Bioinformatics (Attwood et al.,) - Yimg

fleagoldfishBiotechnology

Oct 2, 2013 (3 years and 8 months ago)

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Bioinformatics :

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Definitions of Bioinformatics


The study of the information content and information
flow in biological systems and processes (Michael Lieman).


is the field of science in which biology, computer science,
and information technology merge to form a single
discipline (www.ncbi.nlm.nih.gov)


Bioinformatics may be broadly defined as the interface
between Life Sciences and Computational Sciences
(
www.bic.nus.edu.sg
)


Is an interdicsiplinary research area at the interface
between computer science and biological science (Jin
Xiong, 2006)


Bioinformatics involves the technology that uses
computers for storage, retrievel, manipulation, and
distribution of information related to biological
macromolecules such as DNA, RNA, and proteins.



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Information Technology

Bioinformatics

Computer Science

Life Sciences

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BIOFORMATICS VS
COMPUTATIONAL BIOLOGY

Bioinformatics

is

limited

to

sequence,

structural

and

functional

analysis

of

genes

and

genomes

and

their

corresponding

products

and

is

often

considered

computational

molecular

biology
.


Computational

Biology

encompasses

all

biological

areas

that

involve

computation
.

For

example,

mathematical

modeling

of

ecosystem,

population

dynamics,

applications

of

the

game

theory

in

behaviour

studies
.


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GOAL OF BIOINFORMATICS

1.
Is to better understand a living cell and how it function
at the molecular level.

2.
By analyzing raw molecular sequence and structural
data, bioinformatics research can generate new insight
and provide a global perspective of the cell (The flow
of genetic information is dictated by the central dogma
of biology DNA , RNA and protein

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Bioinformatics
-
TimeLine


Single Structure :


Modeling &geometry


Simulation


Docking


Sequence, sequence
-
structure relationship:


Aligment


Structre prediction


Fold recognition


Genomic :


Dealing with many sequence


Gene finding & genome annotation


Databases


Intregrative Analysis :


Expression & proteomic data


Data mining


Simulation again…. (whole cells)

1980

1985

1990

1995

2000

2005

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Why Do We Need Bioinformatics


Data flow in biology :


Human genome project : DNA sequence


Microarray : RNA expression and levels


Proteomics : protein expression and
concentration in cells


Structural proteomic or genomic : protein
structur (and function)


Functional genomics protein function

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Human Genome Project

Pertumbuhan
database mencapai
2
-
3 Terabyte DNA

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Study of Bioinformatics

1.
Informations networks

2.
Protein information resources

3.
Genome information resources

4.
DNA sequence analysis

5.
Pairwise alignment techniques

6.
Multiple sequence alignment

7.
Secondary database searching

8.
Building a sequence search protocol
Analysis packages

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Post
-
Genome Wish List

1.
Drug Design

2.
Designer Protein and Biomaterials

3.
Genetic Engineering and gene
therapy

4.
Vaccine design

5.
Personalized medicine

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Gene Bank


National Center Biotechnology
Information

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STUDI KASUS FLU BURUNG (VIRUS H5N1)

15

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URUTAN DNA DARI VIRUS H5N1

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STRUKTUR 3D DARI VIRUS H5N1
(domain neuraminidase)

Struktur 3D untuk
mempelajari &
desain obat (new
drug desain) H5N1

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DATABASE FLU BURUNG (VIRUS H5N1)

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SEARCH FLU BURUNG (VIRUS H5N1) INDONESIA

20

HASIL DATABASE FLU BURUNG (VIRUS H5N1)

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STUDI FILOGENETIKA VIRUS H5N1

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http://www.sith.itb.ac.id/mgbm/adi.htm

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