2012_MIP 225 syllabus

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1 Οκτ 2013 (πριν από 3 χρόνια και 8 μήνες)

101 εμφανίσεις

Syllabus

for
Advanced Bacteriology

MICRO 2
25


Li Shen

lshen@lsuhsc.edu

MEB6217

568
-
4076

Joy Sturtevant


jsturt@lsuhsc.edu

MEB6207

568
-
6116



Major objectives:
introduc
e

core
Knowledge:

1)

Overview of disease(s) associated with bacterial family (pathogens and microflora)

2)

Genome, structure, physiology
, and environmental requirements

of bacteria
.

3)

A
ntibacterial reagents and drug resistance

3)

Mechanism of pathogenesi
s

4)

Techniques used in Bacteriology

Research

5)

Applications of bioinformatics in basic bacterial research

6
)

Discussion of current literature relevant to topics presented


Articles will be chosen that
focus on bacteria pathogen and host interaction


Pa
rt I

Principles and basic concepts of
M
edical
B
acteriology


This section will focus on basic characteristics of bacteria and overall themes that are shared by bacteria with regard to
initiating pathogenesis and survival strategies in the host.

Problem Set
s will reinforce concepts taught in lectures and
test the students on ability to apply concepts to
solving theoretical experimental problems focusing on bacteria
-
host
interactions.


Part II

Advanced topics

in Bacterial Pathogenesis.

Classes in part II w
ill focus in detail upon specific examples of
bacterial

pathogenesis related attributes and the
experimental approaches which have been used to study them. This section will focus on how the

concepts and

techniques presented in Part I
are applied
.


Each se
ction will consist of two days.

On day one the general topic will be introduced and then the focus will usually be
on one
or two
organism
s

which

will be covered in more detail.
On day two

students will participate in discussion and
presentation

of journal
article(s).


Part III

Metagenomics, Microbiome, Bioinformatics

This section will focus on application of bioinformatics to bacterial disease. It will showcase new technology
that
can
provide more effective methods to provide information about the microbi
ome. This will include current methodologies
of deep sequencing and

corresponding

data analysis.



Resources
:

1)

Schaechter’s

Mechanisms of Microbial Disease

2)

http://www.
textbookofbacteriology.net/


EVALUATION

Participation in class discussions

20%

Problem sets and journal article discussion/ critiques

20%

Midterm exam covering material presented in Part I: short answer

20%

Final
Exam:

2 sessions during week of Dec 3

40%

CLASSES:
TUES
/
THURS

9
-

11:00
,
SMALL

MIP CONFERENCE ROOM


PART

1




Thu

Aug
1
6

Overview of Course;
Establishment of
I
nfection
D
iseases




Li Shen



Tue

Aug
2
1

Biology of Bacteria
I


Ken Johnston


Thu

Aug
2
3


Biology of Bacteria II



Ken

Johnston


Tue

Aug
28

Approaches to
S
tudy
B
acteria
l

P
athogenesis

(Genetics/ Gene expression)

Li Shen

Thu Aug 30

Approaches to
S
tudy
B
acteria
l

P
athogenesis (
Classical
)

Ken Johnston


T
ue

Sep 4

Problem Day

*

STAFF

Thu Sep 6

Bacterial Toxins and Secretion Systems


Li Shen









Tue
Sep
1
1


Strategies to Fight Bacterial Infections

Joy Sturtevant



Thu

Sep

1
3

Bacterial Survival Strategies

Joy Sturtevant




Tue Sep 18


Antibiotics and Antibiotic Drug Resistance



Jeff

Hobden


Thu

Sep
2
0

Resistant

/ susceptibility testing/ clinical implications

Jeff Hobden






Tue

Sep
2
5

Problem Day

*

STAFF

Thu

Sep
2
7

Midterm exam* (in class)




PART 2

Advanced
T
opics:
B
acteria
l

Pathogenesis

Examples of
Types of Bacterial Infections

Tue

Oct

2


Gram
+

B
acterial
I
nf
ection
s

I
: Staphylococcus and Streptococcus

Ken

Johnston

Thu

Oct

4

Gram+

B
acterial
I
nfection
s

II

Ken

Johnston


Tue
Oct
9

Gram
-

Bacterial Infections I
: Pseudomonas and others

Jeff Hobden




Thu

Oct

11

Gram
-

Bacterial Infections II

Jeff Hobden


Tue

Oct

16

Chlamydia

I
:

STD Infections and other types

Li

Shen


Thu

Oct

18

Chlamydia

II



Li Shen





Tue
Oct
23

Mycoplasmas I: STD infections and others types

Chris McGowin




Thu
Oct 25

Mycoplasmas II

Chris McGowin


Tues
Oct

30


Biofilm
s I

Tom Wen


Thu Nov
1

Biofilms II

Tom Wen





Tue

Nov
6

I
ntracellular
P
athogens

I:

M
ycobacteria


Arnold Zea


Thu
Nov
8

Intracellular Pathogens II: Mycobacteria

Arnold

Z
ea



Tue

Nov
13

Plague: Past, Present, and Future

Sturtevant, Ramsay


BIOINFORMATICS


Chris McGowin, Chris Taylor

Thu Nov 15

Metagenomics, microbiome, bioinformatics I



Tue Nov 20

Metagenomics, microbiome, bioinformatics II

Thu

Nov
2
2

Thanksgiving







Tue

Nov
2
7

Metagenomics, microbiome, bioinformatics III

Thu Nov 29

Metagenomics, microbiome, bioinformatics IV





FINAL


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