Evaluation of yeast responses to different stresses

dasypygalstockingsBiotechnology

Oct 2, 2013 (4 years and 10 days ago)

103 views

http://creativecommons.org/licenses/by
-
sa/2.0/

Medical Bioinformatics

Prof:Rui Alves

ralves@cmb.udl.es

973702406

Dept Ciencies Mediques Basiques,

1st Floor, Room 1.08

Website of the
Course:http://web.udl.es/usuaris/pg193845/Courses/Bioinformatics_2007
/

Course: http://10.100.14.36/Student_Server/

What is Medical Informatics?


What is Medical Bioinformatics?


Medical informatics has to do with all
aspects of understanding and promoting
the effective organization, analysis,
management, and use of information in
health care. MI emphasizes technology
as an integral tool to help organize,
analyze, manage, and use information.


What is Medical Informatics?


What REALLY is Medical Bioinformatics?


The science of managing information for
health care, research, education, and
administration by applying, integrating,
and evaluating information technology
along with its associated policies,
procedures, and organizational cultures.



Three Legs of MI

Policy and
Procedures

Technology

Culture



Technology



Policy



Culture

MI assisting in Medicine


Different tools and approaches of MI can help
in the decision making process.


Regulations/Privacy/Security


Database/Literature Searching
--

EMB


Public Health Informatics


Outcomes Research


Standards Development


Decision Support


Electronic Medical Record’s Development


Telemedicine


Simulation


Tools for literature search/public
health applications


Tools for literature search/public
health applications


Problems


Changing the culture of medical
doctors


These tools will become more useful as
more people use them and input data


Medical doctors are notorious for not
adapting to new tools that do not have
an instant and direct effect on their
practice and for not sharing information
freely

MI assisting in Medicine


Different tools and approaches of MI can help
in the decision making process.


Regulations/Privacy/Security


Database/Literature Searching
--

EMB


Public Health Informatics


Outcomes Research


Standards Development


Decision Support


Electronic Medical Record’s Development


Telemedicine


Simulation


Decision Making in Medicine


Decision Making obeys a hierarchy of
evidence levels.


Anecdotal Accounts


Expert Opinion


Consensus Opinion


Retrospective Analysis


Prospective Analysis (Open study)


Single Blind


Double Blind Placebo Controlled


MI assisting in Decision Making


Working in a clinic is very similar to monitoring a
continuous process.


Let physicians do what they do best:


Pattern recognition


Examine & Interact with patients


Collect and filter data


Apply the art of medicine


Let computers do what they do best:


Provide the physician with the right amount of
information they need WHERE and WHEN they need
it


Keep track of ALL the details ALL of the time

The Fundamental Principle of
Decision Theory

THE BAYES THOREM

[New Knowledge] = [Experimentation] x [Old Knowledge]

Application: Making Diagnosis

[Old Knowledge]

-

we know disease
D

prevalence,
p(D)

[New Knowledge]

-

we need to know if the patient has


disease
D

if he has symptom
S
,
p(D
|
S)

[Experimentation]

-

Bayes Theorem builds the Likelihood


Function:

L(D|S)

=
p(S
|
D)

/ {
p(S
|
D) p(D)

+
p(S
|
’D) p(‘D)
}


Now this Likelihood Function modifies the Old Knowledge:

p(D|S)

=
L(D|S) p(D)

Medical Decision Support

to mention a few

Clinical Systems

Financial

Medical Records

Comprehensive

Diagnostic Systems

QMR, Iliad, DXPlain, etc.

Pharmaceutical Prescriptions

Research

Data Mining

Health System Modeling

Medical Decision Support

Clinical Systems

Computerized Medical Record systems :

TMR

-

CMR from Duke Medical Center



Pharmaceutical System for Multiple Drug

Therapy in ICU,
Pharm
-
X



Comprehensive system for VCU HealthSystem

.

Medical Decision Support

Diagnostic Systems

Knowledge Engineering, Expert Systems, AI

are discussed in class

observations

knowledge base

decision mechanism

diagnoses

explanations

feedback to adjust observations

Medical Decision Support

Health Systems Modeling
-

1

All over the world, with an aging population, there is a
problem of how many physicians schools need to form.

People have used different types of modeling to predict
the evolution of the health care system needs

Neural

Nets

Medical Decision Support

Health Systems Modeling
-

2

With the increase of population population, there is a problem of how
many physicians schools need to form.

People have used stochastic modeling to predict the number of MDs
needed to keep the health care system working properly.

Master
Equation

Medical Decision Support

Health Systems Modeling
-

3

Medical Decision Support

Intensive Care Unit

At the ICU of Arnau Vilanova the team has developed a decision
tree method to assist them in making decisions regarding
diagnostic and treatment

Handbook of Medical Informatics


http://www.mieur.nl/mihandbook


http://www.mihandbook.stanford.edu/

Handbook of Medical Informatics

Unfortunately lacks the details on the Internet

Next: Ester Vilaprinyo


Different tools and approaches or MI can help
in the decision making process.


Regulations
/Privacy/Security


Database/Literature Searching
--

EMB


Public Health Informatics


Outcomes Research


Standards Development


Decision Support


Electronic Medical Record’s Development


Telemedicine


Simulation