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BIOT Division Awards 2008


Weichang Zhou, ACS BIOT Awards

Chair



The Biochemical Technology (BIOT) Division of the American Chemical Society (ACS)
will present
six

division awards at the ACS national meeting in

Philadelphia
,
Pennsylvania,
August 17
-
21, 20
08
.

These awards
are the David Perlman Lecture, the
Marvin J. Johnson Award, the James M. Van Lanen Distinguished Service Award, the
Industrial Biotechnology Award, Young Investigator Award
, and the 2007 W.H. Peterson
Award
.

Another division award, Alan S
Michaels Award for the Recovery of Biological
Products will be presented every two years starting in 2007 and the next one will be in
2009. The Awards selection process starts with nominations by our division members.
Nomination packages are reviewed and j
udged by individual selection committees, which
decide the winner for the Awards. Details about these Awards, their nomination and
selection process can be found at our division website:
http:
//membership.acs.org/b/biochem/awards.html
.
In
addition,
the
2008
Elmer Gaden
Award,
D.I.C. Wang Award
and the ACS Murphree Award
in Industrial & Engineering
Chemistry

will
be presented in thi
s year’s BIOT division program.



The David Perlman Lecture



T
he BIOT division selected Robert R. Ruffolo, Jr.,
Ph.D., D.Sc. (h), D.Eng. (h)

currently
President of Research & Development for Wyeth Pharmaceuticals, and Senior Vice
President of Wyeth (Corporation) to deliver this year's Perlman Lecture. This award,
whi
ch is sponsored by Genzyme Corp., recognizes many of Dr. Ruffolo's achievements
in leading discovery and development of a number of pharmaceuticals and
biopharmaceuticals including Dobutamine (Dobutrex) for the acute management of
congestive heart failure,

Ropinerole (Requip) for Parkinson's Disease, Eprosartan
(Teveten) for hypertension and Carvedilol (Coreg/Kredex) for hypertension, angina,
myocardial infarction and congestive heart failure. His award lecture titled "

The Trials
and Tribulations of a Medi
cal Breakthrough: The Discovery and Development of
Carvedilol (Coreg) for the Treatment of Heart Failure" is scheduled for August 17.



Prior to joining Wyeth in 2000, Dr. Ruffolo he spent and 17 years at SmithKline
Beecham Pharmaceuticals (now GlaxoSmithK
line) and 6 years at Lilly Research
Laboratories. Dr. Ruffolo also holds academic positions as

Professor of Physiology and
Pharmacology at West Virginia University School of Medicine and Professor of
Pharmacology at The Ohio State University College of Pha
rmacy. Dr. Ruffolo

is a
member of

the Science & Regulatory Section Executive Committee of the
Pharmaceutical Research and Manufacturers of America (PhRMA) and the Board of
Directors of the Biotechnology Industry Organization (BIO). Dr. Ruffolo received his

B.S. degree in Pharmacy in 1973, and his Ph.D. degree in Pharmacology in 1976, both
from The Ohio State University. He has authored

nearly 500 full length publications and
200 abstracts, and has edited 17 books.


He has served on the editorial boards of 2
9
international scientific journals,

and he is the Editor
-
in
-
Chief of
Current Opinions in
Pharmacology
.


Dr. Ruffolo has received a number of prestigious awards, including the
2008 Discoverer's Award for his pioneering work on the discovery and development

of
Coreg for Congestive Heart Failure, Centennial Award for Drug Discovery (2006),
George B. Koelle Award for Scientific Excellence (2005), Chief Scientific Officer of the
Year (2004), Lorenzini Gold Medal for Biomedical Research (1999), John Jacob Abel
A
ward in Pharmacology (1988), Prix Galien Special Commendation for Excellence and
Innovation in Research (1996) and the Distinguished Alumni Award from The Ohio State
University (1989).
Dr. Ruffolo has been awarded an Honorary
Doctor of Science

degree
from
West Virginia University and

an
Honorary Doctor of Engineering

degree from the
University of Catania, Italy.


The
American Society for Information Science &
Technology

designated Dr. Ruffolo as a
Highly Cited Scientist

for being among the top
100 most cite
d Pharmacologists in the world over the past two decades.



The Marvin J. Johnson Award in Microbial and Biochemical Technology


This year’s winner of the Marvin J. Johnson Award in Microbia
l and Biochemical
Technology is Barry C. Buckland, Ph.D., Research

Vice President of BioProcess R&D,
Merck &Co., Inc.
This award, which is sponsored by Pfizer, Inc., recognizes many of
Dr.
Buckland’s

contributions to the field ranging

from enzymatic catalysis in solvents and
microbial fermentations to pioneering work in
cell culture,

metabolic engineering, and
vaccine process development. Dr. Buckland

will receive the award and present the award
lecture titled “
Lowering Cholesterol and Raising Antibodies” on August 19
.


Dr. Buckland
received a Ph.D. in

Biochemical Enginee
ring in 1974

from
University
College London

and has had an outstanding industrial career
.
In his early industrial
career, he worked at Abbott Laboratories as a Biochemical Engineer and at Lederle
Laboratories as a Senior Biochemical Engineer. In 1980, he j
oined Merck Research
Laboratories as a Director of Biochemical Process R&D,
and moved through the ranks to
become
Vice President of Bioprocess R&D in 1996.
He has made numerous significant
contributions to process development and transfer for manufacturing

of a number of
biologically made products including Ivermectin (Ivomec® and Mectizan®), Lovastatin
(Mevacor® and Zocor®), Hepatitis B vaccine (Recombivax HB®), Hepatitis A vaccine
(Vaqta®), PRP conjugate vaccine (Pedvax HIB®), chickenpox vaccine (Varivax®
),
pneumonia vaccine (Pneumovax® 23), multivalent pediatric vaccine (Hexavac®),

Echinocandin antifungal (Cancidas®), Measles
-
mumps
-
rubella
-
varicella vaccine
(PROQUAD®), Rotavirus vaccine (RotaTeq®), shingles (Zostavax®), and human
papillomavirus (Gardasil®
). In addition, he
has
held

an academic position as “Visiting
Professor” at University College London

since 1989
.

Dr. Buckland

has received
numerous recognition
s and honors for his achievements. He was elected as a member of
National Academy of Engineering

in 1997, a Fellow of American Institute of Medical
and Biological Engineering and a Fellow of International Institute of Biotechnology in
1994,
a
Fellow of University College London in 1998. He was awarded Donald Medal by
UK Institute of Chemical Engineer
ing in 2002. Dr. Buckland is currently an Associate
Edito
r for Metabolic Engineering. He has also served in numerous

leadership roles in

many engineering organizations including chairing or co
-
chairing Engineering
Conferences International’s (ECI) Cell Cul
ture Engineering, Metabolic Engineering,
Vaccine Technology and serving as
ECI’s
President
and Board of Directors.



The James M. Van Lanen Distinguished Service Award

This year's winner of the BIOT James M. Van Lanen Distinguished Service Award is


Jonath
an Coffman, Ph.D from Wyeth. The award recognizes Jon's dedication and
leadership on many fronts, but especially as the 2003 division program co
-
chair, the
division secretary between 2004 and 2006, and the Web Seminar Program Coordinator
since 2005. He has

been a very active contributor to the division's success over many
years.


Due to his work with BIOT, Dr. Coffman was featured in the 2007 ACS Annual
Report, as well as on posters at the 2007 Fall Annual meeting.

Dr. Coffman graduated with a Ph.D. in Chem
ical Engineering from University of
Wisconsin under Professor Edwin Lightfoot in 1994.

He began his industrial career at
BioSepra, then joined Genetics Institute in 1998. Genetics Institute became part of Wyeth
in 2001.

Dr. Coffman has made numerous contr
ibutions to the development and transfer
of purification processes for manufacturing of biological products including Wyeth's
platform two column purification process, and the regular use of high throughput
screening in downstream process development. He h
as been responsible for the transfer
of over ten molecules to downstream clinical manufacturing. His work has influenced the
development of all of the downstream processes of

protein therapeutics developed at
Wyeth over the last five years. He has been the

Development Team Leader coordinating
the overall

technology transfer for two clinical molecules for Wyeth BioPharma. He is
currently the purification lead on a major commercial technology transfer. He has been
granted more than four patents, with six more

pending. He has published more than
eleven articles, five of which are appearing in Biotech Bioengineering in the next few
months. He has presented at many conferences, including BIOT, IBC, Recovery of
Biological Products, the Lorne conference in Australi
a and DECHEMA in Munich.


The Industrial Biotechnology Award


BIOT will present the Industrial Biotechnology Award to
Wyeth BioPharma
Development for outstanding accomplishments in developing

a high titer, high capacity
platform process for clinical and c
ommercial

biopharmaceutical manufacturing that
embodies concepts of simplicity in

design and execution. Dr. Jeffrey S. Deetz, Assistant
Vice President,

Technology and Innovation, Biotech Process Development will accept
the

award and present the award lectu
re titled "Realizing the Vision of

Biology over
Steel: Wyeth BioPharma's Strategy for Platform Process

Development" on August 19.


The
Wyeth BioPharma
manufacturing platform integrates all aspects of process
development from molecular selection and promot
er choice to final formulation
optimization.
Traits of

the platform

include high
ly

productiv
e cell lines
developed
without gene amplification, completely defined culture medium

devoid of animal
-
derived
products

and
a two
-
column purification process

with hi
gh purity yiel
ds and robust viral
clearance. In addition to traditional activities such as cell line, bioreactor and purification
development, the platform includes applying business practices designed to streamline
activities and reduce resources as well
as systematic application of innovative
technology.



The Young Investigator Award


Huimin Zhao
, a Professor of
Chemical and Biomolecular Engineering
at the
University
of Illinois at Urbana
-
Champaign (UIUC)
is the third recipient of the ACS BIOT Young
Inve
stigator Award.


This award, established in 2006 and sponsored by Genentech,
intends to recognize an outstanding young contributor to the field of biochemical
technology and active participant in the division programs. This year’s award
recognizes

Professo
r Zhao’s outstanding contributions in the area of directed evolution
for industrial and medical biotechnology applications. The award will be presented on
August 20, followed by the award lecture titled “
Directed Evolution for Fun and Profit”.


Professor Z
hao received a Ph.D. in Chemistry in 1998 from the California Institute of
Technology. After a brief industrial career at the Dow Chemical Company, he joined
UIUC in 2000 as an Assistant Professor of Chemical and Biomolecular Engineering. He
became an Asso
ciate Professor in 2006, and was recently promoted to Professor of
Chemical and Biomolecular Engineering. He currently holds joint appointment or
affiliate at the Departments of Chemistry, Biochemistry, and Bioengineering, Institute for
Genomic Biology, an
d Center for Biophysics and Computational Biology at UIUC.
Professor Zhao has authored and co
-
authored over 70 research articles and 12 patents
with several being licensed by industry. Professor Zhao has received many awards,
honors and recognitions inclu
ding Outstanding Overseas Young Chinese Scholars Award
in 2007, DuPont Young Professor Award in 2005, and NSF CAREER Award in 2004.
Professor Zhao has served as a consultant for over 10 companies such as Pfizer,
Maxygen, British Petroleum, and Gevo. His pr
imary research interests are in the directed
evolution and rational design of proteins, pathways, and genomes for biotechnological
and biomedical applications, and in the fundamental aspects of enzyme catalysis and
gene regulation.



The Alan S Michaels

Award for the Recovery of Biological Products


The Alan S Michaels Award for the Recovery of Biological Products
was established in
2006, and is sponsored by the Recovery of Biological Products Conference Series, which
Dr. Alan Michaels helped to start in

1981. The first two award recipients were
Professor
Steven Cramer, Rensselaer Polytechnic Institute in 2006 and Professor

Maria
-
Regina
Kula, formerly Director of Institute of Enzyme Technology, Heinrich
-
Heine Dusseldorf,
Germany in 2007. This award
is
now

presented once every two years in

the BIOT
program starting 2007. Thus no award will be presented in 2008 and the next award will
be presented in 2009.



The W.H. Peterson Award

The W.H. Peterson Award is granted each year by
t
he Division of Biochemical
T
echnology to student members who present outstanding research work in sessions
sponsored by the division at ACS national meetings in the previous year. The 2007
Award was organized by Tony Cano, Michael Laska, and Gargi Seth, and sponsored by
Gibco Cell Cu
lture, Invitrogen. The winner of the 2007 Peterson Award for the best oral
presentation is Rohan Fernandez, a Graduate Student from Professor William E.
Bentley’s lab at University Maryland
-
College Park for his presentation titled
"Nanofactories for synthe
sis and delivery of signaling molecules: A tool for engineering
metabolism" The recipient of the award for
best poster

is
Chris Morrison

from
Rensselaer Polytechnic Institute for his poster presentation titled "Investigation of
chemically sensitive displa
cers using robotic High Throughput Screening, SPR, NMR
and MD simulations

" . He is co
-
advised by Professors Steven Cramer and Jonathan
Dordick.



The Elmer Gaden Award

& B&B D.I.C. Wang Award


William M. Pardridge, M.D.

Professor of Medicine,
University

o
f California
Los Angeles
Dr. Pardridge will

receive the Elmer Gaden Award honoring his 2007 publication in
“Biotechnology & Bioengineering”

titled
"Humanization of anti
-
human insulin receptor
antibody for drug targeting acros
s the human blood
-
brain barrier
"
.

The award is
sponsored by John Wiley & Sons and is presented for a paper of exceptional originality
and likely impact. Professor P
ardridge

will

present his lecture
on August 18.



Matthew DeLisa, Assistant Professor, Department of Chemical and Biomolecu
lar
Eng
ineering at Cornell University is the
winner of the
inaugural
B&B D.I.C. Wang
Award. The award, which honors a distinguished young researcher who has shown a
sustained commitment to B&B, was initiated in 2008. The award presentation will take
place

on August 18
.


The E. V. Murphree Award in Industrial & Engineering Chemistry


The E. V. Murphree Award in Industrial & Engineering Chemistry

will be presented in
the 2008 BIOT program.

Georges Belfort
, an BIOT division member and
Russell Sage
Professor of

Chem
ical and Biological Engineering from
Rensselaer Polytechnic Institute

was
named the 2008 recipient of the American Chemical Society (ACS) E.V. Murphree
Award in Industrial and Engineering Chemistry.

The award and award lecture will be
presented on Aug
ust 18.


The award recognizes outstanding theoretical or experimental research in industrial or
chemical engineering.
It recognizes

P
rofessor
Belfort’s seminal contributions in liquid
-
phase pressure
-
driven membrane
-
based processes, bioseparations engineeri
ng, interfacial
science, and affinity separations.