DVD- Cracking the Code- DeCode and

gooseliverBiotechnology

Oct 22, 2013 (3 years and 7 months ago)

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DVD
-

Cracking the Code
-

DeCode and
Iceland


Controversy in Iceland

A. deCODE a biotechnology company

may use health, genealogical, and
genetic information of 270,000
residents.


B. Why did deCODE choose Iceland?

Low genetic diversity in the population


Successes: ID of genes for various





diseases



Problem: Privacy is in jeopardy


1866 Mendel’s work is published


1886 Advances in microscopes=chromosomes


1880’s 1890’s Mitosis/meiosis


1900 Correns confirms Mendel’s work


early1900’s Sutton and Boveri
-
Chromosome
Theory of Inheritance


Early 1900’s Mutations discoveries led to gene
mapping


1920’s
-
1940’s Avery, McLeod, McCarty

DNA
carries information


1952
-
Watson and Crick
-
double helix




Mendel is the starting point for
Genetics

(the
study of heredity and variation)


1860’s used garden peas


Identified patterns of inheritance


His work was ignored until Correns in 1900’s
confirmed his work


Genes
(units of inheritance)occur in pairs and
control traits


Chromosome numbers in sexual reproduction



Diploid number

(2n)
-

46 for humans



Homologous chromosomes



one set from
Mom and one set from Dad (23 each for
humans)



Haploid number

(n)
-

23 for humans


Sutton and Boveri

Chromosome Theory of
Inheritance

= genes are carried on
chromosomes


Fruity Fly studies led to discoveries:


Terms:

Mutation
(inherited change in

gene)

Allele
(alternate forms of a gene)

Phenotype
(observable features of genes)


Until 1940’s proteins were thought to be the
source of genetic material



Proteins are abundant in the cell and are
diverse in structure and function BUT



Fruit Flies, bacteria, and viruses led to the
discovery that DNA


Alphabets
(Genetic Code)


DNA is made of
nucleotides
(A,T, G, C)


RNA is made of nucleotides (A, U, G, C)


Watson and Crick
-
double helix with
complimentary relationships


A
-
T(U) G
-
C

`
Transcription
-

DNA to RNA



Central Dogma




of Genetics



Translation
-

RNA to protein