Diapositiva 1

Hospital Clínico
Universitario



Medical Research

Foundation


Valencia (Spain)

Dr. Juan R. Viña. Director

ONCOLOGY

PRIOR RESEARCH LINES

ONCOLOGY

CARDIOVASCULAR


DISEASE

PRIOR RESEARCH LINES

ONCOLOGY

CARDIOVASCULAR


DISEASE

METABOLISM AND
TISSUE DAMAGE

PRIOR RESEARCH LINES

ONCOLOGY

CARDIOVASCULAR


DISEASE

METABOLISM AND
TISSUE DAMAGE

NEUROSCIENCE

PRIOR RESEARCH LINES

TYPES OF RESEARCH

RESEARCH PROJECTS

•

Spanish Government

•

Valencia Regional Government


•

European Commission


CLINICAL TRIALS

SPANISH GOVERMENT



2004

2005

2006

2007

2008

2009

MINISTRY
OF
HEALTH

NETWORKS

10

10

-

-

-

-

CAIBER

-

-

-

-

1

1

CIBER

-

-

-

-

1

1

RETICS

-

-

5

5

6

4

BIOBANK

-

-

-

-

-

1

RESEARCH PROJECTS

15

13

19

26

19

26

NON COMERTIAL
CLINICAL TRIAL

-

-

-

-

4

4

MINISTRY OF SCIENCE AND
INNOVATION

2

3

2

6

7

5

VALENCIA REGIONAL
GOVERNMENT

2007

2008

2009

REGIONAL MINISTRY
OF HEALTH

16

15

15

REGIONAL MINISTRY
OF EDUCATION

4

10

8

EUROPEAN
COMMISSION

7th FRAMEWORK PROGRAMME

2

6th FRAMEWORK PROGRAMME

1

Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

0
5
10
15
20
25
30
35
40
45
Number of Clinical Trials

Clinical

Trials

Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

0
5
10
15
20
25
30
35
40
45
2005
2006
2007
2008
2009
INCLUDED PATIENTS

DEVELOPMENT PHASE I TRIALS PATIENT INCLUSION

LAB

AND

CORE FACILITIES



Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

LAB AND CORE FACILITIES

-

Unit of Genotyping and Genetic diagnosis

-

Multi
-
Gene analysis Unit (Affymetrix)

-

Genetic analysis by Maldi
-
TOF

(SEQUENOM)

-

Proteomics Unit. 2D electrophoresis DIGE

system

-

Metabolomics and Molecular Imaging by

MNR

-

Tissue culture facility

Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

LAB AND CORE FACILITIES

-

Confocal microscopy Unit

-

Citomics Unit. Flow cytometry and AMNIS

system

-

Radioactivity Unit. PET
-
CT for animal research

-

Animal Research Centre (Surgery rooms)

(SPF facility)

-

Cytogenetic Unit


HAEMATOLOGIC
NODE

SOLID TUMORS
NODE

NON TUMORAL DESEASE NODE

BIOBANK

OUR EXPERIENCE
IN EUROPEAN

COMMISSION

PROJECTS



Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

COMOESTAS PROJECT

-

Call

ICT
-
2007.5.2:

Advanced ICT for Risk

Assessment and Patient Safety (FP7)


-

Participants:

10


-

Objective:

develop an innovative

computerized system that allows patients

with
Medication Overuse Headache

to

receive continuous and personalised

treatment.

Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

MAIN OBJECTIVES

-

Developing

a
fully

operational

Interactive


Electronic

Patient's

Record (IEPR)
-

based

system
.


-

Improving

the

quality

and
efficiency

of

health

care

systems
.

Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

MAIN OBJECTIVES

-

Increasing patient safety.


-

Reducing the burden of disease.


-

Reducing direct (consultations,

hospitalizations, etc.) and indirect

(i.e. linked to the disability and

complications caused by the

disease) costs of the disease.


Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

e
-
TUMOR PROJECT

-

Call


LIFESCIHEALTH 503094

(FP6)


-

Budget:

7.5 million
€


-

Participants:


17 Universities


7 Enterprises


15 Hospitals


Dr. Monleon (
Scientific Manager)


Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

RESULTS

-

Consensed protocols for biopsy

handling and molecular data

acquisition and processing.


-

A unique database with clinical,

radiological, metabolic and genetic

data from more than 1,200 brain

tumor patients across Europe.


Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

RESULTS



-

Development of methodology for

classification and pattern recognition of

brain tumors based on molecular data.


-

Characterization of molecular profiles for

different brain tumor types, classes and

grades.



Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

RESULTS



e
-
TUMOUR software
development
:

It

helps

to

the

use of molecular
imaging

by

MRS in
the

clinical

environment

for

brain

tumor
management

by

following
:


-

Quality

control


-

Semiautomated

assingments


-

Multimodality

visualization


-

Comparison

against

data base
spectra


-

Tumor
classification

score

Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

InGenious Hypercare

-

Reference

LSHM
-
CT
-
2006
-
037093
(FP6):

Life, sciences, genomics and

biotechnology for health



-

Participants
:

27



Dr.
Redón

(
Coordinator

Substudy


JRPB2)

Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

NETWORK EXCELENCE


A1.
Genetics and Genomics of Autonomic

Cardiovascular Control


A2.
Genetics, Genomics and Proteomics

of Oxidative Stress and Inflammation


A3.
Genetics and Genomics of Sodium

Homeostasis in Hypertension and

LVH



Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

NETWORK EXCELENCE


B1.

Genetics and Genomics of

Hypertension and Stroke


B2.

Genetics, Genomics and Proteomics of

Hypertension Associated with


Renal


B3.

Genetics, Genomics and Proteomics of

Heart Failure in Hypertension



OUR PRESENT


AND

NEAR FUTURE



Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

-

Increase the Phase I Oncology Clinical

Trial Unit activity


-

Develop a Phase I Adults Vaccine Unit


-

Stimulate

translational

medicine


-

Improve

telemedicine

system

to

control

ICU
pediatric

patients

OUR PRESENT AND

NEAR FUTURE


Fundación Investigación Clínico de Valencia

Instituto de Investigación Sanitaria INCLIVA

Thanks

for

your

attention