TP1. Indicative topics - Archimedes

drawerbeamerBiotechnology

Dec 6, 2012 (4 years and 7 months ago)

160 views

The Sixth RTD Framework
Programme 2002
-
2006

Thematic Priority 1

Life Sciences: Genomics &
Biotechnology for Health


http://europa.eu.int/comm/research/fp6/index_en.html

http://www.cordis.lu/fp6/

Focussing and integrating Community
research: 7 Thematic priorities


Budget (million


)

1. Life sciences: genomics & biotechnology


for health


2,255

2. Information society technologies



3,625

3. Nanotechnologies & nanosciences….


1,300

4. Aeronautics & space





1,075

5. Food quality & safety





685

6. Sustainable development, global change


and ecosystems


2,120

7. Citizens and governance…. 225

TP1. Life sciences: genomics &
biotechnology for health

Why focus on genomics ?



卥煵敮e楮朠潦o桵h慮a来g潭o ⡡湤 潴桥爠来g潭o猩



䵡橯爠潰o潲瑵湩ty 瑯t業i牯癥r桵h慮a桥h汴l



却業S汵l 景爠扵b楮i獳s慣a楶楴y



Needs to transform mass of raw data into useful
knowledge



T漠扥b捯c灥瑩瑩癥 w楴栠啓⁡湤n䩡J慮a w攠湥n搠瑯t桡h攠
愠a潯牤楮慴a搠慰a牯慣r 慴a瑨攠䕵牯灥慮a汥l敬⁦潲o浡湹
topics in genomics.



EU will invest by scientific interest and for avoiding to
become a “client”

Integration with other approaches


M畬瑩摩獣楰汩湡物iy

First call expected 17 December 2002
Deadline 25 March 2003


Thematic priority 1.

First call & Work programme


Illustrations only!



focusing on Networks of Excellence and
Integrated Projects

TP1. Life sciences: genomics &
biotechnology for health

Funding instruments

New
(inclusion of new partners during project life
-
time)

-

Networks of Excellence

-

Integrated Projects

“Traditional”

-

Specific Targeted Research Projects (STREP)

-

Co
-
ordination actions (CA)

-

Specific Support Actions (SSA)

Also don’t miss other opportunities (including fellowships)
across the whole Sixth Framework Programme!

TP1. Life sciences: genomics &
biotechnology for health

Total budget for first call:


513 million,

broken down as follows:

Instrument








(million)

Integrated project or network of excellence

385


410


Specific targeted research project or

co
-
ordination action





92


121



Specific support actions




8


10

TP1. First call: indicative budget

TP1. First call: indicative budget




15% of FP Thematic Priorities budget is for
participation of small and medium sized enterprises
(SMEs)


Specific activities



Co
-
operative research’
: carried out by research centres for SMEs

or by high
-

tech SMEs in collaboration with research centres and

universities



Collective research’
: carried out by research centres for industrial

associations or industry groupings in entire sectors of industry

dominated by SMEs

i.

Advanced genomics and its applications for health


(


1,100 m)

a. Fundamental knowledge and basic tools for functional


genomics in all organisms

(FP5: Generic Activities, Research into Genomes and diseases of
genetic origin)

b. Application of knowledge and technologies in the field


of genomics and biotechnology for health

(FP5: Key Action 3, The “Cell Factory”

TP1. Life sciences: genomics &
biotechnology for health

TP1. Life sciences: genomics &
biotechnology for health

ii.
Combating major diseases

(


1,155 m)

a. Applications
-

oriented genomic approaches to
medical knowledge and technologies

(FP5: GA 7
-
Chronic and degenerative diseases, diabetes,

cardiovascular diseases and rare diseases, GA9
-
Neurosciences,
KA6
-
Ageing population)

b. Combating cancer
(FP5: GA7)

c. Confronting the major communicable diseases


linked to poverty (AIDS, tuberculosis, malaria)

(FP5: KA2 Control of Infectious Diseases)

Expressions of Interest


Report on the analysis of expressions of interest 2002


Thematic priority 1


“Genomics and biotechnology for health”


http://www.cordis.lu/fp6/eoi
-
analysis.htm


>
Potential topics that could be used for first and
subsequent calls of FP6

>
To help potential participants become familiar with the
new instruments

TP1. Life sciences: genomics &
biotechnology for health





i.

Advanced genomics and





its applications for health

a. Fundamental knowledge and basic tools for
functional genomics in all organisms


to foster basic understanding of genomic information, by
developing the knowledge base, tools and resources needed to
decipher the function of genes and gene products relevant to
human health

TP1. Life sciences: genomics
& biotechnology for health

-

Gene expression and proteomics

-

Structural genomics

-

Comparative genomics and population genetics

-

Bioinformatics

-

Multidisciplinary functional genomics approaches


to basic biological processes

TP1. Indicative topics/
instruments for first call




Gene expression and proteomics


(2 topics in first call) (1 indicative topic for next call
(s)
)


Developing high throughput tools and approaches for monitoring
gene expression and protein profiles and for determining protein
function and protein interactions




Development of advanced array technologies


(IP/NoE)

-

for the analysis, with high precision and sensitivity,


of large sets of proteins, DNA and RNA and for


functional cell arrays

Technology development


TP1. Indicative topics/
instruments for first call






Structural genomics

(3) (2)


Developing high throughput approaches for determining


high
-
resolution 3
-
D structures of macromolecules.





Development of new hardware and software for the


implementation of innovative automated technologies at


synchrotron sites (IP)



-

developing, assembling, standardising and providing


highly integrated and automated technological platforms
at synchrotron research centres for high throughput
structural genomics



Specific and ambitious objectives


Infrastructures can be part of IP and NoE





Comparative genomics and population





genetics

(2) (4)

Developing model organisms and transgenic tools; developing
epidemiology tools and standardised genotyping protocols.




Integrated tools for functional genomics of non
-


mammalian vertebrate models for human development


and disease mechanisms (IP)



-

develop and use high throughput tools, technologies


and approaches ….

for harvesting large data sets on


gene functions...



Model organisms: to complement the ‘integrated


project’ on mouse functional genomics (funded by the


QoL programme in FP5)

TP1. Indicative topics/
instruments for first call







Bioinformatics

(1) (2)


Developing bioinformatics tools and resources for data storage,
mining and processing; developing computational biology approaches for
in silico prediction of gene function and for the simulation of complex
regulatory networks.





Developing methods and resources in bioinformatics


to focus on the annotation of human and other


genomes (NoE)

-

cooperation between life scientists and


bioinformaticians to coordinate … the design and


development of new integrated bioinformatics tools


and approaches...


Structuring the field
-

life scientists & bioinformaticians


Spreading excellence

TP1. Indicative topics/
instruments for first call



Multidisciplinary functional genomics


approaches to basic biological processes

(7) (8)


Elucidation of the mechanisms underlying fundamental
cellular processes, to identify the genes involved and to decipher
their biological functions in living organisms.



Integrated comparative and functional genomics


approaches for studying the cell cycle (IP/ NoE)

-

multidisciplinary functional genomics approaches in


different model organisms for elucidating .. Basic


mechanisms controlling the cell cycle


Basic knowledge
-

wide implications in health research

TP1. Indicative topics/
instruments for first call

Multidisciplinary functional genomics approaches to
basic biological processes

(continued)




Multidisciplinary approaches of functional genomics


to study chronic inflammation processes in human


disease (NoE)


-

co
-
ordination of research activities …


Specific diseases can be addressed ..but the emphasis


should be on basic mechanisms


Basic mechanisms
-

implications in many diseases

TP1. Indicative topics/
instruments for first call



Research areas
-

1st call
-

STREP/CA/SSA




transcription activation, signal transduction, intra
-
cellular communication, the role of non
-
coding genomic
information, mechanisms of integration of genes



in silico

prediction of gene function and simulation of
complex regulatory networks



development of new tools and approaches, including
the standardisation of protocols, to facilitate generation
of new knowledge in functional and structural genomics


TP1. Indicative topics/
instruments for first call

1
.

Advanced

genomics

and

its

applications

to

health


b. Applications of knowledge and technologies in the
field of genomics and biotechnology for health




to foster the competitiveness of Europe’s


biotechnology industry



the integration of small and medium sized


enterprises (SMEs) in projects is essential

TP1. Indicative topics/
instruments for first call

Technological

platforms

for

developments

in

the

fields

of

new

diagnostic,

prevention

and

therapeutic

tools


-

New, safer, more effective drugs, pharmacogenomics


approaches
(4) (3)


-

New diagnostics
(1) (2)


-

New in vitro tests to replace animals
(1) (1)


-

New preventive and therapeutic tools (e.g. stem cells,


immunotherapies)
(3) (6)

-

Innovative post
-
genomic research with high potential


for application

(2) (4)

TP1. Indicative topics/
instruments for first call




New, safer, more effective drugs,



pharmacogenomics approaches (4)(3)


translation of the knowledge and methods derived from
genomics into concrete applications for drug design and
development




Genome
-
based individualised medicines (NoE)



-

structuring of efforts devoted to characterisation of


drug targets.. to optimise individual drug selection,


dosage and delivery .. to improve the benefit / risk


ratio of drugs


Cooperation of research and clinical centres, ethical
bodies, regulatory authorities, healthcare providers,
pharmaceutical industry

TP1. Indicative topics/
instruments for first call






New

diagnostics

(
1
)(
2
)



early diagnosis, monitoring of disease progression


and interpretation of in
-
vivo data





Non
-
invasive diagnostics and diagnostic procedures;


development of markers for ante
-

and neo
-
natal


screening (NoE)



-

structuring of efforts devoted to development of non
-


invasive tools for pre
-
natal diagnosis and the


translation of genomics data into diagnostic


applications….


Translational research; cooperation of academia,
ethical bodies, regulatory authorities, pharmaceutical
industry

TP1. Indicative topics/
instruments for first call






New

in

vitro

tests

to




replace

animal

experimentation

(
1
)(
1
)



Directive

86/609/EEC


regarding the protection of
animals used for experimental and other scientific purposes





Combination and application of in vitro cell and
sensor technologies in the field of animal in vivo
toxicology (IP
)



-

research should focus on in vitro cell
-
based
toxicological and pharmacological tests

for screening
drug compounds


Technology development

TP1. Indicative topics/
instruments for first call




New preventative and therapeutic tools (3)(6)



integration of different research activities in genetics,
fundamental and clinical research and ethics to provide
standardised research materials such as stem cell banks, clinical
research protocols and novel preventive and therapeutic
instruments at a European level
.




New advances in cell
-
based therapies for the


regeneration of connective tissue (IP)



-

application of mesenchymal stem cell research, gene


transfer and tissue engineering for the treatment of


connective tissue diseases….. defining quality and


safety standards for tissue regeneration ... leading to


new biological implants capable of functional load


bearing



Several disciplines involved


Industry, regulatory authorities

TP1. Indicative topics/
instruments for first call



Post
-
genomics

with

high

application

potential

(
2
)(
4
)



use cutting edge technologies in a multidisciplinary
approach to address areas of research that will benefit from the
developments resulting from genomics




Plant platforms for immunotherapeutic biomolecule


production (IP)



-

focus on pharmaceuticals (vaccines, other


immunotherapeutics) for which a plant
-
based


production system offers real advantage and potential



Appropriate participation of developing countries


Experimental design to minimise ecological impact

TP1. Indicative topics/
instruments for first call





Research

areas

-

1
st

call

-

STREP/CA/SSA

New

drugs

targeting

G
-
protein

coupled

receptors

through

pharmacogenomics


Educational

schemes

utilising

interdisciplinary

approaches

for

the

integration

of

pre
-
clinical

and

clinical

research

(e
.
g
.

training

events,

workshops)


Development

of

novel

non
-
invasive

and

repeatable

diagnostics

using

bioinformatic

tools


New diagnostic tools for prion associated diseases


TP1. Indicative topics/
instruments for first call





Research

areas

-

1
st

call

-

STREP/CA/SSA


Technology

foresight

meeting

on

test

development,

validation

and

implementation


Workshop

on

business

opportunities

in

pharmaceutical

toxicology


Partnership

event

on

the

development

and

manufacture

of

toxicology

test

methods

for

regulatory

testing

needs


Forum on the achievements in raising awareness on the use of
alternative methods in Candidate Countries

TP1. Indicative topics/
instruments for first call

TP1. Life sciences: genomics &
biotechnology for health

ii. Combating major diseases

a. Applications
-

oriented genomic approaches to
medical knowledge and technologies


-

Cardiovascular disease, diabetes, rare diseases

-

Resistance to antibiotics and other drugs

-

Brain

and

combating

diseases

of

the

nervous

system

-

Human development and the ageing process

TP1. Life sciences: genomics &
biotechnology for health

ii. Combating major diseases

a. Applications
-

oriented genomic approaches to
medical knowledge and technologies


to develop improved strategies for the prevention and
management


using also advanced technologies for health
-

of
human disease and for living and ageing healthily


integrate

a

genomic

approach

through

all

relevant

organisms

into

more

established

medical

approaches

for

investigating

disease

and

health

determinants


translational

research

aimed

at

bringing

basic

knowledge

through

to

clinical

application



TP1. Indicative topics/
instruments for first call


Cardiovascular, diabetes, rare diseases (6)(4)

>
Integrating clinical expertise and resources with relevant


model systems and advanced tools in functional genomics


==>> breakthroughs in prevention and disease management

>

Pool Europe’s research resources to tackle rare diseases



Genomics of heart muscle development and disease
(NoE)




-

durable integration of researchers working on nor
-
mal/abnormal development of the heart… translation
of new knowledge to the treatment of complications
of heart disease (heart failure, arrhythmias)


Child health: congenital cardiovascular malformation

TP1. Indicative topics/
instruments for first call


Resistance to antibiotics and other drugs

(2)(4)

>
Exploitation of knowledge of microbial genomes and host
-


pathogen interactions ==>> vaccines, alternative strategies;

>

Strategies for optimal use of antimicrobials

>

Support EC network on epidemiological surveillance and


control of communicable diseases.



Testing anti
-
viral drug resistance and understanding
resistance development

(IP or NoE)




-

setting up a broad approach towards testing and
following up antiviral drug resistance in human virus
infections…. integrate basic, clinical,
pharmacological, immunological and virological
research


Brain, combating diseases of the nervous system
(6)(5)


use genome information to understand better brain function,
damage, plasticity and repair, learning, memory, cognition

in
order to gain new insight into mental processes, to combat
neurological disorders and diseases, and to improve brain
repair



Human brain tissue research (NoE)




-

research and studies on genetic and environmental

influences on brain diseases

-

standardisation of tissue sampling, shared use,
diagnosis, ethical issues, clinical history, genotyping,
accessibility and training




Infrastructural aspects, structuring the field


Spreading excellence

TP1. Indicative topics/
instruments for first call



Human development and the ageing process

(2)(4)


Human genome sequence, genomic and postgenomic research
applied to understand human development and healthy ageing
in order to develop the evidence base for improving public
strategies and to promote healthy living and healthy ageing



Genetic factors of longevity and healthy ageing


(IP/NoE)




-

to compare health status, family history, different age
and gender groups, genetic background to identify
genetic markers and expression profiles for the
prediction of … longevity and healthy ageing




Population studies, special expertise and facilities in
Europe

TP1. Indicative topics/
instruments for first call





Research

areas

-

1
st

call

-

STREP/CA/SSA


Rare disorders of plasma membrane transporters for amino
-
acids, lipids and sugars

Workshop on the structuring of European research activities
to more effectively combat drug resistant hospital infections

Specific brain research support actions

Molecular mechanisms of bone homeostasis
-

prevention or
treatment of osteoporosis


TP1. Indicative topics/
instruments for first call

ii. Combating major diseases






b. Combating cancer
(6) (8)


Establishing facilities for exploitation of research (evidence
-
based
guidelines for good clinical practice and improved public health
strategies), supporting clinical research/clinical trials, supporting
translational reseach



Translating basic knowledge of functional onco
-
genomics into cancer diagnosis and treatment (IP/NoE)


-


large
-
scale analysis to identify signalling pathways,
oncogenes, tumour supressor genes

-

epigenetic mechanisms and genomic instability

-

new molecular targets for anticancer drug discovery




Translational research


TP1. Indicative topics/
instruments for first call





c. Confronting the major communicable






diseases linked to poverty
(5) (5)


Developing candidate interventions, establishing a clinical trials
programme, establishing an AIDS Therapy Trials Network




-

HIV/AIDS



-

malaria



-

tuberculosis



Also: European and Developing Countries Clinical Trials
Partnership (EDCTP)
-

action through Treaty Article 169


TP1. Indicative topics/
instruments for first call

ii. Combating major diseases







A
dditional SSAs to be supported:


Promotion

of

SME

participation



Stimulating

international

co
-
operation



Linking

with

Candidate

Countries



Stimulating

exploitation
:

of

research

results

stemming

from

past

and

present

EU

programmes


Realising

ERA

objectives
:

activities

such

as

pilot

initiatives

on

benchmarking,

cartography,

networking,

the

debate

on

human

values

and

technology

options,

or

the

collective

management

of

the

knowledge

infrastructures

of

the

future,

etc


EU

Strategy

for

Life

Sciences

and

Biotechnology
.

Action

Plan

attached

to

COM(
2002
)
27


Supporting
future research
policy development

TP1. Indicative topics/
instruments for first call

EC contribution ?


Integrated project

Rough estimate:


10
-
15 million
-

but higher possible

(compare QoL integrated projects in FP5)

http://europa.eu.int/comm/research/fp6/pdf/ip_provisions_111102f
inal.pdf


Network of excellence (examples)


100 researchers, 25 PhD students ca


10.5 million

200 researchers, 50 PhD students ca


18.5 million

http://europa.eu.int/comm/research/fp6/pdf/noe_111102final.pdf

TP1. First call

How many integrated projects/ network of excellence
will be funded for the first call in TP1?


53 topics to be published in the call

Budget available for IP or NoE


385


410 million


Therefore, competition between proposals for the
same topic, as well as between topics


Some topics may not be funded

TP1. First call





Indicative schedule


First call published : 17 December 2002


First deadline : (25) March 2003


Other tentative deadlines :





November 2003




November 2004




November 2005

TP1. First call







Other FP6 actions






related to Life Sciences (health)





“ERA
-
NET”



Supporting the cooperation and coordination of research
activities carried out at national or regional level


Health of key groups (major diseases, rare diseases,
poverty
-
related diseases, alternative/non
-
conventional
medicine)

http://europa.eu.int/comm/research/fp6/era
-
net.html

http://europa.eu.int/comm/research/fp6/pdf/11385
-
2_en.pdf







Other FP6 actions






related to Life Sciences (health)




Anticipating science and technology needs







(“Priority 8”
-

FP5: GA10
-
11)


>
Research responding to health policy requirements:



implementation of the European Social Agenda



public health and consumer protection

>
Health determinants, provision of high quality and
sustainable health care services (ageing, demographic
change)

>
Public health issues, including epidemiology for
disease prevention

>
Impact of environmental issues on health

>
Handicapped / disabled people







Other FP6 actions






related to Life Sciences (health)




TP
2. Information society technologies



bioinformatics; data handling; communication


TP3. Nanotechnologies …
nanobiotechnology; clean
technologies; nanodevices for drug delivery; biosensors; tissue
regeneration; biomaterials (FP5: Growth and QoL KA3)




TP5. Food quality and safety
nutrition; plant and animal
biotech; food diseases and allergies; GMO traceability; functional
food; pathogenic microorganisms; BSE (FP5: QoL KA1 & 4)



TP6. Sustainable development and global change

renewable energies; marine and terrestrial biodiversity and
ecosystems (FP5: EESD)

Fundamental genomics:


manuel.hallen@cec.eu.int

Applied genomics & biotech:


alfredo.aguilar
-
romanillos@cec.eu.int

Major diseases:


alain.vanvossel@cec.eu.int

Cancer:


maria
-
jose.vidal
-
ragout@cec.eu.int

Poverty related diseases:


arnd.hoeveler@cec.eu.int

Research related to structuring / strengthening ERA:
timothy.hall@cec.eu.int

Further Information

TP1. Life sciences: genomics &
biotechnology for health