change during 2000-2002… - IVA

Firms that produce, analyse, or use biological systems

on a micro
-
, cellular
-
, or molecular level or firms that develops

tools and supplies for these purposes.

Biotechnology

Food

Agriculture

Pharmaceuticals

Medical Technology

Forestry

Pulp & Paper

Environment

Instruments

& equipment

Chemistry

THE BIOTECH INDUSTRY:

•

Agrobiotechnology

-

plant improvement and biological
plant protection


•

Bioproduction

-

biomolecular or micro
-
organism production

•

Biotech tools and supplies

-

services, processes,
equipment and instruments for biotechnological use

•

Environmental biotechnology

-

soil, water, and waste
treatment

•

Functional food and feed

-

mainly probiotics

•

Pharmaceuticals and medicine

-

drug discovery and drug
development, diagnostics and medical technology

The Swedish biotech industry

Number of biotechnology companies

in different countries year 2000


0
200
400
600
800
1000
1200
1400
No. of
Companies
USA
Japan
Korea
Canada
Germany
UK
China
France
Sweden
Spain
Italy
Australia
Israel
Taiwan
Netherlands
Finland
Switzerland
Denmark
Belgium
Norway
Russia
South Africa
India
Estonia
Latvia
Lithuania
Poland
Slovakia
Country
0
200
400
600
800
1000
1200
1400
No. of
Companies
USA
Japan
Korea
Canada
Germany
UK
China
France
Sweden
Spain
Italy
Australia
Israel
Taiwan
Netherlands
Finland
Switzerland
Denmark
Belgium
Norway
Russia
South Africa
India
Estonia
Latvia
Lithuania
Poland
Slovakia
Country
Source: The Swedish Trade council,

”Global perspectives on bioscience 2002”

*

Number of companies and employees

Year

2677

3233

3391

3760

3975

0

20

40

60

80

100

120

140

160

180

200

1997

1998

1999

2000

2001

0

500

1000

1500

2000

2500

3000

3500

4000

4500

Number of

companies

Number of

employees

The regional distribution of the Swedish biotech industry 1999*

* The sizes of the circles are proportional to the number of employees/companies.

Only micro
-
, and small sized companies (<200 employees) are included.

The distribution is based on the seat of the county government.

No. of employees

No. of companies

Number of companies

0

20

40

60

80

100

120

1997

1998

1999

2000

2001

Agrobiotechnology

Bioproduction

Biotech tools & supplies

Environmental biotechnology

Functional food & feed

Pharmaceuticals & medicine

Number of

companies

Year

Number of employees

0

500

1000

1500

2000

2500

1997

1998

1999

2000

2001

Agrobiotechnology

Bioproduction

Biotech tools & supplies

Environmental biotechnology

Functional food & feed

Pharmaceuticals & medicine

Number of

employees

Year

Turnover

0

500

1000

1500

2000

2500

1997

1998

1999

2000

Year

Turnover

(MSEK)

Agrobiotechnology

Bioproduction

Biotech tools & supplies

Environmental biotechnology

Functional food & feed

Pharmaceuticals & medicine

Number of companies

pharmaceuticals & medicine

0

10

20

30

40

50

60

1997

1998

1999

2000

2001

Diagnostics

Drug delivery

Drug discovery & development

Medical technology

Number of

companies

Year

Number of employees in

pharmaceuticals & medicine

0

200

400

600

800

1000

1200

1997

1998

1999

2000

2001

Diagnostics

Drug delivery

Drug discovery & development

Medical technology

Number of

employees

Year

Median equity/assets ratio

Year

20

30

40

50

60

70

80

1997

1998

1999

2000

Finacial strength,

median (%)

Agrobiotechnology

Bioproduction

Biotech tools & supplies

Environmental biotechnology

Functional food & feed

Pharmaceuticals & medicine

Net profits/losses in surviving companies in


the different biotech sectors, 1998
–

2001

-
1200

-
1000

-
800

-
600

-
400

-
200

0

200

1998

1999

2000

2001

Year


MSEK

Total

Agrobiotechnology

Bioproduction

Biotech tools & supplies

Environmental biotechnology

Functional food & feed

Pharmaceuticals & medicine

Share of surviving companies with net profit

1998
-
2001 in total and in each sector

0

20

40

60

80

100

1998

1999

2000

2001

Year

Per cent

Agrobiotechnology

Bioproduction

Biotech tools & supplies

Environmental biotechnology

Functional food & feed

Pharmaceuticals & medicine

Total

Size of sector in Sweden

•

PHARMACEUTICALS AND MEDICAL TECHNOLOGY


Approximately 30 000 employees and a turnover of 60 billion SEK


•

BIOTECHNOLOGY


•

The
fourth largest biotechnology industry in Europe after

Great Britain, Germany, and France * and the ninth in the world
**


•

183 SMEs (< 500 emp. each), increase by 35% 1997
-
2001


•

About
4000 employees,
increase by 48% 1997
-
2001


•

Turnover 4.4 billion SEK (2000), increase by
30 % 1997
-
2000***


•

Increased financial strength
and

net losses 1997
-
2001

* European Commission; Ernst & Young

** The Swedish Trade Council

*** Fixed prices

Reasons for the development

UNTIL 1999

•
The science base

•
The presence of Astra and Pharmacia

•
An internationally growing market

•
Success stories inspires

•
Changed attitudes

•
Good availability of seed and venture capital


CHANGE DURING 2000
-
2002…2003

•
Development at the stock exchange

•
Cautious venture capital companies

•
Lack of seed capital

The Swedish science base in international comparison

THE SWEDISH SCIENTIFIC PERFORMANCE IN GENERAL


•

The trend is increased quantity but at the same time there are


signs of decreasing quality.


PERFORMANCE IN A SELECTION OF LIFE SCIENCE FIELDS


•

First, second or third ranking of publication volumes in relation to


population in the selected seven subject fields.


•

Five out of seven fields showed increasing shares of the world’s


total publication volume.


•

Four out of seven fields showed increased citation levels but


still Swedish citation levels are loosing their top position


1986
-
1989

1990
-
1993

1994
-
1997

1998
-
2001

Total

87
-
01

Biochemistry & Biophysics

2

2

2

2

2

Biotechnol & Appl Microbiol

3

4

3

1

2

Cell & Developmental Biol

3

3

2

2

2

Immunology

1

2

2

2

2

Microbiology

2

2

4

3

3

Molecular Biology & Genetics

2

2

3

2

2

Neurosciences & Behavior

1

1

1

1

1

Swedish ranking in relation to population

1986
-
2001

Relative citation levels in

biochemistry and biophysics

0.6

1.0

CANADA

DENMARK

EUROPEAN UNION

FINLAND

FRANCE

GERMANY

ISRAEL

NETHERLANDS

SWEDEN

SWITZERLAND

UK

USA

1.2

1.4

1.6

0.8

Relative citation levels in

neurosciences and behavior

0.4

0.6

0.8

1.0

1.2

1.4

CANADA

DENMARK

EUROPEAN UNION

FINLAND

FRANCE

GERMANY

ISRAEL

NETHERLANDS

SWEDEN

SWITZERLAND

UK

USA

0
5
10
15
20
25
30
35
40
1987-
1989
1990-
1992
1993-
1995
1996-
1998
1999-
2001
Year
Per cent
KAROLINSKA
INST
LUND UNIV
UPPSALA UNIV
GOTHENBURG
UNIV
UMEA UNIV
STOCKHOLM
UNIV
SLU
LINKOPING
UNIV
SMI
Volume shares for the nine most productive Swedish public
research organisations of the total Swedish publication volume

in biotechnology
-
related science, 1987
-
2001

Co
-
authorship pattern between organisations with the largest

publication volumes in biotechnology related science 1997
-
2001


’

0

1

2

3

4

1987
-
1989

1990
-
1992

1993
-
1995

1996
-
1998

1999
-
2001

The Swedish percentage of the world
´
s total

publication volume within a selection of life

science fields during

five periods (1987
-
2001)

0

1

2

87
-
91

88
-
92

89
-
93

90
-
94

91
-
95

92
-
96

93
-
97

94
-
98

95
-
99

96
-
00

97
-
01

Relative citation levels for Swedish articles within a selection
of life science fields during 1987
-
1997 (Index world=1)

Inventor origin for biotechnology patents

in the US patent system 1987
-
2001*

USA
63,9%
Great Britain
3,6%
Canada
2,6%
Germany
4,6%
Japan
11,4%
France
2,9%
Other
11,0%
* Sweden < 1%

0

1

2

3

1987
-
1989

1990
-
1992

1993
-
1995

1996
-
1998

1999
-
2001

Swedish inventor shares of the world’s total patenting volume
during five periods in different areas compared to the
Swedish average share in all fields 1987
-
2001

Number of patents for Astra and Pharmacia

0

10

20

30

40

50

60

70

80

YEAR

NUMBER OF PATENTS

AstraZeneca AB

Pharmacia Corporation