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disturbedtonganeseBiotechnology

Oct 2, 2013 (4 years and 11 days ago)

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MICROBES

Grand Challenge in
Comparative
Endocrinology

GPCR Models

Bioinformatics, genomics

Molecular

Comparative

Endocrinology

Comparative

Genomes

Structure
-
Activity

Relationships

Identifying and Mapping New
Comparative Genomes:

Novel Receptors

can be identified from
where they are annotated as to their
sequence and their percent identity

Use of
gene prediction models
; Phylogenetic
analysis

Receptors
of interest can be cloned,
expressed and tested for function

Compare to newly sequenced genomes


Frontiers in Comparative Endocrinology


GPCR Models

B
ioinformatics

Molecular

Biology

Medical &
Therapeutic
Development

Structure
-
Activity

Relationships

MOLECULAR COMPARATIVE

ENDOCRINOLOGY:

Site
-
directed mutagenesis

Pharmacological Studies

Identify binding sites

Determine activation, binding sites and
signaling pathways

Propose new
ligand

molecules


Example: NOVEL
RECEPTORS ARE
IDENTIFIED

Comparative
Endocinology

Basic, Applied and
Therapeutic/Medical Models

Discovery of Novel
Hormones and
Signaling pathways;

Discovery of New
Pharmaceuticals to
treat human disease;

Hormonally based
strategies for pest
control;

Development of

Endocrinomics


high
through put analysis


Support New
Key/alternate
model
organisms in
evolution;

Mechanisms
of Evolution
via genome
discoveries

Research
Cooperative
Networks


Highlight Cutting Edge
Discoveries

Implementation of Grand Challenges in Comparative Endocrinology

Dissemination of
Information to
public; scientists

Comparative

Endocrinology

North American Society for Comparative
Endocrinology (NASCE)

Purpose: To promote the study of hormones, hormone action in diverse animal
species; to foster interdisciplinary collaborations; to promote the development
of databases and other research tools for comparative endocrinology; to
advocate for funding for comparative endocrinology research

The NASCE will become incorporated as a nonprofit organization in the spring of
2010. A website is under development and a solicitation for charter membership
will be sent out at this time .

The society will include scientists from Canada, the USA and Mexico.

Co
-
chairs of the organizing committee:


Bob Denver, Univ. of Michigan, USA
rdenver@umich.edu

Vance Trudeau, University of Ottawa, Canada
trudeauv@uottawa.ca


Meetings of the NASCE will be held once every two years in the summer, to alternate
with meetings of the European Society of Comparative Endocrinologists.

Comparative
Endocinology

Neuroendocrine

System

Developmental,

Physiology

Behavior

Organismal

Form,

Function,

Survival

Interactions with
the

Environment

Frontiers in Comparative Endocrinology

CLIMATE CHANGE

Comparative

Endocrinology