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Nov 7, 2013 (3 years and 11 months ago)

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SATHYABAMA UNIVERSITY

(Established under section 3 of UGC Act,1956)


Course & Branch :M.Tech


BIN





Max. Marks:80

Title of the Paper :Systems Biology and Metabolic Engineering

Sub. Code :SBIX5008 (2011)






Time : 3 Hours

Date :01/10/2012








Session :FN

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__


PART
-

A (6 x 5 = 30)


Answer ALL the Questions

1.

When DBRF method is used in systems biology? Explain.


2.

Name an algorithm used to predict the hereditary changes.


3.

What is program tree?


4.

List the applications of Bayesian networks.


5.

Give an ex
pression for coefficients of control analysis.


6.

List the forces on protein
-
DNA and protein
-
protein interactions.


PART


B


(5 x 10 = 50)

Answer ALL the Questions


7.

Explain in detail about the diseases due to alteration of gene
regulation in human sys
tem.

(or)

8.

What is the principle and application of human genome
landscape?


9.

Brief about the approaches adopted for preparing standard
models of metabolic engineering and add a note on metabolic
networks.

(or)

10.

Elucidate on the theorems of
metabolic control theory.


11.

How do you model gene expression under stochastic conditions?

(or)

12.

Write a detailed description on E
-
cell project.


13.

What are Quasispecies and hypercycles in the model of
evolutionary studies? Explain in detail.

(or)

1
4.

Illustrate how to model protein
-
DNA and protein
-
protein
interaction in system biology.


15.

Add a detailed note on the significance of mathematica and
matlab in modeling and visualization of systems.

(or)

16.

Citing suitable examples give an essay abou
t system biology
databases and the tools available on internet.