Ohio State Talk, October 2004 - Statistical Bioinformatics - Texas ...

dasypygalstockingsBiotechnology

Oct 2, 2013 (4 years and 10 days ago)

94 views

Bioinformatics Training Program

Raymond J. Carroll

Department of Statistics

Faculty of Nutrition


Texas A&M University

http://stat.tamu.edu/~carroll



Official Name


Biostatistics, Bioinformatics and the Biological
Basis of Nutrition and Cancer



Hence the clever acronym:
http://www.stat.tamu.edu/b3nc

History


Roughly in 1997, Steve Safe started
the idea of a Center for
Environmental and Rural Health



He needed a Biostatistics Research
Core, and Jim Calvin nominated me.


History


A major point of the CERH was to
foster interdisciplinary contacts



Steve and Jim said: well you do
nutrition, go talk to them



I met Nancy Turner at a reception to
start off



History


Nancy first started telling me
about her data, namely the
idea of colonic crypts



She drew these by hand: I
wished I had saved the original
pictures


History


I then started talking with
Nancy, Joanne Lupton and their
student, Meeyoung Hong



Very cool: hierarchical
functional data!



With location effects!


History


Naisyin Wang and I then gave
the problem of these data to
our student, Jeff Morris



Jeff started spending lots of
time in the lab, and became
very knowledgeable about the
biology


History


I was at U
-
Penn for 2 years,
and just before coming back
spent a week at the Canyon
Ranch in Tucson



Very fancy food, nothing to do


History


I wrote the first draft of the
original Bioinformatics training
program grant at Canyon ranch



I called a person at the NCI,
and she suggested that I apply
for a R25T, rather than a T32.



The difference: faculty salary
money!

History


We also met Ed Dougherty of
EE, who wrote an early paper
on cDNA arrays



Robb Chapkin was a huge help
in the proposal as well

Our Goal


Our goal is to train statistically oriented
individuals (Biostatisticians, Statisticians,
Signal Processors, etc.)



To function as independent researchers in
a multidisciplinary environment focusing
on Nutrition and cancer.

The Challenge


Even the Program Officer at the NCI
thought we would not be able to recruit
trainees



Because of the restriction to U.S. citizens
and permanent residents

They Were Wrong!


We recruited a Danh Nguyen from
statistics (2001)



Aniruddha Datta from EE

Recruits in 2002


Two statisticians:



Qi Zheng



Mahlet Tadesse



Our First Pre
-
doc (2002)




Christie Spinka



Recruits in 2003


Ivan Ivanov




Kimberley Drews




Wenjiang Fu


Recruits in 2004


Michael Swartz


He has a twin brother Richard, but
these are actually two of Michael (I
think)

Resubmission in 2005


We have added a rotation through the
Genomics Facility Core



We have a systematic plan for rotations
through labs, with a final choice late in fall
of year 1

Resubmission in 2005


We received the best score in our round!!



We are now funded through July 2011



I am looking forward (not!) to 2010
resubmission

Recruits in 2005


Erchin Serepedin





Lan Zhou


Recruits in 2006


Ann Chen





Sujay Datta


Other Mentors

Marina Vannucci

Guoyao Wu

Rosemary Walzem

David Dahl

Jerry Tsai

Phil Mirkes

Laurie Davidson

Bani Mallick

Future Plans

Administrative Assistant

Joyce Sutherland runs
the day
-
to
-
day operations
for our Program, and for
the proposed new


Center for Statistical
Bioinformatics

Thanks!

http://stat.tamu.edu/~carroll