Dear Bioinformatics Student,

fabulousgalaxyBiotechnology

Oct 1, 2013 (4 years and 1 month ago)

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1

Introduction to Genes and Biochemistry (809C7) (option course for MSc students)
and Introduction to Biochemistry (C7130) (option course for year 1 Chemists and
V&E students)


Course C
onvenor : Dr Darren Thompson (d.thompson
@sussex.ac.uk)


Course Descripti
on

This course will provide background knowledge of five basic units of Biochemistry and the
relationship between genes and proteins within the cell. Unit 1 deals with the molecules of
life, DNA, RNA, nucleotides and the central dogma of molecular biology.

Unit 2 covers the
decoding of the genetic code through the processes of transcription and translation. Unit 3
deals with proteins, their structure properties and amino acid building blocks. Unit 4 deals
with enzymes and simple enzyme catalysed reactions.
A drug design example is also
included ‘
Cycloxogenase, ibuprofen and the asprin story’
. Unit 5 covers metabolism and
uses glycolysis and Kebbs cycle as examples of typical pathways


bioenergentics is
briefly introduced. The course is suitable for those w
ith Chemisty A
-
level, a biology A
-
level
is not essential but is helpful. Where ever possible emphasis is placed on core principles


Mode
: Each unit consists
of a 2 hour seminar


Learning Outcomes



Explain the central dogma of molecular biology, and explain
the composition and
function of DNA and RNA molecules within the cell.



To be become familiar with genetic differences between eukaryotes and
prokaryotes.



Define what an enzyme is and explain the nature of catalytic mechanisms.



Describe the basic mechanisms

of energy metabolism and its importance.



Explain the significance of biological molecular recognition.

This is a modular course with a strong element of self study to assist you in gaining
familiarity with five core units of Biochemistry. It is suitable
for chemists wanting to broaden
their knowledge of biochemistry and as an introduction to Biochemistry and Molecular
Biology.



2

The course will run on Friday mornings from 9am to 11
-
00am in the SB121 (Silverstone
Building, next to Arts D). The first session

will be a double lecture / workshop with a short
break in the m
iddle.
There are two alternative standard textbooks
‘Biochemistry and
Molecular Biology’ 2
nd

(Ed. by Elliott and Elliott) and ‘Lehninger
-

Principles of
Biochemistry’ (Nelson and Cox 5
th

Ed),
both are available in the library


follow the
recommended reading in one of these
.


Ot
her textbooks can also be used:

e.g. Biochemistry. 5th Edition. Berg, Tymocko & Stryer. Freeman (2002), again use
chapter headings to follow the topics.

Course timetable

of topics and recommended re
ading.


Study Unit


Week


Topic


Time and
venue



Reading
Chapters



1.

DNA & Gene
structure

1.


8
th

Oct

Nature and
structure of DNA,
introduction to
eukaryotic and
prokaryotic genes

Dr. Darren
Thompson
(DT
)

9
-
11am
SB121

E&
E Ch 20, or
L Ch 8 and 9.

Further study
E&E Ch 21 or L
Ch24


lecture







2.

Proteins

3.

2nd

Oct

The nature of
amino acids,
hierarchy of protein
structure and
folding

DT


9
-
11am
SB121


E&E Ch 3

or L
Ch
3 & 4


Lecture


4.


29
th
Oct

MCQ test

Will be
inf
ormed



test

3.

Transcription
& Translation

5.


5
thNo
v

How the chemical
message is
decoded first into
RNA then into a
protein

Cr Neil
Crickmore
(NC)

9
-
11am
SB121


E&E Ch 22 and

Ch 24 or L Ch
26 & 27


Lecture







4.

Enzymes

7.


19
th

Nov

Nature of cat
alysis
and molecular
recognition


DT

9
-
11
-
00am
SB121


E&E Ch. 2 or L
5


Lecture







5.

Metabolism

9.


3rd

Dec

Gycolysis, Krebbs
cycle and oxidative
phosporylation

Dr. Louise
Serpell
(LCS)

9
-
11
-
00am

SB121



E&E Ch. 9 or
L 14, 16 &19

Further study
E&E Ch
. 1 & 8



10.

10
th

Dec

MCQ Test( C7130
only)


Will be
informed


test


3


ASSESMENT


Students on both C7130 and 809C7 will have a 1 hour MCQ test in week 4. This will count
for 30% of your overall module mark and will cover material covered in your first 2 t
opics.
Students on the C7130 course will have a MCQ test in week 10 and students taking
course 809C7 with have an MCQ test in the Spring term. This test will count as 70 % of
your overall module mark and will cover all material taught during the course.