Introduction to Genes and Biochemistry (809C7) (option course for MSc students)
and Introduction to Biochemistry (C7130) (option course for year 1 Chemists and
onvenor : Dr Darren Thompson (d.thompson
This course will provide background knowledge of five basic units of Biochemistry and the
relationship between genes and proteins within the cell. Unit 1 deals with the molecules of
life, DNA, RNA, nucleotides and the central dogma of molecular biology.
Unit 2 covers the
decoding of the genetic code through the processes of transcription and translation. Unit 3
deals with proteins, their structure properties and amino acid building blocks. Unit 4 deals
with enzymes and simple enzyme catalysed reactions.
A drug design example is also
Cycloxogenase, ibuprofen and the asprin story’
. Unit 5 covers metabolism and
uses glycolysis and Kebbs cycle as examples of typical pathways
briefly introduced. The course is suitable for those w
ith Chemisty A
level, a biology A
is not essential but is helpful. Where ever possible emphasis is placed on core principles
: Each unit consists
of a 2 hour seminar
Explain the central dogma of molecular biology, and explain
the composition and
function of DNA and RNA molecules within the cell.
To be become familiar with genetic differences between eukaryotes and
Define what an enzyme is and explain the nature of catalytic mechanisms.
Describe the basic mechanisms
of energy metabolism and its importance.
Explain the significance of biological molecular recognition.
This is a modular course with a strong element of self study to assist you in gaining
familiarity with five core units of Biochemistry. It is suitable
for chemists wanting to broaden
their knowledge of biochemistry and as an introduction to Biochemistry and Molecular
The course will run on Friday mornings from 9am to 11
00am in the SB121 (Silverstone
Building, next to Arts D). The first session
will be a double lecture / workshop with a short
break in the m
There are two alternative standard textbooks
Molecular Biology’ 2
(Ed. by Elliott and Elliott) and ‘Lehninger
Biochemistry’ (Nelson and Cox 5
both are available in the library
recommended reading in one of these
her textbooks can also be used:
e.g. Biochemistry. 5th Edition. Berg, Tymocko & Stryer. Freeman (2002), again use
chapter headings to follow the topics.
of topics and recommended re
DNA & Gene
structure of DNA,
E Ch 20, or
L Ch 8 and 9.
E&E Ch 21 or L
The nature of
hierarchy of protein
E&E Ch 3
3 & 4
How the chemical
decoded first into
RNA then into a
E&E Ch 22 and
Ch 24 or L Ch
26 & 27
Nature of cat
E&E Ch. 2 or L
cycle and oxidative
E&E Ch. 9 or
L 14, 16 &19
. 1 & 8
MCQ Test( C7130
Students on both C7130 and 809C7 will have a 1 hour MCQ test in week 4. This will count
for 30% of your overall module mark and will cover material covered in your first 2 t
Students on the C7130 course will have a MCQ test in week 10 and students taking
course 809C7 with have an MCQ test in the Spring term. This test will count as 70 % of
your overall module mark and will cover all material taught during the course.