Faculty Slides (PPT) - The Scripps Research Institute

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Chemistry Faculty

La Jolla Campus

Total Synthesis and Methodologies for Drug Discovery

Phil S. Baran, Professor of Chemistry, The Scripps Research Institute, 2003
-
present




Post Doctoral Associate 2003, Harvard University



Ph. D. Chemistry 2001, The Scripps Research Institute



Young investigator awards from GSK, Amgen, Roche, DuPont, AstraZeneca, Eli Lilly, BMS,
and Pfizer



Searle Scholar Award, 2005



NSF CAREER Award, 2006
-
2010



Alfred P. Sloan Foundation Fellow, 2006
-
2008



Beckman Foundation Fellow, 2006
-
2008



Hirata Gold Metal, 2007



National Fresenius Award, ACS, 2007



Raymond and Beverly Sackler Prize in Physical Sciences, 2009



ACS Award in Pure Chemistry, 2010



Thieme
-
IUPAC Prize in Synthetic Organic Chemistry, 2010



ISHC Katrizky Heterocyclic Chemistry Award, 2011



ACS San Diego Section Distinguished Scientist Award, 2012



Fellow, AAAS, 2012
-
Present




33 Ph.D. and 42 Postdoctoral Students



>125 Publications



>250 Invited Lectures


Synthesis routes and methods that harness innate reactivity and
embrace the logic of C

H functionalization are developed in order to
procure multi
-
gram quantities of complex natural products as well as to
invent reactions with broad utility in industrial settings.


Chemical Biology and Organocatalysis

Carlos F. Barbas, III, Professor of Chemistry and Molecular Biology

The Scripps Research Institute, 1990
-
present




Ph.D. Organic Chemistry, 1989, Texas A&M University



Faculty: Department of Molecular Biology and Chemistry, TSRI, 1991
-
present



Janet

and

W
.

Keith

Kellogg

II

Endowed

Chair,

1997
-
present



Director,

Cold

Spring

Harbor

Laboratory

Annual

Fall

Course

“Antibody

Engineering

and

Phage

Display”

1992
-
present




Scholar

of

The

American

Foundation

for

AIDS

Research,

1992
-
1995



Investigator

Award,

Cancer

Research

Institute,

1993
-
1997



Co
-
recipient

of

Presidential

Green

Chemistry

Award,

2003




Fellow,

American

Association

for

the

Advancement

of

Science,

2005




Founder

of

the

biotechnology

companies

Prolifaron

Inc
.

(acquired

by

Alexion

Pharmaceuticals

in

2000
),

CovX

Pharmaceuticals

Inc
.

(acquired

by

Pfizer

in

2008
),

and

Zyngenia

Inc
.


Tetrahedron

Young

Investigator

Award

-

Bioorganic

&

Medicinal

Chemistry,

2009


Arthur

C
.

Cope

Scholar

Award

(CSM),

2009



Recipient

NIH

Director’s

Pioneer

Award,

2010


Ranked

among

100

top

chemists

of

the

decade

2001
-
2010

by

Thomson

Reuters,

2011






Development of new therapeutic approaches to human diseases through studies at the
interface of synthetic organic chemistry, molecular biology, and medicine


According to ISI, among Top 1% Cited Chemists in citations in each of the areas of
Chemistry, Biology, Biochemistry, and Microbiology and highly cited Researcher in 2005
;
h

index = 86



19 Ph.D. and 92 Postdoctoral students



Authored >320 scientific publications



Inventor on >50 issued U.S. patents


Kinetic and Mechanistic Studies of Organic Reactions

Donna G. Blackmond, Professor of Chemistry

The Scripps Research Institute, 2010
-
present




Ph.D. Chemical Engineering 1984, Carnegie Mellon University, NSF Fellow 1981
-
84



Faculty: Department of Chemical Engineering, University of Pittsburgh, 1984
-
92



Associate Director, Merck & Co, 1992
-
95



Group Leader, Max
-
Planck
-
Institut für Kohlenforschung (DE), 1996
-
99



Faculty: Department of Chemistry, University of Hull (UK), 1999
-
2003



Faculty: Departments of Chemistry and Chemical Engineering, Imperial College (UK), 2004
-
2010




NSF Presidential Young Investigator Award, 1986
-
91



Max
-
Planck
-
Gesellschaft Award for Outstanding Women Scientists, 1998



Paul H. Emmett Award in Fundamental Catalysis, 2001



Rylander Award in Organic Reactions Catalysis, 2003



Woodward Scholar, Harvard University, 2002
-
03



Miller Institute Fellow, Berkeley, 2003



Royal Society of Chemistry Award in Process Technology, 2003



ACS A.C. Cope Scholar, 2005



Royal Society Wolfson Research Merit Award, 2007
-
2010



Royal Society of Chemistry Christopher Ingold Award, 2009




> 125 Publications



>200 Invited Lectures

Mechanistic studies in asymmetric catalysis,

Studies of the emergence of biological homochirality

Natural Products and Medicinal Chemistry

Dale L. Boger, Chairman and Professor, Department of Chemistry

The Scripps Research Institute, 1990
-
present




Ph. D. Chemistry 1980, Harvard University, NSF Fellow 1975
-
78



Faculty: Department of Medicinal Chemistry, University of Kansas, 1980
-
85



Faculty: Department of Chemistry, Purdue University, 1985
-
90



Searle Scholar Award, inaugural award recipient: 1981
-
84



NIH Research Career Development Award Recipient, 1983
-
88



Alfred P. Sloan Fellow, 1985
-
89



ACS A. C. Cope Scholar, 1988



ISHC Katritzky Award in Heterocyclic Chemistry, 1997



ACS Aldrich Award for Creativity in Organic Synthesis, 1999



Paul Janssen Prize for Creativity in Organic Synthesis, 2002



Adrien Albert Medal, RSC, 2003



Elected American Academy of Arts and Sciences, 2006



ACS Guenther Award in Natural Products, 2007



Fellow, Royal Society of Chemistry, 2009



Fellow, American Chemical Society, 2010



ACS Portoghese Lecturer, 2011



ACS Hirschmann Award in Peptide Chemistry, 2013




Among Top 100 Cited Chemists



Honorary Ph.D., Laurea Honors Causa, Univ. Ferrara, 2000



Editor
-
in
-
Chief:
Bioorganic & Medicinal Chemistry

Letters



57 Ph.D. and 160 Postdoctoral Students



530 Publications, 2 Books



>600 Invited Lectures

Natural product total synthesis and
mechanism of

action, new synthetic
methodology, medicinal chemistry,
and chemical biology

Synthetic Protein Chemistry

Philip E. Dawson, Associate Professor of Chemistry

Associate

Dean of Graduate and Postdoctoral
Studies

The Scripps Research Institute, 1997
-
present



Ph. D. Protein
Chemistry,
The Scripps Research
Institute,
1996


Postdoctoral
Associate, California Institute of Technology, 1997


Faculty, The Scripps Research Institute, 1997
-


Alfred P. Sloan
Fellow,
1999
-
2001


Elected Councilor, American Peptide Society,
2006
-
2012


Vincent du
Vigneaud

Award for
outstanding achievement in

peptide
research
, 2010


Gold Medal of the Max Bergmann
K
reis
,
2011


Chairman, American Peptide
Symposium,
2011


Elected Chairman, Gordon
Research Conference, 2016



>75
Invited
lectures


4 Scientific
Advisory Boards


4

Journal Editorial Boards


>
100 Peer Reviewed Publications


>
1,400
citations (ISI) for publication on Native Chemical Ligation


>30 graduate and postdoctoral students





Development of new methods for the chemical synthesis of proteins and
chemoselective protein bioconjugation with applications focused on the
development of antiviral agents and vaccines; biological imaging with
nanoparticles and basic research into protein folding and catalysis.


Catalysis and Organic Synthesis

Valery V. Fokin, Associate Professor

The Scripps Research Institute, 2000
-
present




Ph.D. in Chemistry 1998, University of Southern California



Among Top 10 Most Cited Chemists (ISI/Thomson, 2011)



Society of Synthetic Organic Chemistry of Japan Award (2008)



Pfizer Young Investigator Award (2002)





6 graduate students, 28 postdoctoral fellows



> 100 scientific publications



> 80 invited lectures



Inventor on 11 U.S. patents and patent applications





The

research

in

Prof
.

Fokin

s

laboratory

is

centered

on

the

discovery

of

new

catalytic

processes

and

chemical

reactivity

and

on

applying

it

to

the

studies

of

macromolecular

and

biological

phenomena
.

Projects

involve

new

reaction

development,

studies

of

the

organic

and

organometallic

mechanism,

medicinal

chemistry,

and

materials

science
.


Kim D. Janda. Ph.D.

Ely R. Callaway Jr. Chair in Chemistry,

The Skaggs Institute for Chemical Biology

Director, Worm Institute for Research & Medicine (WIRM)

Education:

B.S., Clinical Chemistry, University of South Florida, 1980

M.S., Organic Chemistry, University of Arizona, 1983

Ph.D., Organic Chemistry, University of Arizona, 1984



NIH FIRST award 1990


A.P. Sloan Fellowship 1993


A.C. Cope Scholar Award 1999


J. Clarence Karcher Lecture 2000


Outstanding Alumnus in Chemistry USF 2001


Shire BioChem Lecture 2002


Fellow AAAS 2003


Office of Life Sciences Distinguished Lecture NUS 2006


Doctor of Philosophy honoris causa, U. of Helsinki 2009


Harold A. Iddles Lecture U. of New Hampshire 2010


Harvey W. McFadden Jr. Lecture U. Nebraska Medical Center


Arran Thomas Amadeo Streppa Memorial Lecture Sealy Center for Vaccine Development 2012


Raymond N. Castle Plenary Lecture USF 2012



460 publications, 1 Book


340 Invited Lectures


Discover magazine

s Top 100 Science Stories of 2006


Bioorganic & Medicinal Chemistry American Regional Editor


PLoS ONE Associate Editor



Companies Founded: CombiChem, Drug Abuse Sciences, AIPartia


Nucleic Acid Chemistry and Biochemistry

Gerald F. Joyce, Professor of Molecular Biology and Chemistry

The Scripps Research Institute, 1989
-
present




Ph.D. 1984, University of California, San Diego



M.D. 1984, University of California, San Diego



Postdoctoral Fellow, The Salk Institute, 1985

1989



Member, U.S. National Academy of Sciences



Member, American Academy of Arts & Sciences



Chair, JASON Scientific Advisory Panel for U.S. National Security



U.S. National Academy of Sciences Award in Molecular Biology, 1994



Pfizer Award in Enzyme Chemistry, 1995



Herbert W.
Dickerman

Award, 1997



Hans
Sigrist

Prize, 1997



Head of Faculty in Chemical Biology,
F1000
, 2000

present



H.C. Urey Award, 2005



Dannie
Heineman

Prize, 2009



Technical Advisory Council, BP, 2009

present



U.S. National Academy of Sciences Miller Award, 2010

Directed evolution of nucleic acid enzymes,
synthetic biology, origins of life



10 Ph.D. students and 28 postdoctoral fellows



150 scientific publications



12 issued U.S. patents


Chemical Biology

Michael A. Marletta, Professor of Chemistry, The Scripps Research Institute

2012
-
present



Ph.D., Pharmaceutical Chemistry 1978, University of California, San Francisco


NIH Postdoctoral Fellow, MIT, 1978
-
80


Faculty: Department of Applied Biological Sciences, MIT, 1980
-
87


Faculty: Departments of Medicinal Chemistry (Pharmacy) and Biological chemistry (Medical
School), University of Michigan 1987
-
2001


Investigator: HHMI, 1997
-
2001


John G. Searle Chair, University of Michigan, 1991
-
2001


Faculty: Departments of Chemistry and Molecular and Cell Biology, University of California,
Berkeley, 2001
-
2012


Aldo DeBenedictis Distinguished Professor of Chemistry, UCB, 2001
-
12


President and CEO, The Scripps Research Institute, 2012
-
present


MacArthur Fellowship, 1995


Institute of Medicine, 1997


Harrison Howe Award, ACS, 2004


National Academy of Sciences, 2006


Repligen Award, ACS, 2007


Kaiser Award, Protein Society, 2007


Esselen Award for Chemistry in the Public Interest, ACS, 2007


Fellow, Royal Society of Chemistry 2009



>200 papers


41 Ph.D. and 35 Postdoctoral Students


Editorial Board,
PNAS


Chemistry of novel enzyme
reactions, protein structure and
function

Total Synthesis of Biologically Active
Natural and Designed Molecules

K.C. Nicolaou

Skaggs Professor of Chemical Biology

&

Distinguished Professor of Chemistry

Department of Chemistry



Department of Chemistry & Biochemistry

The Scripps Research Institute


University of California, San Diego

_________________________________________

Honors


Fellow, American Academy of Arts and Sciences


Member, National Academy of Sciences, USA


Corresponding Member, Academy of Athens, Greece


Member, German Academy of Sciences Leopoldina


Member, American Philosophical Society

Awards


Benjamin Franklin Medal in Chemistry


ACS Arthur C. Cope Award


Tetrahedron Prize for Creativity in Organic Synthesis


ACS Linus Pauling Medal

_________________________________________


750 Publications and 5 Books


66 Patents (Issued)


>450 Postdoctoral Fellows and Graduate Students

Total synthesis of natural products, new synthetic
technologies, chemical biology, medicinal chemistry.

Molecular Recognition and Self
-
Assembly

Julius Rebek, Jr., Director, Skaggs Institute for Chemical Biology and

Professor of Chemistry, The Scripps Research Institute, 1996
-
present



Ph. D. Chemistry 1970, MIT; NSF Fellow 1967
-
70



Faculty: Department of Chemistry, UCLA, 1970
-
76



Faculty: Department of Chemistry, Univ. of Pittsburgh, 1976
-
89



Faculty: MIT, Camille Dreyfus Professor 1989
-
96



Alfred P. Sloan Fellow, 1976
-
78



Guggenheim Fellow, 1986



ACS A. C. Cope Scholar, 1991



American Academy of Arts and Sciences, 1993



National Academy of Science, 1994



NIH Merit Award, 1996
-
2006



ACS Norris Award for Physical Organic Chemistry, 1997



Hungarian Academy of Science, 2001



ACS Breslow Award in Biomimetic Chemistry, 2004



European Academy of Science, 2005



Distinguished Scientist Award, ACS, San Diego, 2006



Fellow, Royal Society of Chemistry, 2009



Humboldt Senior Scientist Award, Germany, 2009



Honorary Doctorate, University of Bonn, 2010



Nichols Medal, ACS New York 2011



Prelog Medal, ETH Zurich, 2012



Among Top 100 Cited Chemists



>50 Ph.D. and > 220 Postdoctoral co
-
workers



550 Publications



>60 Named Lectureships

Molecular self
-
replication,
encapsulation and assembly;

antidotes and sensors for nerve
agents.

Ed Roberts

Ed

Roberts

is

a

Professor

in

the

Department

of

Chemistry

at

the

Scripps

Research

Institute

(TSRI)

where

he

works

on

translational

programs

in

several

therapeutic

areas

such

as

pain/inflammation,

pervasive

developmental

disorders,

multiple

sclerosis,

epilepsy,

alcohol/substance

abuse,

depression,

stress

and

anxiety
.

Much

of

his

work

revolves

around

the

design

of

compounds

exhibiting

selective

polypharmacology

and

allosteric

modulators

for

peptidergic

GPCRs
.

With

3

decades

of

medicinal

chemistry

experience,

Ed

has

enjoyed

a

very

successful

career

within

the

Pharmaceutical

industry

and

has

helped

progress

many

compounds

into

clinical

trials

and

beyond

at

Parke
-
Davis

(now

Pfizer),

AstraZeneca

and

latterly

as

Senior

Vice

President

and

head

of

all

discovery

chemistry

at

F
.

Hoffmann
-
La

Roche

in

Switzerland
.

Ed

has

been

involved

in

the

start
-
up

of

3

companies,

All

in

preclinical/clinical

development

for

Rheumatoid

Arthritis,

Cancer,

Multiple

Sclerosis

and

IBD’s
.

Ed

is

a

graduate

of

the

University

of

Sussex,

University

of

Newcastle

upon

Tyne,

Columbia

Business

school,

IMD

(Lausanne)

and

London

Business

school
.

He

was

Adjunct

Professor

at

McGill

University

(Montreal)

and

a

member

of

the

Board

of

Directors

of

Centre

Recherche

Calcul

Applique

(CERCA),

Montreal
.

Ed

is

also

past

President

of

the

Basler

Chemishe

Gasellschaft
.

Dr
.

Roberts

is

currently

Fellow

of

the

Royal

Society

of

Chemistry,

Fellow

of

the

Royal

Society

of

Medicine,

Chartered

Chemist,

Chartered

Scientist

and

Adjunct

Professor

UNE
.

Floyd E. Romesberg, Associate Professor of Chemistry,

The Scripps Research Institute, 1999
-
present




Ph. D. Chemistry 1994, Cornell Univ., NIH Fellow 1994
-
1996



Baxter Foundation Award, 2002



Camille Dreyfus Teacher Scholar Award, 2003



Susan B. Komen Breast Cancer Foundation Award, 2003
-
2006



Discover Magazine Technology Innovation Award, 2004



NSF CAREER Award, 2004


present



Member, Institute for Defense Analysis, Defense Science Study
Group, 2008
-
2009


PLoS One Editorial Board, 2006


present


CPCh Current Protocols Editorial Board, 2010


present


Founder of the biotechnology companies Achaogen, Inc. and
RQx Pharmaceuticals, Inc.




17 Ph.D. and 34 Postdoctoral Students



>100 Publications



> 80 Invited Lectures

Chemical, Biological, and Biophysical Approaches to Understanding and Manipulating Evolution

Chemical biology, microbiology, molecular biology, and biophysics are used
as part of an effort to expand the genetic alphabet and create a semi
-
synthetic organism, develop novel broad
-
spectrum antibiotics, and
understand how the evolution of protein dynamics contributes to biological
function.

New Chemical Biology from Ancient Enzymes (Aminoacyl tRNA Synthetases)


Paul Schimmel, Ernest and Jean Hahn Professor of Molecular Biology and Chemistry


Ph.D. Biophysical Chemistry, MIT 1966, Postdoctoral Fellow, Stanford University 1966
-
1967


Faculty: MIT Department of Biology 1967
-
1997 (last position, John D. and Catherine T. MacArthur Professor of
Biochemistry and Biophysics)


Faculty: The Scripps Research Institute, Departments of Molecular Biology and Chemistry (current position, Ernest and
Jean Hahn Professor of Molecular Biology and Chemistry) 1997
-
present


Faculty, Visiting Professor, Institute for Advanced Study, Hong Kong University of Science and Technology 2008
-
present


Alfred P. Sloan Fellow, 1970
-
72


Pfizer Award in Enzyme Chemistry, 1978


Elected American Academy of Arts and Sciences, 1987


Elected US National Academy of Sciences, 1990


Elected American Philosophical Society, 1999


Biophysical Society Emily M. Gray Award for Significant Contributions (co
-
recipient), 2000


Nucleic Acids Award, British Biochemical Society and Royal Society of Chemistry, 2004


Elected Institute of Medicine of US National Academy of Sciences, 2005


David Perlman Award, The American Chemical Society, 2005


Chinese Biopharmaceutical Association Brilliant Achievement Award, 2006


Ohio Wesleyan University Distinguished Achievement Award, 2007


Stein and Moore Award, The Protein Society, 2007


San Diego BioPharma Award, 2011


Frank H. Westheimer Medal, Harvard University, 2012



Author or co
-
author of over 450 scientific publications


Co
-
author of widely used 3
-
volume textbook on Biophysical Chemistry


Service on 11 journal editorial boards


Service (including chairmanships) on 25 corporate boards for profit and non
-
profit enterprises


Chairmanships and memberships on 33 committees for outside academic, scientific and government organizations





The focus of our research is the synthesis of molecules and molecular assemblies with novel physical, chemical or biological
properties and functions. We pursue a biologically inspired approach to synthesis in which the molecules and processes of liv
ing

organisms are combined with the principles and tools of chemistry to create molecules with new functions difficult to generat
e b
y
either approach alone. By studying the properties of the resulting molecules, new insights are gained into the molecular
mechanisms of complex biological and chemical systems.


Ph.D., Organic Chemistry, California Institute of Technology (1984)


Postdoctoral Fellow, Massachusetts Institute of Technology (1984)


Faculty, University of California, Berkeley, Department of Chemistry (1985
-
1998)


Principal Investigator, Lawrence Berkeley Laboratory (1985
-
2003)


Howard Hughes Medical Investigator (1994
-
2006)


Founder and Director, Genomics Institute of the Novartis Research Foundation (1999
-
2012)


Founder and Director:
Affymax

Research Institute,
Syrrx
, Kalypsys,
Phenomix
, Ambrx,
Ilypsa
, Wildcat Discovery
Technologies, Ardelyx


Founder and Director, California Institute for Biomedical Research (2012
-
present)


Scientific Advisory Board, Welch Foundation (2003
-
present)



Alan T. Waterman Award, National Science Foundation (1998)


American Chemical Society Award in Pure Chemistry (1990)


College of Chemistry Teaching Award, University of California, Berkeley (1992)


National Academy of Sciences, USA (1993)


Wolf Prize in Chemistry (1994)


Institute of Medicine of the National Academy of Sciences (1998)


2002 Paul Ehrlich
-
and Ludwig
Darmstaedter

Prize (2003)


Arthur C. Cope Award, American Chemical Society (2006)



Over 510 published manuscripts


Approximately 350 previous
predoctoral

and postdoctoral trainees


(~90 are university faculty throughout the world)



Biological Chemistry

Peter G. Schultz, Scripps Family Chair Professor, Department of Chemistry

The Scripps Research Institute, 1999
-
present



Catalysis: Biological and Abiological

K. Barry Sharpless, W.M. Keck Professor of Chemistry


The Scripps Research Institute, 1990
-
present




PhD, Stanford University (E. E. van Tamelen), 1968



postdoctoral, Stanford University (J. P. Collman), 1968



postdoctoral, Harvard University (K. Bloch), 1969

Massachusetts Institute of Technology, 1970

77, 1980

90


Arthur C. Cope Professor, 1987

90

Stanford University, 1977

80

American Academy of Arts & Sciences, 1984

National Academy of Sciences, 1985

Award for Creative Work in Organic Synthesis, 1983

Tetrahedron Prize (with Noyori), 1993

Arthur C. Cope Award, 1992

King Faisal Prize for Science, Saudi Arabia, 1995

Roger Adams Award in Organic Chemistry, 1997

Wolf Prize (with Kagan & Noyori), Weizmann Institute, 2001

Nobel Prize in Chemistry (with Knowles & Noyori), 2001


>400 Publications, 30 patents

Homogeneous Catalysis, Organic Synthesis,

Click Chemistry, Target
-
templated
in situ

Drug Design


Complex Molecule Synthesis and Methods Development

Development

of

new

anti
-
proliferative

and

antimalarial

chemotypes
;

development

of

new

methods

for

C
-
N

bond

formation




5 Ph.D. and 3 Postdoctoral Students



16 scientific publications



2 issued U.S. patents

Ryan A. Shenvi, Assistant Professor of Chemistry

The Scripps Research Institute, 2010
-
present



Boehringer
-
Ingelheim Young Investigator Award, 2012



Eli Lilly New Faculty Award, 2011



NIH Ruth L. Kirschstein Fellowship, 2008

2010

• Roche
Excellence in Chemistry Award, 2007

• Lesly Starr Shelton
Award, 2007

• NDSEG Predoctoral Fellow, TSRI, 2005

2008



Pfizer Summer Research Fellow, 2002



John and Elizabeth Holmes Teas Scholarship, 2001



William G. and Elizabeth K. Leitzell Scholarship, 2000



National Merit Corporate Scholarship, 1999


2003



Ph.D. Chemistry, 2008, The Scripps Research Institute



Postdoctoral Fellow, 2008
-
2010, Harvard University

Structure and Dynamics of Ribonucleoprotein Assemblies

James R. Williamson, Departments of Integrated Structural and Computational
Biology and Chemistry, The Scripps Research Institute, 1998
-
present

Dean of Graduate and Postdoctoral Studies




Ph. D. Chemistry, 1988, Stanford University



Jane Coffin Childs Fellow 1998
-
1990



Faculty, Department of Chemistry, MIT 1990
-
1997



Pfizer
Laubach

Professorship 1991



Searle Scholar Award, 1991



Rita Allen Scholar Award 1994



Alfred P. Sloan Fellow 1995



Camille Dreyfus Teacher
-
Scholar Award 1995



American Academy of Arts and Sciences 2010



Founder of the biotechnology company Cassia, LLC




18 Ph.D. students



37 postdoctoral fellows



> 150 publications



> 300 Invited lectures



Study of RNA
-
protein complexes using a wide variety of biophysical techniques, include X
-
ray
crystallography, NMR spectroscopy, fluorescence spectroscopy, and Electron Microscopy.

Focus on the dynamics of ribosome assembly and structures of assembly intermediates, RNA
-
protein
complexes that regulate T
-
cell activation, and DEAD
-
box helicases involved in HIV replication

Bioorganic and Carbohydrate Chemistry

Chi
-
Huey Wong, Professor of Chemistry, The Scripps Research Institute, 1989
-
present



Ph.D. Chemistry 1982, Massachusetts Institute of Technology



Faculty: Department of Chemistry, Texas A&M University, 1983
-
89



Ernest W. Hahn Chair in Chemistry, The Scripps Research Institute, 1989

2006



Professor of Chemistry, The Scripps Research Institute, 2006
-
present



Director of the Genomics Research Center at Academia Sinica, Taipei,

2003
-
2006



President, Academia Sinica, Taipei, Taiwan, 2006
-
present



ACS Cope Scholar, 1993



ACS Claude S. Hudson Award in Carbohydrate Chemistry, 1999



Presidential Green Chemistry Challenge Award, 2000



ACS Award for
Creative Work
in Organic Chemistry, 2005



F. A. Cotton Medal for Excellence in Chemical Research, 2008



ACS Arthur C. Cope Award, 2012



Nikkei Asia Prize for Science, Technology and Innovation, 2012



Elected American Academy of Arts and Sciences, 1996



Elected Member of the US National Academy of Sciences, 2002



Among Top 100 Cited Chemists, H
-
index 93



Over 680 Publications, 100 patents and 5 Books


Interests are in bioorganic and synthetic chemistry and biocatalysis, including
synthesis of complex carbohydrates, glycoproteins and small
-
molecule probes
for the study of carbohydrate
-
mediated biological recognition, post
-
translational glycosylation, and drug discovery.

Kurt Wüthrich
is the Cecil H. and Ida M. Green Professor of Structural Biology at
The Scripps Research Institute, La Jolla, CA, USA and Professor of Biophysics at the
ETH Zürich, Zürich, Switzerland. His research interests are in molecular structural
biology, and in structural genomics. His specialty is nuclear magnetic resonance
(NMR) spectroscopy with biological macromolecules, where he contributed the NMR
method of three
-
dimensional structure determination of proteins and nucleic acids in

solution. Kurt Wüthrich’s achievements have been
recognized by the Prix Louis Jeantet de Médecine, the
Kyoto Prize in Advanced Technology, the Nobel Prize in
Chemistry, and by a number of other awards and honorary
degrees.

Nuclear Magnetic Resonance (NMR) Spectroscopy

Regioselective and Enantioselective C
-
H Activation
Reactions

Jin
-
Quan Yu, Professor of Chemistry, The Scripps Research Institute


2010
-
present




Ph. D. Chemistry 1999, Cambridge University



St John’s College Research Fellow, Cambridge University, 1999
-
20
03



Postdoctor: Harvard University, 2001
-
20
02



Royal Society University Fellowship: Cambridge University 2003



Faculty: Department of Chemistry, Brandeis University, 2004
-
2007



Mukaiyama Award, Society of Organic Synthesis, Japan, 2012



ACS Cope Scholar Award, 2012



98 Publications, 6 patents

C
-
H activation/C
-
C bond and C
-
heteroatom bond forming reactions


Short synthesis of pharmaceutically interesting compounds
via

C
-
H bond
disconnection; New methods for heterocycle synthesis


Structural diversifications of biologically active natural products through C
-
H

functionalization method


Late
-
stage installation of radioactive markers for biological studies



Chemistry Faculty

Florida Campus

Chemistry and Chemical Biology

Kate S. Carroll, Associate Professor of Chemistry, The Scripps Research Institute,
2010
-
present





Damon Runyon Post Doctoral Fellow 2003, UC Berkeley



Ph. D. Biochemistry 2002, Stanford University



Faculty: Department of Chemistry, University of Michigan, 2006
-
2010



Leukemia and Lymphoma Society Special Fellow Award, 2006



Biological Sciences Scholar Award, University of Michigan, 2006



American Heart Association Scientist Development Award, 2008



Camille Dreyfus Teacher
-
Scholar Award, 2010



ACS Pfizer Award in Enzyme Chemistry, 2013




Editorial Board:
Journal of Biological Chemistry, FASEB Journal



Board of Directors: TargAnox Biotechnology Company



6 Ph.D. and 10 Postdoctoral Students



>50 Publications



>75 Invited Lectures

Protein post
-
translational modifications that contribute to human health
and disease with specific projects in the areas of cancer, inflammation,
and bacterial infection. We use the techniques of organic synthesis,
biochemistry, and chemoproteomics as tools to study and manipulate
complex cellular processes.

Designer Small Molecules Targeting RNA

Matthew D. Disney, Associate Professor of Chemistry, The Scripps Research Institute,





2010
-
present




Ph. D. Chemistry 2003, University of Rochester



Postdoctoral Associate MIT and ETH, Zurich 2003
-
2005



Faculty: Department of Chemistry and Center of Excellence in


Bioinformatics, University at Buffalo, SUNY 2005
-
2010



American Chemical Society Eli Lilly Award in Biological Chemistry. 2013



American Chemical Society Carbohydrate Division


David Y. Gin Award. 2012



University at Buffalo, Exceptional Scholar. 2011



Camille & Henry Dreyfus Teacher
-
Scholar Award. 2010



Research Corporation Cottrell Scholar Award. 2008



NYSTAR James D. Watson Young Investigator Award. 2007



Camille & Henry Dreyfus New Faculty Award. 2005



Howard Hughes Medical Institute Research Fellow. 1997





3 Ph.D. and 11 Postdoctoral Students



>60 publications



>40 Invited Lectures

Structural and Chemical Biology

of RNA

Chemistry, Biochemistry and Medicine

Thomas Kodadek, Vice
-
Chairman and Professor of Chemistry & Cancer Biology

The Scripps Research Institute, Scripps Florida 2009
-
present




Ph. D. Organic Chemistry 1985, Stanford University



Post
-
doctoral: Biochemistry & Molecular Biology, 1985
-
1987, UCSF



Assistant, Assoiate. and Professor of Chemistry & Biochemistry, Univ. of Texas at Austin, 1987
-
1998



Professor of Internal Medicine & Molecular Biology, UT
-
Southwestern Medical Center, 1998
-
2009



Director, Division of Translational Research, UT Southwestern Medical Center, 2005
-
2009

• American Cancer Society Junior Faculty Research Award (1989
-
1991)

• Fellow of the AAAS (elected 1999)

• NIH Director’s Pioneer Award (2006
-
2011).

• Founding Chief of the Editorial Board, Molecular BioSystems,


Royal Society of Chemistry, 2004
-
2009

• Associate Editor, Chemistry & Biology, 1999
-
2003

• Editorial Board, Chemistry & Biology, 1998
-
Present

• Editorial Board, Curr. Op. In Chemical Biology, 2000
-
present

• Scientific Advisory Boards, Stratagene, Opko, Sigma
-
Aldrich,


Receptors, LLC

Research:

Dr.
Kodadek’s

laboratory develops chemical tools for
medicine and biology. He has made fundamental contributions
to our understanding of organometallic atom transfer reactions,
the biochemistry of genetic recombination and transcription and
to the study of protein
-
protein interactions His current work
focuses on the discovery of serum biomarkers for the early
diagnosis of disease and the development of highly selective
drugs and chemical probes.

Synthetic Methods and Natural Products

Glenn C. Micalizio, Associate Professor of Chemistry, The Scripps Research Institute


2008
-
present



• Postdoctoral Fellow 2003, Harvard University


(Helen Hay Whitney Fellow)

• Ph. D. Chemistry 2001, University of Michigan


(American Chemical Society Division of Organic Chemistry Fellow)



Faculty: Department of Chemistry, Yale University, 2003
-
2008




Lilly Grantee Award, 2006



Boehringer Ingelheim New Investigator Award, 2007



American Cancer Society Research Scholar Award, 2006



Beckman Young Investigator Award, 2005



Boehringer Ingelheim Award, 2005



Lilly New Faculty Award, 2003

• Rackham Predoctoral Fellow, 2000






17 Ph.D. and 13 Postdoctoral Students



> 50 Publications



> 78 Invited Lectures



Inventor on 2 U.S. Patents

Natural product total synthesis,
natural product
-
inspired function
-
oriented synthesis,

new synthetic methodology

Chemical and Biological Engineering

Brian M. Paegel, Assistant Professor of Chemistry & Molecular Therapeutics,

The Scripps Research Institute, 2009
-
present




Ph. D. Chemistry 2003, UC Berkeley



NIH NRSA Postdoctoral Fellow, TSRI 2005
-
2006



NIH Pathway to Independence Award 2007
-
2011



Faculty: Department of Chemistry, 2009




NIH Director’s New Innovator Award, 2011



Lasker Lecturer, 2010

















1 Ph.D. and 3 Postdoctoral Students



16 Publications



6 patents

microfluidics

protein evolution

supramolecular chemistry

high
-
throughput screening

encoded combinatorial synthesis

Organometallic Chemistry

Roy A. Periana, Professor of Chemistry, Director of Scripps Energy & Materials Center,
The Scripps Research Institute, Florida, 2007


present




Ph. D. Organic Chemistry 1985, University of California, Berkley


Graduate Scholastic Honor Society, University of California, Berkley,


1983
-
1985


Science

publications, 1993, 1998, 2003


Co
-
Founder and Vice President of Research, Catalytica, 1994


2000


Professor of Chemistry, Department of Chemistry and Loker Hydrocarbon


Research Institute, University of Southern California, 2000


2007


Japan Society for the Promotion of Science (JSPS) Fellowship, 2007


Visiting Associate: Chemistry and Chemical Engineering,


California Institute of Technology (Caltech), 2001


present


Faculty Associate: Power Environmental & Energy Research Center,


California Institute of Technology, 2003


present



Co
-
Founder & Board Member: Qateomix, Inc., 2005


present



Management Committee, The Center for Catalytic Hydrocarbon


Functionalization, 2009


present


13 Ph.D., 6 Undergraduate, and 9 Postdoctoral Students



79 Publications


21 Patents


110 Invited Lectures

Synthesis, reaction mechanisms
and homogeneous catalysis
with a focus on developing new,
low temperature, selection
conversion chemistry of small
molecules such as
CH
4
, O
2
,
H
2
O, CO
2

and N
2
.

Natural Products and Medicinal Chemistry

William R. Roush, Professor of Chemistry

The Scripps Research Institute, 2005
-
present




Ph. D. Chemistry, Harvard University 1977



Faculty: Department of Chemistry, MIT, 1978
-
86



Faculty: Department of Chemistry, Indiana University, 1987
-
97



Faculty: Warner
-
Lambert Park Davis Professor of Chemistry,

Department of Chemistry, University of Michigan, 1997
-
2004



Chair, Department of Chemistry, University of Michigan, 2002
-
04



Alfred P. Sloan Fellow, 1982
-
86



Alan R. Day Award of Philadelphia Organic Chemists Club, 1994



ACS A. C. Cope Scholar, 1994



ACS Paul G.
Gassman

Distinguished Service Award, 2002



ACS Guenther Award in Natural Products, 2004


Fellow of the American Association for the

Advancement of Science, 2006


Fellow of the American Chemical Society, 2009



80 Ph.D. (74 completed) and 82 Postdoctoral Students



>300 Publications



>500 Invited Lectures

Natural product total synthesis, development of new synthetic

methodology , stereochemistry of organic reactions, structure

based drug design, chemical biology and medicinal chemistry

Natural Products Chemistry

Ben Shen, Professor of Chemistry and Molecular Therapeutics

The Scripps Research Institute, 2011
-
present




Ph.D., Chemistry, 1991, Oregon State University



Faculty, Department of Chemistry, UC Davis, 1995
-
01



Faculty, Department of Chemistry and Division of Pharmaceutical Sciences, UW
-
Madison, 2001
-
10



Searle Scholar Award, 1997
-
2000



NSF CAREER Award, 1998
-
03



American Society of Pharmacognosy, Matt Suffness Award, 2000



NIH Independent Scientist Award, 2001
-
06



American Society of Pharmacognosy Jack L. Beal Award, 2002



Charles M. Johnson Distinguished Chair, UW
-
Madison, 2004
-
10



Fellow, American Academy of Microbiology, 2011



Fellow, American Association for the Advancement of Science, 2011




12 Ph.D. and 58 Postdoctoral Students



175 Publications



210 Invited Lectures

Natural product isolation and structural elucidation

Natural product biosynthesis, engineering, and structural diversity

Natural product mode of action and chemical biology

Natural product anticancer and antiinfectious drug discovery

Enzyme reaction mechanism and structural biology

Metabolic pathway engineering and synthetic biology

Enzymology and Chemical Biology

Paul R. Thompson, Associate Professor of Chemistry

The Scripps Research Institute, 2010
-
present




Ph. D. Biochemistry, 2000, McMaster University, Canada



Faculty: Department of Chemistry and Biochemistry, University of South Carolina, 2003
-
2010.



Faculty: Department of Chemistry, TSRI, 2010
-
present.


Chair and Associate Chair, Enzymes, Coenzymes & Metabolic Pathways Gordon Research
Conference 2013
-
2014


2010 South Carolina Governor’s Young Scientist Award for Excellence in Scientific Research


Camille Dreyfus Teacher Scholar Award 2009


Executive Committee, Department of Chemistry and Biochemistry, University of South Carolina,
08/2008
-
05/2010.


American Chemical Society Division of Biological Chemistry Nominating Committee, 2008
--
11.


New Investigator of the American Heart Association, 2005


Canadian Institutes for Health Research Post Doctoral Fellowship,

2000
-
2003


Thomas Neilson Scholarship, McMaster University, 1996


NSERC Graduate Student Fellowship (PGS B), 1996
-
1998


NSERC Graduate Student Fellowship (PGS A), 1994
-
1996


Graduated Summa Cum Laude, McMaster University, 1994

Works at the interface of chemistry and biology to validate new therapeutic
targets for inflammatory diseases and cancer, with an emphasis on arginine
modifying enzymes.


11 Ph.D. and 15 Postdoctoral Students



Authored >75 scientific publications



Inventor on >3 issued U.S. patents