Cyclophosphamide Home Care

voraciousdrabΛογισμικό & κατασκευή λογ/κού

14 Δεκ 2013 (πριν από 3 χρόνια και 10 μήνες)

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V11.0526. Information taken from
http://www.smallanimaloncology.com

Home care for your pet on
C
yclophosphamide


C
yclophosphamide

-

The brand name of this drug is
Cytoxan
.

C
yclophosphamide

is

given
either orally or by injection to treat certain types of cancers as well as some other conditions.
The drug is metabolized to its active form by the liver.


Handling of Waste Products

-

C
yclophosphamide

should not be handled by pregnant women at
all
. This drug can be absorbed

through skin contact and therefore should always be handled
while wearing protective

gloves. After removing gloves, wash your hands with soap and water.
Any time skin

contact occurs, the area should be washed immediately with
soap and water.

C
yclophosphamide

may be absorbed through the skin via contact with urine, feces, saliva
, vomit
and blood
. You should wear nitrile gloves, or double gloves with the regular kind, if you need to
clean up any bodily fluids. Any washable ite
ms that come into contact with these should be
handled wearing gloves and a protective gown if needed, then washed twice. Pregnant owners
should not clean up any wastes at all and should avoid significant contact with saliva for about 3
days. It will als
o be a good idea to not sit with the pet on your lap. Use thes
e precautions for a
minimum of 36

to
48

hours.


When to call the vet

-

Call us if your pet is:


Vomiting more than 3 times in an hour or 6 times in a day.


Suddenly lethargic or febrile.


Not ea
ting.


Passing blood from any orifice.


Appearing to be painful or anxious.


Adverse effects

-

C
yclophosphamide

can cause vomiting and nausea
.
To help prevent nausea
and vomiting, we will give a medication called Cerenia before each administration and
recom
mend one dose the next day and as needed after that. If diarrhea occurs, we will send you
with a medication called
metronidazole

to give as needed. Although chemotherapy agents can
cause hair loss, we rarely see this in pets. It is more likely to be see
n with certain breeds such as
Poodles, Old English Sheepdogs and terrier breeds.


C
yclophosphamide

will often suppress bone marrow, which can lead to low platelet
counts and lowering of a certain white blood cell called neutrophils. Low platelets can lead to
increased bruising or bleed and low neutrophils will increase the patient’s susceptibility to
infections. We recommend routine blood work immediately prior to
C
yclophosphamide

administration, 10 days after each administration and whenever there are any problems or
concerns. This will help to monitor these effects as well as others.


Effects on th
e bone marrow usually peak at about 7 to 14 days and may take up to 4
weeks for the bone marrow to fully recover.


Our goal is to avoid all of the above side effects, though realistically some dogs may be
affected. If side effects are significant, dosage
may need to be changed or in severe cases, the
drug may have to be removed from the protocol. If any of the above signs seem serious or
persistent, please give us a call.



It is not recomm
ended for us in pregnant animals

and has been shown to cause st
erility
in males
. It is excreted in breast milk, so nursing offspring should be bottle fed while the mother
is being treated.


V11.0526. Information taken from
http://www.smallanimaloncology.com


A unique adverse effect of this drug is a condition called sterile hemorrhagic cystitis,
which initially presents itself with pa
inful urination and/or blood in the urine. If these signs
occur, treatment with cyclophosphamide should be discontinued and the pet should be seen by
the veterinarian for further tests. Other, less common side effects include depression, infiltrates
and
fibrosis of the lungs, reduced sodium content in the body and immunosuppression.


Drug interactions


Phenobarbital and similar drugs can increase the metabolism of this drug,
which may increase the occurrence of toxic effects. Allopurinol and thiazide
-
type diuretics can
increase the bone marrow suppression seen with this drug. The absorption of digoxin
can be
decreased by treatment with cyclophosphamide. Use with other cardiotoxic agents such as
doxorubicin can increase the risk of cardiotoxicity.