LUB 605 Bioinformatics

austrianceilBiotechnology

Oct 1, 2013 (3 years and 6 months ago)

61 views

Bioinformatics

LUB

605 / 05


Coordinator:

Trantírek L.

Other lecturers:

Oborník M.

Žurovec M.

m牥牥煵楳q瑥猺



LUB
〲0



Základy buněčné biologie

C牥摩d猺

6

䡯畲ly⁤潴a瑩潮⡬oc瑵牥猯灲éc瑩ces⤺

㈯2

啮楴r

汥l瑵牥猺

桯畲猯睥e欠

啮楴r映灲ac瑩ca汳l

桯畲猯睥e欠

Se浥獴m爺

獵浭e爠

Sc桥摵汥d

汥l瑵牥搠dvery yea爠

Ty灥映fxa浩湡瑩潮o

c潭扩湥搠dxa洠

佢橥c瑩癥猺

周T⁳畢 ec琠慩浳⁡琠t渠楮瑲潤畣瑩潮⁩湴漠o灰汩e搠
扩潩湦潲浡瑩捳⸠呥c桮楱he猠s湤⁡灰汩ca瑩潮猠潦o

e⁢楯 湦潲浡瑩捳⁩渠瑨攠浯汥m畬慲
-
扩潬og楣á氠慮l
扩潣桥浩ca氠牥searc栠h猠睥汬⁡猠楮⁴桥
扩潴ec桮潬潧y a牥 g楶敮á

C潮瑥湴o散瑵牥猺

ㄮ1I湴牯摵c瑩潮⁩湴漠扩潩湦潲浡瑩捳
佢l牮r
䡩獴潲yⱤ,晩湩瑩潮ⱴ敲浩湯汯ny⁡湤整桯摯汯gy
潦⁢楯楮景o浡瑩捳㈮⁓敱me湣e

da瑡扡獥猠
⡏扯牮bSe煵qnc楮g映䑎䄬A乁⁤a瑡扡se猬s
獥a牣桩hg⁩渠䑎䄠摡瑡ta獥猬si䅓吠A潯汳Ⱐ楮á
獩s楣漠瑲a湳污瑩潮映䑎AⱰ牯瑥楮á
摡瑡扡獥猬獥arc桩湧⁩渠灲潴敩渠摡瑡扡獥献″⸠
䝥湯浩c⁤ 瑡ta獥猠⡏扯牮楫r䝥湯浥n
獥煵q湣楮gⱳ瑲,瑥gáe猠潦sge湯ne
獥煵q湣楮g⹃潭o
汥瑥⁳ q略湣e猠潦⁰牯歡ry潴oc
a湤⁥畫ury潴oc 来湯浥n
-
牥污瑥搠
摡瑡扡獥献s物湣楰áe猠潦sbS味⸠T
-
㘮⁍潬ec畬慲
灨y汯gene瑩c猠⡏扯牮b 䡯e⁴漠慬楧渠湵c汥潴楤攠
a湤⁡浩湯nc楤⁳敱áe湣es⹐hy汯来湥瑩c
reconstructions, methods for phylogenetic
analyses.Models for nuc
leotide and amino acid
substitutions.Phylogenetic artifacts and methods
for their elimination.Evolution of an organism,
evolution of a gene.Multiprotein
-
based
phylogeny.Evolution of metabolic pathways. 7.
Introduction into biomolecular stereochemistry
and
reactivity (Trantírek) Terminology,
introduction into protein and nucleic acid
reactivity. 8
-
9. Protein structure, function and
chemical and phzsical properties of proteins
(Trantírek) Classification of the protein structures.
In silico methods for a predi
ction of the function,
physical and chemical properties of the
proteins.Prediction of the spectral properties of
the proteins and their use for interpretation of the
experimental data. 10. Protein families (Trantírek)
Structural blocks of the protein struc
ture.Method
for protein structure prediction and
determination.Functional vs. structural homology.
11. Protein localization (Obornik) Protein
targeting and in silico prediction of their
intracellular localization 12. Databases and web
-
tools for structural
genomics and proteomics
(Trantírek) 13. Structure
-
function relationship for
nucleic acids (Trantírek) 14. Structure
-
function
relationship for saccharides
and small organic
compounds. Bioinformatics approaches to drug
design and development (Trantirek) 15.
Bioinformatics approaches to gene expression:
microarray data analysis ( Žurovec)

Content of practices:

Practical training of the methods covered by the
lectures

Literature:



Bioinformatics and Functional Genomics
(2003) Wiley
-
Liss, USA.



A.M. Lesk: Introduction to Protein
Architecture, Oxford University Press,
20013.



M. Obornik, L. Trantirek: Úvod do
bioinformatiky, in preparation