Current topics in microbial genomics and bioinformatics

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1 Οκτ 2013 (πριν από 3 χρόνια και 10 μήνες)

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Short course on

Microbial Genomics and Bioinformatics

S. DasSarma,
Summer

2012

University of Maryland, Baltimore


Course summary:

With

the
advent

of
g
enomics and bioinformatics
in the late
20
th

century
,
biologists

have
no longer need
ed

to
be
reducti
onists
,

a
nd
may
study biological

systems

from
holistic
and

integrative perspective
s
.
T
his 6 week

course

begin
s

with a retrospective on

the

technological

developments le
a
d
ing

to
th
e genomics revolution. The course
then
explores a

novel group of
microorganisms,
salt
-
loving halophilic Archaea
,

or
Haloarchaea
,

as model
s

for

how genomic and bioinformatic studies
are leading to new knowledge and
paradigm shifts in
gene and genome function
.

S
equencing

and annotation
,
comparative genomic
s, functional genomics, and tra
nslational research

approaches are
explored
, as is

the
potential for

advancing

current and
future
applications in biotechnology.


Instructor:

Prof. Shiladitya DasSarma, Department of Microbiology and
Immunology, and Institute of Marine and Environmental T
echnology,
University
of Maryland,
Baltimore MD, USA
. Email:
sdassarma@som.umaryland.edu


Lecture topics:

Date

Time

Title

June 2
9

11 am


noon

From genes to genomes:
Historical development of
genomics

and bioinformatics

Ju
ly

6

11 am


noon

Sequencing, annotation, and the power of comparative
genomics: Revealing the genome’s core and signature

July
13

11 am


noon

A functional genomic
s

approach: Transcriptional responses
and reactions to environment
al perturbations

July
20

11 am


noon

Functional genomic analysis of DNA replication, repair, and
recombination

and Computer databases

July 2
7

11 am


noon

Genome structure and dynamics:
Biology and evolution of
a large plasmid

Aug 3

11 am
-

noon

Metag
enomic and t
ranslational research: Archaea and
human diseases