PHM3192

echinoidclapBiotechnology

Dec 1, 2012 (4 years and 9 months ago)

249 views

Modified by Muhammad Taher

Date: 5/5/2006

1

COURSE OUTLINE


Kulliyyah:

Pharmacy

Department
:

Pharmaceutical Technology

Programme

B. Pharm.

Course Title

Biotechnology

and Biopharmaceuticals

Course Code

PHM3192

Status

Elective

Level

3
000 (Y
ear
3
)

Credit Hours

2

Contact hours

L = 2
4
h,
T

=
4
h. T
otal =
28

hours

Pre
-
requisites

Nil


Co
-
requisites

Nil

Teaching
Methodology

Lecture

Assignment

Tutorial


Methods of Evaluation

Mid semester
examination



40%


MCQs 10 questions





10%

Duration: 20 minutes


Short essays 2 of 3 questions


15%

Long essays
1 of 2 questions




15%

Duration: 1 hour.


End semester examinat
ion




60%


Assignment

10%

Short essays
4
out of
6

questions


20
%

Long essays 2 out of 4

questions



3
0
%

Duration: 1 hour 45

minutes


Course Coordinators:


Instructor
(
s
)
:


Asst. Prof. Dr. Muhammad Taher


Asst. Prof. Dr. Muhammad Taher


Semester offered


1








Modified by Muhammad Taher

Date: 5/5/2006

2

Course Objectives

Recent advances in the field of
biotechnology

have facilitated
the utilization of this technology for the production of various
biopharmace
u
ticals, which may exceed by m
o
re than half of
the total number of pharmaceuticals being produced in neat
future. The aim of this course
to introduce the students

to the
concept of biotechnology and biopharmaceuticals
. Second, to
give the students knowledge in biotechnology and
biopharmaceuticals technology. Third, to give the students an
understanding on the role pharmacist in biotechnology and
biopharmaceuticals

technology.


Course Synopsis

Transforming proteins and genes into therapeutics.
Therapeutics based on biotechnology and future directions.



Course Outlines

1.

Introduction to Bio
pharmaceuticals.

2.

Comparative drug development of proteins a
nd genes
versus sm
all molecule.

3.

Biotechnology industry pe
rspective on drug
development.

4.

B
iopharmaceuticals technologies and

processes in
drug development.

5.

T
herapeutics based on biotechnology, hema
topoe
t
i
c
growth f
actors and coagulation factors.

6.

I
nterferons and cytokines for

ant
i
-
infective and cancer
therapy.

7.

Hormones
.

8.

Vaccines.

9.

Advanced drug delivery.

10.

I
ntegration of
pharmacokinetic

an
d p
harmacogene
tic
principles in drug therapy.

11.

Gene and cell therapy.

12.

T
he role of genomics and proteomics.










Weeks

Topic

Instructor/Refe
rences

Modified by Muhammad Taher

Date: 5/5/2006

3


1



2







3


Introduction to Bio
phar
m
a
ceuticals



Comparative Drug Development of Proteins
and Genes

Transforming new molecular entities into drug
differences between development of
biotechnology products of macromolecule current
trends in drug
development


Biotechnology Industry Perspective on Drug
Development

Role of the orphan drug act

Clinical Leverage strategy in accelerating drug
development therapeutic consideration


Dr. Muhammad Taher

Ref. 1 p.3
-
10


Dr. Muhammad Taher

Ref. 1 p.11
-
20






Dr. Muhammad Taher

Ref. 1 p.21
-
34




4







5



6




7







8







9

Biopharmaceutical Technologies and Processes
in Drug Development

Application of biotechnologies in drug discovery
and development

Large
-
scale production of recombinant proteins

Biologic drug development and approval.


Tutorial



Therapeutics Based on Biotechnology

Hematopoietic growth factrs and coagulation
factors


Intreferons and Cytokines for Antiinfective
and Cancer Therapy

Iterferons

in cancer therapy

Interferons in viral hepatitis

Interferon
-
B in the treatment of multiple sclerosis



Hormones

Protein hormones as therapeutics

Enzymes

Enzymes therapy




Vaccines

Dr. Muhammad Taher

Ref.1 p.35
-
95









Dr. Muhammad Taher

Ref.1 p.125
-
160



Dr. Muhammad Taher

Ref. 1 p. 161
-
207






Dr. Muhammad Taher

Ref. 1 p.209
-
250






Dr. Muhammad Taher

Modified by Muhammad Taher

Date: 5/5/2006

4







10






11











12





13








14


Why vaccines?

How do vaccines work

Traditional vaccines approaches

Subcel
lular and recombinant subunit vaccines

Future directions


Advanced Drug Delivery

Rationale and basic principles

Physiology and mechanistic approaches

Approaches using devices

Molecular approaches


Integration of Pharmacokinetic and
Pharmacogenetic Principl
es in Drug Therapy


Perspective on pha
r
macogenetics

Pharmacogenetics: Drug metabolism and
transport

Pharmacogenetiecs:
Therapeutic

response

Individualized gene
-
based medicine

Current and potential application of
pharmacogenetics


Gene and Cell Therapy

Over
view of gene and cell therapeutics

Delivery and expression of genes encode
functional proteins


The Role of Genomics and Proteomics

Genomics: the first link between sequences and
drug
targets

Proteomic: From
sequences

to functions

Integrating proteomic and

genomic tools to
accelerate drug development.



Tutorial


Ref. 1. p.313
-
323






Dr. Muhammad Taher

Ref.1 p.339
-
374





Dr. Muhammad Taher

Ref. 1 p.381
-
398










Dr. Muhammad Taher

Ref.1 p.402
-
425




Dr. Muhammad Taher

Ref.1 p.427
-
443


References

Required



1.

Ho, R.J.Y., and Gibaldi, M. 2003.
Biotechnology

and Pharmaceuticals.
John
Wiley

and Sons, New Jersey.

2.

Thieman, W.J and Palladino M.A. (2004).
Introduction to Biotechnology. Benjamin
Cummings. San Francisco.

Modified by Muhammad Taher

Date: 5/5/2006

5

Proposed Start Date (Semester)

Year 2003/2004 Semester 2

Batch of students to be Affected

Year 2003/2004. (All Batch
es)