial
genome. The branch of technology that produces ne
w organisms or products by
transferring genes between cells is called
genetic engineering
.




Describe the process scientists use to manipulate DNA. (pgs.322
-
325)















What is a transgenic organism? (pgs. 331)








List one practical application for e
ach of the following: transgenic bacteria,
transgenic animals, and transgenic plants. (pgs.331
-
332)