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Nov 24, 2013 (3 years and 6 months ago)

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State Research Center of Russian Federation
Federal State Unitary Enterprise

«
Karpov Institute of Physical Chemistry
»

Obninsk Branch

Location:
109
km south
-
west of Moscow


Area: more than 70 ha



Leading

Center of radiation Chemistry in Russia

Branch of Federal State Unitary Enterprise

«
Karpov Institute of Physical Chemistry
»

Address
:


109 km, Kievskoye Shosse, Obninsk
Kaluga Region

Telephone
: (48439)6
-
39
-
32, 7
-
47
-
50

Fax
: (48439)6
-
39
-
11

E
-
mail: fci@KarpovIPC.ru

Branch of Federal State Unitary Enterprise


«
Karpov Institute of Physical Chemistry
»


-

high
-
energy chemistry
;

-

radiochemistry
;

-

nuclear chemistry and physics
;

-

development of new radiopharmaceuticals
;

-

chemistry of high
-
molecular weight compounds
;

-

solid state physics
;

-

radiation
-
chemical technologies
;

-

radiation and space materials technology;

-

neutron diffraction investigation and dynamics of different
class crystals
.


Areas of scientific research and development
:

Branch of Federal State Unitary Enterprise


«
Karpov Institute of Physical Chemistry
»


Up
-
to
-
date experimental and technological facilities,
including
:

-

nuclear reactor WWR
-
c
;

-

electron beam accelerators
;

-

powerful radionuclide sources of gamma radiation
;

-

wide range of technological facilities
;

-

testing and research units to investigate organic and
inorganic materials in the frames of radiation and space
materials technology projects;

-

experimental
-
production shop
.


Nuclear
-
chemical technologies


Branch of Federal State Unitary Enterprise


«
Karpov Institute of Physical Chemistry
»



Leading producer and supplier of
radiopharmaceuticals and technetium
-
99m
generators in Russia.



Karpov’s radionuclide and radiopharmaceutical
products are delivered to all Russian clinics.



Development and production of
radiopharmaceuticals for diagnostics and therapy
are realized as an integrated production cycle




.

Generator

Preparation of
reagent kits


Preparation of
radiopharmac
euticals

Nuclear reactor or cyclotron
-
based production of
radionuclides

Recovery of
radionuclides

Synthesis of
carrier
-
molecules

Labeling

Clinic

Production of
radiopharmaceuticals

Reactor WWR
-
c

Number of hot cells


9, each
handling
10000
g
-
equ
.
Ra


Number of heavy chemical
boxes
-

5

Power


1
0

MW

Fluence



5
×

10
13
n
/
cm
2

s


Number of experimental
channels



31
, including 9
horizontal


Experimental and production facilities

Currently produced radiopharmaceuticals

Isotope

Chemical form

Application

Mo
-
99

T
1/2
=
66
.0
2

h

Sodium molybdate

Technetium
-
99m

Generator

Tc
-
99m

E

=〮ㄴ〠䵥0

T1/2
=6.01 h

Sodium pertechnetate

Technetium
-
99m
generator

Diagnostics with RIA kits

Iodine
-
131

E

=〮㌶㔠䵥5

T1/2
=8.04 day

Sodium iodide in
isotonic solution

Thyroid gland, diagnostics and
therapy

Sodium iodide for
injections

Thyroid gland, diagnostics and
therapy

Sodium iodide in
capsules

Thyroid gland, diagnostics and
therapy

Ortho
-
Iodohippurate of
sodium

Kidney, diagnostics

Meta
-
Iodobenzyl
Guanidine

Adrenal, diagnostics

Samarium
-
153

E
βav.
=0.233 MeV

T
1/2
=46.7 h

Samarium oxabiphor

Palliative therapy of skeleton

Currently produced radiopharmaceuticals

Isotope

Chemical form

Application

Ferrum
-
59

E

=1.2 MeV

T1/2
=44.5 day

“Ferrum Sulphate,
59
Fe 29kBq”

Mammary gland,
diagnostics`


Carbon
-
14

E
β av.
=0.049 MeV


T
1/2
=5730 year


T
1/2 bio
=2.5 h

Urea
-
14
C

“Ureacaps,
14
C 37 kBq”

Diagnostics of
gastrointestinal
diseases:
ulcer,
malignant tumours

Technetium
-
99m generator

The design makes it possible
-

to decrease the number of
procedures, which ensure
operation condition of the
generator;

-
to use light biological
shielding;

-
to install a bactericide filter
to obtain aseptic eluate of
sodium pertechnetate
.

GMP production line
for loading Tc
-
99m
generators is under
construction

N
C
2
H
5
O
P
P
O
C
H
3
H
3
C
O
O
C
H
3
H
3
C
O
T
c
N
S
S
N
O
C
2
H
5
O
C
2
H
5
1
2
3
I
O
H
O
Radiopharmaceuticals being developed



Diagnostics of myocardial
infarction


For diagnostics of myocardial
preinfarction condition




based on fat
phenylmethylpentadecanoic acid

labeled with
123
I




99
m
TcN
-
DBODC
5
-
heterocomplex
composed of PNP
5
and
dithiocarbamate ligand

Thermoselfcollapsing
therapeutical radiopharmaceutical


Х

=
153Sm,
188
Re
, 90Y
,
117mSn

C
C
H
C
H
2
N
H
O
C
H
H
3
C
C
H
3
C
C
C
H
2
O
O
C
H
2
H
C
9
5
5
C
H
3
C
H
2
O
H
O
D
T
P
A
(
P
h
A
)
X
Nuclear
-
doped semiconductor materials

(silicon, gallium arsenide, etc. for power
electronics)

Radiation
-
modified minerals (topazes, etc.)

Items produced by radiation
-
chemical technology



to

build

up

a

facility

for

Technetium
-
99
m

generator

loading

in

accordance

with

GMP

requirements
;




to

build
-
up

an

up
-
to
-
date

facility

for

radiochemical

production

of

radionuclides

and

radiopharmaceuticals

(
investment

project

developed
)
;




to

develop

a

technology

and

build

up

a

facility

for

production

of

alpha
-
emitters

actinium
-
225

and

radium
-
223
;




to

launch

molybdenum
-
99

production

from

low
-
enriched

uranium

targets
.


Pilot projects
:


RADIATION
-


CHEMICAL TECHNOLOGIES


curing of paint coatings
on the surface of wooden, metallic and
gypsum products
;

modification
of rubber
products

(
tires, etc.
)
;

production of composite materials
(
binders and
prepregs


for
further manufacturing high
-
strength and heat
-
resistant
products
);

modification of
polyolefins

(
production of foamed
polyethylene materials and products, hot water supply and
heating pipes
,
gas distribution piping
,
heat

shrinkable tapes
for electric insulation
);

sterilization
of medical products
,
drugs
,
herbal raw material
;

synthesis of polymer latexes

for wall
-
paper and tanning
industry,

gel production for perfumery and pharmaceuticals
;

Radiation
-
chemical technologies developed by

Karpov Institute




monomer grafting onto polymer products
(
to obtain
adhesion
-
bonding surfaces and separation materials for
chemical current sources)
;



processing of minerals and microelectronic products

(
to
obtain marketable semi
-
precious stones and to increase
microchip characteristics
);



destruction of Teflon
;


radiation
-
chemical modification of Teflon;


production of porous filters
(
to purify water, air, fuel,
aggressive liquids
)

Radiation
-
chemical technologies developed by

Karpov Institute

Accelerator

Developed by

Basic technical characteristics

Energy, MeV

Power, kW

ЭЛВ
-
2

ИЯФ СО РАН

0,8


1,5

20

УЭВТ
-
0,5
-
20
-
Т
-
100
-
1

ИЯФ СО РАН

0,4


0,7

20

«Электроника У
-
003»

ЦНИИ
«Электроника»

4
-

8

5

ЭЛУ
-

4

ЦНИИ
«Электроника»

3
-

5

5

«ЭЛЕКТРОН
-
3
М»

НИИЭФА им.
Д.В.Ефремова

0,4


0,7

7

УЭЛР
-
10

10
-
Т
-
80

НИИЭФА им.
Д.В.Ефремова

8
-

10

10


Electron beam accelerators

УЭЛР
-
10
-
10
-
Т
-
80
in a trench

Locally
-
shielded
accelerator
“Electron
-
3M”


Experimental and production facilities

Technological facility for PE cross
-
linking.

Production of foamed polyethylene and heat
-
shrinkable insulation tape
.

Technical characteristics of Co
-
60

γ
-
facilities
,
total activity

1490
kCi


С
o
-
60

gamma

ray

facility

Activity,

kCi

Max

absorbed

doze,

rad/sec
.

Irradiator

dimensions
.

mm

Raise

time,

sec
.

KCB
-
500

650

550

Ø 90, h=125

180

PARKET

300

170

300 x100 x90

240

PX
-
gamma
-
30

(Researcher)

20

70

Ø 20, h=20

60

K
-
120
,

Build
.

KU

80

70

Ø 50, h=40

120

K
-
200

140

200

Ø 30, h=40

120

UGRA

100

250

Ø 30, h=30

0.5

VULKAN
1

100

250

Ø 50, h=100

0.5

VULKAN
2

100

250

0.5

Products made from
foamed polyethylene
sheets

Items produced by radiation
-
chemical technology

Heat
-
resistant polyethylene pipes

Items produced by radiation
-
chemical technology


Radiation
-
modified heat
-
shrinkable items

Items produced by radiation
-
chemical technology


Pore size,

m




-

㄰1

T潴o氠灯牯獩sy

%


†† ††††

-


䕦晩捩敮捹e潦 睡瑥爠灵物晩r慴楯i 晲f洠ㄠ


灡牴r捬敳Ⱐ%


†† †††† †††† ††
㤹⸵5

T
m
ax
,
O
C





100

To purify
:


drinking water,


beverages,


paints and resins,


photoemulsions,


water and reagents for microelectronics,


magnetic paint,


lubricants and cooling liquids.

Polyethylene filters

Branch of Federal State Unitary Enterprise


«
Karpov Institute of Physical Chemistry
»

PILOT PROJECTS



-

center of radiation sterilization and decontamination
of medical wastes;


-

specialized facility for radiation modification of
polytetrafluoroethylene